Abstract Title:

Yeast, beef and pork extracts counteract Clostridium difficile toxin A enterotoxicity.

Abstract Source:

FEMS Microbiol Lett. 2009 Jun;295(2):218-25. Epub 2009 Apr 14. PMID: 19416358

Abstract Author(s):

Peter I Duncan, Grigorios Fotopoulos, Elisabeth Pasche, Nadine Porta, Isabelle Masserey Elmelegy, Jose-Luis Sanchez-Garcia, Gabriela E Bergonzelli, Irène Corthésy-Theulaz

Article Affiliation:

Nestlé Research Center, Lausanne, Switzerland. [email protected]


Clostridium difficile is responsible for a large proportion of nosocomial cases of antibiotic-associated diarrhoea and pseudomembranous colitis. The present study provides evidence that yeast, beef and pork extracts, ingredients commonly used to grow bacteria, can counteract C. difficile toxin A enterotoxicity in vitro and in vivo. In model intestinal epithelial cells the individual extracts could prevent the toxin A-induced decrease in epithelial barrier function and partially prevented actin disaggregation and cell rounding. Mice with ad libitum access to individual extracts for 1 week had almost complete reduction in toxin A-induced fluid secretion in intestinal loops. Concomitantly, the toxin A-induced expression of the essential proinflammatory mediator Cox-2 was normalized. Moreover this protective effect was also seen when mice received only two doses of extract by intragastric gavage within 1 week. These results show that yeast, beef and pork extracts have the potential to counteract the intestinal pathogenesis triggered by C. difficile toxin A.

Study Type : Animal Study

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