Results for SARS-CoV-2 Spike Protein

Adverse effects of COVID-19 vaccines and measures to prevent them.

Article Published Date : Jun 04, 2022
Study Type : Commentary
Additional Links
Diseases : Vaccination: Coronavirus
Additional Keywords : Antibody-Dependent Enhancement, SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)
Adverse Pharmacological Actions : Immunosuppressive : CK(289) : AC(55)

Be aware of SARS-CoV-2 spike protein: There is more than meets the eye.

Article Published Date : Jan 07, 2021
Study Type : Commentary
Additional Links
Substances : Luteolin : CK(711) : AC(393)
Diseases : Coronavirus Infection : CK(3250) : AC(986), Vaccination: Coronavirus
Pharmacological Actions : Antioxidants : CK(34553) : AC(14500)
Additional Keywords : SARS-CoV-2 Spike Protein

Biodistribution of mRNA COVID-19 vaccines in human breast milk.

Article Published Date : Sep 18, 2023
Study Type : Human Study
Additional Links
Diseases : Vaccination: Coronavirus, Vaccine-induced Toxicity : CK(3603) : AC(666)
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

Bovine lactoferrin inhibits SARS-CoV-2 and SARS-CoV-1.

Article Published Date : Nov 02, 2022
Study Type : Animal Study
Additional Links
Substances : Lactoferrin : CK(813) : AC(308)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

Cannabinoids block cellular entry of SARS-CoV-2 and the emerging variants.

Article Published Date : Jan 27, 2022
Study Type : In Vitro Study
Additional Links
Substances : Cannabinoids : CK(2714) : AC(922)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

Cardiac side effects of RNA-based SARS-CoV-2 vaccines.

Article Published Date : Oct 11, 2023
Study Type : In Vitro Study
Additional Links
Diseases : Cardiomyopathy : CK(390) : AC(171), Vaccine-induced Toxicity : CK(3603) : AC(666)
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)
Adverse Pharmacological Actions : Cardiotoxic : CK(1290) : AC(230)

CBD is a powerful inhibitor of SARS-CoV-2 spike protein enterotoxicity in vitro.

Article Published Date : Oct 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol : CK(3371) : AC(1007)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39739) : AC(15859), Interleukin-18 upregulation : CK(20) : AC(11), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)
Additional Keywords : SARS-CoV-2 Spike Protein

Certain natural compounds could help minimize the neuro- aspects of long covid.

Article Published Date : Feb 21, 2023
Study Type : Review
Additional Links
Substances : Eriodictyol : CK(83) : AC(55), Oleuropein : CK(322) : AC(202), Sulforaphane : CK(1344) : AC(630)
Diseases : Brain: Microglial Activation : CK(205) : AC(118), Brain Inflammation : CK(1784) : AC(928), Coronavirus Infection : CK(3250) : AC(986), Covid: Long : CK(219) : AC(40)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39739) : AC(15859), Antiviral Agents : CK(3095) : AC(1702), Neuroprotective Agents : CK(20061) : AC(7949)
Additional Keywords : Long Covid, SARS-CoV-2 Spike Protein

Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

Article Published Date : Jan 12, 2022
Study Type : Review
Additional Links
Substances : Luteolin : CK(711) : AC(393), Quercetin : CK(1876) : AC(855)
Diseases : Coronavirus Infection : CK(3250) : AC(986), Covid: Long : CK(219) : AC(40), Vaccination: Coronavirus
Additional Keywords : Long Covid, SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

COVID-19/SARS-CoV-2 virus spike protein-related delayed inflammatory reaction to hyaluronic acid dermal fillers.

Article Published Date : Dec 31, 2021
Study Type : Human: Case Report
Additional Links
Diseases : Inflammation : CK(16108) : AC(5498), Vaccine-induced Toxicity : CK(3603) : AC(666)
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

Curcumin-based virtual screening identifies inhibitors of SARS-CoV-2 spike protein and ACE2 receptor binding.

