Latest GMI Study Abstracts

Latest GMI Study Abstracts

Hesperidin alleviates bupivacaine anesthesia-induced neurotoxicity in SH-SY5Y cells by regulating apoptosis and oxidative damage.

Article Published Date : Apr 07, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hesperidin : CK(375) : AC(148)
Diseases : Surgery: Anesthesiology : CK(52) : AC(5)
Pharmacological Actions : Anti-Apoptotic : CK(1620) : AC(932), Anti-Inflammatory Agents : CK(12461) : AC(4729), Antioxidants : CK(14410) : AC(5758), Neuroprotective Agents : CK(6374) : AC(2801)
Problem Substances : Bupivacaine : CK(10) : AC(1)

Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2.

Article Published Date : Mar 25, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hesperidin : CK(375) : AC(148), Zinc : CK(1067) : AC(165)
Diseases : Coronavirus Infection : CK(1) : AC(1)
Pharmacological Actions : Antiviral Agents : CK(1307) : AC(596)

Preventing and treating neurological disorders with the flavonol fisetin.

Article Published Date : Feb 08, 2021
Study Type : Review
Additional Links
Substances : Fisetin : CK(173) : AC(112)
Diseases : Neurodegenerative Diseases : CK(6185) : AC(1785)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Antioxidants : CK(14410) : AC(5758), Neuroprotective Agents : CK(6374) : AC(2801)

Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2.

Article Published Date : Mar 29, 2021
Study Type : Review
Additional Links
Substances : Biochanin A : CK(9) : AC(8), Diosmin : CK(175) : AC(30), EGCG (Epigallocatechin gallate) : CK(890) : AC(477), Epicatechin : CK(17) : AC(12), Flavonoids : CK(1616) : AC(523), Genistein : CK(650) : AC(296), Hesperidin : CK(375) : AC(148), Luteolin : CK(235) : AC(153), Naringenin : CK(241) : AC(139), Quercetin : CK(846) : AC(392), Rutin : CK(217) : AC(99), Silymarin : CK(241) : AC(53)
Diseases : Coronavirus Infection : CK(1) : AC(1)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729)
Additional Keywords : Cytokine Storm : CK(5) : AC(4)

Biochanin A attenuates ovariectomy-induced cognition deficit.

Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Biochanin A : CK(9) : AC(8)
Diseases : Postmenopausal Disorders: Memory Impairment : CK(25) : AC(11)
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758), Neuroprotective Agents : CK(6374) : AC(2801)
Additional Keywords : Ovariectomy-Induced Changes : CK(84) : AC(39)

Anticancer potential of selected flavonols: fisetin, kaempferol, and quercetin on head and neck cancers.

Article Published Date : Mar 04, 2021
Study Type : Review
Additional Links
Substances : Fisetin : CK(173) : AC(112), Quercetin : CK(846) : AC(392)
Diseases : Head and Neck Cancer : CK(374) : AC(85)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846)

Kaempferol might be a novel promising therapeutic agent for spinal cord injury.

Article Published Date : Apr 02, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Kaempferol : CK(102) : AC(65)
Diseases : Inflammation : CK(6531) : AC(1986), Oxidative Stress : CK(6519) : AC(2436), Spinal Cord Injuries : CK(319) : AC(120)
Pharmacological Actions : Interleukin-18 down-regulation : CK(20) : AC(7), Interleukin-1 beta downregulation : CK(1743) : AC(868), Neuroprotective Agents : CK(6374) : AC(2801), NF-kappaB Inhibitor : CK(2446) : AC(1436)

Kaempferol protects blood vessels from damage induced by oxidative stress and inflammation.

Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol : CK(102) : AC(65)
Diseases : Inflammation : CK(6531) : AC(1986), Oxidative Stress : CK(6519) : AC(2436)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Antioxidants : CK(14410) : AC(5758), Heme oxygenase-1 up-regulation : CK(73) : AC(40), Nrf2 activation : CK(177) : AC(86)

Paraquat induces pulmonary fibrosis through Wnt/β-catenin signaling pathway and myofibroblast differentiation.

Article Published Date : Oct 14, 2020
Study Type : Animal Study
Additional Links
Diseases : Herbicide Toxicity : CK(12) : AC(7), Pulmonary Fibrosis : CK(140) : AC(49)
Problem Substances : Paraquat : CK(10) : AC(5)

Sublethal paraquat confers multidrug tolerance in Pseudomonas aeruginosa.

Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Diseases : Herbicide Toxicity : CK(12) : AC(7), Pseudomonas aeruginosa : CK(197) : AC(145)
Additional Keywords : Increased Risk : CK(1600) : AC(192)
Problem Substances : Paraquat : CK(10) : AC(5)

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