Latest GMI Study Abstracts

Latest GMI Study Abstracts

Aqueous Bupleuri Radix extract could promote hepatic HDL uptake in vitro.

Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Bupleurum : CK(231) : AC(125), Saikosaponin : CK(77) : AC(57)
Diseases : High Fat Diet : CK(2152) : AC(1036)
Pharmacological Actions : Hepatoprotective : CK(9787) : AC(4162), Hypolipidemic : CK(9770) : AC(2179)

These findings provide evidence that Saikosaponin d could ameliorate depression-like behaviors.

Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : Bupleurum : CK(231) : AC(125), Saikosaponin : CK(77) : AC(57)
Diseases : Depression : CK(10231) : AC(1902)
Pharmacological Actions : Anti-Inflammatory Agents : CK(43571) : AC(17460), Antidepressive Agents : CK(8542) : AC(1601), NF-kappaB Inhibitor : CK(6593) : AC(3829)
Additional Keywords : MicroRNA-155

Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation.

Article Published Date : Feb 29, 2020
Study Type : Animal Study
Additional Links
Substances : Bupleurum : CK(231) : AC(125), Saikosaponin : CK(77) : AC(57)
Diseases : Depression : CK(10231) : AC(1902), Lipopolysaccharide-Induced Toxicity : CK(3555) : AC(2073)
Pharmacological Actions : Anti-Inflammatory Agents : CK(43571) : AC(17460), Antidepressive Agents : CK(8542) : AC(1601), Interleukin-1 beta downregulation : CK(6750) : AC(3272), Interleukin-6 Downregulation : CK(10222) : AC(3976), NF-kappaB Inhibitor : CK(6593) : AC(3829), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(12769) : AC(5258)

Saikosaponin-d alleviates renal inflammation and cell apoptosis in a mouse model of sepsis.

Article Published Date : Sep 23, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bupleurum : CK(231) : AC(125)
Diseases : Inflammation : CK(17280) : AC(5954), Sepsis : CK(1627) : AC(569)
Pharmacological Actions : Anti-Inflammatory Agents : CK(43571) : AC(17460), Apoptotic : CK(10472) : AC(8099), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1229) : AC(773)

Effects and mechanisms of saikosaponin D improving the sensitivity of human gastric cancer cells to cisplatin.

Article Published Date : Jul 26, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bupleurum : CK(231) : AC(125)
Diseases : Gastric Cancer : CK(1735) : AC(800)
Pharmacological Actions : Chemosensitizer : CK(1767) : AC(1350)
Additional Keywords : Chemotherapeutic Synergy: Cisplatin : CK(456) : AC(362)

Antitumor effect of saikosaponin A on human neuroblastoma cells.

Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bupleurum : CK(231) : AC(125)
Diseases : Neuroblastoma : CK(233) : AC(151)
Pharmacological Actions : Antiproliferative : CK(11069) : AC(8288), Apoptotic : CK(10472) : AC(8099)
Additional Keywords : Plant Extracts : CK(19681) : AC(7214)

Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics.

Article Published Date : Nov 30, 2021
Study Type : Review
Additional Links
Substances : Bupleurum : CK(231) : AC(125)
Diseases : Cancers: All : CK(38000) : AC(15266)
Pharmacological Actions : Anti-metastatic : CK(3091) : AC(2351), Antiproliferative : CK(11069) : AC(8288), Apoptotic : CK(10472) : AC(8099)

Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling.

Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Bupleurum : CK(231) : AC(125)
Diseases : Liver Fibrosis : CK(989) : AC(451)
Pharmacological Actions : Anti-Fibrotic : CK(2551) : AC(1210)

Saikosaponin D inhibits peritoneal fibrosis in rats with renal failure.

Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Bupleurum : CK(231) : AC(125)
Diseases : Kidney Failure : CK(355) : AC(59), Retroperitoneal Fibrosis : CK(4) : AC(2)
Pharmacological Actions : Anti-Fibrotic : CK(2551) : AC(1210)

Saikosaponin D attenuates pancreatic injury.

Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bupleurum : CK(231) : AC(125)
Diseases : Pancreatitis : CK(562) : AC(212)
Pharmacological Actions : Anti-Inflammatory Agents : CK(43571) : AC(17460), Pancreato Protective Agents : CK(590) : AC(319)

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