Results for Gut-liver axis

Aluminum-induced oxidative stress promotes changes in the structure of the gut microbiota and liver deficiency.

Article Published Date : Aug 29, 2024
Study Type : Animal Study
Additional Links
Diseases : Aluminum Toxicity : CK(735) : AC(318), Inflammation : CK(16094) : AC(5496), Oxidative Stress : CK(14758) : AC(5716)
Additional Keywords : Gut-liver axis
Problem Substances : Aluminum : CK(1075) : AC(356)

Anti-inflammatory activities of green tea catechins along the gut-liver axis in nonalcoholic fatty liver disease.

Article Published Date : Aug 11, 2020
Study Type : Review
Additional Links
Substances : Catechin : CK(965) : AC(313), Green Tea : CK(4491) : AC(1379)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)
Additional Keywords : Gut-liver axis

Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice

Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Spirulina : CK(1017) : AC(292)
Diseases : Obesity : CK(11004) : AC(2672)
Additional Keywords : Anti-Obesity Agents : CK(5172) : AC(1320), Gut-liver axis

Arctic berry extracts target the gut-liver axis to alleviate metabolic endotoxaemia, insulin resistance and hepatic steatosis.

Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Berries: All : CK(5404) : AC(1523), Blueberry : CK(1151) : AC(334), Cloudberry : CK(16) : AC(5), Crowberry : CK(11) : AC(9), Lingonberry : CK(92) : AC(37)
Diseases : Endotoxemia : CK(359) : AC(127), Hepatic Steatosis : CK(434) : AC(180), Insulin Resistance : CK(4864) : AC(1098), Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis, Plant Extracts : CK(18762) : AC(6782)

Astaxanthin, Haematococcus pluvialis and Haematococcus pluvialis residue alleviate liver injury in D-galactose-induced aging.

Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(1627) : AC(648)
Diseases : Aging : CK(6221) : AC(1510), Liver Damage : CK(4109) : AC(1872), Oxidative Stress : CK(14758) : AC(5716)
Additional Keywords : Gut-liver axis

Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects.

Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids : CK(4698) : AC(2176)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Gastrointestinal Agents : CK(7657) : AC(2274), NF-kappaB Inhibitor : CK(5952) : AC(3464)
Additional Keywords : Gut-liver axis

Bisphenol A exposure induces gut microbiota dysbiosis and consequent activation of gut-liver axis leading to hepatic steatosis.

Article Published Date : May 28, 2020
Study Type : Animal Study
Additional Links
Diseases : Bisphenol Toxicity : CK(4416) : AC(1329), Dysbiosis : CK(2038) : AC(586), Hepatic Steatosis : CK(434) : AC(180)
Additional Keywords : Gut-liver axis
Problem Substances : Bisphenol A : CK(4570) : AC(1323)

Bisphenol F exposure induces depression-like changes.

Article Published Date : Jan 21, 2024
Study Type : Animal Study
Additional Links
Diseases : Bisphenol Toxicity : CK(4416) : AC(1329), Depression : CK(9514) : AC(1751)
Additional Keywords : Gut-liver axis
Problem Substances : Bisphenol A : CK(4570) : AC(1323)

Blueberry attenuated liver fibrosis, protected intestinal epithelial barrier, and maintained the homeostasis of the gut microbiota.

Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Blueberry : CK(1151) : AC(334)
Diseases : Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Anti-Fibrotic : CK(2209) : AC(1052), Gastrointestinal Agents : CK(7657) : AC(2274), Gastroprotective : CK(1692) : AC(701), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Coffee prevents fatty liver disease induced by a high-fat diet by modulating pathways of the gut-liver axis.

Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Coffee : CK(1669) : AC(209)
Diseases : High Fat Diet : CK(2040) : AC(984), Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Continued alcohol misuse in human cirrhosis is associated with an impaired gut-liver axis.

Article Published Date : Sep 18, 2017
Study Type : Human Study
Additional Links
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Cirrhosis: Liver : CK(740) : AC(210)
Additional Keywords : Gut-liver axis

Diallyl disulfide ameliorates ethanol-induced liver steatosis and inflammation by maintaining the fatty acid catabolism and regulating the gut-liver axis.

Article Published Date : May 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Organosulfur Compounds : CK(2174) : AC(1022)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Fatty Liver : CK(4309) : AC(1216), Inflammation : CK(16094) : AC(5496)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis.

