Results for Apoptotic

A comprehensive review on anticancer mechanisms of crocin.

Article Published Date : Jul 02, 2017
Study Type : Review
Additional Links
Substances : Crocin : CK(117) : AC(62)
Diseases : Cancers: All : CK(22165) : AC(7896)
Pharmacological Actions : Anti-metastatic : CK(1284) : AC(927), Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Chemotherapeutic : CK(397) : AC(152), Telomerase Inhibitor : CK(55) : AC(35)
Additional Keywords : Anti-metastatic, Antiproliferative : CK(65) : AC(52), Apoptotic, Cancers: All, Chemotherapeutic, Crocin, Telomerase Inhibitor

A wasabi extract exhibits anti-colon cancer properties through the induction of apoptosis and autophagy.

Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Wasabi : CK(23) : AC(18)
Diseases : Colon Cancer : CK(1217) : AC(742)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Autophagy Up-regulation : CK(296) : AC(197)
Additional Keywords : Apoptotic, Autophagy Up-regulation, COLON CANCER, Plant Extracts : CK(11762) : AC(4236), Wasabi

A water-soluble polysaccharide is able to reduce the number of fat cells and the mass of adipose tissue.

Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : White Mulberry : CK(94) : AC(34)
Diseases : Obesity : CK(4406) : AC(1073)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Anti-Obesity Agents : CK(1519) : AC(430), Apoptotic, obesity, Plant Extracts : CK(11762) : AC(4236), Polysaccharides : CK(5) : AC(3), White Mulberry

Alkaloids from Peganum harmala could be a promising candidate for the therapy of leukemia.

Article Published Date : Nov 02, 2015
Study Type : In Vitro Study
Additional Links
Substances : Syrian rue : CK(1) : AC(1)
Diseases : Leukemia : CK(1284) : AC(586)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Apoptotic, leukemia, Syrian rue

An extract of Litchi seed has potential for development into a safe and potent alternative therapy for prostate cancer patients.

Article Published Date : Jan 29, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Litchi : CK(29) : AC(17)
Diseases : Prostate Cancer : CK(2097) : AC(687)
Pharmacological Actions : Anti-metastatic : CK(1284) : AC(927), Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006), P21 Activation : CK(72) : AC(47)
Additional Keywords : Anti-metastatic, Apoptotic, Cell cycle arrest, Litchi, P21 Activation, Plant Extracts : CK(11762) : AC(4236), prostate cancer

An extract of Lotus may be a powerful agent against colon cancer cells.

Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(153) : AC(108)
Diseases : Colon Cancer : CK(1217) : AC(742)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Bcl-2 protein down-regulation : CK(419) : AC(295), Bcl-xL down-regulation : CK(1) : AC(1), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(551) : AC(315), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(543) : AC(337), NF-kappaB Inhibitor : CK(2446) : AC(1436)
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, COLON CANCER, Lotus, Plant Extracts : CK(11762) : AC(4236)

Anti-cancerous effect of Inonotus taiwanensis polysaccharide extract on human acute monocytic leukemia cells.

Article Published Date : Jan 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Medicinal Mushrooms : CK(1190) : AC(544)
Diseases : Leukemia: Monocytic : CK(24) : AC(5)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Autophagy Inhibitors : CK(26) : AC(13)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Autophagy Inhibitors : CK(5) : AC(4), Leukemia: Monocytic, Medicinal Mushrooms, Polysaccharides : CK(5) : AC(3)

Apigenin induces the apoptosis of colon cancer cells.

Article Published Date : Mar 06, 2018
Study Type : In Vitro Study
Additional Links
Substances : Apigenin : CK(295) : AC(165)
Diseases : Colon Cancer : CK(1217) : AC(742)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Bcl-xL down-regulation : CK(1) : AC(1)
Additional Keywords : Antiproliferative : CK(65) : AC(52), APIGENIN, Apoptotic, Bcl-xL down-regulation, COLON CANCER

Avocado defensin could induce intrinsic apoptosis in breast cancer cells.

Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Avocado : CK(91) : AC(30)
Diseases : Breast Cancer : CK(5066) : AC(1738)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Caspase-7 Activation : CK(2) : AC(2), Caspase-9 Activation : CK(30) : AC(19)
Additional Keywords : Apoptotic, Avocado, Breast Cancer : CK(2) : AC(1), Caspase-7 Activation, Caspase-9 Activation

Baicalein induces cancer cell apoptosis and cause cell cycle arrest.

