Article Publish Status: FREE
Abstract Title:

Zingerone suppresses angiogenesis via inhibition of matrix metalloproteinases during tumor development.

Abstract Source:

Oncotarget. 2016 Jul 26 ;7(30):47232-47241. PMID: 27323807

Abstract Author(s):

Woom-Yee Bae, Jae-Sun Choi, Ja-Eun Kim, Chan Park, Joo-Won Jeong

Article Affiliation:

Woom-Yee Bae


Angiogenesis is an essential step for tumor survival and progression, and the inhibition of angiogenesis is a good strategy for tumor therapeutics. In this study, we investigated the therapeutic effect of zingerone in a mouse tumor model. Zingerone suppressed tumor progression and tumor angiogenesis. Moreover, we found that zingerone inhibited the angiogenic activities of endothelial cells by both direct and indirect means. A mechanistic study showed that the activities of MMP-2 and MMP-9 in tumor cells were decreased by treatment with zingerone. Interestingly, zingerone-mediated inhibition of MMP-2 and MMP-9 was involved in the JNK pathway. In conclusion, zingerone showed strong anti-angiogenic activity via the inhibition of MMP-2 and MMP-9 during tumor progression, suggesting that zingerone may be a potential therapeutic drug for human cancers.

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