Results for SARS-CoV-2 Spike Protein

Adverse effects of COVID-19 vaccines and measures to prevent them.

Article Published Date : Jun 04, 2022
Study Type : Commentary
Additional Links
Diseases : Vaccination: Coronavirus
Additional Keywords : Antibody-Dependent Enhancement, SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(3) : AC(1)
Adverse Pharmacological Actions : Immunosuppressive : CK(234) : AC(46)

Be aware of SARS-CoV-2 spike protein: There is more than meets the eye.

Article Published Date : Jan 07, 2021
Study Type : Commentary
Additional Links
Substances : Luteolin : CK(381) : AC(247)
Diseases : Coronavirus Infection : CK(1230) : AC(410), Vaccination: Coronavirus
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856)
Additional Keywords : SARS-CoV-2 Spike Protein

CBD is a powerful inhibitor of SARS-CoV-2 spike protein enterotoxicity in vitro.

Article Published Date : Oct 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol : CK(2644) : AC(774)
Diseases : Coronavirus Infection : CK(1230) : AC(410)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Interleukin-18 upregulation : CK(6) : AC(4), Interleukin-1 beta downregulation : CK(3041) : AC(1567), Interleukin-6 Downregulation : CK(5029) : AC(1994), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(6736) : AC(2815)
Additional Keywords : SARS-CoV-2 Spike Protein

Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

Article Published Date : Jan 12, 2022
Study Type : Review
Additional Links
Diseases : Coronavirus Infection : CK(1230) : AC(410), Vaccination: Coronavirus
Additional Keywords : Long Covid, SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(3) : AC(1)

Dieckol and Its derivatives as potential inhibitors of SARS-CoV-2 spike protein.

Article Published Date : Apr 24, 2021
Study Type : In Vitro Study
Additional Links
Substances : Phlorotannins : CK(1) : AC(1)
Diseases : Coronavirus Infection : CK(1230) : AC(410)
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)
Additional Keywords : SARS-CoV-2 Spike Protein

Eugenol inhibits the interaction between SARS-CoV-2 spike S1 and ACE2 to induce therapeutic responses.

Article Published Date : Oct 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Eugenol : CK(128) : AC(74)
Diseases : Coronavirus Infection : CK(1230) : AC(410)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Antiviral Agents : CK(1957) : AC(1034), Interleukin-1 beta downregulation : CK(3041) : AC(1567), Interleukin-6 Downregulation : CK(5029) : AC(1994), NF-kappaB Inhibitor : CK(3536) : AC(2098), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(6736) : AC(2815)
Additional Keywords : SARS-CoV-2 Spike Protein

First case of postmortem study in a patient vaccinated against SARS-CoV-2.

Article Published Date : May 31, 2021
Study Type : Human: Case Report
Additional Links
Diseases : Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(3) : AC(1)

In silico targeting SARS-CoV-2 spike protein and main protease by biochemical compounds.

Article Published Date : Sep 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Kaempferol : CK(102) : AC(65)
Diseases : Coronavirus Infection : CK(1230) : AC(410)
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)
Additional Keywords : SARS-CoV-2 Spike Protein

In vitro effect of Taraxacum officinale leaf aqueous extract on the interaction between ACE2 cell surface receptor and SARS-CoV-2 spike protein D614 and four mutants.

Article Published Date : Oct 16, 2021
Study Type : In Vitro Study
Additional Links
Substances : Dandelion : CK(262) : AC(134)
Diseases : Coronavirus Infection : CK(1230) : AC(410)
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)
Additional Keywords : SARS-CoV-2 Spike Protein

Interactions of spike-RBD of SARS-CoV-2 and platelet factor 4: new insights in the etiopathogenesis of thrombosis.

Article Published Date : Aug 08, 2021
Study Type : Human In Vitro
Additional Links
Diseases : Thrombosis : CK(338) : AC(93), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(3) : AC(1)

Molecular mimicry between SARS-CoV-2 and the female reproductive system.

Article Published Date : Aug 17, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Coronavirus Infection : CK(1230) : AC(410), Infertility: Female : CK(541) : AC(127), Vaccination: Coronavirus
Additional Keywords : Molecular Mimicry : CK(102) : AC(29), SARS-CoV-2 Spike Protein

Oroxylin A is a severe acute respiratory syndrome coronavirus 2-spiked pseudotyped virus blocker.

Article Published Date : May 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids : CK(2352) : AC(870)
Diseases : Coronavirus Infection : CK(1230) : AC(410), Severe Acute Respiratory Syndrome : CK(115) : AC(27)
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)
Additional Keywords : SARS-CoV-2 Spike Protein

Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro.