Article Published Date : Apr 22, 2025
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7249) : AC(3320)
Diseases : Coronavirus Disease (Covid-19) : CK(1338) : AC(330)
Additional Keywords : SARS-CoV-2 Spike Protein

Dieckol and Its derivatives as potential inhibitors of SARS-CoV-2 spike protein.

Article Published Date : Apr 24, 2021
Study Type : In Vitro Study
Additional Links
Substances : Phlorotannins : CK(148) : AC(98)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

Eugenol inhibits the interaction between SARS-CoV-2 spike S1 and ACE2 to induce therapeutic responses.

Article Published Date : Oct 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Eugenol : CK(219) : AC(133)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39739) : AC(15859), Antiviral Agents : CK(3095) : AC(1702), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)
Additional Keywords : SARS-CoV-2 Spike Protein

First case of postmortem study in a patient vaccinated against SARS-CoV-2.

Article Published Date : May 31, 2021
Study Type : Human: Case Report
Additional Links
Diseases : Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

Full-length spike protein unbound by antibodies was detected in the plasma of individuals with postvaccine myocarditis.

Article Published Date : Jan 03, 2023
Study Type : Human Study
Additional Links
Diseases : Myocarditis : CK(284) : AC(45), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)
Adverse Pharmacological Actions : Cardiotoxic : CK(1290) : AC(230)

Functionalized fullerene for inhibition of SARS-CoV-2 variants.

Article Published Date : Mar 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Carbon 60 : CK(79) : AC(48)
Diseases : Coronavirus Disease (Covid-19) : CK(1339) : AC(331)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

Ginkgolic acids inhibit SARS-CoV-2 and its variants.

Article Published Date : Jan 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba : CK(2047) : AC(658)
Diseases : Coronavirus Disease (Covid-19) : CK(1339) : AC(331)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

IgG4 antibodies induced by repeated vaccination may generate immune tolerance to the SARS-CoV-2 spike protein.

Article Published Date : May 16, 2023
Study Type : Review
Additional Links
Diseases : Coronavirus Disease (Covid-19) : CK(1339) : AC(331), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

In silico targeting SARS-CoV-2 spike protein and main protease by biochemical compounds.

Article Published Date : Sep 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7256) : AC(3324), Kaempferol : CK(354) : AC(229)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

In vitro effect of Taraxacum officinale leaf aqueous extract on the interaction between ACE2 cell surface receptor and SARS-CoV-2 spike protein D614 and four mutants.

Article Published Date : Oct 16, 2021
Study Type : In Vitro Study
Additional Links
Substances : Dandelion : CK(370) : AC(200)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 spike protein.

Article Published Date : Jul 22, 2024
Study Type : In Vitro Study
Additional Links
Diseases : Cystic Fibrosis : CK(797) : AC(124), Inflammation : CK(16108) : AC(5498), Vaccine-induced Toxicity : CK(3603) : AC(666)
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)
Adverse Pharmacological Actions : Inflammatory : CK(554) : AC(176)

Inhibition of multiple SARS-CoV-2 variants entry by Lycium barbarum L. polysaccharides.

Article Published Date : Feb 29, 2024
Study Type : In Vitro Study
Additional Links
Substances : Goji : CK(425) : AC(185)
Diseases : Coronavirus Disease (Covid-19) : CK(1339) : AC(331)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : Polysaccharides : CK(1328) : AC(749), SARS-CoV-2 Spike Protein

Interactions of spike-RBD of SARS-CoV-2 and platelet factor 4: new insights in the etiopathogenesis of thrombosis.

Article Published Date : Aug 08, 2021
Study Type : Human In Vitro
Additional Links
Diseases : Thrombosis : CK(448) : AC(123), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

Intramyocardial inflammation after COVID-19 vaccination: an endomyocardial biopsy-proven case series.

Article Published Date : Jun 21, 2022
Study Type : Human Study
Additional Links
Diseases : Inflammation : CK(16108) : AC(5498), Vaccine-induced Toxicity : CK(3603) : AC(666)
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)
Adverse Pharmacological Actions : Cardiotoxic : CK(1290) : AC(230), Inflammatory : CK(554) : AC(176)

Lactoferrin for COVID-19 prevention, treatment, and recovery.

Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Lactoferrin : CK(813) : AC(308)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702), Prophylactic Agents : CK(1700) : AC(335)
Additional Keywords : SARS-CoV-2 Spike Protein

Lonicerae japonicae attenuates neutrophilic inflammation by inhibiting oxidative stress.

Article Published Date : Sep 08, 2022
Study Type : In Vitro Study
Additional Links
Substances : Honeysuckle : CK(250) : AC(145)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39739) : AC(15859), Antioxidants : CK(34553) : AC(14500)
Additional Keywords : SARS-CoV-2 Spike Protein

MMP-9 from Spike protein-stimulated microglia could contribute to the development of long COVID.

Article Published Date : Dec 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Luteolin : CK(711) : AC(393)
Diseases : Coronavirus Disease (Covid-19) : CK(1339) : AC(331), Covid: Long : CK(219) : AC(40)
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1141) : AC(720)
Additional Keywords : SARS-CoV-2 Spike Protein

Molecular mimicry between SARS-CoV-2 and the female reproductive system.

Article Published Date : Aug 17, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Coronavirus Infection : CK(3250) : AC(986), Infertility: Female : CK(822) : AC(197), Vaccination: Coronavirus
Additional Keywords : Molecular Mimicry : CK(109) : AC(32), SARS-CoV-2 Spike Protein

mulberrofuran G might be a promising therapeutic candidate for preventing SARS-CoV-2.

Article Published Date : Oct 06, 2022
Study Type : In Vitro Study
Additional Links
Substances : Mulberry : CK(546) : AC(274)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

Mulberry component kuwanon C exerts potent therapeutic efficacy in vitro against COVID-19.

Article Published Date : Oct 18, 2022
Study Type : In Vitro Study
Additional Links
Substances : White Mulberry : CK(156) : AC(66)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

Nattokinase exhibits potential for the inhibition of SARS-CoV-2 infection via S protein degradation.

Article Published Date : Aug 23, 2022
Study Type : In Vitro Study
Additional Links
Substances : Nattokinase : CK(152) : AC(34)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin.

Article Published Date : Aug 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan : CK(866) : AC(451)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

Near-infrared light exposure triggers ROS to downregulate inflammatory cytokines induced by SARS-CoV-2 spike protein in human cell culture.

Article Published Date : Oct 01, 2023
Study Type : In Vitro Study
Additional Links
Diseases : Coronavirus Disease (Covid-19) : CK(1339) : AC(331)
Therapeutic Actions : Photobiomodulation : CK(17459) : AC(3331)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39739) : AC(15859), Antioxidants : CK(34553) : AC(14500)
Additional Keywords : SARS-CoV-2 Spike Protein

Oroxylin A is a severe acute respiratory syndrome coronavirus 2-spiked pseudotyped virus blocker.

Article Published Date : May 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids : CK(4698) : AC(2176)
Diseases : Coronavirus Infection : CK(3250) : AC(986), Severe Acute Respiratory Syndrome : CK(116) : AC(28)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

Postbiotic preparation of Lacticaseibacillus rhamnosus GG against diarrhea and oxidative stress induced by spike protein of SARS-CoV-2.

Article Published Date : Oct 18, 2023
Study Type : In Vitro Study
Additional Links
Substances : Lactobacillus rhamnosus GG : CK(660) : AC(147)
Diseases : Coronavirus Disease (Covid-19) : CK(1339) : AC(331), Diarrhea : CK(1075) : AC(189)
Pharmacological Actions : Antioxidants : CK(34553) : AC(14500), Gastrointestinal Agents : CK(7667) : AC(2275)
Additional Keywords : SARS-CoV-2 Spike Protein

Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro.

Article Published Date : Apr 12, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids : CK(4698) : AC(2176)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

Potential autoimmunity resulting from molecular mimicry between SARS-CoV-2 spike and human proteins.

Article Published Date : Jun 27, 2022
Study Type : In Vitro Study
Additional Links
Diseases : Autoimmune Diseases : CK(12040) : AC(2692), Vaccine-induced Toxicity : CK(3603) : AC(666)
Additional Keywords : Molecular Mimicry : CK(109) : AC(32), SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

Prenol of fruit binds to SARS-CoV-2 spike S1 to inhibit viral entry.

