Dietary interventions to increase the dihomo-gamma-linoleic acid to arachidonic acid ratio may not necessarily decrease PGE2 synthesis in tissues where COX-1 enzymes predominate over COX-2.

Article Published Date : Jul 15, 2002

Study Type : In Vitro Study

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Therapeutic Actions : Dietary Modification: Alteration of Dietary Fat Types and/or Ratios : CK(2) : AC(1)

Pharmacological Actions : Prostaglandin PGE2 downregulation : CK(193) : AC(88)

Additional Keywords : Anti-Inflammatory Agents, arachidonic acid, Cyclooxygenase Inhibitors, Essential Fatty Acids : CK(10) : AC(0), Gamma-Linoleic Acid GLA, Inflammation : CK(128) : AC(57), omega-6 fatty acids, Prostaglandin E2

Sesame lignans inhibit delta-5 desaturase activity, increasing dihomo-gamma-linoleic acid levels and decreasing prostaglandin E2 synthesis.

Article Published Date : Mar 01, 1998

Study Type : Animal Study

Additional Links

Substances : Lignans : CK(253) : AC(82)

Pharmacological Actions : Prostaglandin PGE2 downregulation : CK(193) : AC(88)

Additional Keywords : Anti-Inflammatory Agents, arachidonic acid, Gamma-Linoleic Acid GLA, Inflammation : CK(128) : AC(57), Prostaglandin E2

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