Results for Cyclooxygenase 2 Inhibitors

Adlay bran ethanolic extract suppressed 1,2-dimethylhydrazine-indued preneoplastic lesions of the colon.

Article Published Date : Jul 13, 2010
Study Type : Animal Study
Additional Links
Substances : Adlay : CK(128) : AC(79)
Diseases : Colon Cancer : CK(1920) : AC(1203)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemopreventive : CK(6580) : AC(2166), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327)
Additional Keywords : Adlay, Anti-Inflammatory Agents, Chemopreventive, COLON CANCER, Cyclooxygenase 2 Inhibitors, Plant Extracts : CK(18762) : AC(6782)

Curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects.

Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Depression
Pharmacological Actions : Antidepressive Agents : CK(7908) : AC(1466), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327)
Additional Keywords : Antidepressive Agents, CURCUMIN : CK(25) : AC(18), Cyclooxygenase 2 Inhibitors, Depression : CK(108) : AC(19)

Extracts of the fruits of Maqui-berry may provide a potential therapeutic approach for inflammation associated disorders.

Article Published Date : Dec 27, 2016
Study Type : In Vitro Study
Additional Links
Substances : Maqui : CK(46) : AC(17)
Diseases : Inflammation : CK(16094) : AC(5496), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327)
Additional Keywords : Anti-Inflammatory Agents, Antioxidants : CK(303) : AC(126), Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Maqui, oxidative stress, Plant Extracts : CK(18762) : AC(6782)

Panax ginseng anthocyanins pre-administration can significantly prevent cisplatin-induced nephrotoxicity.

Article Published Date : Jul 20, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins : CK(1599) : AC(492), Panax Ginseng : CK(94) : AC(45)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)
Pharmacological Actions : Chemoprotective Agents : CK(4278) : AC(1621), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Nitric Oxide Inhibitor : CK(705) : AC(356)
Additional Keywords : Anthocyanins : CK(11) : AC(9), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Panax Ginseng

Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin.

Article Published Date : Feb 29, 2012
Study Type : Animal Study
Additional Links
Substances : Phloretin : CK(232) : AC(137)
Diseases : Skin Cancer : CK(1759) : AC(833)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), NF-kappaB Inhibitor : CK(5952) : AC(3464)
Additional Keywords : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Phloretin, skin cancer

The combination of β-caryophyllene, baicalin and catechin exerts synergistic suppressive effects on macrophages in vitro.

Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene : CK(171) : AC(92), Catechin : CK(965) : AC(313)
Diseases : Inflammation : CK(16094) : AC(5496)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327)
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative : CK(75) : AC(61), Beta-Caryophyllene, Catechin, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Natural Substance Synergy : CK(1400) : AC(669)

These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.

Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Inflammation : CK(16094) : AC(5496)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464), Nitric Oxide Inhibitor : CK(705) : AC(356), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)
Additional Keywords : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Interleukin-1 beta downregulation, thymoquinone

These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Diabetic Retinopathy : CK(483) : AC(211)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Shikonin

This report confirms the anti-inflammatory potential of this traditionally employed herbal medicine in vitro.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Justicia gendarussa : CK(10) : AC(8)
Diseases : Inflammation : CK(16094) : AC(5496), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)
Pharmacological Actions : 5-Lipoxygenase Inhibitor : CK(48) : AC(31), Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464)
Additional Keywords : 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Interleukin-6 Downregulation, Justicia gendarussa, Lipopolysaccharide-Induced Toxicity, NF-kappaB Inhibitor, Plant Extracts : CK(18762) : AC(6782)

Walnut leaf extract exert protective effects against diabetic retinopathy.

Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Walnut : CK(803) : AC(198)
Diseases : Diabetic Retinopathy : CK(483) : AC(211)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Walnut

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