Results for Shikonin

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Bladder Cancer : CK(795) : AC(332)
Pharmacological Actions : Antiproliferative : CK(10605) : AC(7954), Apoptotic : CK(10032) : AC(7768), Chemosensitizer : CK(1735) : AC(1325)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(447) : AC(355), Dose Response : CK(1780) : AC(701), Shikonin

Shikonin and temozolomide may constitute a powerful new tool for Glioblastoma treatment by reducing therapy resistance and tumor recurrence.

Article Published Date : Apr 10, 2017
Study Type : Human In Vitro
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Glioblastoma : CK(747) : AC(419)
Pharmacological Actions : Anti-metastatic : CK(3009) : AC(2285), Antiproliferative : CK(10605) : AC(7955), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(978) : AC(610), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1190) : AC(747)
Additional Keywords : Anti-metastatic, Antiproliferative : CK(75) : AC(61), Chemotherapeutic Synergy: Temozolomide : CK(67) : AC(51), Glioblastoma, Shikonin

Shikonin attenuated hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Liver Injury: Ischemia/reperfusion : CK(188) : AC(102)
Pharmacological Actions : Anti-Apoptotic : CK(6049) : AC(3435), Autophagy Inhibitors : CK(310) : AC(192), Hepatoprotective : CK(9584) : AC(4061)
Additional Keywords : Anti-Apoptotic, Autophagy Inhibitors : CK(8) : AC(6), Hepatoprotective, Liver Injury: Ischemia/reperfusion, Shikonin

These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Diabetic Retinopathy : CK(512) : AC(224)
Pharmacological Actions : Anti-Apoptotic : CK(6049) : AC(3435), Anti-Inflammatory Agents : CK(42487) : AC(17012), Cyclooxygenase 2 Inhibitors : CK(2338) : AC(1372)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Shikonin

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