Abstract Title:

Ovulation-inducing drugs and ovarian cancer risk: results from an extended follow-up of a large United States infertility cohort.

Abstract Source:

Fertil Steril. 2013 Dec ;100(6):1660-6. Epub 2013 Sep 5. PMID: 24011610

Abstract Author(s):

Britton Trabert, Emmet J Lamb, Bert Scoccia, Kamran S Moghissi, Carolyn L Westhoff, Shelley Niwa, Louise A Brinton

Article Affiliation:

Britton Trabert


OBJECTIVE: To examine the relationship of ovulation-inducing drugs and ovarian cancer.

DESIGN: Retrospective cohort study, with additional follow-up since initial report.

SETTING: Five large reproductive endocrinology practices.

PATIENT(S): In a retrospective cohort of 9,825 women evaluated for infertility at five clinical sites in the United States between 1965 and 1988 with follow-up through 2010, we examined the relationship of ovulation-inducing drugs and ovarian cancer (n = 85).


MAIN OUTCOME MEASURE(S): Hazard rate ratios (RR) and 95% confidence intervals (CI) for ovarian cancer.

RESULT(S): Among women evaluated for infertility, there was no association of ovarian cancer risk with ever use of clomiphene citrate (CC) (adjusted RR 1.34, 95% CI 0.86-2.07) or gonadotropins (RR 1.00, 95% CI 0.48-2.08) and no evidence that any of several more detailed subgroups of usage were related to an increased risk with one exception: women who used CC and remained nulligravid did demonstrate much higher risks than those who successfully conceived compared with nonusers (respectively, RR 3.63, 95% CI 1.36-9.72 vs. RR 0.88, 95% CI 0.47-1.63).

CONCLUSION(S): Our overall results were reassuring and consistent with other studies. A reason for an association between CC use and ovarian cancer among persistently nulligravid women remains to be determined. Given the large and increasing number of women treated with ovulation-inducing drugs, the increased risk of ovarian cancer among the subset of women who remained nulligravid should be further monitored.

Study Type : Human Study
Additional Links
Adverse Pharmacological Actions : Carcinogenic : CK(1048) : AC(155)

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