Abstract Title:

Young Barley Indicates Antitumor Effects in Experimental Breast Cancer In Vivo and In Vitro.

Abstract Source:

Nutr Cancer. 2016 May-Jun;68(4):611-21. Epub 2016 Apr 4. PMID: 27042893

Abstract Author(s):

Peter Kubatka, Martin Kello, Karol Kajo, Peter Kruzliak, Desanka Výbohová, Karel Šmejkal, Petr Maršík, Anthony Zulli, Gabriela Gönciová, Ján Mojžiš, Andrea Kapinová, Radovan Murin, Martin Péč, Marián Adamkov, Ronald M Przygodzki

Article Affiliation:

Peter Kubatka


The effect of dietary administered young barley containing a mixture of phytochemicals to female rats for the prevention of N-methyl-N-nitrosourea-induced mammary carcinogenesis was evaluated. After carcinogen administration (14 wk), mammary tumors were removed and prepared for histopathological and immunohistochemical analysis. Moreover, in vitro evaluation of possible mechanisms in MCF-7 breast cancer cell line was performed. Barley (0.3%) demonstrated mild antitumor effect in mammary carcinogenesis, yet 3% barley did not further improve this effect. Immunohistochemical analysis of rat tumor cells in treated groups showed significant increase in caspase-3 expression and significant reduction in Ki67 expression. In addition, 3% barley significantly decreased dityrosine levels versus control. Barley in higher dose significantly decreased serum low-density lipoprotein-cholesterol in rats. In vitro studies showed that barley significantly decreased survival of MCF-7 cells in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and significantly decreased 5-bromo-20-deoxyuridine incorporation versuscontrol. Barley prevented cell cycle progression and extended incubation with barley showed significant increase in the percentage of annexin V/propidium iodide-positive MCF-7 cells. Our results propose an antitumor effect for the mixture of phytochemicals present in young barley in a breast cancermodel.

Study Type : Animal Study, In Vitro Study

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