Results for Chemosensitizer

Andrographolide enhances cisplatin-mediated anticancer effects in lung cancer cells.

Article Published Date : Jul 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide : CK(251) : AC(179)
Diseases : Lung Cancer : CK(3014) : AC(1409)
Pharmacological Actions : Autophagy Inhibitors : CK(299) : AC(186), Chemosensitizer : CK(1636) : AC(1259), Chemotherapeutic : CK(4281) : AC(1596)
Additional Keywords : Andrographolidem, Autophagy Inhibitors : CK(8) : AC(6), Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(427) : AC(336), lung cancer

Chemo-sensitization resulting from fasting may in fact be an effect of enhanced immune surveillance.

Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Cancers: All : CK(35914) : AC(14179)
Therapeutic Actions : Fasting/Caloric Restriction : CK(798) : AC(172)
Pharmacological Actions : Chemosensitizer : CK(1636) : AC(1259)
Additional Keywords : Cancer : CK(50) : AC(12), cancer cure, Chemosensitizer, Chemotherapy : CK(45) : AC(8), Fasting

Curcumin might be a potential adjuvant for non-small-cell lung cancer patients during Paclitaxel treatment.

Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7066) : AC(3242)
Diseases : Carcinoma: Non-Small-Cell Lung : CK(692) : AC(423)
Pharmacological Actions : Chemosensitizer : CK(1636) : AC(1259)
Additional Keywords : Carcinoma: Non-Small-Cell Lung, Chemosensitizer, Chemothapeutic Synergy: Paclitaxel : CK(163) : AC(119), CURCUMIN : CK(25) : AC(18)

Diallyl trisulfide suppresses tumor growth and potentiates cisplatin efficacy in gastric cancer treatment.

Article Published Date : Mar 26, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Dimethyl trisulfide (DMTS) : CK(14) : AC(8)
Diseases : Gastric Cancer : CK(1611) : AC(719)
Pharmacological Actions : Apoptotic : CK(9480) : AC(7298), Cell cycle arrest : CK(2111) : AC(1706), Chemosensitizer : CK(1636) : AC(1259)
Additional Keywords : Apoptotic, Cell cycle arrest, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(427) : AC(336), Dimethyl trisulfide (DMTS), gastric cancer

Egyptian sweet orange hesperidin ameliorates the cytotoxic effect of doxorubicin while enhancing its anti-tumor effect.

Article Published Date : Mar 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hesperidin : CK(950) : AC(358), Sweet Orange : CK(48) : AC(17)
Diseases : Ehrlich carcinoma : CK(97) : AC(53)
Pharmacological Actions : Chemoprotective Agents : CK(4211) : AC(1598), Chemosensitizer : CK(1636) : AC(1259)
Additional Keywords : Chemoprotective Agents, Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(340) : AC(261), Ehrlich carcinoma, Hesperidin, Sweet Orange

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Bladder Cancer : CK(771) : AC(318)
Pharmacological Actions : Antiproliferative : CK(9855) : AC(7389), Apoptotic : CK(9480) : AC(7298), Chemosensitizer : CK(1636) : AC(1259)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(427) : AC(336), Dose Response : CK(1770) : AC(700), Shikonin

Neferine enhances oxaliplatin sensitivity through an inhibition of EMT in liver cancer cells.

Article Published Date : Jan 29, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Liver Cancer : CK(3100) : AC(1627)
Pharmacological Actions : Chemosensitizer : CK(1636) : AC(1259)
Additional Keywords : Chemosensitizer, Chemotherapeutic Synergy: Oxaliplatin : CK(77) : AC(50), liver cancer, Lotus

Neferine reduces the cisplatin dose requirement in cancer chemotherapy.

