New Study Finds CoQ10 as Effective as Steroid for Oral Lichen Planus

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What if an antioxidant enzyme could conquer mouth inflammation and discomfort better than steroids? New research pioneers promising natural alternatives for stubborn oral conditions.

A randomized controlled trial published in BMC Oral Health demonstrates that topical coenzyme Q10 (CoQ10) significantly improves painful symptoms and clinical signs of oral lichen planus (OLP), an inflammatory condition affecting mouth tissues.

Importantly, mucoadhesive CoQ10 tablets used 3 times daily for 4 weeks reduced OLP symptoms comparably to topical triamcinolone, a corticosteroid medication. Both treatments notably decreased patient-reported pain and objective lesion severity.

OLP causes uncomfortable white patches or red erosions in the mouth. Steroids are commonly prescribed to reduce inflammation, but long-term use risks side effects. Seeking safer alternatives, researchers evaluated if antioxidant and anti-inflammatory effects of CoQ10 could mitigate OLP.

34 patients with symptomatic OLP were randomly assigned to receive either topical CoQ10 tablets or topical triamcinolone in an adhesive paste, several times daily for one month. Pain levels using a standardized 10-point scale and clinical lesion sizes were assessed weekly. Salivary antioxidant levels were also analyzed.

Over four weeks, both groups experienced statistically and clinically significant improvements in pain symptoms and lesion appearance. Pain decreased from severe levels to almost none, while lesions shrank markedly. 

Importantly, comparisons between groups showed no significant differences in therapeutic efficacy at any timepoint. Both treatments worked equally well according to patients and clinicians.  

Levels of inflammatory salivary markers also decreased in both groups, further validating clinical improvements. Enhanced antioxidant capacity of CoQ10 likely contributed additional anti-inflammatory benefits.

Patients reported high satisfaction with symptom relief from CoQ10, affirming effectiveness equaling a standard medication. This demonstrates natural options like CoQ10 can succeed in controlling challenging inflammatory conditions without concerning steroid side effects.

CoQ10 is a safe nutritional compound supporting cellular energy and neutralizing oxidative damage. Taken orally or topically, patients can utilize CoQ10's antioxidant and anti-inflammatory properties to address various health conditions without interacting with medications.

For OLP sufferers desperate for pain relief, this exciting research pioneers accessible, evidence-based alternatives to steroids. Under physician supervision, topical CoQ10 presents a promising substitution for steroids in oral inflammatory conditions, benefiting patient safety and autonomy.

Learn more about the Database on Natural Substances Vs. Drugs

We also have a section called "Natural Substances versus Drugs" with an additional 292 studies relevant to 242 diseases where there is established at least an equi-potency between the natural and conventional treatment.

It is extremely encouraging to the natural health movement to know that research actually proves the potential superiority of ancient, natural interventions versus conventional ones. The point of bringing this information to the attention of the public is to show that, at the very least, there is a legitimate place for natural medicine alongside the conventional, drug-based form, and that this is not based strictly on subjective or anecdotal experience (which is valuable), but also the scientific evidence itself, which many critics of complementary and alternative medicine (CAM) often claim does not even exist.

If you like what you see here, please consider supporting our research project by becoming a member, which provides significantly enhanced features intended to expand and optimize the evidence-base of their health practice(s) and/or advocacies. Learn more here. (add link to membership) 

The database contains over 10,000 sections outlining the evidence behind natural healing alternatives. One particularly striking section is titled "Superiority of Natural Substances vs Drugs."

This database subsection currently includes research on over 250 natural substances that have demonstrated superiority over pharmaceutical drugs for the same health condition in preclinical, animal, and human studies. The database cites studies across over 270 diseases where natural options like herbs, vitamins, minerals and other food components perform better than would-be drug treatments.

Some highlights include curcumin outperforming 11 pharmaceuticals across 30+ diseases, ginger beating drugs in 8 conditions, and vitamin D demonstrating greater efficacy than drugs in over 50 conditions. In addition, Greenmedinfo has a database on Natural Substances vs Drugs with studies on 242 diseases where natural options have established at least equivalent efficacy to conventional medications.

To learn more about the health benefits of coenzyme Q10 visit our database on the subject here.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

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