Results for Chemosensitizer

Andrographolide enhances cisplatin-mediated anticancer effects in lung cancer cells.

Article Published Date : Jul 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide : CK(267) : AC(189)
Diseases : Lung Cancer : CK(3133) : AC(1461)
Pharmacological Actions : Autophagy Inhibitors : CK(305) : AC(190), Chemosensitizer : CK(1700) : AC(1305), Chemotherapeutic : CK(4479) : AC(1661)
Additional Keywords : Andrographolidem, Autophagy Inhibitors : CK(8) : AC(6), Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(441) : AC(350), lung cancer

Chemo-sensitization resulting from fasting may in fact be an effect of enhanced immune surveillance.

Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Cancers: All : CK(37101) : AC(14656)
Therapeutic Actions : Fasting/Caloric Restriction : CK(840) : AC(178)
Pharmacological Actions : Chemosensitizer : CK(1700) : AC(1305)
Additional Keywords : Cancer : CK(50) : AC(12), cancer cure, Chemosensitizer, Chemotherapy : CK(45) : AC(8), Fasting

Curcumin might be a potential adjuvant for non-small-cell lung cancer patients during Paclitaxel treatment.

Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(8460) : AC(3744)
Diseases : Carcinoma: Non-Small-Cell Lung : CK(750) : AC(444)
Pharmacological Actions : Chemosensitizer : CK(1700) : AC(1305)
Additional Keywords : Carcinoma: Non-Small-Cell Lung, Chemosensitizer, Chemothapeutic Synergy: Paclitaxel : CK(169) : AC(125), CURCUMIN : CK(25) : AC(18)

Diallyl trisulfide suppresses tumor growth and potentiates cisplatin efficacy in gastric cancer treatment.

Article Published Date : Mar 26, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Dimethyl trisulfide (DMTS) : CK(14) : AC(8)
Diseases : Gastric Cancer : CK(1651) : AC(743)
Pharmacological Actions : Apoptotic : CK(9804) : AC(7559), Cell cycle arrest : CK(2147) : AC(1740), Chemosensitizer : CK(1700) : AC(1305)
Additional Keywords : Apoptotic, Cell cycle arrest, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(441) : AC(350), Dimethyl trisulfide (DMTS), gastric cancer

Egyptian sweet orange hesperidin ameliorates the cytotoxic effect of doxorubicin while enhancing its anti-tumor effect.

Article Published Date : Mar 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hesperidin : CK(977) : AC(369), Sweet Orange : CK(48) : AC(17)
Diseases : Ehrlich carcinoma : CK(97) : AC(53)
Pharmacological Actions : Chemoprotective Agents : CK(4441) : AC(1687), Chemosensitizer : CK(1700) : AC(1305)
Additional Keywords : Chemoprotective Agents, Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(362) : AC(280), Ehrlich carcinoma, Hesperidin, Sweet Orange

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Bladder Cancer : CK(789) : AC(326)
Pharmacological Actions : Antiproliferative : CK(10311) : AC(7712), Apoptotic : CK(9804) : AC(7559), Chemosensitizer : CK(1700) : AC(1305)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(441) : AC(350), Dose Response : CK(1780) : AC(701), Shikonin

Neferine enhances oxaliplatin sensitivity through an inhibition of EMT in liver cancer cells.

Article Published Date : Jan 29, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Liver Cancer : CK(3199) : AC(1671)
Pharmacological Actions : Chemosensitizer : CK(1700) : AC(1305)
Additional Keywords : Chemosensitizer, Chemotherapeutic Synergy: Oxaliplatin : CK(80) : AC(53), liver cancer, Lotus

Neferine reduces the cisplatin dose requirement in cancer chemotherapy.