Article Published Date : Jul 31, 2016
Study Type : Review
Additional Links
Substances : Baicalein : CK(106) : AC(75)
Diseases : Cancers: All : CK(22165) : AC(7896)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Baicalein, Cancer : CK(1) : AC(1), Cell cycle arrest

Butyrate induced apoptosis and inhibited cell proliferation via enhancing the intracellular expression of miR-22.

Article Published Date : Mar 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Butyrate : CK(12) : AC(9)
Diseases : Liver Cancer : CK(1953) : AC(852)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Histone deacetylase inhibitor : CK(48) : AC(37), MicroRNA modulator : CK(264) : AC(145)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Butyrate, Histone deacetylase inhibitor, liver cancer, MicroRNA modulator

Caffeic acid and caffeic acid phenethyl ester induce apoptosis and cell cycle arrest of breast cancer cells MDA-MB-231.

Article Published Date : Sep 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Caffeic Acid : CK(43) : AC(25), Caffeic acid phenethyl ester : CK(58) : AC(30)
Diseases : Breast Cancer: Triple Negative : CK(551) : AC(337)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Breast Cancer: Triple Negative, Caffeic Acid, Caffeic acid phenethyl ester, Cell cycle arrest

Carnosic acid cooperates with tamoxifen to induce apoptosis in breast cancer cells.

Article Published Date : Apr 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid : CK(39) : AC(27)
Diseases : Breast Cancer : CK(5066) : AC(1738)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Bcl-2 protein down-regulation : CK(419) : AC(295), Bcl-xL down-regulation : CK(1) : AC(1)
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Breast Cancer : CK(2) : AC(1), Carnosic Acid, Synergy with Tamoxifen : CK(6) : AC(5)
Problem Substances : Tamoxifen : CK(338) : AC(51)

Carnosic acid induces apoptosis of hepatocellular carcinoma cells.

Article Published Date : Oct 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid : CK(39) : AC(27)
Diseases : Liver Cancer : CK(1953) : AC(852)
Pharmacological Actions : Antineoplastic Agents : CK(1594) : AC(982), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Antineoplastic Agents : CK(75) : AC(33), Apoptotic, Carnosic Acid, liver cancer

Cinnamon extract from Sanyangxuedai may be effective for treating leukemia.

Article Published Date : Aug 18, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cinnamon : CK(394) : AC(141)
Diseases : Leukemia : CK(1284) : AC(586)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Cell cycle arrest, cinnamon, leukemia, Plant Extracts : CK(11762) : AC(4236)

Combination therapy with low concentrations of sorafenib and betulinic acid had the capacity to induce high levels of cell death.

Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid : CK(28) : AC(18)
Diseases : Carcinoma: Non-Small-Cell Lung : CK(264) : AC(161)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Betulinic acid, Carcinoma: Non-Small-Cell Lung, Natural Substance/Drug Synergy : CK(352) : AC(142)

Combined use of lower concentrations of jerantinine A and γ-tocotrienol induced potent cytotoxic effects on U87MG cancer cells.

Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol : CK(44) : AC(28)
Diseases : Glioblastoma : CK(398) : AC(193)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006), Chemoprotective Agents : CK(356) : AC(146), Chemosensitizer : CK(772) : AC(577), Chemotherapeutic : CK(397) : AC(152), Tumor Suppressor Protein p53 Upregulation : CK(480) : AC(343)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Cell cycle arrest, Glioblastoma, Natural Substance/Drug Synergy : CK(352) : AC(142), Vitamin E: Gamma-tocotrienol

Cucurbitacin E may delay cancer cell growth by apoptosis via upregulation of DR5 gene expression.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin E : CK(14) : AC(13)
Diseases : Cervical Cancer : CK(594) : AC(288)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Cervical Cancer, Cucurbitacin E, Gene Expression Regulation : CK(431) : AC(214)

Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells.

Article Published Date : Jun 07, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4844) : AC(2458)
Diseases : Glioma : CK(333) : AC(169)
Pharmacological Actions : Anti-metastatic : CK(1284) : AC(927), Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Anti-metastatic, Antiproliferative : CK(65) : AC(52), Apoptotic, CURCUMIN : CK(2) : AC(1), Glioma

Curcumin induced leukemic cell apoptosis via an IFIT2-dependent signalling pathways.

