Results for Apoptotic

A comprehensive review on anticancer mechanisms of crocin.

Article Published Date : Jul 02, 2017
Study Type : Review
Additional Links
Substances : Crocin : CK(745) : AC(319)
Diseases : Cancers: All : CK(37812) : AC(15221)
Pharmacological Actions : Anti-metastatic : CK(3081) : AC(2344), Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Chemotherapeutic : CK(4540) : AC(1700), Telomerase Inhibitor : CK(103) : AC(71)
Additional Keywords : Anti-metastatic, Antiproliferative : CK(75) : AC(61), Apoptotic, Cancers: All, Chemotherapeutic, Crocin, Telomerase Inhibitor

A wasabi extract exhibits anti-colon cancer properties through the induction of apoptosis and autophagy.

Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Wasabi : CK(47) : AC(23)
Diseases : Colon Cancer : CK(1974) : AC(1240)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060), Autophagy Up-regulation : CK(914) : AC(604)
Additional Keywords : Apoptotic, Autophagy Up-regulation, COLON CANCER, Plant Extracts : CK(19610) : AC(7189), Wasabi

A water-soluble polysaccharide is able to reduce the number of fat cells and the mass of adipose tissue.

Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : White Mulberry : CK(156) : AC(66)
Diseases : Obesity : CK(11514) : AC(2794)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Anti-Obesity Agents : CK(5479) : AC(1390), Apoptotic, obesity, Plant Extracts : CK(19610) : AC(7189), Polysaccharides : CK(1559) : AC(874), White Mulberry

Alkaloids from Peganum harmala could be a promising candidate for the therapy of leukemia.

Article Published Date : Nov 02, 2015
Study Type : In Vitro Study
Additional Links
Substances : Syrian rue : CK(84) : AC(51)
Diseases : Leukemia : CK(2150) : AC(952)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Apoptotic, leukemia, Syrian rue

An extract of Litchi seed has potential for development into a safe and potent alternative therapy for prostate cancer patients.

Article Published Date : Jan 29, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Litchi : CK(36) : AC(24)
Diseases : Prostate Cancer : CK(2904) : AC(1095)
Pharmacological Actions : Anti-metastatic : CK(3081) : AC(2344), Apoptotic : CK(10324) : AC(8060), Cell cycle arrest : CK(2243) : AC(1836), P21 Activation : CK(213) : AC(149)
Additional Keywords : Anti-metastatic, Apoptotic, Cell cycle arrest, Litchi, P21 Activation, Plant Extracts : CK(19610) : AC(7189), prostate cancer

An extract of Lotus may be a powerful agent against colon cancer cells.

Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Colon Cancer : CK(1974) : AC(1240)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060), Bcl-2 protein down-regulation : CK(756) : AC(573), Bcl-xL down-regulation : CK(41) : AC(30), Cyclooxygenase 2 Inhibitors : CK(2372) : AC(1401), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(1001) : AC(630), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1218) : AC(771), NF-kappaB Inhibitor : CK(6521) : AC(3811)
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, COLON CANCER, Lotus, Plant Extracts : CK(19610) : AC(7189)

Anti-cancerous effect of Inonotus taiwanensis polysaccharide extract on human acute monocytic leukemia cells.

Article Published Date : Jan 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Medicinal Mushrooms : CK(2674) : AC(1343)
Diseases : Leukemia: Monocytic : CK(38) : AC(20)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Autophagy Inhibitors : CK(314) : AC(195)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Autophagy Inhibitors : CK(8) : AC(6), Leukemia: Monocytic, Medicinal Mushrooms, Polysaccharides : CK(1559) : AC(874)

Apigenin induces the apoptosis of colon cancer cells.

Article Published Date : Mar 06, 2018
Study Type : In Vitro Study
Additional Links
Substances : Apigenin : CK(705) : AC(411)
Diseases : Colon Cancer : CK(1974) : AC(1240)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Bcl-xL down-regulation : CK(41) : AC(30)
Additional Keywords : Antiproliferative : CK(75) : AC(61), APIGENIN, Apoptotic, Bcl-xL down-regulation, COLON CANCER

Avocado defensin could induce intrinsic apoptosis in breast cancer cells.

Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Avocado : CK(201) : AC(63)
Diseases : Breast Cancer : CK(8546) : AC(3188)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060), Caspase-7 Activation : CK(9) : AC(7), Caspase-9 Activation : CK(72) : AC(48)
Additional Keywords : Apoptotic, Avocado, Breast Cancer : CK(113) : AC(34), Caspase-7 Activation, Caspase-9 Activation

Baicalein induces cancer cell apoptosis and cause cell cycle arrest.

