Results for Chemoprotective Agents

A short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicity

Article Published Date : Dec 12, 2016
Study Type : Human Study
Additional Links
Substances : Magnesium : CK(3063) : AC(401)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1340) : AC(645)
Pharmacological Actions : Chemoprotective Agents : CK(4562) : AC(1746)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Magnesium : CK(11) : AC(2)

Combination therapy of rosmarinic acid and lycopene shows better protective effects than the corresponding monotherapy.

Article Published Date : Nov 23, 2016
Study Type : Animal Study
Additional Links
Substances : Lycopene : CK(1268) : AC(373), Rosmarinic acid : CK(200) : AC(113)
Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(206) : AC(108)
Pharmacological Actions : Chemoprotective Agents : CK(4562) : AC(1746), Renoprotective : CK(4902) : AC(2130)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Gentamicin, lycopene, Renoprotective, Rosmarinic acid

Egyptian sweet orange hesperidin ameliorates the cytotoxic effect of doxorubicin while enhancing its anti-tumor effect.

Article Published Date : Mar 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hesperidin : CK(1002) : AC(381), Sweet Orange : CK(48) : AC(17)
Diseases : Ehrlich carcinoma : CK(97) : AC(53)
Pharmacological Actions : Chemoprotective Agents : CK(4562) : AC(1746), Chemosensitizer : CK(1756) : AC(1344)
Additional Keywords : Chemoprotective Agents, Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(386) : AC(295), Ehrlich carcinoma, Hesperidin, Sweet Orange

Folic acid may be a novel therapeutic approach to attenuate doxorubicin induced cardiomyopathy.

Article Published Date : Jun 12, 2017
Study Type : Animal Study
Additional Links
Substances : Folic Acid : CK(1332) : AC(210)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(914) : AC(455)
Pharmacological Actions : Antioxidants : CK(37177) : AC(15613), Cardioprotective : CK(9981) : AC(3158), Chemoprotective Agents : CK(4562) : AC(1746)
Additional Keywords : Antioxidants : CK(303) : AC(126), Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, folic acid

Ginsenosides Rk2 and Rh3 have kidney protective effects of against cisplatin.

Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides : CK(2649) : AC(1457)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1340) : AC(645)
Pharmacological Actions : Chemoprotective Agents : CK(4562) : AC(1746), Renoprotective : CK(4902) : AC(2130)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Ginsenosides, Renoprotective

Ginsenosides Rk3 and Rh4 protect the kidney from cisplatin-induced oxidative injury.

Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides : CK(2649) : AC(1457)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1340) : AC(645)
Pharmacological Actions : Antioxidants : CK(37177) : AC(15613), Chemoprotective Agents : CK(4562) : AC(1746), Renoprotective : CK(4902) : AC(2130)
Additional Keywords : Antioxidants : CK(303) : AC(126), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Ginsenosides, Renoprotective

Honey can decrease the side effects of chemotherapy on reproductive system and prevent sterility.

Article Published Date : May 22, 2018
Study Type : Animal Study
Additional Links
Substances : Honey : CK(1300) : AC(343)
Diseases : Chemotherapy and Radiation Toxicity : CK(2637) : AC(631)
Pharmacological Actions : Chemoprotective Agents : CK(4562) : AC(1746)
Additional Keywords : Chemoprotective Agents, Chemotherapy and Radiation Toxicity, Honey : CK(22) : AC(9)

Melatonin could be used as an adjuvant agent with rapamycin in head and neck cancers.

Article Published Date : Dec 15, 2017
Study Type : In Vitro Study
Additional Links
Substances : Melatonin : CK(2959) : AC(926)
Diseases : Head and Neck Cancer : CK(825) : AC(197)
Pharmacological Actions : Chemoprotective Agents : CK(4562) : AC(1746), Chemotherapeutic : CK(4540) : AC(1699)
Additional Keywords : Chemoprotective Agents, Chemotherapeutic, Head and Neck Cancer, melatonin, Natural Substance/Drug Synergy : CK(1654) : AC(769)

Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin.