Article Published Date : Jan 01, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4844) : AC(2458)
Diseases : Leukemia : CK(1284) : AC(586)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Apoptotic, CURCUMIN : CK(2) : AC(1), leukemia

Curcumin may serve as a promising anticancer agent by inducing a chronic ER stress mediated cell death and activation of cell cycle arrest.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4844) : AC(2458)
Diseases : Prostate Cancer : CK(2097) : AC(687)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Apoptotic, CURCUMIN : CK(2) : AC(1), prostate cancer

Diallyl trisulfide suppresses tumor growth and potentiates cisplatin efficacy in gastric cancer treatment.

Article Published Date : Mar 26, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Dimethyl trisulfide (DMTS) : CK(8) : AC(5)
Diseases : Gastric Cancer : CK(836) : AC(341)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006), Chemosensitizer : CK(772) : AC(577)
Additional Keywords : Apoptotic, Cell cycle arrest, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(137) : AC(103), Dimethyl trisulfide (DMTS), gastric cancer

Effects of thymol on human gastric adenocarcinoma cells in vitro.

Article Published Date : Feb 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Thymol : CK(41) : AC(28)
Diseases : Gastric Cancer : CK(836) : AC(341)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Apoptotic, gastric cancer, Thymol

EGCG is effective in decreasing cell viability, apoptosis induction and enhancement of caspase 3 and Fas expression level in jurkat cells.

Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(890) : AC(477)
Diseases : Leukemia: T-cell acute Lymphoblastic : CK(21) : AC(11)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, EGCG (Epigallocatechin gallate), Leukemia: T-cell acute Lymphoblastic

Ethanol extract of Antrodia camphorata inhibits proliferation of HCT-8 human colorectal cancer cells.

Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Antrodia camphorata : CK(32) : AC(19)
Diseases : Colorectal Cancer : CK(2874) : AC(1192)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Antrodia camphorata, Apoptotic, Cell cycle arrest, COLORECTAL CANCER

Extracts of Parmelia sulcata and Usnea filipendula induced apoptosis-like cell death by causing DNA damage, to cancer cells.

Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lichens : CK(72) : AC(49)
Diseases : Glioma : CK(333) : AC(169), Liver Cancer : CK(1953) : AC(852), Lung Cancer : CK(1741) : AC(742)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Dose Response : CK(1519) : AC(574), Glioma, Lichens, liver cancer, lung cancer, Parmelia sulcata, Plant Extracts : CK(11762) : AC(4236)

Forced inhibition of PDE1A expression might be a new therapeutic strategy for the management of acute lymphoblastic leukemia.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Acute lymphoblastic leukemia (ALL) : CK(130) : AC(39)
Pharmacological Actions : Antineoplastic Agents : CK(1594) : AC(982), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Acute lymphoblastic leukemia (ALL), Antineoplastic Agents : CK(75) : AC(33), Apoptotic, thymoquinone

Fucoidan inhibited cell growth, induced apoptosis and suppressed angiogenesis in thyroid cancer cells.

Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan : CK(401) : AC(228)
Diseases : Thyroid Cancer : CK(237) : AC(55)
Pharmacological Actions : Angiogenesis Inhibitors : CK(114) : AC(62), Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Angiogenesis Inhibitors, Antiproliferative : CK(65) : AC(52), Apoptotic, Dose Response : CK(1519) : AC(574), Fucoidan, Thyroid Cancer

Gallic acid remarkably ameliorated the destabilization of liver tissue architecture caused by N-nitrosodiethylamine.

Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Gallic Acid : CK(58) : AC(33)
Diseases : Liver Cancer : CK(1953) : AC(852)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Anticarcinogenic Agents : CK(1577) : AC(756), Antioxidants : CK(14410) : AC(5758), Apoptotic : CK(5217) : AC(3846), Chemopreventive : CK(4220) : AC(1326)
Additional Keywords : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants : CK(1) : AC(1), Apoptotic, Chemopreventive, Gallic Acid, liver cancer
Problem Substances : N-nitrosodiethylamine : CK(2) : AC(1)

Gamma-tocotrienol profoundly alters sphingolipids in cancer cells.