Article Published Date : Jul 31, 2016
Study Type : Review
Additional Links
Substances : Baicalein : CK(371) : AC(245)
Diseases : Cancers: All : CK(37812) : AC(15221)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Cell cycle arrest : CK(2243) : AC(1836)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Baicalein, Cancer : CK(50) : AC(12), Cell cycle arrest

Butyrate induced apoptosis and inhibited cell proliferation via enhancing the intracellular expression of miR-22.

Article Published Date : Mar 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Butyrate : CK(63) : AC(35)
Diseases : Liver Cancer : CK(3324) : AC(1766)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Histone deacetylase inhibitor : CK(119) : AC(84), MicroRNA modulator : CK(1567) : AC(903)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Butyrate, Histone deacetylase inhibitor, liver cancer, MicroRNA modulator

Caffeic acid and caffeic acid phenethyl ester induce apoptosis and cell cycle arrest of breast cancer cells MDA-MB-231.

Article Published Date : Sep 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Caffeic Acid : CK(152) : AC(92), Caffeic acid phenethyl ester : CK(313) : AC(190)
Diseases : Breast Cancer: Triple Negative : CK(1017) : AC(701)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Cell cycle arrest : CK(2243) : AC(1836)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Breast Cancer: Triple Negative, Caffeic Acid, Caffeic acid phenethyl ester, Cell cycle arrest

Carnosic acid cooperates with tamoxifen to induce apoptosis in breast cancer cells.

Article Published Date : Apr 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid : CK(167) : AC(112)
Diseases : Breast Cancer : CK(8546) : AC(3188)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060), Bcl-2 protein down-regulation : CK(756) : AC(573), Bcl-xL down-regulation : CK(41) : AC(30)
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Breast Cancer : CK(113) : AC(34), Carnosic Acid, Synergy with Tamoxifen : CK(38) : AC(31)
Problem Substances : Tamoxifen : CK(401) : AC(68)

Carnosic acid induces apoptosis of hepatocellular carcinoma cells.

Article Published Date : Oct 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid : CK(167) : AC(112)
Diseases : Liver Cancer : CK(3324) : AC(1766)
Pharmacological Actions : Antineoplastic Agents : CK(2499) : AC(1678), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Antineoplastic Agents : CK(78) : AC(35), Apoptotic, Carnosic Acid, liver cancer

Cinnamon extract from Sanyangxuedai may be effective for treating leukemia.

Article Published Date : Aug 18, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cinnamon : CK(698) : AC(205)
Diseases : Leukemia : CK(2150) : AC(952)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Cell cycle arrest : CK(2243) : AC(1836)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cell cycle arrest, cinnamon, leukemia, Plant Extracts : CK(19610) : AC(7189)

Combination therapy with low concentrations of sorafenib and betulinic acid had the capacity to induce high levels of cell death.

Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid : CK(292) : AC(203)
Diseases : Carcinoma: Non-Small-Cell Lung : CK(799) : AC(481)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Betulinic acid, Carcinoma: Non-Small-Cell Lung, Natural Substance/Drug Synergy : CK(1654) : AC(772)

Combined use of lower concentrations of jerantinine A and γ-tocotrienol induced potent cytotoxic effects on U87MG cancer cells.

Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol : CK(51) : AC(33)
Diseases : Glioblastoma : CK(757) : AC(428)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Cell cycle arrest : CK(2243) : AC(1836), Chemoprotective Agents : CK(4562) : AC(1748), Chemosensitizer : CK(1756) : AC(1344), Chemotherapeutic : CK(4540) : AC(1700), Tumor Suppressor Protein p53 Upregulation : CK(807) : AC(592)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cell cycle arrest, Glioblastoma, Natural Substance/Drug Synergy : CK(1654) : AC(772), Vitamin E: Gamma-tocotrienol

Cucurbitacin E may delay cancer cell growth by apoptosis via upregulation of DR5 gene expression.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin E : CK(62) : AC(47)
Diseases : Cervical Cancer : CK(1032) : AC(634)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cervical Cancer, Cucurbitacin E, Gene Expression Regulation : CK(1435) : AC(630)

Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells.

Article Published Date : Jun 07, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(8693) : AC(3798)
Diseases : Glioma : CK(705) : AC(333)
Pharmacological Actions : Anti-metastatic : CK(3081) : AC(2344), Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Anti-metastatic, Antiproliferative : CK(75) : AC(61), Apoptotic, CURCUMIN : CK(25) : AC(18), Glioma

Curcumin induced leukemic cell apoptosis via an IFIT2-dependent signalling pathways.