Article Published Date : Apr 12, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids : CK(2352) : AC(870)
Diseases : Coronavirus Infection : CK(1230) : AC(410)
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)
Additional Keywords : SARS-CoV-2 Spike Protein

SARS-2-cov spike protein alone without the rest of the viral components is sufficient to elicit cell signaling in human pulmonary arterial endothelial cells.

Article Published Date : Aug 21, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Coronavirus Infection : CK(1230) : AC(410), Endothelial Dysfunction : CK(2115) : AC(440), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(3) : AC(1)

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19.

Article Published Date : Jan 03, 2020
Study Type : Human Study
Additional Links
Diseases : Coronavirus Infection : CK(1230) : AC(410), Inflammation : CK(9572) : AC(3089), Thrombosis : CK(338) : AC(93), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(3) : AC(1)

SARS-CoV-2 spike impairs DNA damage repair and inhibits V(D)J recombination in vitro.

Article Published Date : Jan 12, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Vaccination: Coronavirus
Additional Keywords : BRCA Gene : CK(38) : AC(7), SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(3) : AC(1)

SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS.

Article Published Date : Aug 26, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Inflammation : CK(9572) : AC(3089), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(3) : AC(1)

SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate.

Article Published Date : Oct 28, 2021
Study Type : Animal Study
Additional Links
Diseases : Thrombosis : CK(338) : AC(93), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein

SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE2.

Article Published Date : Dec 03, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Endothelial Damage : CK(188) : AC(50), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein

SARS-CoV-2 spike protein induces paracrine senescence and leukocyte adhesion in endothelial cells.

Article Published Date : Jan 09, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Coronavirus Infection : CK(1230) : AC(410), Endothelial Damage : CK(188) : AC(50), Endothelial Dysfunction : CK(2115) : AC(440), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(3) : AC(1)

SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells.

Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Diseases : Coronavirus Infection : CK(1230) : AC(410), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(3) : AC(1)

Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 spike protein.

Article Published Date : May 03, 2021
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane : CK(930) : AC(452)
Diseases : Vaccination: Coronavirus
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Interleukin-6 Downregulation : CK(5029) : AC(1994), Interleukin-8 downregulation : CK(581) : AC(231)
Additional Keywords : SARS-CoV-2 Spike Protein

Targeting CoV-2 spike RBD and ACE-2 interaction with flavonoids of Anatolian propolis.

Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids : CK(2352) : AC(870), Propolis: Bee : CK(138) : AC(50)
Diseases : Coronavirus Infection : CK(1230) : AC(410)
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)
Additional Keywords : SARS-CoV-2 Spike Protein

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier.

Article Published Date : Jan 11, 2020
Study Type : In Vitro Study
Additional Links
Diseases : Coronavirus Infection : CK(1230) : AC(410), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein

The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury.

Article Published Date : Dec 31, 2020
Study Type : Human In Vitro, Transgenic Animal Study
Additional Links
Diseases : Coronavirus Infection : CK(1230) : AC(410), Lung Injury: Acute : CK(321) : AC(159), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(3) : AC(1)

This is a comprehensive investigation of the pathophysiological changes, including detailed immunological alterations in people after COVID-19 vaccination.

Article Published Date : Oct 25, 2021
Study Type : Human Study
Additional Links
Diseases : Inflammation : CK(9572) : AC(3089), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(3) : AC(1)
Adverse Pharmacological Actions : Immunoreactive : CK(237) : AC(54), Immunosuppressive : CK(234) : AC(46), Inflammatory : CK(423) : AC(132)

Tinospora cordifolia reversed SARS-CoV-2 viral spike-protein induced disease phenotype.

Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Guduchi : CK(93) : AC(21)
Diseases : Coronavirus Infection : CK(1230) : AC(410), Vaccination: Coronavirus
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Renoprotective : CK(2404) : AC(1075)
Additional Keywords : Natural Substances Versus Drugs : CK(2375) : AC(479), SARS-CoV-2 Spike Protein

Ultramicronized palmitoylethanolamide inhibits NLRP3 inflammasome expression and pro-inflammatory response activated by SARS-CoV-2 spike protein.

Article Published Date : Sep 01, 2021
Study Type : In Vitro Study
Additional Links
Substances : Palmitoylethanolamide : CK(2) : AC(1)
Diseases : Coronavirus Infection : CK(1230) : AC(410)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Interleukin-1 beta downregulation : CK(3041) : AC(1567), Interleukin-6 Downregulation : CK(5029) : AC(1994), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(6736) : AC(2815)
Additional Keywords : SARS-CoV-2 Spike Protein

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