Article Published Date : Apr 11, 2017
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol : CK(44) : AC(28)
Diseases : Cancers: All : CK(22165) : AC(7896)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Autophagy Up-regulation : CK(296) : AC(197)
Additional Keywords : Apoptotic, Autophagy Up-regulation, Cancers: All, Vitamin E: Gamma-tocotrienol

Ganoderma lucidum triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas.

Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom : CK(277) : AC(138)
Diseases : Breast Cancer : CK(5066) : AC(1738), Skin Cancer : CK(1175) : AC(495)
Pharmacological Actions : Anticarcinogenic Agents : CK(1577) : AC(756), Apoptotic : CK(5217) : AC(3846), Bcl-2 protein down-regulation : CK(419) : AC(295), Bcl-xL down-regulation : CK(1) : AC(1), Chemopreventive : CK(4220) : AC(1326), Cyclin D1 Down-Regulation : CK(42) : AC(28)
Additional Keywords : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Breast Cancer : CK(2) : AC(1), Chemopreventive, Cyclin D1 Down-Regulation, Reishi Mushroom, skin cancer

Garcinone E exerts anticancer activities by inducing apoptosis and suppressing migration and invasion in ovarian cancer cells.

Article Published Date : Sep 05, 2017
Study Type : In Vitro Study
Additional Links
Substances : Garcinia Mangostana : CK(9) : AC(1)
Diseases : Ovarian Cancer : CK(654) : AC(263)
Pharmacological Actions : Anti-metastatic : CK(1284) : AC(927), Apoptotic : CK(5217) : AC(3846), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(551) : AC(315), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(543) : AC(337)
Additional Keywords : Anti-metastatic, Apoptotic, Garcinia Mangostana, ovarian cancer

Genistein treatment significantly suppressed proliferation and anchorage-independent growth of the human retinoblastoma cell line Y79 in vitro.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Genistein : CK(650) : AC(296)
Diseases : Retinoblastoma : CK(43) : AC(12)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), MicroRNA modulator : CK(264) : AC(145)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Genistein, MicroRNA modulator, Retinoblastoma

Harmaline induces cell cycle arrest and apoptosis in SGC-7901 cells.

Article Published Date : Dec 17, 2015
Study Type : Animal Study
Additional Links
Substances : Syrian rue : CK(1) : AC(1)
Diseases : Gastric Cancer : CK(836) : AC(341)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Cell cycle arrest, gastric cancer, Syrian rue

Harmine might be a potent inducer of apoptosis and autophagy in gastric carcinoma.

Article Published Date : May 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Syrian rue : CK(1) : AC(1)
Diseases : Gastric Cancer : CK(836) : AC(341)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Autophagy Up-regulation : CK(296) : AC(197)
Additional Keywords : Apoptotic, Autophagy Up-regulation, gastric cancer, Syrian rue

Honokiol is a good candidate for further studies as a possible treatment for malignant melanoma.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Honokiol : CK(103) : AC(63)
Diseases : Malignant Melanoma : CK(34) : AC(16)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006)
Additional Keywords : Apoptotic, Cell cycle arrest, Honokiol, Malignant Melanoma

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(108) : AC(63)
Diseases : Bladder Cancer : CK(521) : AC(176)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Chemosensitizer : CK(772) : AC(577)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(137) : AC(103), Dose Response : CK(1519) : AC(574), Shikonin

Neferine enhances the antitumor effect of mitomycin-c in hela cells.

Article Published Date : Mar 21, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(153) : AC(108)
Diseases : Cervical Cancer : CK(594) : AC(288)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Apoptotic, Cervical Cancer, Chemotherapeutic Synergy: Mitomycin C : CK(6) : AC(5), Lotus

Neferine reduces the cisplatin dose requirement in cancer chemotherapy.

Article Published Date : Feb 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(153) : AC(108)
Diseases : Lung Cancer : CK(1741) : AC(742)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Chemosensitizer : CK(772) : AC(577), Vascular Endothelial Growth Factor Inhibitors : CK(123) : AC(61)
Additional Keywords : Apoptotic, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(137) : AC(103), Lotus, lung cancer, Vascular Endothelial Growth Factor Inhibitors

P. sulcata inhibited the growth in a dose-dependent manner and induced caspase-independent apoptosis at low doses.

Article Published Date : Apr 30, 2015
Study Type : Human In Vitro
Additional Links
Substances : Lichens : CK(72) : AC(49)
Diseases : Breast Cancer : CK(5066) : AC(1738), Breast Cancer: Triple Negative : CK(551) : AC(337)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Caspase-3 Activation : CK(137) : AC(90)
Additional Keywords : Apoptotic, Breast Cancer : CK(2) : AC(1), Breast Cancer: Triple Negative, Caspase-3 Activation, Dose Response : CK(1519) : AC(574), Lichens

Peganum harmala's extract decreases the growth rate of the cancer cell line through inducing apoptosis.

Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Syrian rue : CK(1) : AC(1)
Diseases : Breast Cancer : CK(5066) : AC(1738), Breast Cancer: Triple Negative : CK(551) : AC(337)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Apoptotic, Breast Cancer : CK(2) : AC(1), Breast Cancer: Triple Negative, Syrian rue

Piperine is a promising candidate for targeting G-quadruplex DNA.

Article Published Date : Dec 19, 2016
Study Type : In Vitro Study
Additional Links
Substances : Piperine : CK(225) : AC(109)
Diseases : Lung Cancer : CK(1741) : AC(742)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, lung cancer, Piperine

Polysaccharide from Pleurotus nebrodensis induces apoptosis via a mitochondrial pathway in HepG2 cells.

Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Pleurotus nebrodensis : CK(3) : AC(2)
Diseases : DNA damage : CK(1482) : AC(545)
Pharmacological Actions : Antineoplastic Agents : CK(1594) : AC(982), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Antineoplastic Agents : CK(75) : AC(33), Apoptotic, DNA damage, Pleurotus nebrodensis, Polysaccharides : CK(5) : AC(3)

Quercetrin from Toona sinensis leaves induces cell cycle arrest and apoptosis in human colorectal cancer SW620 cells.

Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Quercetin : CK(846) : AC(392), Toona sinensis : CK(27) : AC(16)
Diseases : Colorectal Cancer : CK(2874) : AC(1192)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, COLORECTAL CANCER, QUERCETIN, Toona sinensis

Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis.

Article Published Date : Oct 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bloodroot : CK(37) : AC(13)
Diseases : Gastric Cancer : CK(836) : AC(341)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846), Caspase-3 Activation : CK(137) : AC(90), Chemosensitizer : CK(772) : AC(577)
Additional Keywords : Apoptotic, Bloodroot, Caspase-3 Activation, Chemosensitizer, gastric cancer

Sulforaphane alone or in combination with other therapies may be potentially useful for glioblastoma therapy.

Article Published Date : Jan 05, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane : CK(691) : AC(339)
Diseases : Glioblastoma : CK(398) : AC(193)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Cancer Stem Cells : CK(274) : AC(194), glioblastoma (GBM), Sulforaphane

Tangeretin may be a therapeutic agent for glioblastoma treatment.

Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Tangeretin : CK(38) : AC(24)
Diseases : Glioblastoma : CK(398) : AC(193)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Cell cycle arrest, Glioblastoma, Tangeretin

Tea polyphenols induce S phase arrest and apoptosis in gallbladder cancer cells.

Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Polyphenols : CK(1353) : AC(489)
Diseases : Gallbladder Cancer : CK(65) : AC(13)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Cell cycle arrest : CK(1289) : AC(1006)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Cell cycle arrest, Gallbladder Cancer, POLYPHENOLS : CK(1) : AC(1)

These findings indicate that mangiferin effectively inhibits cell growth and induces apoptosis of gastric cancer cells.

Article Published Date : Dec 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin : CK(179) : AC(106)
Diseases : Gastric Cancer : CK(836) : AC(341)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, Dose Response : CK(1519) : AC(574), gastric cancer, Mangiferin

These results indicate a chemopreventive potential of in vitro fermented hazelnuts.

Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Fermented Foods and Beverages : CK(1673) : AC(386), Hazelnut : CK(46) : AC(8)
Diseases : Colon Cancer : CK(1217) : AC(742), DNA damage : CK(1482) : AC(545)
Pharmacological Actions : Anticarcinogenic Agents : CK(1577) : AC(756), Antineoplastic Agents : CK(1594) : AC(982), Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Anticarcinogenic Agents, Antineoplastic Agents : CK(75) : AC(33), Antiproliferative : CK(65) : AC(52), Apoptotic, COLON CANCER, DNA damage, Fermented Foods and Beverages, Hazelnut

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