Article Published Date : Jan 01, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(8693) : AC(3798)
Diseases : Leukemia : CK(2150) : AC(952)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Apoptotic, CURCUMIN : CK(25) : AC(18), leukemia

Curcumin may serve as a promising anticancer agent by inducing a chronic ER stress mediated cell death and activation of cell cycle arrest.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(8693) : AC(3798)
Diseases : Prostate Cancer : CK(2904) : AC(1095)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Apoptotic, CURCUMIN : CK(25) : AC(18), prostate cancer

Diallyl trisulfide suppresses tumor growth and potentiates cisplatin efficacy in gastric cancer treatment.

Article Published Date : Mar 26, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Dimethyl trisulfide (DMTS) : CK(14) : AC(8)
Diseases : Gastric Cancer : CK(1708) : AC(792)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060), Cell cycle arrest : CK(2243) : AC(1836), Chemosensitizer : CK(1756) : AC(1344)
Additional Keywords : Apoptotic, Cell cycle arrest, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(455) : AC(361), Dimethyl trisulfide (DMTS), gastric cancer

Effects of thymol on human gastric adenocarcinoma cells in vitro.

Article Published Date : Feb 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Thymol : CK(151) : AC(106)
Diseases : Gastric Cancer : CK(1708) : AC(792)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Apoptotic, gastric cancer, Thymol

EGCG is effective in decreasing cell viability, apoptosis induction and enhancement of caspase 3 and Fas expression level in jurkat cells.

Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1637) : AC(842)
Diseases : Leukemia: T-cell acute Lymphoblastic : CK(28) : AC(18)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, EGCG (Epigallocatechin gallate), Leukemia: T-cell acute Lymphoblastic

Ethanol extract of Antrodia camphorata inhibits proliferation of HCT-8 human colorectal cancer cells.

Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Antrodia camphorata : CK(52) : AC(33)
Diseases : Colorectal Cancer : CK(5133) : AC(2434)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Cell cycle arrest : CK(2243) : AC(1836)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Antrodia camphorata, Apoptotic, Cell cycle arrest, COLORECTAL CANCER

Extracts of Parmelia sulcata and Usnea filipendula induced apoptosis-like cell death by causing DNA damage, to cancer cells.

Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lichens : CK(78) : AC(55)
Diseases : Glioma : CK(705) : AC(333), Liver Cancer : CK(3324) : AC(1766), Lung Cancer : CK(3230) : AC(1535)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Dose Response : CK(1780) : AC(701), Glioma, Lichens, liver cancer, lung cancer, Parmelia sulcata, Plant Extracts : CK(19610) : AC(7189)

Forced inhibition of PDE1A expression might be a new therapeutic strategy for the management of acute lymphoblastic leukemia.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1256) : AC(736)
Diseases : Acute lymphoblastic leukemia (ALL) : CK(258) : AC(96)
Pharmacological Actions : Antineoplastic Agents : CK(2499) : AC(1678), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Acute lymphoblastic leukemia (ALL), Antineoplastic Agents : CK(78) : AC(35), Apoptotic, thymoquinone

Fucoidan inhibited cell growth, induced apoptosis and suppressed angiogenesis in thyroid cancer cells.

Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan : CK(867) : AC(452)
Diseases : Thyroid Cancer : CK(495) : AC(168)
Pharmacological Actions : Angiogenesis Inhibitors : CK(761) : AC(508), Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Angiogenesis Inhibitors, Antiproliferative : CK(75) : AC(61), Apoptotic, Dose Response : CK(1780) : AC(701), Fucoidan, Thyroid Cancer

Gallic acid remarkably ameliorated the destabilization of liver tissue architecture caused by N-nitrosodiethylamine.

Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Gallic Acid : CK(342) : AC(213)
Diseases : Liver Cancer : CK(3324) : AC(1766)
Pharmacological Actions : Anti-Inflammatory Agents : CK(43396) : AC(17387), Anticarcinogenic Agents : CK(2161) : AC(1024), Antioxidants : CK(37177) : AC(15623), Apoptotic : CK(10324) : AC(8060), Chemopreventive : CK(6671) : AC(2217)
Additional Keywords : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants : CK(303) : AC(126), Apoptotic, Chemopreventive, Gallic Acid, liver cancer
Problem Substances : N-nitrosodiethylamine : CK(10) : AC(5)

Gamma-tocotrienol profoundly alters sphingolipids in cancer cells.

