Results for Nrf2 activation

A leaf extract of Dandelion and its main compound activated nuclear factor erythroid 2-related factor 2 and induced heme oxygenase 1.

Article Published Date : Dec 26, 2016
Study Type : In Vitro Study
Additional Links
Substances : Dandelion : CK(411) : AC(222)
Diseases : Oxidative Stress : CK(15923) : AC(6215)
Pharmacological Actions : Antioxidants : CK(36480) : AC(15286), Heme oxygenase-1 inducer : CK(63) : AC(43), Nrf2 activation : CK(3338) : AC(1899)
Additional Keywords : Antioxidants : CK(303) : AC(126), Dandelion, Heme oxygenase-1 inducer, Nrf2 activation, oxidative stress, Plant Extracts : CK(19288) : AC(7051)

Adlay is a potential chemopreventive TCM to block multistage carcinogenesis with anti-initiation, promotion and progression properties.

Article Published Date : Sep 30, 2012
Study Type : Review
Additional Links
Substances : Adlay : CK(128) : AC(79)
Diseases : Cancers: All : CK(37373) : AC(14854)
Pharmacological Actions : Antioxidants : CK(36480) : AC(15286), Antiproliferative : CK(10533) : AC(7891), Chemopreventive : CK(6655) : AC(2206), Nrf2 activation : CK(3338) : AC(1899)
Additional Keywords : Adlay, Antioxidants : CK(303) : AC(126), Antiproliferative : CK(75) : AC(61), Cancers: All, Chemopreventive, Nrf2 activation

Allicin provides protection against arsenic trioxide induced liver injury.

Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Allicin : CK(361) : AC(197)
Diseases : Arsenic Poisoning : CK(414) : AC(137), Oxidative Stress : CK(15923) : AC(6215)
Pharmacological Actions : Antioxidants : CK(36480) : AC(15286), NF-kappaB Inhibitor : CK(6287) : AC(3640), Nrf2 activation : CK(3338) : AC(1899)
Additional Keywords : Allicin, Antioxidants : CK(303) : AC(126), Arsenic Poisoning, NF-kappaB Inhibitor, Nrf2 activation, oxidative stress
Problem Substances : Arsenic Trioxide : CK(45) : AC(27)

Astaxanthin promotes Nrf2/ARE signalling to inhibit high glucose induced renal fibrosis in GMCs.

Article Published Date : Apr 04, 2018
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(1681) : AC(663)
Diseases : Diabetic Nephropathy : CK(1512) : AC(567), Kidney Fibrosis : CK(267) : AC(151)
Pharmacological Actions : Antioxidants : CK(36480) : AC(15286), Nrf2 activation : CK(3338) : AC(1899), Renoprotective : CK(4806) : AC(2087)
Additional Keywords : Antioxidants : CK(303) : AC(126), Astaxanthin, Diabetic Nephropathy, Kidney Fibrosis, Nrf2 activation, Renoprotective

Carnosic acid prevents dextran sulfate sodium-induced acute colitis.

Article Published Date : Sep 07, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid : CK(167) : AC(112)
Diseases : Colitis : CK(1650) : AC(784)
Pharmacological Actions : Antioxidants : CK(36480) : AC(15286), Nrf2 activation : CK(3338) : AC(1899)
Additional Keywords : Antioxidants : CK(303) : AC(126), Carnosic Acid, Colitis, Nrf2 activation

Fucoxanthin provides neuroprotection in models of traumatic brain injury.

Article Published Date : Apr 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fucoxanthin : CK(271) : AC(166)
Diseases : Brain Injury: Traumatic : CK(388) : AC(134)
Pharmacological Actions : Antioxidants : CK(36480) : AC(15286), Neuroprotective Agents : CK(21318) : AC(8447), Nrf2 activation : CK(3338) : AC(1899)
Additional Keywords : Antioxidants : CK(303) : AC(126), Brain Injury: Traumatic, Fucoxanthin, Neuroprotective Agents, Nrf2 activation

Phloretin has a strong chemopreventive effect against aflatoxin B1.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Phloretin : CK(275) : AC(165)
Diseases : Liver Damage: Aflatoxin-Induced : CK(112) : AC(52)
Pharmacological Actions : Chemopreventive : CK(6655) : AC(2206), Nrf2 activation : CK(3338) : AC(1899)
Additional Keywords : Chemopreventive, Dose Response : CK(1780) : AC(701), Liver Damage: Aflatoxin-Induced, Nrf2 activation, Phloretin
Problem Substances : Aflatoxin : CK(245) : AC(95)

Piper nigrum might be a promising candidate for the treatment of inflammatory diseases.

Article Published Date : Feb 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : Black Pepper : CK(844) : AC(347)
Diseases : Inflammation : CK(16899) : AC(5768)
Pharmacological Actions : Heme oxygenase-1 inducer : CK(63) : AC(43), Nrf2 activation : CK(3338) : AC(1899)
Additional Keywords : Black Pepper, Heme oxygenase-1 inducer, Inflammation : CK(128) : AC(57), Nrf2 activation

Sulforphane's antioxidant properties make it an effective neuroprotective agent. More studies are needed to determine the exact implications in neurological disease.

Article Published Date : Apr 01, 2019
Study Type : Review
Additional Links
Substances : Sulforaphane : CK(1345) : AC(631)
Therapeutic Actions : antioxidant, antioxidants, neuro-protective
Pharmacological Actions : Antioxidant, Antioxidant Effects : CK(161) : AC(46), Antioxidants : CK(36480) : AC(15286), Neuroprotective Agents : CK(21318) : AC(8447), NF-E2-Related Factor-2 (Nrf2) Modulator : CK(74) : AC(42), Nrf2 activation : CK(3338) : AC(1899)
Additional Keywords : Antioxidant effects, Antioxidant Systems : CK(3) : AC(3), Cruciferous Vegetables, Neurodegenerative diseases, Neuroprotective Agents, Nrf2 activation, Phytotherapy : CK(4061) : AC(1058), Sulforaphane

The effect of rutin and hesperidin on the expression of Nrf2- and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachloride

Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Hesperidin : CK(1002) : AC(381), Rutin : CK(468) : AC(225)
Pharmacological Actions : Antioxidants : CK(36480) : AC(15286), Heme oxygenase-1 up-regulation : CK(1422) : AC(824), Nrf2 activation : CK(3338) : AC(1899)
Additional Keywords : Antioxidants : CK(303) : AC(126), Calcium Carbonate, Gene Expression Regulation : CK(1434) : AC(629), Heme oxygenase-1 up-regulation, Hesperidin, Nrf2 activation, Rutin
Problem Substances : Calcium Carbonate : CK(198) : AC(21)

Thymoquinone protects against cobalt chloride-induced neurotoxicity.

Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1203) : AC(706)
Diseases : Neurodegenerative Diseases : CK(13626) : AC(4502)
Pharmacological Actions : Antioxidants : CK(36480) : AC(15286), Neuroprotective Agents : CK(21318) : AC(8447), Nrf2 activation : CK(3338) : AC(1899)
Additional Keywords : Antioxidants : CK(303) : AC(126), Cobalt, Neurodegenerative diseases, Neuroprotective Agents, Nrf2 activation, thymoquinone
Problem Substances : Cobalt : CK(21) : AC(14)

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