Article Publish Status: FREE
Abstract Title:

Zinc sensitizes prostate cancer cells to sorafenib and regulates the expression of Livin.

Abstract Source:

Acta Biochim Biophys Sin (Shanghai). 2013 May ;45(5):353-8. Epub 2013 Feb 21. PMID: 23435194

Abstract Author(s):

Xiaochi Chen, Xiangyu Che, Jianbo Wang, Feng Chen, Xuejian Wang, Zhiwei Zhang, Bo Fan, Deyong Yang, Xishuang Song

Article Affiliation:

Xiaochi Chen


In prostate carcinogenesis, normal zinc-accumulating epithelial cells are transformed into malignant cells that do not accumulate zinc. Increased levels of zinc have been shown to induce apoptosis through a caspase-dependent mechanism with down-regulated anti-apoptotic proteins in prostate cancer cells. Our previous study showed that, as a member of the inhibitor of apoptosis proteins (IAPs) family, Livin could play an important role in the initiation of human prostate cancer and promote cell proliferation by altering the G1-S cell cycle transition. In the present study, we measured the apoptosis sensitivity of prostate cancer cells to zinc and sorafenib and found that zinc sensitized prostate cancer cells to sorafenib-induced apoptosis. Surprisingly, we also found that, unlike its counterparts Survivin and cIAP2, Livin was not decreased all the time; instead, it was compensatively increased in zinc-mediated apoptosis at 48 h in prostate cancer cells. Our results offer potential treatment combinations that may augment the effect of sorafenib, and also reveal, for the first time, that increased Livin expression may play a role in the early cell death response of prostate cancer cells to zinc.

Study Type : In Vitro Study

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