Abstract Title:

The influence of zinc supplementation on metabolic status in gestational diabetes: a meta-analysis of randomized controlled studies.

Abstract Source:

J Matern Fetal Neonatal Med. 2019 Sep 12:1-6. Epub 2019 Sep 12. PMID: 31438733

Abstract Author(s):

Xiujuan Li, Jinqiu Zhao

Article Affiliation:

Xiujuan Li


Zinc supplementation has emerged as an important approach to improve metabolic status in gestational diabetes. However, its use has not been well established. We conduct a systematic review and meta-analysis to evaluate the efficacy of zinc supplementation to improve metabolic status for gestational diabetes.PubMed, Embase, and the Cochrane Central Register of Controlled Trials are searched. Randomized controlled trials (RCTs) assessing the influence of zinc supplementation (or its combination) versus placebo on metabolic status of gestational diabetes are included. Two investigators independently have searched articles, extracted data, and assessed the quality of included studies. Meta-analysis is performed using the random-effect model.Five RCTs involving 263 patients are included in the meta-analysis. Compared with control intervention for gestational diabetes, zinc supplementation is associated with significantly reduced FPG (std. MD = -0.52; 95% CI = -0.82 to -0.21; = .0008), insulin (std. MD = -0.68; 95% CI = -0.98 to -0.37; < .0001), HOMA-IR (std. MD = -0.77; 95% CI = -1.08 to -0.45;<.00001), and increased QUICKI (std. MD = 0.58; 95% CI = 0.28-0.89; = .0002) as well as zinc change (std. MD = 0.90; 95% CI = 0.58-1.21; < .00001), but has no remarkable influence on LDL-cholesterol (std. MD = -0.13; 95% CI = -0.43-0.17; = .40), and total cholesterol (std. MD = -0.28; 95% CI = -0.63-0.07; = .11).Zinc supplementation is effective to decrease FPG, insulin, HOMA-IR and improve QUICKI in gestational diabetes, but has no significant impact on LDL-cholesterol and total cholesterol.

Study Type : Meta Analysis

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