Article Published Date : Feb 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Lung Cancer : CK(3133) : AC(1461)
Pharmacological Actions : Apoptotic : CK(9804) : AC(7559), Chemosensitizer : CK(1700) : AC(1305), Vascular Endothelial Growth Factor Inhibitors : CK(626) : AC(341)
Additional Keywords : Apoptotic, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(441) : AC(350), Lotus, lung cancer, Vascular Endothelial Growth Factor Inhibitors

Neferine revealed higher toxicity toward paclitaxel and doxorubicin-resistant breast, lung or colon cancer cells.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Breast Cancer : CK(8435) : AC(3103), Cancers: Multi-Drug Resistant : CK(197) : AC(159), Colon Cancer : CK(1942) : AC(1215), Lung Cancer : CK(3133) : AC(1461)
Pharmacological Actions : Chemosensitizer : CK(1700) : AC(1305), Chemotherapeutic : CK(4479) : AC(1661)
Additional Keywords : Breast Cancer : CK(113) : AC(34), Cancers: Multi-Drug Resistant, Chemosensitizer, Chemotherapeutic, COLON CANCER, Lotus, lung cancer

Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(3290) : AC(1541)
Diseases : Lung Cancer : CK(3133) : AC(1461), Melanoma : CK(963) : AC(563)
Pharmacological Actions : Anti-metastatic : CK(2928) : AC(2231), Chemoprotective Agents : CK(4441) : AC(1687), Chemosensitizer : CK(1700) : AC(1305)
Additional Keywords : Anti-metastatic, Chemoprotective Agents, Chemosensitizer, lung cancer, melanoma, RESVERATROL

Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis.

Article Published Date : Oct 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bloodroot : CK(37) : AC(13)
Diseases : Gastric Cancer : CK(1651) : AC(743)
Pharmacological Actions : Apoptotic : CK(9804) : AC(7559), Caspase-3 Activation : CK(137) : AC(90), Chemosensitizer : CK(1700) : AC(1305)
Additional Keywords : Apoptotic, Bloodroot, Caspase-3 Activation, Chemosensitizer, gastric cancer

Synergistic anti-breast-cancer effects of combined treatment with oleuropein and doxorubicin.

Article Published Date : Jun 22, 2017
Study Type : Animal Study
Additional Links
Substances : Oleuropein : CK(322) : AC(202)
Diseases : Breast Cancer : CK(8435) : AC(3103)
Pharmacological Actions : Chemosensitizer : CK(1700) : AC(1305)
Additional Keywords : Breast Cancer : CK(113) : AC(34), Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(362) : AC(280), Oleuropein

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.

Article Published Date : Oct 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Genistein : CK(946) : AC(435)
Diseases : Breast Cancer : CK(8435) : AC(3103), Breast Cancer: Triple Negative : CK(995) : AC(681)
Pharmacological Actions : Chemosensitizer : CK(1700) : AC(1305)
Additional Keywords : Breast Cancer : CK(113) : AC(34), Breast Cancer: Triple Negative, Chemosensitizer, Genistein, Natural Substance/Drug Synergy : CK(1614) : AC(743), Selective Cytotoxicity : CK(274) : AC(201)

This review describes the role of antioxidants like sulforaphane and curcumin in combatting chemoresistance and chemotherapy-induced oxidative stress through NF-kappaB and HIF-1a inhibition.

Article Published Date : Jun 29, 2019
Study Type : Review
Additional Links
Substances : Broccoli Sprouts : CK(303) : AC(55), Curcumin : CK(8460) : AC(3744), Sulforaphane : CK(1345) : AC(631), Turmeric : CK(10691) : AC(4344)
Pharmacological Actions : Anti Inflammatory, Antioxidant Effects : CK(159) : AC(45), Chemosensitizer : CK(1700) : AC(1305), Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor : CK(404) : AC(247), NF-kappaB Inhibitor : CK(6136) : AC(3568), Nrf2 activation : CK(3288) : AC(1869)
Additional Keywords : Anti-cancer, Chemoresistance : CK(7) : AC(6), Chemosensitizer, Chemotherapy : CK(45) : AC(8)
Problem Substances : Chemotherapy : CK(459) : AC(79)

Vitamin C and K can sensitize cancer cells to conventional chemotherapy.

Article Published Date : Mar 19, 2018
Study Type : Review
Additional Links
Substances : Vitamin C : CK(6128) : AC(1420), Vitamin K : CK(1000) : AC(162)
Diseases : Cancers: All : CK(37101) : AC(14656)
Pharmacological Actions : Chemosensitizer : CK(1700) : AC(1305)
Additional Keywords : Cancers: All, Chemosensitizer, Vitamin C : CK(48) : AC(13), Vitamin K

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