Article Publish Status: FREE
Abstract Title:

The effect ofand carvacrol on wheezing, FEV1 and plasma levels of nitrite in asthmatic patients.

Abstract Source:

Avicenna J Phytomed. 2017 Nov-Dec;7(6):531-541. PMID: 29299436

Abstract Author(s):

Azam Alavinezhad, Mahdiyeh Hedayati, Mohammad Hossein Boskabady

Article Affiliation:

Azam Alavinezhad


Objective: The preventive effect ofin animal models of asthma has been reported. In the present study, its effect on wheezing, forced expiratory volume in 1 second, and plasma nitrite (NO) in asthmatic patients was studied.

Materials and Methods: In this study, forty asthmatic patients including 15 males and 25 females (aged 45.8±6.21 years) were randomly allocated in four groups including placebo group (P), and three treatment groups which received two doses of(groups Z low and Z high that received 5 and 10 mg/kg/day, respectively) and carvacrol (group C treated with 1.2 mg/kg/day). All patients were treated for two months in a double-blind manner. At three time points (before starting the treatment (pretreatment), and one and two month after treatment), wheezing during day and exercise, forced expiratory volume in 1 second and NOwere measured.

Results: Day wheeze and exercise wheeze were significantly reduced in treated groups with carvacrol and both doses ofcompared to pretreatment (p<0.05 to p<0.01). However, FEV% was significantly increased in treated groups with carvacrol and both doses of(p<0.05 to p<0.001). Plasma level of NOwas also significantly decreased in Z high and carvacrol groups after two months of treatment (p<0.01 to p<0.001). However, most of evaluated parameters in placebo group did not show significant changes during the study.

Conclusion: and its constituent, carvacrol, improved FEV% while reduced wheezing and plasma level of NOin asthmatic patients. Therefore, a possible therapeutic potential for this plant and its constituent, carvacrol could be suggested to be used against asthma.

Study Type : Human Study

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