Article Published Date : Sep 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(914) : AC(455)
Pharmacological Actions : Anti-Inflammatory Agents : CK(43311) : AC(17345), Cardioprotective : CK(9981) : AC(3158), Chemoprotective Agents : CK(4562) : AC(1746)
Additional Keywords : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents, Lotus

Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy.

Article Published Date : Mar 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1340) : AC(645)
Pharmacological Actions : Autophagy Up-regulation : CK(914) : AC(604), Chemoprotective Agents : CK(4562) : AC(1746)
Additional Keywords : Autophagy Up-regulation, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Lotus

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.

Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(2051) : AC(525), Thymoquinone : CK(1256) : AC(736)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1340) : AC(645)
Pharmacological Actions : Chemoprotective Agents : CK(4562) : AC(1746)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone

Nigella sativa oil may help prevent the accompanying gastrointestinal dysfunction in cisplatin chemotherapy.

Article Published Date : Feb 14, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(2051) : AC(525)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1340) : AC(645)
Pharmacological Actions : Chemoprotective Agents : CK(4562) : AC(1746), Gastroprotective : CK(1809) : AC(758)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Gastroprotective, Nigella sativa (aka Black Seed)

Panax ginseng anthocyanins pre-administration can significantly prevent cisplatin-induced nephrotoxicity.

Article Published Date : Jul 20, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins : CK(1677) : AC(528), Panax Ginseng : CK(94) : AC(45)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1340) : AC(645)
Pharmacological Actions : Chemoprotective Agents : CK(4562) : AC(1746), Cyclooxygenase 2 Inhibitors : CK(2372) : AC(1399), Nitric Oxide Inhibitor : CK(721) : AC(365)
Additional Keywords : Anthocyanins : CK(11) : AC(9), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Panax Ginseng

Phloretin has an anti-apoptotic effect on cisplatin-induced apoptosis in HEI-OC1 auditory cells.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Phloretin : CK(275) : AC(165)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1340) : AC(645)
Pharmacological Actions : Anti-Apoptotic : CK(6196) : AC(3516), Chemoprotective Agents : CK(4562) : AC(1746), Heme oxygenase-1 inducer : CK(63) : AC(43)
Additional Keywords : Anti-Apoptotic, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Heme oxygenase-1 inducer, Phloretin

Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(3318) : AC(1546)
Diseases : Lung Cancer : CK(3223) : AC(1528), Melanoma : CK(995) : AC(592)
Pharmacological Actions : Anti-metastatic : CK(3067) : AC(2336), Chemoprotective Agents : CK(4562) : AC(1746), Chemosensitizer : CK(1756) : AC(1344)
Additional Keywords : Anti-metastatic, Chemoprotective Agents, Chemosensitizer, lung cancer, melanoma, RESVERATROL

These results highlight the protective effects of tangeretin against cisplatin-induced acute hepatic injury.

Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Tangeretin : CK(206) : AC(114)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1340) : AC(645)
Pharmacological Actions : Anti-Apoptotic : CK(6196) : AC(3516), Anti-Inflammatory Agents : CK(43311) : AC(17345), Antioxidants : CK(37177) : AC(15613), Chemoprotective Agents : CK(4562) : AC(1746)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants : CK(303) : AC(126), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin

This study suggests the use of neferine for amelioration of doxorubicin -mediated cardiotoxicity.

Article Published Date : Jul 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(914) : AC(455)
Pharmacological Actions : Cardioprotective : CK(9981) : AC(3158), Chemoprotective Agents : CK(4562) : AC(1746)
Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Lotus

Zingiber officinale Roscoe ameliorates anticancer antibiotic doxorubicin-induced acute cardiotoxicity.

Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Ginger : CK(1600) : AC(484)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(914) : AC(455)
Pharmacological Actions : Cardioprotective : CK(9981) : AC(3158), Chemoprotective Agents : CK(4562) : AC(1746)
Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Ginger

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