Results for Shikonin

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Bladder Cancer : CK(782) : AC(320)
Pharmacological Actions : Antiproliferative : CK(9968) : AC(7464), Apoptotic : CK(9565) : AC(7364), Chemosensitizer : CK(1644) : AC(1266)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(430) : AC(339), Dose Response : CK(1770) : AC(700), Shikonin

Shikonin and temozolomide may constitute a powerful new tool for Glioblastoma treatment by reducing therapy resistance and tumor recurrence.

Article Published Date : Apr 10, 2017
Study Type : Human In Vitro
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Glioblastoma : CK(709) : AC(396)
Pharmacological Actions : Anti-metastatic : CK(2863) : AC(2176), Antiproliferative : CK(9968) : AC(7464), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(944) : AC(588), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1139) : AC(718)
Additional Keywords : Anti-metastatic, Antiproliferative : CK(75) : AC(61), Chemotherapeutic Synergy: Temozolomide : CK(65) : AC(49), Glioblastoma, Shikonin

Shikonin attenuated hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Liver Injury: Ischemia/reperfusion : CK(175) : AC(95)
Pharmacological Actions : Anti-Apoptotic : CK(5531) : AC(3135), Autophagy Inhibitors : CK(302) : AC(188), Hepatoprotective : CK(8926) : AC(3810)
Additional Keywords : Anti-Apoptotic, Autophagy Inhibitors : CK(8) : AC(6), Hepatoprotective, Liver Injury: Ischemia/reperfusion, Shikonin

These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Diabetic Retinopathy : CK(481) : AC(210)
Pharmacological Actions : Anti-Apoptotic : CK(5531) : AC(3135), Anti-Inflammatory Agents : CK(39407) : AC(15721), Cyclooxygenase 2 Inhibitors : CK(2251) : AC(1319)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Shikonin

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