Latest GMI Study Abstracts

Latest GMI Study Abstracts

Vitamin E and K 1 as anti-quorum sensing agents against Pseudomonas aeruginosa.

Article Published Date : Apr 04, 2021
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E : CK(2077) : AC(371), Vitamin K : CK(802) : AC(125)
Diseases : Pseudomonas aeruginosa : CK(197) : AC(145)
Pharmacological Actions : Anti-Bacterial Agents : CK(2088) : AC(821), Quorum Sensing Inhibition : CK(1) : AC(1)
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

γ-tocotrienol exhibits time and dose-dependent anti-proliferative, pro-apoptotic and antioxidant effects on U937 and KG-1 cell lines.

Article Published Date : Nov 16, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Gamma : CK(36) : AC(21), Vitamin E : CK(2077) : AC(371)
Diseases : Leukemia: Acute myelogenous leukemia (AML) : CK(111) : AC(34)
Pharmacological Actions : Antineoplastic Agents : CK(1594) : AC(982), Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006)

γ-tocotrienol and α-tocopherol ether acetate enhance docetaxel activity in drug-resistant prostate cancer cells.

Article Published Date : Jan 17, 2020
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Gamma : CK(36) : AC(21), Vitamin E : CK(2077) : AC(371), Vitamin E: alpha tocopherol : CK(2358) : AC(431)
Diseases : Cancers: Drug Resistant : CK(562) : AC(369), Prostate Cancer : CK(2097) : AC(687)
Pharmacological Actions : Antineoplastic Agents : CK(1594) : AC(982)
Additional Keywords : Chemotherapeutic Synergy: Docetaxel : CK(25) : AC(13)

Beta-tocotrienol exhibits more cytotoxic effects than gamma-tocotrienol on breast cancer cells.

Article Published Date : Jan 08, 2020
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E : CK(2077) : AC(371)
Diseases : Breast Cancer : CK(5066) : AC(1738)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006), Tumor Suppressor Protein p53 Upregulation : CK(480) : AC(343)

Tocotrienol regulates osteoclastogenesis in rheumatoid arthritis.

Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E : CK(2077) : AC(371)
Diseases : Rheumatoid Arthritis : CK(1140) : AC(209)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Interleukin-17 downregulation : CK(39) : AC(13)

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine.

Article Published Date : Apr 14, 2012
Study Type : Animal Study
Additional Links
Substances : Tocotrienol: Gamma : CK(36) : AC(21), Vitamin E : CK(2077) : AC(371)
Diseases : Gastric Cancer : CK(836) : AC(341)
Pharmacological Actions : Anti-metastatic : CK(1284) : AC(927), Bcl-2 protein down-regulation : CK(419) : AC(295), Chemosensitizer : CK(772) : AC(577), Cyclin D1 Down-Regulation : CK(42) : AC(28), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(543) : AC(337), NF-kappaB Inhibitor : CK(2446) : AC(1436)
Additional Keywords : Natural Substance/Drug Synergy : CK(352) : AC(142)

Curcumin sensitizes human colorectal cancer to capecitabine.

Article Published Date : Oct 31, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4844) : AC(2458)
Diseases : Colorectal Cancer : CK(2874) : AC(1192)
Pharmacological Actions : Anti-metastatic : CK(1284) : AC(927), Antineoplastic Agents : CK(1594) : AC(982), Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(543) : AC(337), NF-kappaB Inhibitor : CK(2446) : AC(1436)
Additional Keywords : Natural Substance/Drug Synergy : CK(352) : AC(142)

Curcumin enhances the effect of chemotherapy against colorectal cancer cells.

Article Published Date : Jan 01, 2013
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4844) : AC(2458)
Diseases : Colorectal Cancer : CK(2874) : AC(1192)
Pharmacological Actions : Antineoplastic Agents : CK(1594) : AC(982), Apoptotic : CK(5217) : AC(3846), NF-kappaB Inhibitor : CK(2446) : AC(1436)
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil : CK(65) : AC(43)

Low curcumin concentration enhances the anticancer effect of 5-fluorouracil against colorectal cancer.

Article Published Date : Mar 16, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4844) : AC(2458)
Diseases : Colorectal Cancer : CK(2874) : AC(1192)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Chemosensitizer : CK(772) : AC(577)
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil : CK(65) : AC(43)

Prenatal exposure to bisphenols affects pregnancy outcomes and offspring development.

Article Published Date : Feb 25, 2021
Study Type : Animal Study
Additional Links
Diseases : Bisphenol Toxicity : CK(1832) : AC(549), Fetal Origin of Adult Disease : CK(103) : AC(23), Oxidative Stress : CK(6519) : AC(2436), Prenatal Chemical Exposures : CK(1220) : AC(265)
Problem Substances : Bisphenol A : CK(2216) : AC(646)

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