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Article Publish Status: FREE
Abstract Title:

Zerumbone mediates apoptosis and induces secretion of proinflammatory cytokines in breast carcinoma cell culture.

Abstract Source:

Iran J Basic Med Sci. 2021 Nov ;24(11):1538-1545. PMID: 35317109

Abstract Author(s):

Muttiah Barathan, Kumutha Malar Vellasamy, Zaridatul Aini Ibrahim, Vanitha Mariappan, See Mee Hoong, Jamuna Vadivelu

Article Affiliation:

Muttiah Barathan

Abstract:

Objectives: To investigate the potential anti-breast cancer activity of zerumbone in regulating apoptotic mediators and cytokines in comparison with paclitaxel (positive control).

Materials and Methods: In this study, assays such as viability, apoptosis, reactive oxygen species, cell cycle, DNA fragmentation, and cytokines were carried out on MCF-7 cells after treatment with zerumbone and paclitaxel.

Results: The results showed that zerumbone demonstrated a higher (18-fold) ICvalue (126.7µg/ml) than paclitaxel (7.29 µg/ml) in order to suppress proliferation and induce cell death of MCF-7. The cell cycle arrest at the G0/G1 phase and excessive intracellular ROS production during thezerumbone treatment indicated occurrence of apoptotic cell death although nuclear DNA fragmentation was not observed. The flow cytometer analysis of treated cells revealed secretion of proinflammatory cytokines suggesting the potential immunomodulatory activity of zerumbone.

Conclusion: Although, zerumbone exhibited a higher ICvalue compared with paclitaxel yet its anticancer activity against MCF-7 cells is still parallel to paclitaxel hence zerumbone has the potential to be an antineoplastic agent in the treatment of breast cancer especially the luminal type A.

Study Type : In Vitro Study

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