Results for arachidonic acid

Dietary interventions to increase the dihomo-gamma-linoleic acid to arachidonic acid ratio may not necessarily decrease PGE2 synthesis in tissues where COX-1 enzymes predominate over COX-2.

Article Published Date : Jul 15, 2002
Study Type : In Vitro Study
Additional Links
Therapeutic Actions : Dietary Modification: Alteration of Dietary Fat Types and/or Ratios : CK(15) : AC(5)
Pharmacological Actions : Prostaglandin PGE2 downregulation : CK(194) : AC(89)
Additional Keywords : Anti-Inflammatory Agents, arachidonic acid, Cyclooxygenase Inhibitors, Essential Fatty Acids : CK(15) : AC(5), Gamma-Linoleic Acid GLA, Inflammation : CK(128) : AC(57), omega-6 fatty acids, Prostaglandin E2

Insulin induces the expression of delta-5 desaturase (FADS1) in a dose-dependent manner which may explain insulin's regulation of dihomo-gamma-linoleic acid to inflammatory arachidonic acid.

Article Published Date : Jul 01, 2011
Study Type : In Vitro Study
Additional Links
Additional Keywords : arachidonic acid, Dose Response : CK(1770) : AC(700), High Sugar Diet, hyperinsulinemia, Inflammation : CK(128) : AC(57), Insulin Resistance
Problem Substances : Insulin : CK(502) : AC(87)
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(151) : AC(37), Inflammatory : CK(554) : AC(176)

Sesame lignans inhibit delta-5 desaturase activity, increasing dihomo-gamma-linoleic acid levels and decreasing prostaglandin E2 synthesis.

Article Published Date : Mar 01, 1998
Study Type : Animal Study
Additional Links
Substances : Lignans : CK(343) : AC(107)
Pharmacological Actions : Prostaglandin PGE2 downregulation : CK(194) : AC(89)
Additional Keywords : Anti-Inflammatory Agents, arachidonic acid, Gamma-Linoleic Acid GLA, Inflammation : CK(128) : AC(57), Prostaglandin E2

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