Article Published Date : Apr 11, 2017
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol : CK(51) : AC(33)
Diseases : Cancers: All : CK(37812) : AC(15221)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060), Autophagy Up-regulation : CK(914) : AC(604)
Additional Keywords : Apoptotic, Autophagy Up-regulation, Cancers: All, Vitamin E: Gamma-tocotrienol

Ganoderma lucidum triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas.

Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom : CK(668) : AC(357)
Diseases : Breast Cancer : CK(8546) : AC(3188), Skin Cancer : CK(1887) : AC(882)
Pharmacological Actions : Anticarcinogenic Agents : CK(2161) : AC(1024), Apoptotic : CK(10324) : AC(8060), Bcl-2 protein down-regulation : CK(756) : AC(573), Bcl-xL down-regulation : CK(41) : AC(30), Chemopreventive : CK(6671) : AC(2217), Cyclin D1 Down-Regulation : CK(151) : AC(112)
Additional Keywords : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Breast Cancer : CK(113) : AC(34), Chemopreventive, Cyclin D1 Down-Regulation, Reishi Mushroom, skin cancer

Garcinone E exerts anticancer activities by inducing apoptosis and suppressing migration and invasion in ovarian cancer cells.

Article Published Date : Sep 05, 2017
Study Type : In Vitro Study
Additional Links
Substances : Garcinia Mangostana : CK(22) : AC(13)
Diseases : Ovarian Cancer : CK(1067) : AC(537)
Pharmacological Actions : Anti-metastatic : CK(3081) : AC(2344), Apoptotic : CK(10324) : AC(8060), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(1001) : AC(630), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1218) : AC(771)
Additional Keywords : Anti-metastatic, Apoptotic, Garcinia Mangostana, ovarian cancer

Genistein treatment significantly suppressed proliferation and anchorage-independent growth of the human retinoblastoma cell line Y79 in vitro.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Genistein : CK(951) : AC(439)
Diseases : Retinoblastoma : CK(81) : AC(38)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), MicroRNA modulator : CK(1567) : AC(903)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Genistein, MicroRNA modulator, Retinoblastoma

Harmaline induces cell cycle arrest and apoptosis in SGC-7901 cells.

Article Published Date : Dec 17, 2015
Study Type : Animal Study
Additional Links
Substances : Syrian rue : CK(84) : AC(51)
Diseases : Gastric Cancer : CK(1708) : AC(792)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Cell cycle arrest : CK(2243) : AC(1836)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cell cycle arrest, gastric cancer, Syrian rue

Harmine might be a potent inducer of apoptosis and autophagy in gastric carcinoma.

Article Published Date : May 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Syrian rue : CK(84) : AC(51)
Diseases : Gastric Cancer : CK(1708) : AC(792)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060), Autophagy Up-regulation : CK(914) : AC(604)
Additional Keywords : Apoptotic, Autophagy Up-regulation, gastric cancer, Syrian rue

Honokiol is a good candidate for further studies as a possible treatment for malignant melanoma.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Honokiol : CK(468) : AC(291)
Diseases : Malignant Melanoma : CK(97) : AC(48)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060), Cell cycle arrest : CK(2243) : AC(1836)
Additional Keywords : Apoptotic, Cell cycle arrest, Honokiol, Malignant Melanoma

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Bladder Cancer : CK(802) : AC(339)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Chemosensitizer : CK(1756) : AC(1344)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(455) : AC(361), Dose Response : CK(1780) : AC(701), Shikonin

Neferine enhances the antitumor effect of mitomycin-c in hela cells.

Article Published Date : Mar 21, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Cervical Cancer : CK(1032) : AC(634)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Apoptotic, Cervical Cancer, Chemotherapeutic Synergy: Mitomycin C : CK(8) : AC(7), Lotus

Neferine reduces the cisplatin dose requirement in cancer chemotherapy.

Article Published Date : Feb 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Lung Cancer : CK(3230) : AC(1535)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060), Chemosensitizer : CK(1756) : AC(1344), Vascular Endothelial Growth Factor Inhibitors : CK(639) : AC(351)
Additional Keywords : Apoptotic, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(455) : AC(361), Lotus, lung cancer, Vascular Endothelial Growth Factor Inhibitors

P. sulcata inhibited the growth in a dose-dependent manner and induced caspase-independent apoptosis at low doses.

Article Published Date : Apr 30, 2015
Study Type : Human In Vitro
Additional Links
Substances : Lichens : CK(78) : AC(55)
Diseases : Breast Cancer : CK(8546) : AC(3188), Breast Cancer: Triple Negative : CK(1017) : AC(701)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060), Caspase-3 Activation : CK(137) : AC(90)
Additional Keywords : Apoptotic, Breast Cancer : CK(113) : AC(34), Breast Cancer: Triple Negative, Caspase-3 Activation, Dose Response : CK(1780) : AC(701), Lichens

Peganum harmala's extract decreases the growth rate of the cancer cell line through inducing apoptosis.

Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Syrian rue : CK(84) : AC(51)
Diseases : Breast Cancer : CK(8546) : AC(3188), Breast Cancer: Triple Negative : CK(1017) : AC(701)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Apoptotic, Breast Cancer : CK(113) : AC(34), Breast Cancer: Triple Negative, Syrian rue

Piperine is a promising candidate for targeting G-quadruplex DNA.

Article Published Date : Dec 19, 2016
Study Type : In Vitro Study
Additional Links
Substances : Piperine : CK(731) : AC(286)
Diseases : Lung Cancer : CK(3230) : AC(1535)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, lung cancer, Piperine

Polysaccharide from Pleurotus nebrodensis induces apoptosis via a mitochondrial pathway in HepG2 cells.

Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Pleurotus nebrodensis : CK(9) : AC(6)
Diseases : DNA damage : CK(2388) : AC(887)
Pharmacological Actions : Antineoplastic Agents : CK(2499) : AC(1678), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Antineoplastic Agents : CK(78) : AC(35), Apoptotic, DNA damage, Pleurotus nebrodensis, Polysaccharides : CK(1559) : AC(874)

Quercetrin from Toona sinensis leaves induces cell cycle arrest and apoptosis in human colorectal cancer SW620 cells.

Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Quercetin : CK(1922) : AC(875), Toona sinensis : CK(46) : AC(30)
Diseases : Colorectal Cancer : CK(5133) : AC(2434)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, COLORECTAL CANCER, QUERCETIN, Toona sinensis

Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis.

Article Published Date : Oct 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bloodroot : CK(37) : AC(13)
Diseases : Gastric Cancer : CK(1708) : AC(792)
Pharmacological Actions : Apoptotic : CK(10324) : AC(8060), Caspase-3 Activation : CK(137) : AC(90), Chemosensitizer : CK(1756) : AC(1344)
Additional Keywords : Apoptotic, Bloodroot, Caspase-3 Activation, Chemosensitizer, gastric cancer

Sulforaphane alone or in combination with other therapies may be potentially useful for glioblastoma therapy.

Article Published Date : Jan 05, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane : CK(1345) : AC(631)
Diseases : Glioblastoma : CK(757) : AC(428)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cancer Stem Cells : CK(515) : AC(375), glioblastoma (GBM), Sulforaphane

Tangeretin may be a therapeutic agent for glioblastoma treatment.

Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Tangeretin : CK(206) : AC(114)
Diseases : Glioblastoma : CK(757) : AC(428)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Cell cycle arrest : CK(2243) : AC(1836)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cell cycle arrest, Glioblastoma, Tangeretin

Tea polyphenols induce S phase arrest and apoptosis in gallbladder cancer cells.

Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Polyphenols : CK(2952) : AC(1093)
Diseases : Gallbladder Cancer : CK(120) : AC(41)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060), Cell cycle arrest : CK(2243) : AC(1836)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cell cycle arrest, Gallbladder Cancer, POLYPHENOLS : CK(16) : AC(5)

These findings indicate that mangiferin effectively inhibits cell growth and induces apoptosis of gastric cancer cells.

Article Published Date : Dec 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin : CK(376) : AC(223)
Diseases : Gastric Cancer : CK(1708) : AC(792)
Pharmacological Actions : Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Dose Response : CK(1780) : AC(701), gastric cancer, Mangiferin

These results indicate a chemopreventive potential of in vitro fermented hazelnuts.

Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Fermented Foods and Beverages : CK(3488) : AC(861), Hazelnut : CK(100) : AC(23)
Diseases : Colon Cancer : CK(1974) : AC(1240), DNA damage : CK(2388) : AC(887)
Pharmacological Actions : Anticarcinogenic Agents : CK(2161) : AC(1024), Antineoplastic Agents : CK(2499) : AC(1678), Antiproliferative : CK(10913) : AC(8254), Apoptotic : CK(10324) : AC(8060)
Additional Keywords : Anticarcinogenic Agents, Antineoplastic Agents : CK(78) : AC(35), Antiproliferative : CK(75) : AC(61), Apoptotic, COLON CANCER, DNA damage, Fermented Foods and Beverages, Hazelnut

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