Results for Cyclooxygenase 2 Inhibitors

Adlay bran ethanolic extract suppressed 1,2-dimethylhydrazine-indued preneoplastic lesions of the colon.

Article Published Date : Jul 13, 2010
Study Type : Animal Study
Additional Links
Substances : Adlay : CK(128) : AC(79)
Diseases : Colon Cancer : CK(1887) : AC(1180)
Pharmacological Actions : Anti-Inflammatory Agents : CK(35225) : AC(14931), Chemopreventive : CK(6381) : AC(2130), Cyclooxygenase 2 Inhibitors : CK(2067) : AC(1256)
Additional Keywords : Adlay, Anti-Inflammatory Agents, Chemopreventive, COLON CANCER, Cyclooxygenase 2 Inhibitors, Plant Extracts : CK(18030) : AC(6686)

Curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects.

Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(6902) : AC(3209)
Diseases : Depression
Pharmacological Actions : Antidepressive Agents : CK(7300) : AC(1414), Cyclooxygenase 2 Inhibitors : CK(2067) : AC(1256)
Additional Keywords : Antidepressive Agents, CURCUMIN : CK(25) : AC(18), Cyclooxygenase 2 Inhibitors, Depression : CK(108) : AC(19)

Extracts of the fruits of Maqui-berry may provide a potential therapeutic approach for inflammation associated disorders.

Article Published Date : Dec 27, 2016
Study Type : In Vitro Study
Additional Links
Substances : Maqui : CK(46) : AC(17)
Diseases : Inflammation : CK(15183) : AC(5116), Oxidative Stress : CK(13443) : AC(5355)
Pharmacological Actions : Anti-Inflammatory Agents : CK(35225) : AC(14931), Antioxidants : CK(32218) : AC(13955), Cyclooxygenase 2 Inhibitors : CK(2067) : AC(1256)
Additional Keywords : Anti-Inflammatory Agents, Antioxidants : CK(303) : AC(126), Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Maqui, oxidative stress, Plant Extracts : CK(18030) : AC(6686)

Panax ginseng anthocyanins pre-administration can significantly prevent cisplatin-induced nephrotoxicity.

Article Published Date : Jul 20, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins : CK(1540) : AC(489), Panax Ginseng : CK(94) : AC(45)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1170) : AC(583)
Pharmacological Actions : Chemoprotective Agents : CK(3736) : AC(1539), Cyclooxygenase 2 Inhibitors : CK(2067) : AC(1256), Nitric Oxide Inhibitor : CK(693) : AC(349)
Additional Keywords : Anthocyanins : CK(11) : AC(9), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Panax Ginseng

Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin.

Article Published Date : Feb 29, 2012
Study Type : Animal Study
Additional Links
Substances : Phloretin : CK(232) : AC(137)
Diseases : Skin Cancer : CK(1664) : AC(805)
Pharmacological Actions : Anticarcinogenic Agents : CK(2126) : AC(1010), Cyclooxygenase 2 Inhibitors : CK(2067) : AC(1256), NF-kappaB Inhibitor : CK(5541) : AC(3331)
Additional Keywords : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Phloretin, skin cancer

The combination of β-caryophyllene, baicalin and catechin exerts synergistic suppressive effects on macrophages in vitro.

Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene : CK(170) : AC(92), Catechin : CK(959) : AC(309)
Diseases : Inflammation : CK(15183) : AC(5116)
Pharmacological Actions : Anti-Inflammatory Agents : CK(35225) : AC(14931), Antiproliferative : CK(9389) : AC(7265), Cyclooxygenase 2 Inhibitors : CK(2067) : AC(1256)
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative : CK(75) : AC(61), Beta-Caryophyllene, Catechin, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Natural Substance Synergy : CK(1339) : AC(654)

These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.

Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1152) : AC(681)
Diseases : Inflammation : CK(15183) : AC(5116)
Pharmacological Actions : Anti-Inflammatory Agents : CK(35225) : AC(14931), Cyclooxygenase 2 Inhibitors : CK(2067) : AC(1256), Interleukin-1 beta downregulation : CK(5277) : AC(2791), Interleukin-6 Downregulation : CK(8975) : AC(3463), NF-kappaB Inhibitor : CK(5541) : AC(3331), Nitric Oxide Inhibitor : CK(693) : AC(349), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(10605) : AC(4587)
Additional Keywords : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Interleukin-1 beta downregulation, thymoquinone

These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin : CK(324) : AC(242)
Diseases : Diabetic Retinopathy : CK(455) : AC(195)
Pharmacological Actions : Anti-Apoptotic : CK(4942) : AC(2980), Anti-Inflammatory Agents : CK(35225) : AC(14931), Cyclooxygenase 2 Inhibitors : CK(2067) : AC(1256)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Shikonin

This report confirms the anti-inflammatory potential of this traditionally employed herbal medicine in vitro.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Justicia gendarussa : CK(10) : AC(8)
Diseases : Inflammation : CK(15183) : AC(5116), Lipopolysaccharide-Induced Toxicity : CK(2918) : AC(1800)
Pharmacological Actions : 5-Lipoxygenase Inhibitor : CK(47) : AC(30), Anti-Inflammatory Agents : CK(35225) : AC(14931), Cyclooxygenase 2 Inhibitors : CK(2067) : AC(1256), Interleukin-6 Downregulation : CK(8975) : AC(3463), NF-kappaB Inhibitor : CK(5541) : AC(3331)
Additional Keywords : 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Interleukin-6 Downregulation, Justicia gendarussa, Lipopolysaccharide-Induced Toxicity, NF-kappaB Inhibitor, Plant Extracts : CK(18030) : AC(6686)

Walnut leaf extract exert protective effects against diabetic retinopathy.

Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Walnut : CK(799) : AC(195)
Diseases : Diabetic Retinopathy : CK(455) : AC(195)
Pharmacological Actions : Anti-Apoptotic : CK(4942) : AC(2980), Anti-Inflammatory Agents : CK(35225) : AC(14931), Cyclooxygenase 2 Inhibitors : CK(2067) : AC(1256)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Walnut

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