Article Published Date : Feb 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Lung Cancer : CK(3014) : AC(1409)
Pharmacological Actions : Apoptotic : CK(9480) : AC(7298), Chemosensitizer : CK(1636) : AC(1259), Vascular Endothelial Growth Factor Inhibitors : CK(606) : AC(332)
Additional Keywords : Apoptotic, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(427) : AC(336), Lotus, lung cancer, Vascular Endothelial Growth Factor Inhibitors

Neferine revealed higher toxicity toward paclitaxel and doxorubicin-resistant breast, lung or colon cancer cells.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Breast Cancer : CK(8185) : AC(3005), Cancers: Multi-Drug Resistant : CK(192) : AC(154), Colon Cancer : CK(1903) : AC(1192), Lung Cancer : CK(3014) : AC(1409)
Pharmacological Actions : Chemosensitizer : CK(1636) : AC(1259), Chemotherapeutic : CK(4281) : AC(1596)
Additional Keywords : Breast Cancer : CK(113) : AC(34), Cancers: Multi-Drug Resistant, Chemosensitizer, Chemotherapeutic, COLON CANCER, Lotus, lung cancer

Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(3218) : AC(1507)
Diseases : Lung Cancer : CK(3014) : AC(1409), Melanoma : CK(913) : AC(544)
Pharmacological Actions : Anti-metastatic : CK(2843) : AC(2161), Chemoprotective Agents : CK(4211) : AC(1598), Chemosensitizer : CK(1636) : AC(1259)
Additional Keywords : Anti-metastatic, Chemoprotective Agents, Chemosensitizer, lung cancer, melanoma, RESVERATROL

Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis.

Article Published Date : Oct 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bloodroot : CK(37) : AC(13)
Diseases : Gastric Cancer : CK(1611) : AC(719)
Pharmacological Actions : Apoptotic : CK(9480) : AC(7298), Caspase-3 Activation : CK(137) : AC(90), Chemosensitizer : CK(1636) : AC(1259)
Additional Keywords : Apoptotic, Bloodroot, Caspase-3 Activation, Chemosensitizer, gastric cancer

Synergistic anti-breast-cancer effects of combined treatment with oleuropein and doxorubicin.

Article Published Date : Jun 22, 2017
Study Type : Animal Study
Additional Links
Substances : Oleuropein : CK(322) : AC(202)
Diseases : Breast Cancer : CK(8185) : AC(3005)
Pharmacological Actions : Chemosensitizer : CK(1636) : AC(1259)
Additional Keywords : Breast Cancer : CK(113) : AC(34), Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(340) : AC(261), Oleuropein

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.

Article Published Date : Oct 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Genistein : CK(932) : AC(431)
Diseases : Breast Cancer : CK(8185) : AC(3005), Breast Cancer: Triple Negative : CK(958) : AC(652)
Pharmacological Actions : Chemosensitizer : CK(1636) : AC(1259)
Additional Keywords : Breast Cancer : CK(113) : AC(34), Breast Cancer: Triple Negative, Chemosensitizer, Genistein, Natural Substance/Drug Synergy : CK(1519) : AC(715), Selective Cytotoxicity : CK(269) : AC(200)

This review describes the role of antioxidants like sulforaphane and curcumin in combatting chemoresistance and chemotherapy-induced oxidative stress through NF-kappaB and HIF-1a inhibition.

Article Published Date : Jun 29, 2019
Study Type : Review
Additional Links
Substances : Broccoli Sprouts : CK(303) : AC(55), Curcumin : CK(7066) : AC(3242), Sulforaphane : CK(1342) : AC(629), Turmeric : CK(9184) : AC(3796)
Pharmacological Actions : Anti Inflammatory, Antioxidant Effects : CK(159) : AC(45), Chemosensitizer : CK(1636) : AC(1259), Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor : CK(355) : AC(233), NF-kappaB Inhibitor : CK(5829) : AC(3392), Nrf2 activation : CK(3111) : AC(1770)
Additional Keywords : Anti-cancer, Chemoresistance : CK(7) : AC(6), Chemosensitizer, Chemotherapy : CK(45) : AC(8)
Problem Substances : Chemotherapy : CK(459) : AC(79)

Vitamin C and K can sensitize cancer cells to conventional chemotherapy.

Article Published Date : Mar 19, 2018
Study Type : Review
Additional Links
Substances : Vitamin C : CK(6050) : AC(1402), Vitamin K : CK(971) : AC(161)
Diseases : Cancers: All : CK(35914) : AC(14179)
Pharmacological Actions : Chemosensitizer : CK(1636) : AC(1259)
Additional Keywords : Cancers: All, Chemosensitizer, Vitamin C : CK(48) : AC(13), Vitamin K

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