Results for thymoquinone

Administration of thymoquinone reduced renal fibrosis and permeability and improved oxidative stress status.

Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Kidney Fibrosis : CK(26) : AC(13)
Pharmacological Actions : Anti-Fibrotic : CK(46) : AC(29), Antioxidants : CK(14410) : AC(5758)
Additional Keywords : Anti-Fibrotic, Antioxidants : CK(1) : AC(1), Kidney Fibrosis, thymoquinone

Forced inhibition of PDE1A expression might be a new therapeutic strategy for the management of acute lymphoblastic leukemia.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Acute lymphoblastic leukemia (ALL) : CK(130) : AC(39)
Pharmacological Actions : Antineoplastic Agents : CK(1594) : AC(982), Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Acute lymphoblastic leukemia (ALL), Antineoplastic Agents : CK(75) : AC(33), Apoptotic, thymoquinone

N. sativa and thymoquinone may prove clinically useful in the treatment of diabetics and in the protection of β-cells against oxidative stress.

Article Published Date : Nov 30, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(934) : AC(279), Thymoquinone : CK(386) : AC(227)
Diseases : Diabetes: Oxidative Stress : CK(131) : AC(40)
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758), Malondialdehyde Down-regulation : CK(1452) : AC(466), Pancreato Protective Agents : CK(40) : AC(23), Superoxide Dismutase Up-regulation : CK(1039) : AC(415)
Additional Keywords : Antioxidants : CK(1) : AC(1), Diabetes: Oxidative Stress, Nigella sativa (aka Black Seed), Phytotherapy : CK(2309) : AC(597), Plant Extracts : CK(11762) : AC(4236), thymoquinone

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.

Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(934) : AC(279), Thymoquinone : CK(386) : AC(227)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(612) : AC(266)
Pharmacological Actions : Chemoprotective Agents : CK(356) : AC(146)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone

These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.

Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Inflammation : CK(6531) : AC(1986)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645), Interleukin-1 beta downregulation : CK(1743) : AC(868), Interleukin-6 Downregulation : CK(3054) : AC(1144), NF-kappaB Inhibitor : CK(2446) : AC(1436), Nitric Oxide Inhibitor : CK(390) : AC(196), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(4357) : AC(1763)
Additional Keywords : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(2) : AC(2), Interleukin-1 beta downregulation, thymoquinone

Thymoquinone abolishes a number of factors known to be involved in rheumatoid arthritis pathogenesis.

Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Inflammation : CK(6531) : AC(1986), Rheumatoid Arthritis : CK(1140) : AC(209)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Antiproliferative : CK(4773) : AC(3450), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645), Interleukin-1 beta downregulation : CK(1743) : AC(868), NF-kappaB Inhibitor : CK(2446) : AC(1436), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(4357) : AC(1763)
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative : CK(65) : AC(52), Inflammation : CK(2) : AC(2), rheumatoid arthritis, thymoquinone

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells.

Article Published Date : Sep 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Multiple Myeloma : CK(227) : AC(75)
Pharmacological Actions : Antineoplastic Agents : CK(1594) : AC(982), Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Chemosensitizer : CK(772) : AC(577), Interleukin-6 Downregulation : CK(3054) : AC(1144), STAT3 Inhibitor : CK(53) : AC(31)
Additional Keywords : Antineoplastic Agents : CK(75) : AC(33), Antiproliferative : CK(65) : AC(52), Apoptotic, Multiple Myeloma, thymoquinone

Thymoquinone inhibits the migration and invasion of cervical cancer cells.

Article Published Date : Dec 03, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Cervical Cancer : CK(594) : AC(288)
Pharmacological Actions : Anti-metastatic : CK(1284) : AC(927)
Additional Keywords : Anti-metastatic, Cervical Cancer, thymoquinone

Thymoquinone is a promising agent in the treatment of head and neck cancer due to its anti-proliferative and radiosensitizing properties.

Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Head and Neck Cancer : CK(374) : AC(85)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Radiosensitizer : CK(244) : AC(142)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Head and Neck Cancer, Radiosensitizer, thymoquinone

Thymoquinone may be considered for topical application alone in the treatment of acute otitis externa.

Article Published Date : Dec 13, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Otitis : CK(10) : AC(1)
Pharmacological Actions : Anti-Bacterial Agents : CK(2088) : AC(821), Anti-Inflammatory Agents : CK(12461) : AC(4729)
Additional Keywords : Anti-Bacterial Agents, Anti-Inflammatory Agents, Otitis, Superiority of Natural Substances versus Drugs : CK(1538) : AC(312), thymoquinone

Thymoquinone protects against cobalt chloride-induced neurotoxicity.

Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Neurodegenerative Diseases : CK(6185) : AC(1785)
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758), Neuroprotective Agents : CK(6374) : AC(2801), Nrf2 activation : CK(177) : AC(86)
Additional Keywords : Antioxidants : CK(1) : AC(1), Cobalt, Neurodegenerative diseases, Neuroprotective Agents, Nrf2 activation, thymoquinone
Problem Substances : Cobalt : CK(5) : AC(4)

Thymoquinone use may decrease the destructive effects of methotrexate on testicular tissue of patients using this agent.

Article Published Date : Jul 31, 2011
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Drug Toxicity: Methotrexate : CK(39) : AC(18), Lipid Peroxidation : CK(1178) : AC(476), Oxidative Stress : CK(6519) : AC(2436)
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758)
Additional Keywords : Antioxidants : CK(1) : AC(1), Drug Toxicity: Methotrexate, Lipid Peroxidation, oxidative stress, thymoquinone

Treatment by Thymoquinone restores inflammation-induced liver fibrosis.

Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Fibrosis: Liver : CK(22) : AC(8), Inflammation : CK(6531) : AC(1986), Lipopolysaccharide-Induced Toxicity : CK(1105) : AC(650)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729)
Additional Keywords : Anti-Inflammatory Agents, Fibrosis: Liver, Inflammation : CK(2) : AC(2), Lipopolysaccharide-Induced Toxicity, thymoquinone

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