Results for Chemosensitizer

Andrographolide enhances cisplatin-mediated anticancer effects in lung cancer cells.

Article Published Date : Jul 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide : CK(251) : AC(179)
Diseases : Lung Cancer : CK(3063) : AC(1429)
Pharmacological Actions : Autophagy Inhibitors : CK(302) : AC(188), Chemosensitizer : CK(1657) : AC(1270), Chemotherapeutic : CK(4390) : AC(1635)
Additional Keywords : Andrographolidem, Autophagy Inhibitors : CK(8) : AC(6), Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(430) : AC(339), lung cancer

Chemo-sensitization resulting from fasting may in fact be an effect of enhanced immune surveillance.

Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Cancers: All : CK(36404) : AC(14363)
Therapeutic Actions : Fasting/Caloric Restriction : CK(820) : AC(176)
Pharmacological Actions : Chemosensitizer : CK(1657) : AC(1270)
Additional Keywords : Cancer : CK(50) : AC(12), cancer cure, Chemosensitizer, Chemotherapy : CK(45) : AC(8), Fasting

Curcumin might be a potential adjuvant for non-small-cell lung cancer patients during Paclitaxel treatment.

Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Carcinoma: Non-Small-Cell Lung : CK(710) : AC(428)
Pharmacological Actions : Chemosensitizer : CK(1657) : AC(1270)
Additional Keywords : Carcinoma: Non-Small-Cell Lung, Chemosensitizer, Chemothapeutic Synergy: Paclitaxel : CK(166) : AC(122), CURCUMIN : CK(25) : AC(18)

Diallyl trisulfide suppresses tumor growth and potentiates cisplatin efficacy in gastric cancer treatment.

Article Published Date : Mar 26, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Dimethyl trisulfide (DMTS) : CK(14) : AC(8)
Diseases : Gastric Cancer : CK(1619) : AC(725)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379), Cell cycle arrest : CK(2120) : AC(1715), Chemosensitizer : CK(1657) : AC(1270)
Additional Keywords : Apoptotic, Cell cycle arrest, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(430) : AC(339), Dimethyl trisulfide (DMTS), gastric cancer

Egyptian sweet orange hesperidin ameliorates the cytotoxic effect of doxorubicin while enhancing its anti-tumor effect.

Article Published Date : Mar 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hesperidin : CK(953) : AC(360), Sweet Orange : CK(48) : AC(17)
Diseases : Ehrlich carcinoma : CK(97) : AC(53)
Pharmacological Actions : Chemoprotective Agents : CK(4278) : AC(1621), Chemosensitizer : CK(1657) : AC(1270)
Additional Keywords : Chemoprotective Agents, Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(347) : AC(266), Ehrlich carcinoma, Hesperidin, Sweet Orange

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Bladder Cancer : CK(782) : AC(320)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Chemosensitizer : CK(1657) : AC(1270)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(430) : AC(339), Dose Response : CK(1770) : AC(700), Shikonin

Neferine enhances oxaliplatin sensitivity through an inhibition of EMT in liver cancer cells.

Article Published Date : Jan 29, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Chemosensitizer : CK(1657) : AC(1270)
Additional Keywords : Chemosensitizer, Chemotherapeutic Synergy: Oxaliplatin : CK(78) : AC(51), liver cancer, Lotus

Neferine reduces the cisplatin dose requirement in cancer chemotherapy.

Article Published Date : Feb 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Lung Cancer : CK(3063) : AC(1429)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379), Chemosensitizer : CK(1657) : AC(1270), Vascular Endothelial Growth Factor Inhibitors : CK(611) : AC(335)
Additional Keywords : Apoptotic, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(430) : AC(339), Lotus, lung cancer, Vascular Endothelial Growth Factor Inhibitors

