Results for Chemoprotective Agents

A short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicity

Article Published Date : Dec 12, 2016
Study Type : Human Study
Additional Links
Substances : Magnesium : CK(2799) : AC(368)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)
Pharmacological Actions : Chemoprotective Agents : CK(4246) : AC(1618)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Magnesium : CK(11) : AC(2)

Combination therapy of rosmarinic acid and lycopene shows better protective effects than the corresponding monotherapy.

Article Published Date : Nov 23, 2016
Study Type : Animal Study
Additional Links
Substances : Lycopene : CK(1267) : AC(372), Rosmarinic acid : CK(193) : AC(108)
Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(194) : AC(102)
Pharmacological Actions : Chemoprotective Agents : CK(4246) : AC(1618), Renoprotective : CK(4533) : AC(1963)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Gentamicin, lycopene, Renoprotective, Rosmarinic acid

Egyptian sweet orange hesperidin ameliorates the cytotoxic effect of doxorubicin while enhancing its anti-tumor effect.

Article Published Date : Mar 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hesperidin : CK(951) : AC(359), Sweet Orange : CK(48) : AC(17)
Diseases : Ehrlich carcinoma : CK(97) : AC(53)
Pharmacological Actions : Chemoprotective Agents : CK(4246) : AC(1618), Chemosensitizer : CK(1644) : AC(1266)
Additional Keywords : Chemoprotective Agents, Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(343) : AC(264), Ehrlich carcinoma, Hesperidin, Sweet Orange

Folic acid may be a novel therapeutic approach to attenuate doxorubicin induced cardiomyopathy.

Article Published Date : Jun 12, 2017
Study Type : Animal Study
Additional Links
Substances : Folic Acid : CK(1317) : AC(206)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423)
Pharmacological Actions : Antioxidants : CK(34339) : AC(14395), Cardioprotective : CK(9412) : AC(2945), Chemoprotective Agents : CK(4246) : AC(1618)
Additional Keywords : Antioxidants : CK(303) : AC(126), Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, folic acid

Ginsenosides Rk2 and Rh3 have kidney protective effects of against cisplatin.

Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides : CK(2640) : AC(1452)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)
Pharmacological Actions : Chemoprotective Agents : CK(4246) : AC(1618), Renoprotective : CK(4533) : AC(1963)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Ginsenosides, Renoprotective

Ginsenosides Rk3 and Rh4 protect the kidney from cisplatin-induced oxidative injury.

Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides : CK(2640) : AC(1452)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)
Pharmacological Actions : Antioxidants : CK(34339) : AC(14395), Chemoprotective Agents : CK(4246) : AC(1618), Renoprotective : CK(4533) : AC(1963)
Additional Keywords : Antioxidants : CK(303) : AC(126), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Ginsenosides, Renoprotective

Honey can decrease the side effects of chemotherapy on reproductive system and prevent sterility.

Article Published Date : May 22, 2018
Study Type : Animal Study
Additional Links
Substances : Honey : CK(1187) : AC(309)
Diseases : Chemotherapy and Radiation Toxicity : CK(2555) : AC(617)
Pharmacological Actions : Chemoprotective Agents : CK(4246) : AC(1618)
Additional Keywords : Chemoprotective Agents, Chemotherapy and Radiation Toxicity, Honey : CK(22) : AC(9)

Melatonin could be used as an adjuvant agent with rapamycin in head and neck cancers.

Article Published Date : Dec 15, 2017
Study Type : In Vitro Study
Additional Links
Substances : Melatonin : CK(2891) : AC(911)
Diseases : Head and Neck Cancer : CK(787) : AC(188)
Pharmacological Actions : Chemoprotective Agents : CK(4246) : AC(1618), Chemotherapeutic : CK(4337) : AC(1618)
Additional Keywords : Chemoprotective Agents, Chemotherapeutic, Head and Neck Cancer, melatonin, Natural Substance/Drug Synergy : CK(1523) : AC(718)

Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin.

Article Published Date : Sep 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39410) : AC(15723), Cardioprotective : CK(9412) : AC(2945), Chemoprotective Agents : CK(4246) : AC(1618)
Additional Keywords : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents, Lotus

Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy.

Article Published Date : Mar 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)
Pharmacological Actions : Autophagy Up-regulation : CK(836) : AC(558), Chemoprotective Agents : CK(4246) : AC(1618)
Additional Keywords : Autophagy Up-regulation, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Lotus

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.

Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1912) : AC(494), Thymoquinone : CK(1178) : AC(692)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)
Pharmacological Actions : Chemoprotective Agents : CK(4246) : AC(1618)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone

Nigella sativa oil may help prevent the accompanying gastrointestinal dysfunction in cisplatin chemotherapy.

Article Published Date : Feb 14, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1912) : AC(494)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)
Pharmacological Actions : Chemoprotective Agents : CK(4246) : AC(1618), Gastroprotective : CK(1669) : AC(694)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Gastroprotective, Nigella sativa (aka Black Seed)

Panax ginseng anthocyanins pre-administration can significantly prevent cisplatin-induced nephrotoxicity.

Article Published Date : Jul 20, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins : CK(1598) : AC(491), Panax Ginseng : CK(94) : AC(45)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)
Pharmacological Actions : Chemoprotective Agents : CK(4246) : AC(1618), Cyclooxygenase 2 Inhibitors : CK(2251) : AC(1319), Nitric Oxide Inhibitor : CK(704) : AC(355)
Additional Keywords : Anthocyanins : CK(11) : AC(9), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Panax Ginseng

Phloretin has an anti-apoptotic effect on cisplatin-induced apoptosis in HEI-OC1 auditory cells.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Phloretin : CK(232) : AC(137)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)
Pharmacological Actions : Anti-Apoptotic : CK(5531) : AC(3135), Chemoprotective Agents : CK(4246) : AC(1618), Heme oxygenase-1 inducer : CK(63) : AC(43)
Additional Keywords : Anti-Apoptotic, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Heme oxygenase-1 inducer, Phloretin

Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(3223) : AC(1510)
Diseases : Lung Cancer : CK(3059) : AC(1426), Melanoma : CK(922) : AC(551)
Pharmacological Actions : Anti-metastatic : CK(2863) : AC(2176), Chemoprotective Agents : CK(4246) : AC(1618), Chemosensitizer : CK(1644) : AC(1266)
Additional Keywords : Anti-metastatic, Chemoprotective Agents, Chemosensitizer, lung cancer, melanoma, RESVERATROL

These results highlight the protective effects of tangeretin against cisplatin-induced acute hepatic injury.

Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Tangeretin : CK(163) : AC(93)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)
Pharmacological Actions : Anti-Apoptotic : CK(5531) : AC(3135), Anti-Inflammatory Agents : CK(39410) : AC(15723), Antioxidants : CK(34339) : AC(14395), Chemoprotective Agents : CK(4246) : AC(1618)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants : CK(303) : AC(126), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin

This study suggests the use of neferine for amelioration of doxorubicin -mediated cardiotoxicity.

Article Published Date : Jul 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423)
Pharmacological Actions : Cardioprotective : CK(9412) : AC(2945), Chemoprotective Agents : CK(4246) : AC(1618)
Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Lotus

Zingiber officinale Roscoe ameliorates anticancer antibiotic doxorubicin-induced acute cardiotoxicity.

Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Ginger : CK(1591) : AC(477)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423)
Pharmacological Actions : Cardioprotective : CK(9412) : AC(2945), Chemoprotective Agents : CK(4246) : AC(1618)
Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Ginger

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