Article Published Date : Jun 26, 2019
Study Type : Review
Additional Links
Substances : Prebiotics : CK(440) : AC(112), Probiotics : CK(9740) : AC(1711)
Diseases : Cirrhosis : CK(826) : AC(225), Encephalopathy
Therapeutic Actions : Microbiota Transfer Therapy : CK(227) : AC(66)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274)
Additional Keywords : Gut-liver axis, Microbiota : CK(1256) : AC(346)

Diosgenin alleviates nonalcoholic steatohepatitis through affecting liver-gut circulation.

Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Diosgenin : CK(245) : AC(146)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis.

Article Published Date : Jun 01, 2023
Study Type : Animal Study
Additional Links
Substances : Black Tea : CK(1050) : AC(265)
Diseases : Gastrointestinal Complaints : CK(111) : AC(22)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Gut-liver axis

Eugenol alleviated nonalcoholic fatty liver disease.

Article Published Date : Apr 30, 2022
Study Type : Animal Study
Additional Links
Substances : Eugenol : CK(219) : AC(133)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831), Hypolipidemic : CK(9173) : AC(2038)
Additional Keywords : Gut-brain Axis : CK(686) : AC(289), Gut-liver axis

Fecal microbiota transplantation from female donors restores gut permeability and reduces liver injury and inflammation in middle-aged male mice exposed to alcohol.

Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Diseases : Alcoholic Liver Disease : CK(611) : AC(283)
Therapeutic Actions : Microbiota Transfer Therapy : CK(227) : AC(66)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Fermented ginseng improved alcohol liver injury in association with changes in the gut microbiota of mice.

Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages : CK(3367) : AC(829), Ginseng : CK(4190) : AC(1902)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Folic acid ameliorates alcohol-induced liver injury via gut-liver axis homeostasis.

Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Folic Acid : CK(1317) : AC(206)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Fu brick tea alleviates alcoholic liver injury by modulating the gut microbiota-liver axis.

Article Published Date : Sep 21, 2022
Study Type : Animal Study
Additional Links
Substances : Black Tea : CK(1050) : AC(265)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)
Additional Keywords : Gut-liver axis

Fucoidan from Apostichopus japonicus ameliorates alcoholic liver disease by regulating gut-liver axis homeostasis.

Article Published Date : May 03, 2024
Study Type : Animal Study
Additional Links
Substances : Fucoidan : CK(866) : AC(451)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Ginsenoside Rh4 improves hepatic lipid metabolism and inflammation in a model of NAFLD.

Article Published Date : Jun 25, 2023
Study Type : Animal Study
Additional Links
Substances : Ginsenosides : CK(2640) : AC(1452)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Hypolipidemic : CK(9173) : AC(2038)
Additional Keywords : Gut-liver axis

Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota.

Article Published Date : Jan 19, 2022
Study Type : Animal Study
Additional Links
Substances : Medicinal Mushrooms : CK(2674) : AC(1252)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Gastrointestinal Agents : CK(7657) : AC(2274), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Nrf2 activation : CK(3156) : AC(1794)
Additional Keywords : Gut-liver axis

Gut microbiota and liver metabolomics reveal the potential mechanism of Lactobacillus rhamnosus GG modulating the liver toxicity caused by polystyrene microplastics.

Article Published Date : Dec 27, 2023
Study Type : Animal Study
Additional Links
Substances : Lactobacillus rhamnosus GG : CK(660) : AC(147)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Microplastic Toxicity : CK(1075) : AC(509)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)
Additional Keywords : Gut-liver axis

Gut microbiota participates in polystyrene microplastics-induced hepatic injuries.

Article Published Date : Aug 07, 2023
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Inflammation : CK(16094) : AC(5496), Microplastic Toxicity : CK(1075) : AC(509)
Pharmacological Actions : Gastroprotective : CK(1692) : AC(701)
Additional Keywords : Gut-liver axis
Problem Substances : Polystyrene nanoparticles : CK(535) : AC(269)

Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease.

Article Published Date : Mar 02, 2021
Study Type : Animal Study
Additional Links
Substances : Panax Notoginseng : CK(392) : AC(185)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Hepatoprotective effect of curcumin against bisphenol A-induced hepatic steatosis.

