Latest GMI Study Abstracts

Latest GMI Study Abstracts

Cytotoxicity of juglone and thymoquinone against pancreatic cancer cells.

Article Published Date : Aug 24, 2020
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451), Walnut : CK(589) : AC(137)
Diseases : Pancreatic Cancer : CK(1307) : AC(451)
Pharmacological Actions : Antineoplastic Agents : CK(1847) : AC(1170), Antiproliferative : CK(6801) : AC(5032), Apoptotic : CK(6986) : AC(5304)
Additional Keywords : Drug Synergy : CK(381) : AC(167)

Juglone may improve diabetic atherosclerosis by inhibiting proliferation and migration of VSMCs.

Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Walnut : CK(589) : AC(137)
Diseases : Atherosclerosis : CK(1390) : AC(487), Diabetic Complications : CK(3199) : AC(1009)
Pharmacological Actions : Antiproliferative : CK(6801) : AC(5032), Cyclin D1 Down-Regulation : CK(106) : AC(79), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(786) : AC(505)

Juglone suppresses LPS-induced inflammatory responses and NLRP3 activation in macrophages.

Article Published Date : Jul 06, 2020
Study Type : In Vitro Study
Additional Links
Substances : Walnut : CK(589) : AC(137)
Diseases : Inflammation : CK(9572) : AC(3089), Lipopolysaccharide-Induced Toxicity : CK(1764) : AC(1073)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Interleukin-18 down-regulation : CK(132) : AC(61), Interleukin-1 beta downregulation : CK(3041) : AC(1567)

Juglone induced anticancer effects on promyelocytic HL-60 leukemia cells.

Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Walnut : CK(589) : AC(137)
Diseases : Leukemia : CK(1709) : AC(739), Promyelocytic leukemia : CK(137) : AC(118)
Pharmacological Actions : Antiproliferative : CK(6801) : AC(5032), Apoptotic : CK(6986) : AC(5304)

Juglone can inhibit angiogenesis and metastasis in pancreatic cancer cells by targeting Wnt/β-catenin signaling.

Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Walnut : CK(589) : AC(137)
Diseases : Pancreatic Cancer : CK(1307) : AC(451)
Pharmacological Actions : Angiogenesis Inhibitors : CK(488) : AC(296), Anti-metastatic : CK(1972) : AC(1481), Antiproliferative : CK(6801) : AC(5032), Wnt/β-catenin signaling pathway modulation : CK(208) : AC(149)

Juglone regulates gut microbiota and Th17/Treg balance in DSS-induced ulcerative colitis.

Article Published Date : Jul 31, 2021
Study Type : Animal Study
Additional Links
Substances : Walnut : CK(589) : AC(137)
Diseases : Ulcerative Colitis : CK(666) : AC(196)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Gastrointestinal Agents : CK(3145) : AC(843), Immunomodulatory : CK(4048) : AC(1475), Interleukin-1 beta downregulation : CK(3041) : AC(1567), Interleukin-6 Downregulation : CK(5029) : AC(1994), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(6736) : AC(2815)

Juglone, a novel activator of ferroptosis, induces cell death in endometrial carcinoma Ishikawa cells.

Article Published Date : Jun 07, 2021
Study Type : In Vitro Study
Additional Links
Substances : Walnut : CK(589) : AC(137)
Diseases : Endometrial Cancer : CK(447) : AC(99)
Pharmacological Actions : Apoptotic : CK(6986) : AC(5304)

Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors.

Article Published Date : Aug 17, 2021
Study Type : In Vitro Study
Additional Links
Substances : Walnut : CK(589) : AC(137)
Diseases : Coronavirus Infection : CK(1230) : AC(410)
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)

Juglone suppresses inflammation and oxidative stress in colitis.

Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Walnut : CK(589) : AC(137)
Diseases : Colitis : CK(840) : AC(406), Inflammation : CK(9572) : AC(3089), Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334)

Higher walnut consumption was associated with a lower risk of total and CVD mortality and a greater gained life expectancy among U.S. elder adults.

Article Published Date : Aug 03, 2021
Study Type : Human Study
Additional Links
Substances : Walnut : CK(589) : AC(137)
Diseases : All-Cause Mortality, Cardiac Mortality : CK(1610) : AC(144)
Additional Keywords : Risk Reduction : CK(15144) : AC(1708)

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