Latest GMI Study Abstracts

Latest GMI Study Abstracts

7,8-dihydroxyflavone alleviates anxiety-like behavior induced by chronic alcohol exposure.

Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Diseases : Alcohol Toxicity : CK(855) : AC(332), Anxiety Disorders : CK(1505) : AC(231)
Pharmacological Actions : Anti-Anxiety Agents : CK(2913) : AC(487)

The TrkB agonist 7,8-dihydroxyflavone improves sensory-motor performance and reduces lipid peroxidation in old mice.

Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Diseases : Aging : CK(3728) : AC(933), Lipid Peroxidation : CK(1632) : AC(631), Neurodegenerative Diseases : CK(8689) : AC(2653)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Malondialdehyde Down-regulation : CK(2065) : AC(678), Neuroprotective Agents : CK(10404) : AC(4396)

Baicalein, 7,8-dihydroxyflavone and myricetin as potent inhibitors of human ornithine decarboxylase.

Article Published Date : Dec 16, 2020
Study Type : In Vitro Study
Additional Links
Substances : Baicalein : CK(184) : AC(112), Myricetin : CK(248) : AC(158)
Diseases : Cancers: All : CK(28241) : AC(10590)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Chemopreventive : CK(5374) : AC(1717), Chemotherapeutic : CK(2328) : AC(1086)

Dietary bioactive diindolylmethane enhances the therapeutic efficacy of centchroman in breast cancer cells.

Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer : CK(6327) : AC(2272)
Pharmacological Actions : Chemopreventive : CK(5374) : AC(1717), Chemosensitizer : CK(1124) : AC(854)
Additional Keywords : Natural Substance/Drug Synergy : CK(957) : AC(485)

AKT inhibitor AZD5363 suppresses stemness and promotes anti-cancer activity of 3,3'-diindolylmethane in human breast cancer cells.

Article Published Date : Oct 14, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer : CK(6327) : AC(2272)
Pharmacological Actions : Antiproliferative : CK(6801) : AC(5032)

The flavonoid 7,8-DHF fosters prenatal brain proliferation potency in a mouse model of Down syndrome.

Article Published Date : Jan 17, 2021
Study Type : Animal Study
Additional Links
Diseases : Down Syndrome : CK(124) : AC(22)

Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells.

Article Published Date : May 31, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Bisphenol Toxicity : CK(2930) : AC(882)
Problem Substances : Bisphenol S : CK(514) : AC(172)
Adverse Pharmacological Actions : Neurotoxic : CK(2424) : AC(562)

7,8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer's disease.

Article Published Date : Jun 30, 2021
Study Type : Animal Study
Additional Links
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

These data suggest that targeting BDNF signalling may have therapeutic potential for the treatment of certain symptoms of schizophrenia.

Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Diseases : Schizophrenia : CK(861) : AC(151)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

7,8-Dihydroxyflavone protects retinal ganglion cells against chronic intermittent hypoxia-induced oxidative stress damage.

Article Published Date : May 14, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Hypoxia : CK(289) : AC(179), Sleep Apnea: Obstructive : CK(50) : AC(9)
Pharmacological Actions : Brain-derived neurotrophic factor modulator : CK(458) : AC(166), Neuroprotective Agents : CK(10404) : AC(4396)

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