Article Published Date : Jun 29, 2022
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Bisphenol Toxicity : CK(4416) : AC(1329), Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis
Problem Substances : Bisphenol A : CK(4570) : AC(1323)

Hepatoprotective effect of probiotic Lactobacillus rhamnosus GG in a model of alcoholic liver disease.

Article Published Date : Jun 25, 2019
Study Type : Animal Study
Additional Links
Substances : Lactobacillus rhamnosus GG : CK(660) : AC(147)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Hericium erinaceus polysaccharides ameliorate nonalcoholic fatty liver disease.

Article Published Date : Jun 30, 2024
Study Type : Animal Study
Additional Links
Substances : Lion's Mane (Hericium Erinaceus) : CK(262) : AC(136)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274)
Additional Keywords : Gut-liver axis, Polysaccharides : CK(1326) : AC(748)

Intermittent fasting, especially when associated with coconut oil, had effects comparable with caloric restriction in modulating the parameters of the gut-liver axis.

Article Published Date : Jan 31, 2024
Study Type : Animal Study
Additional Links
Substances : Coconut Oil : CK(478) : AC(106)
Diseases : Obesity : CK(11004) : AC(2672)
Therapeutic Actions : Fasting/Caloric Restriction : CK(820) : AC(176)
Additional Keywords : Gut-liver axis

L. reuteri ZJ617 inhibits inflammatory and autophagy signaling pathways in gut-liver axis in piglet induced by lipopolysaccharide.

Article Published Date : Oct 12, 2021
Study Type : Animal Study
Additional Links
Substances : Lactobacillus reuteri : CK(619) : AC(124)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)
Additional Keywords : Gut-liver axis

Lactobacillus fermentum CQPC06 prevents non-alcoholic fatty liver disease by stabilizing the gut-liver axis.

Article Published Date : Oct 20, 2020
Study Type : Animal Study
Additional Links
Substances : Lactobacillus fermentum : CK(225) : AC(95)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Lactobacillus gasseri CKCC1913 mediated modulation of the gut-liver axis alleviated insulin resistance and liver damage induced by type 2 diabetes.

Article Published Date : Sep 18, 2023
Study Type : Animal Study
Additional Links
Substances : Lactobacillus gasseri : CK(209) : AC(46)
Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Insulin Resistance : CK(4864) : AC(1098)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Lactobacillus plantarum 69-2 combined with galacto-oligosaccharides alleviates d-galactose-induced aging.

Article Published Date : Mar 09, 2021
Study Type : Animal Study
Additional Links
Substances : Galacto-oligosaccharides : CK(68) : AC(10), Lactobacillus plantarum : CK(1008) : AC(308)
Diseases : Aging : CK(6221) : AC(1510)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831), SIRT1 Activator : CK(382) : AC(190)
Additional Keywords : Gut-liver axis

Lupeol improves bile acid metabolism and metabolic dysfunction-associated steatotic liver disease.

Article Published Date : Jun 16, 2024
Study Type : Animal Study
Additional Links
Substances : Lupeol : CK(122) : AC(68)
Diseases : Liver Disease : CK(367) : AC(117)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Lycopene attenuates western-diet-induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut-liver-brain axis.

Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Lycopene : CK(1267) : AC(372)
Diseases : Cognitive Decline/Dysfunction : CK(5292) : AC(1050)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)
Additional Keywords : Gut-brain Axis : CK(686) : AC(289), Gut-liver axis
Anti Therapeutic Actions : Western Diet : CK(601) : AC(151)

Melatonin improves cholestatic liver disease via the gut-liver axis.

Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Melatonin : CK(2891) : AC(911)
Diseases : Cholestasis : CK(163) : AC(53), Liver Cirrhosis : CK(919) : AC(230), Liver Disease : CK(367) : AC(117)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274)
Additional Keywords : Gut-liver axis

Morinda citrifolia extract prevents alcoholic fatty liver disease by improving gut health.

Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Noni : CK(242) : AC(104)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283), Inflammation : CK(16094) : AC(5496)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

MUP1 mediates urolithin A alleviation of chronic alcohol-related liver disease via gut-microbiota-liver axis.

Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Urolithin A : CK(247) : AC(128)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

Obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis.

