Article Publish Status: FREE
Abstract Title:

Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis.

Abstract Source:

Int J Biol Sci. 2019 ;15(11):2497-2508. Epub 2019 Sep 7. PMID: 31595166

Abstract Author(s):

Wenbin Liu, Wei Li, Haidan Liu, Xinfang Yu

Article Affiliation:

Wenbin Liu


Deregulation of glycolysis is a common phenomenon in human colorectal cancer (CRC). In the present study, we reported that Hexokinase 2 (HK2) is overexpressed in human CRC tissues and cell lines, knockout of HK2 inhibited cell proliferation, colony formation, and xenograft tumor growth. We demonstrated that the natural compound, xanthohumol, has a profound anti-tumor effect on CRC via down-regulation of HK2 and glycolysis. Xanthohumol suppressed CRC cell growth bothand. Treatment with xanthohumol promoted the release of cytochrome C and activated the intrinsic apoptosis pathway. Moreover, our results revealed that xanthohumol down-regulated the EGFR-Akt signaling, exogenous overexpression of constitutively activated Akt1 significantly impaired xanthohumol-induced glycolysis suppression and apoptosis induction. Our results suggest that targeting HK2 appears to be a new approach for clinical CRC prevention or treatment.

Study Type : Animal Study, In Vitro Study

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