Abstract Title:

Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms.

Abstract Source:

Arch Womens Ment Health. 2014 Jun ;17(3):213-9. Epub 2014 Mar 25. PMID: 24663685

Abstract Author(s):

Monique Robinson, Andrew J O Whitehouse, John P Newnham, Shelley Gorman, Peter Jacoby, Barbara J Holt, Michael Serralha, Jessica E Tearne, Pat G Holt, Prue H Hart, Merci M H Kusel

Article Affiliation:

Monique Robinson


Pregnancy is a time of vulnerability for vitamin D insufficiency, and there is an emerging literature associating low levels of 25(OH)-vitamin D with depressive symptoms. However, the link between 25(OH)-vitamin D status in pregnancy and altered risk of postnatal depressive symptoms has not been examined. We hypothesise that low levels of 25(OH)-vitamin D in maternal serum during pregnancy will be associated with a higher incidence of postpartum depressive symptoms. We prospectively collected sera at 18 weeks gestation from 796 pregnant women in Perth (1989-1992) who were enrolled in the Western Australian Pregnancy Cohort (Raine) Study and measured levels of 25(OH)-vitamin D. Women reported postnatal depressive symptoms at 3 days post-delivery. Women in the lowest quartile for 25(OH)-vitamin Dstatus were more likely to report a higher level of postnatal depression symptoms than women who were in the highest quartile for vitamin D, even after accounting for a range of confounding variables including season of birth, body mass index and sociodemographic factors. Low vitamin D during pregnancy is a risk factor for the development of postpartum depression symptoms.

Study Type : Human Study

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