Neferine revealed higher toxicity toward paclitaxel and doxorubicin-resistant breast, lung or colon cancer cells.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Breast Cancer : CK(8297) : AC(3043), Cancers: Multi-Drug Resistant : CK(194) : AC(156), Colon Cancer : CK(1920) : AC(1203), Lung Cancer : CK(3063) : AC(1429)
Pharmacological Actions : Chemosensitizer : CK(1657) : AC(1270), Chemotherapeutic : CK(4390) : AC(1635)
Additional Keywords : Breast Cancer : CK(113) : AC(34), Cancers: Multi-Drug Resistant, Chemosensitizer, Chemotherapeutic, COLON CANCER, Lotus, lung cancer

Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(3228) : AC(1513)
Diseases : Lung Cancer : CK(3063) : AC(1429), Melanoma : CK(924) : AC(552)
Pharmacological Actions : Anti-metastatic : CK(2870) : AC(2182), Chemoprotective Agents : CK(4278) : AC(1621), Chemosensitizer : CK(1657) : AC(1270)
Additional Keywords : Anti-metastatic, Chemoprotective Agents, Chemosensitizer, lung cancer, melanoma, RESVERATROL

Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis.

Article Published Date : Oct 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bloodroot : CK(37) : AC(13)
Diseases : Gastric Cancer : CK(1619) : AC(725)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379), Caspase-3 Activation : CK(137) : AC(90), Chemosensitizer : CK(1657) : AC(1270)
Additional Keywords : Apoptotic, Bloodroot, Caspase-3 Activation, Chemosensitizer, gastric cancer

Synergistic anti-breast-cancer effects of combined treatment with oleuropein and doxorubicin.

Article Published Date : Jun 22, 2017
Study Type : Animal Study
Additional Links
Substances : Oleuropein : CK(322) : AC(202)
Diseases : Breast Cancer : CK(8297) : AC(3043)
Pharmacological Actions : Chemosensitizer : CK(1657) : AC(1270)
Additional Keywords : Breast Cancer : CK(113) : AC(34), Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(347) : AC(266), Oleuropein

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.

Article Published Date : Oct 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Genistein : CK(945) : AC(434)
Diseases : Breast Cancer : CK(8297) : AC(3043), Breast Cancer: Triple Negative : CK(970) : AC(659)
Pharmacological Actions : Chemosensitizer : CK(1657) : AC(1270)
Additional Keywords : Breast Cancer : CK(113) : AC(34), Breast Cancer: Triple Negative, Chemosensitizer, Genistein, Natural Substance/Drug Synergy : CK(1526) : AC(720), Selective Cytotoxicity : CK(274) : AC(201)

This review describes the role of antioxidants like sulforaphane and curcumin in combatting chemoresistance and chemotherapy-induced oxidative stress through NF-kappaB and HIF-1a inhibition.

Article Published Date : Jun 29, 2019
Study Type : Review
Additional Links
Substances : Broccoli Sprouts : CK(303) : AC(55), Curcumin : CK(7239) : AC(3319), Sulforaphane : CK(1344) : AC(630), Turmeric : CK(9427) : AC(3904)
Pharmacological Actions : Anti Inflammatory, Antioxidant Effects : CK(159) : AC(45), Chemosensitizer : CK(1657) : AC(1270), Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor : CK(363) : AC(237), NF-kappaB Inhibitor : CK(5952) : AC(3464), Nrf2 activation : CK(3156) : AC(1794)
Additional Keywords : Anti-cancer, Chemoresistance : CK(7) : AC(6), Chemosensitizer, Chemotherapy : CK(45) : AC(8)
Problem Substances : Chemotherapy : CK(459) : AC(79)

Vitamin C and K can sensitize cancer cells to conventional chemotherapy.

Article Published Date : Mar 19, 2018
Study Type : Review
Additional Links
Substances : Vitamin C : CK(6066) : AC(1408), Vitamin K : CK(998) : AC(161)
Diseases : Cancers: All : CK(36404) : AC(14363)
Pharmacological Actions : Chemosensitizer : CK(1657) : AC(1270)
Additional Keywords : Cancers: All, Chemosensitizer, Vitamin C : CK(48) : AC(13), Vitamin K

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