Results for Chemoprotective Agents

A short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicity

Article Published Date : Dec 12, 2016
Study Type : Human Study
Additional Links
Substances : Magnesium : CK(2442) : AC(317)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(881) : AC(388)
Pharmacological Actions : Chemoprotective Agents : CK(2322) : AC(906)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Magnesium : CK(10) : AC(1)

Combination therapy of rosmarinic acid and lycopene shows better protective effects than the corresponding monotherapy.

Article Published Date : Nov 23, 2016
Study Type : Animal Study
Additional Links
Substances : Lycopene : CK(886) : AC(249), Rosmarinic acid : CK(47) : AC(26)
Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(146) : AC(75)
Pharmacological Actions : Chemoprotective Agents : CK(2322) : AC(906), Renoprotective : CK(2404) : AC(1075)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Gentamicin, lycopene, Renoprotective, Rosmarinic acid

Egyptian sweet orange hesperidin ameliorates the cytotoxic effect of doxorubicin while enhancing its anti-tumor effect.

Article Published Date : Mar 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hesperidin : CK(545) : AC(215), Sweet Orange : CK(48) : AC(17)
Diseases : Ehrlich carcinoma : CK(17) : AC(9)
Pharmacological Actions : Chemoprotective Agents : CK(2322) : AC(906), Chemosensitizer : CK(1124) : AC(854)
Additional Keywords : Chemoprotective Agents, Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(220) : AC(168), Ehrlich carcinoma, Hesperidin, Sweet Orange

Folic acid may be a novel therapeutic approach to attenuate doxorubicin induced cardiomyopathy.

Article Published Date : Jun 12, 2017
Study Type : Animal Study
Additional Links
Substances : Folic Acid : CK(1047) : AC(168)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(457) : AC(236)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Cardioprotective : CK(5377) : AC(1675), Chemoprotective Agents : CK(2322) : AC(906)
Additional Keywords : Antioxidants : CK(303) : AC(126), Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, folic acid

Ginsenosides Rk2 and Rh3 have kidney protective effects of against cisplatin.

Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides : CK(1550) : AC(873)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(881) : AC(388)
Pharmacological Actions : Chemoprotective Agents : CK(2322) : AC(906), Renoprotective : CK(2404) : AC(1075)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Ginsenosides, Renoprotective

Ginsenosides Rk3 and Rh4 protect the kidney from cisplatin-induced oxidative injury.

Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides : CK(1550) : AC(873)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(881) : AC(388)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Chemoprotective Agents : CK(2322) : AC(906), Renoprotective : CK(2404) : AC(1075)
Additional Keywords : Antioxidants : CK(303) : AC(126), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Ginsenosides, Renoprotective

Honey can decrease the side effects of chemotherapy on reproductive system and prevent sterility.

Article Published Date : May 22, 2018
Study Type : Animal Study
Additional Links
Substances : Honey : CK(920) : AC(247)
Diseases : Chemotherapy and Radiation Toxicity : CK(2326) : AC(570)
Pharmacological Actions : Chemoprotective Agents : CK(2322) : AC(906)
Additional Keywords : Chemoprotective Agents, Chemotherapy and Radiation Toxicity, Honey : CK(1) : AC(1)

Melatonin could be used as an adjuvant agent with rapamycin in head and neck cancers.

Article Published Date : Dec 15, 2017
Study Type : In Vitro Study
Additional Links
Substances : Melatonin : CK(1911) : AC(647)
Diseases : Head and Neck Cancer : CK(459) : AC(118)
Pharmacological Actions : Chemoprotective Agents : CK(2322) : AC(906), Chemotherapeutic : CK(2328) : AC(1086)
Additional Keywords : Chemoprotective Agents, Chemotherapeutic, Head and Neck Cancer, melatonin, Natural Substance/Drug Synergy : CK(957) : AC(485)

Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin.

Article Published Date : Sep 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(237) : AC(170)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(457) : AC(236)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Cardioprotective : CK(5377) : AC(1675), Chemoprotective Agents : CK(2322) : AC(906)
Additional Keywords : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents, Lotus

Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy.

Article Published Date : Mar 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(237) : AC(170)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(881) : AC(388)
Pharmacological Actions : Autophagy Up-regulation : CK(518) : AC(349), Chemoprotective Agents : CK(2322) : AC(906)
Additional Keywords : Autophagy Up-regulation, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Lotus

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.

Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1250) : AC(356), Thymoquinone : CK(774) : AC(451)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(881) : AC(388)
Pharmacological Actions : Chemoprotective Agents : CK(2322) : AC(906)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone

Nigella sativa oil may help prevent the accompanying gastrointestinal dysfunction in cisplatin chemotherapy.

Article Published Date : Feb 14, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1250) : AC(356)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(881) : AC(388)
Pharmacological Actions : Chemoprotective Agents : CK(2322) : AC(906), Gastroprotective : CK(955) : AC(388)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Gastroprotective, Nigella sativa (aka Black Seed)

Panax ginseng anthocyanins pre-administration can significantly prevent cisplatin-induced nephrotoxicity.

Article Published Date : Jul 20, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins : CK(938) : AC(334), Panax Ginseng : CK(90) : AC(43)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(881) : AC(388)
Pharmacological Actions : Chemoprotective Agents : CK(2322) : AC(906), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926), Nitric Oxide Inhibitor : CK(498) : AC(258)
Additional Keywords : Anthocyanins : CK(7) : AC(6), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Panax Ginseng

Phloretin has an anti-apoptotic effect on cisplatin-induced apoptosis in HEI-OC1 auditory cells.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Phloretin : CK(177) : AC(101)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(881) : AC(388)
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672), Chemoprotective Agents : CK(2322) : AC(906), Heme oxygenase-1 inducer : CK(57) : AC(39)
Additional Keywords : Anti-Apoptotic, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Heme oxygenase-1 inducer, Phloretin

Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(2037) : AC(1112)
Diseases : Lung Cancer : CK(2308) : AC(999), Melanoma : CK(733) : AC(408)
Pharmacological Actions : Anti-metastatic : CK(1972) : AC(1481), Chemoprotective Agents : CK(2322) : AC(906), Chemosensitizer : CK(1124) : AC(854)
Additional Keywords : Anti-metastatic, Chemoprotective Agents, Chemosensitizer, lung cancer, melanoma, RESVERATROL

These results highlight the protective effects of tangeretin against cisplatin-induced acute hepatic injury.

Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Tangeretin : CK(38) : AC(24)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(881) : AC(388)
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672), Anti-Inflammatory Agents : CK(20859) : AC(8334), Antioxidants : CK(21528) : AC(8856), Chemoprotective Agents : CK(2322) : AC(906)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants : CK(303) : AC(126), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin

This study suggests the use of neferine for amelioration of doxorubicin -mediated cardiotoxicity.

Article Published Date : Jul 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(237) : AC(170)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(457) : AC(236)
Pharmacological Actions : Cardioprotective : CK(5377) : AC(1675), Chemoprotective Agents : CK(2322) : AC(906)
Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Lotus

Zingiber officinale Roscoe ameliorates anticancer antibiotic doxorubicin-induced acute cardiotoxicity.

Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Ginger : CK(1261) : AC(363)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(457) : AC(236)
Pharmacological Actions : Cardioprotective : CK(5377) : AC(1675), Chemoprotective Agents : CK(2322) : AC(906)
Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Ginger

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