Results for Cyclooxygenase 2 Inhibitors

Adlay bran ethanolic extract suppressed 1,2-dimethylhydrazine-indued preneoplastic lesions of the colon.

Article Published Date : Jul 13, 2010
Study Type : Animal Study
Additional Links
Substances : Adlay : CK(1) : AC(1)
Diseases : Colon Cancer : CK(1493) : AC(954)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Chemopreventive : CK(5374) : AC(1717), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926)
Additional Keywords : Adlay, Anti-Inflammatory Agents, Chemopreventive, COLON CANCER, Cyclooxygenase 2 Inhibitors, Plant Extracts : CK(14140) : AC(5210)

Curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects.

Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Depression
Pharmacological Actions : Antidepressive Agents : CK(4882) : AC(874), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926)
Additional Keywords : Antidepressive Agents, CURCUMIN : CK(2) : AC(1), Cyclooxygenase 2 Inhibitors, Depression : CK(108) : AC(19)

Extracts of the fruits of Maqui-berry may provide a potential therapeutic approach for inflammation associated disorders.

Article Published Date : Dec 27, 2016
Study Type : In Vitro Study
Additional Links
Substances : Maqui : CK(14) : AC(5)
Diseases : Inflammation : CK(9572) : AC(3089), Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Antioxidants : CK(21528) : AC(8856), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926)
Additional Keywords : Anti-Inflammatory Agents, Antioxidants : CK(303) : AC(126), Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Maqui, oxidative stress, Plant Extracts : CK(14140) : AC(5210)

Panax ginseng anthocyanins pre-administration can significantly prevent cisplatin-induced nephrotoxicity.

Article Published Date : Jul 20, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins : CK(938) : AC(334), Panax Ginseng : CK(90) : AC(43)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(881) : AC(388)
Pharmacological Actions : Chemoprotective Agents : CK(2322) : AC(906), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926), Nitric Oxide Inhibitor : CK(498) : AC(258)
Additional Keywords : Anthocyanins : CK(7) : AC(6), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Panax Ginseng

Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin.

Article Published Date : Feb 29, 2012
Study Type : Animal Study
Additional Links
Substances : Phloretin : CK(177) : AC(101)
Diseases : Skin Cancer : CK(1429) : AC(636)
Pharmacological Actions : Anticarcinogenic Agents : CK(1890) : AC(889), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926), NF-kappaB Inhibitor : CK(3536) : AC(2098)
Additional Keywords : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Phloretin, skin cancer

The combination of β-caryophyllene, baicalin and catechin exerts synergistic suppressive effects on macrophages in vitro.

Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene : CK(2) : AC(1), Catechin : CK(718) : AC(253)
Diseases : Inflammation : CK(9572) : AC(3089)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Antiproliferative : CK(6801) : AC(5032), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926)
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative : CK(65) : AC(52), Beta-Caryophyllene, Catechin, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Natural Substance Synergy : CK(1094) : AC(506)

These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.

Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Inflammation : CK(9572) : AC(3089)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926), Interleukin-1 beta downregulation : CK(3041) : AC(1567), Interleukin-6 Downregulation : CK(5029) : AC(1994), NF-kappaB Inhibitor : CK(3536) : AC(2098), Nitric Oxide Inhibitor : CK(498) : AC(258), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(6736) : AC(2815)
Additional Keywords : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Interleukin-1 beta downregulation, thymoquinone

These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin : CK(108) : AC(63)
Diseases : Diabetic Retinopathy : CK(290) : AC(121)
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672), Anti-Inflammatory Agents : CK(20859) : AC(8334), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Shikonin

This report confirms the anti-inflammatory potential of this traditionally employed herbal medicine in vitro.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Justicia gendarussa : CK(1) : AC(1)
Diseases : Inflammation : CK(9572) : AC(3089), Lipopolysaccharide-Induced Toxicity : CK(1764) : AC(1073)
Pharmacological Actions : 5-Lipoxygenase Inhibitor : CK(35) : AC(21), Anti-Inflammatory Agents : CK(20859) : AC(8334), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926), Interleukin-6 Downregulation : CK(5029) : AC(1994), NF-kappaB Inhibitor : CK(3536) : AC(2098)
Additional Keywords : 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Interleukin-6 Downregulation, Justicia gendarussa, Lipopolysaccharide-Induced Toxicity, NF-kappaB Inhibitor, Plant Extracts : CK(14140) : AC(5210)

Walnut leaf extract exert protective effects against diabetic retinopathy.

Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Walnut : CK(589) : AC(137)
Diseases : Diabetic Retinopathy : CK(290) : AC(121)
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672), Anti-Inflammatory Agents : CK(20859) : AC(8334), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Walnut

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