Latest GMI Study Abstracts

Latest GMI Study Abstracts

Paeoniflorin alleviates high glucose-induced endothelial cell apoptosis in diabetes mellitus by inhibiting HRAS-activated RAS pathway.

Article Published Date : Jul 29, 2024
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin : CK(559) : AC(359)
Diseases : Diabetes Mellitus: Type 2 : CK(11728) : AC(2454), Endothelial Dysfunction : CK(2708) : AC(569)
Pharmacological Actions : Anti-Apoptotic : CK(4942) : AC(2983)

Paeoniflorin suppresses ferroptosis after traumatic brain injury by antagonizing P53 acetylation.

Article Published Date : Sep 30, 2024
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin : CK(559) : AC(359)
Diseases : Traumatic Brain Injury : CK(455) : AC(146)
Pharmacological Actions : Neuroprotective Agents : CK(17667) : AC(7518)

The combination of paeoniflorin and metformin synergistically inhibits the progression of liver fibrosis.

Article Published Date : Oct 14, 2024
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin : CK(559) : AC(359)
Diseases : Liver Fibrosis : CK(862) : AC(388)
Pharmacological Actions : Anti-Fibrotic : CK(1964) : AC(987), Hepatoprotective : CK(8320) : AC(3710)
Additional Keywords : Natural Substance/Drug Synergy : CK(1458) : AC(694)

Targeting STAT3 signaling pathway in the treatment of Alzheimer's disease with compounds from natural products.

Article Published Date : Aug 18, 2024
Study Type : Review
Additional Links
Substances : Paeoniflorin : CK(559) : AC(359), Rutin : CK(455) : AC(218)
Diseases : Alzheimer's Disease : CK(4948) : AC(2119)
Pharmacological Actions : Neuroprotective Agents : CK(17667) : AC(7518), STAT3 Inhibitor : CK(317) : AC(215)

Paeoniflorin alleviates DSS-induced ulcerative colitis.

Article Published Date : Aug 29, 2024
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin : CK(559) : AC(355)
Diseases : Ulcerative Colitis : CK(1378) : AC(430)
Pharmacological Actions : Anti-Apoptotic : CK(4942) : AC(2981), Anti-Inflammatory Agents : CK(35225) : AC(14937), Antioxidants : CK(32218) : AC(13960)

The analgesic effect of paeoniflorin: A focused review.

Article Published Date : Dec 31, 2023
Study Type : Review
Additional Links
Substances : Paeoniflorin : CK(559) : AC(355)
Diseases : Chronic Pain : CK(1098) : AC(224)
Pharmacological Actions : Analgesics : CK(5896) : AC(1006)

Paeoniflorin mitigated liver injury by activating autophagy to suppress oxidative stress and apoptosis.

Article Published Date : Sep 06, 2024
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin : CK(559) : AC(363)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(878) : AC(349), Liver Damage: Drug-Induced : CK(622) : AC(271), Oxidative Stress : CK(13443) : AC(5357)
Pharmacological Actions : Anti-Apoptotic : CK(4942) : AC(2984), Antioxidants : CK(32218) : AC(13963), Hepatoprotective : CK(8320) : AC(3713)
Problem Substances : Acetaminophen

Effect of arctigenin on neurological diseases: A review.

Article Published Date : Oct 27, 2023
Study Type : Review
Additional Links
Substances : Lignans : CK(337) : AC(102)
Diseases : Alzheimer's Disease : CK(4948) : AC(2116)
Pharmacological Actions : Neuroprotective Agents : CK(17667) : AC(7512)

Arctigenin attenuated spatial memory impairment in pR5 mice by regulating mitochondrial energy metabolism.

Article Published Date : Jan 26, 2024
Study Type : Animal Study
Additional Links
Substances : Arctigenin : CK(151) : AC(100)
Diseases : Alzheimer's Disease : CK(4948) : AC(2116), Memory Disorders : CK(1526) : AC(498)
Pharmacological Actions : Neuroprotective Agents : CK(17667) : AC(7512)

Arctigenin promotes mucosal healing in ulcerative colitis through facilitating focal adhesion assembly and colonic epithelial cell migration.

Article Published Date : Feb 14, 2024
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin : CK(151) : AC(100)
Diseases : Colitis : CK(1480) : AC(707), Ulcerative Colitis : CK(1378) : AC(429), Wound Healing : CK(2396) : AC(815)
Pharmacological Actions : Gastrointestinal Agents : CK(6875) : AC(2171)

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