Article Published Date : Mar 25, 2024
Study Type : Animal Study
Additional Links
Diseases : Microplastic Toxicity : CK(1075) : AC(509)
Additional Keywords : Gut-liver axis
Problem Substances : Nano Plastic-and Micro-Particles : CK(557) : AC(257), Polystyrene nanoparticles : CK(535) : AC(269)

Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure.

Article Published Date : Sep 07, 2023
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin : CK(600) : AC(364)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis
Problem Substances : Zinc Oxide : CK(30) : AC(15)

Phyllanthus emblica fruit improves obesity by reducing appetite and enhancing mucosal homeostasis.

Article Published Date : May 07, 2024
Study Type : Animal Study
Additional Links
Substances : Amla Fruit : CK(265) : AC(94)
Diseases : Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Appetite Depressants : CK(84) : AC(14), Gastrointestinal Agents : CK(7657) : AC(2274)
Additional Keywords : Anti-Obesity Agents : CK(5172) : AC(1320), Gut-liver axis, Plant Extracts : CK(18762) : AC(6782)

Polystyrene nanoplastics exacerbate aflatoxin B1-induced hepatic injuries by modulating the gut-liver axis.

Article Published Date : Jul 19, 2024
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Liver Damage: Aflatoxin-Induced : CK(104) : AC(48), Microplastic Toxicity : CK(1075) : AC(509)
Additional Keywords : Gut-liver axis, Increased Risk : CK(8772) : AC(1121)
Problem Substances : Nano Plastic-and Micro-Particles : CK(557) : AC(257), Polystyrene nanoparticles : CK(535) : AC(269)

Polystyrene nanoplastics induce intestinal and hepatic inflammation through activation of NF-κB/NLRP3 pathways and related gut-liver axis.

Article Published Date : Jul 19, 2024
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Inflammation : CK(16094) : AC(5496), Microplastic Toxicity : CK(1075) : AC(509)
Additional Keywords : Gut-liver axis
Problem Substances : Nano Plastic-and Micro-Particles : CK(557) : AC(257), Polystyrene nanoparticles : CK(535) : AC(269)

Seabuckthorn polysaccharide ameliorates high-fat diet-induced obesity.

Article Published Date : Mar 06, 2022
Study Type : Animal Study
Additional Links
Substances : Sea buckthorn : CK(368) : AC(147)
Diseases : Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274)
Additional Keywords : Anti-Obesity Agents : CK(5172) : AC(1320), Gut-liver axis

sesamol could be a potential neuroprotective agent during aging process due to its beneficial effects on liver-brain axis.

Article Published Date : Nov 13, 2018
Study Type : Animal Study
Additional Links
Substances : Sesamol : CK(229) : AC(136)
Diseases : Brain: Oxidative Stress : CK(642) : AC(346), Cognitive Decline/Dysfunction : CK(5292) : AC(1050)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Brain-derived neurotrophic factor modulator : CK(745) : AC(280), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Neuroprotective Agents : CK(20061) : AC(7949), Nrf2 activation : CK(3156) : AC(1794), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)
Additional Keywords : Gut-liver axis

Silibinin decreases hepatic glucose production through the activation of gut-brain-liver axis in diabetic rats.

Article Published Date : Sep 18, 2018
Study Type : Animal Study
Additional Links
Substances : Silibinin : CK(460) : AC(231)
Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Hypoglycemic Agents : CK(9221) : AC(2076)
Additional Keywords : Gut-liver axis

Sulforaphane ameliorates nonalcoholic fatty liver disease induced by high-fat and high-fructose diet.

Article Published Date : Jan 31, 2023
Study Type : Animal Study
Additional Links
Substances : Sulforaphane : CK(1344) : AC(630)
Diseases : High Fat Diet : CK(2040) : AC(984), High Sugar Diet : CK(480) : AC(125), Inflammation : CK(16094) : AC(5496), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis, Risk Reduction : CK(17935) : AC(2006)

The improvement of intestinal dysbiosis and hepatic metabolic dysfunction in dextran sulfate sodium-induced colitis.

Article Published Date : Jul 31, 2023
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Colitis : CK(1542) : AC(735), Inflammatory Bowel Diseases : CK(3196) : AC(926)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Gut-liver axis

The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD).

Article Published Date : Jan 24, 2019
Study Type : Review
Additional Links
Substances : Probiotics : CK(9740) : AC(1711)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Additional Keywords : Gut-liver axis

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