Article Published Date : May 04, 2023
Study Type : Animal Study
Additional Links
Substances : Fruit: All : CK(9437) : AC(2238)
Diseases : Coronavirus Disease (Covid-19) : CK(1339) : AC(331)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

Rosemary may reduce the risk of SARS-CoV-2 infection and the development of COVID-19.

Article Published Date : Dec 05, 2023
Study Type : In Vitro Study
Additional Links
Substances : Rosemary : CK(555) : AC(211)
Diseases : Coronavirus Disease (Covid-19) : CK(1339) : AC(331)
Pharmacological Actions : Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : SARS-CoV-2 Spike Protein

SARS-2-cov spike protein alone without the rest of the viral components is sufficient to elicit cell signaling in human pulmonary arterial endothelial cells.

Article Published Date : Aug 21, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Coronavirus Infection : CK(3250) : AC(986), Endothelial Dysfunction : CK(2733) : AC(581), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19.

Article Published Date : Jan 03, 2020
Study Type : Human Study
Additional Links
Diseases : Coronavirus Infection : CK(3250) : AC(986), Inflammation : CK(16108) : AC(5498), Thrombosis : CK(448) : AC(123), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

SARS-CoV-2 spike aggravates lupus nephritis and lung fibrosis in systemic lupus erythematosus.

Article Published Date : Sep 29, 2024
Study Type : Animal Study
Additional Links
Diseases : Coronavirus Disease (Covid-19) : CK(1339) : AC(331), Fibrosis : CK(383) : AC(185), Lupus Nephritis : CK(128) : AC(33), Systemic Lupus Erythematosus : CK(817) : AC(139)
Additional Keywords : Increased Risk : CK(8772) : AC(1121), SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

SARS-CoV-2 spike impairs DNA damage repair and inhibits V(D)J recombination in vitro.

Article Published Date : Jan 12, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Vaccination: Coronavirus
Additional Keywords : BRCA Gene : CK(40) : AC(9), SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

SARS-Cov-2 spike induces intestinal barrier dysfunction through the interaction between CEACAM5 and Galectin-9.

Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Diseases : Coronavirus Disease (Covid-19) : CK(1339) : AC(331)
Additional Keywords : SARS-CoV-2 Spike Protein
Adverse Pharmacological Actions : Gastrotoxic : CK(199) : AC(73)

SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS.

Article Published Date : Aug 26, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Inflammation : CK(16108) : AC(5498), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

SARS-CoV-2 spike protein accelerates systemic sclerosis by increasing inflammatory cytokines, Th17 cells, and fibrosis.

Article Published Date : Dec 20, 2023
Study Type : In Vitro Study
Additional Links
Diseases : Coronavirus Disease (Covid-19) : CK(1339) : AC(331), Scleroderma: Systemic : CK(51) : AC(10)
Additional Keywords : SARS-CoV-2 Spike Protein
Adverse Pharmacological Actions : Inflammatory : CK(554) : AC(176)

SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate.

Article Published Date : Oct 28, 2021
Study Type : Animal Study
Additional Links
Diseases : Thrombosis : CK(448) : AC(123), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein

SARS-CoV-2 spike protein exacerbates inflammation and hypercoagulation.

Article Published Date : Oct 01, 2024
Study Type : Animal Study
Additional Links
Diseases : Inflammation : CK(16108) : AC(5498), Stroke: Ischemic : CK(1030) : AC(284)
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE2.

Article Published Date : Dec 03, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Endothelial Damage : CK(255) : AC(67), Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein

SARS-CoV-2 spike protein induces hemagglutination: implications for COVID-19 morbidities and therapeutics and for vaccine adverse effects.

Article Published Date : Dec 06, 2022
Study Type : In Vitro Study
Additional Links
Diseases : Vaccination: Coronavirus
Additional Keywords : SARS-CoV-2 Spike Protein
Anti Therapeutic Actions : Vaccination: COVID-19 : CK(961) : AC(213)

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