Results for thymoquinone

Administration of thymoquinone reduced renal fibrosis and permeability and improved oxidative stress status.

Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Kidney Fibrosis : CK(121) : AC(68)
Pharmacological Actions : Anti-Fibrotic : CK(924) : AC(463), Antioxidants : CK(21528) : AC(8856)
Additional Keywords : Anti-Fibrotic, Antioxidants : CK(303) : AC(126), Kidney Fibrosis, thymoquinone

Forced inhibition of PDE1A expression might be a new therapeutic strategy for the management of acute lymphoblastic leukemia.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Acute lymphoblastic leukemia (ALL) : CK(193) : AC(72)
Pharmacological Actions : Antineoplastic Agents : CK(1847) : AC(1170), Apoptotic : CK(6986) : AC(5304)
Additional Keywords : Acute lymphoblastic leukemia (ALL), Antineoplastic Agents : CK(78) : AC(35), Apoptotic, thymoquinone

N. sativa and thymoquinone may prove clinically useful in the treatment of diabetics and in the protection of β-cells against oxidative stress.

Article Published Date : Nov 30, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1250) : AC(356), Thymoquinone : CK(774) : AC(451)
Diseases : Diabetes: Oxidative Stress : CK(492) : AC(182)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Malondialdehyde Down-regulation : CK(2065) : AC(678), Pancreato Protective Agents : CK(358) : AC(194), Superoxide Dismutase Up-regulation : CK(1403) : AC(551)
Additional Keywords : Antioxidants : CK(303) : AC(126), Diabetes: Oxidative Stress, Nigella sativa (aka Black Seed), Phytotherapy : CK(3062) : AC(812), Plant Extracts : CK(14140) : AC(5210), thymoquinone

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.

Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1250) : AC(356), Thymoquinone : CK(774) : AC(451)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(881) : AC(388)
Pharmacological Actions : Chemoprotective Agents : CK(2322) : AC(906)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone

These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.

Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Inflammation : CK(9572) : AC(3089)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926), Interleukin-1 beta downregulation : CK(3041) : AC(1567), Interleukin-6 Downregulation : CK(5029) : AC(1994), NF-kappaB Inhibitor : CK(3536) : AC(2098), Nitric Oxide Inhibitor : CK(498) : AC(258), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(6736) : AC(2815)
Additional Keywords : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Interleukin-1 beta downregulation, thymoquinone

Thymoquinone abolishes a number of factors known to be involved in rheumatoid arthritis pathogenesis.

Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Inflammation : CK(9572) : AC(3089), Rheumatoid Arthritis : CK(1546) : AC(328)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Antiproliferative : CK(6801) : AC(5032), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926), Interleukin-1 beta downregulation : CK(3041) : AC(1567), NF-kappaB Inhibitor : CK(3536) : AC(2098), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(6736) : AC(2815)
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative : CK(65) : AC(52), Inflammation : CK(128) : AC(57), rheumatoid arthritis, thymoquinone

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells.

Article Published Date : Sep 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Multiple Myeloma : CK(330) : AC(129)
Pharmacological Actions : Antineoplastic Agents : CK(1847) : AC(1170), Antiproliferative : CK(6801) : AC(5032), Apoptotic : CK(6986) : AC(5304), Chemosensitizer : CK(1124) : AC(854), Interleukin-6 Downregulation : CK(5029) : AC(1994), STAT3 Inhibitor : CK(53) : AC(31)
Additional Keywords : Antineoplastic Agents : CK(78) : AC(35), Antiproliferative : CK(65) : AC(52), Apoptotic, Multiple Myeloma, thymoquinone

Thymoquinone inhibits the migration and invasion of cervical cancer cells.

Article Published Date : Dec 03, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Cervical Cancer : CK(756) : AC(422)
Pharmacological Actions : Anti-metastatic : CK(1972) : AC(1481)
Additional Keywords : Anti-metastatic, Cervical Cancer, thymoquinone

Thymoquinone is a promising agent in the treatment of head and neck cancer due to its anti-proliferative and radiosensitizing properties.

Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Head and Neck Cancer : CK(459) : AC(118)
Pharmacological Actions : Antiproliferative : CK(6801) : AC(5032), Radiosensitizer : CK(291) : AC(182)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Head and Neck Cancer, Radiosensitizer, thymoquinone

Thymoquinone may be considered for topical application alone in the treatment of acute otitis externa.

Article Published Date : Dec 13, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Otitis : CK(10) : AC(1)
Pharmacological Actions : Anti-Bacterial Agents : CK(2894) : AC(1251), Anti-Inflammatory Agents : CK(20859) : AC(8334)
Additional Keywords : Anti-Bacterial Agents, Anti-Inflammatory Agents, Otitis, Superiority of Natural Substances versus Drugs : CK(1644) : AC(347), thymoquinone

Thymoquinone protects against cobalt chloride-induced neurotoxicity.

Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Neurodegenerative Diseases : CK(8689) : AC(2653)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396), Nrf2 activation : CK(1584) : AC(916)
Additional Keywords : Antioxidants : CK(303) : AC(126), Cobalt, Neurodegenerative diseases, Neuroprotective Agents, Nrf2 activation, thymoquinone
Problem Substances : Cobalt : CK(15) : AC(10)

Thymoquinone use may decrease the destructive effects of methotrexate on testicular tissue of patients using this agent.

Article Published Date : Jul 31, 2011
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Drug Toxicity: Methotrexate : CK(99) : AC(49), Lipid Peroxidation : CK(1632) : AC(631), Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856)
Additional Keywords : Antioxidants : CK(303) : AC(126), Drug Toxicity: Methotrexate, Lipid Peroxidation, oxidative stress, thymoquinone

Treatment by Thymoquinone restores inflammation-induced liver fibrosis.

Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Fibrosis: Liver : CK(32) : AC(13), Inflammation : CK(9572) : AC(3089), Lipopolysaccharide-Induced Toxicity : CK(1764) : AC(1073)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334)
Additional Keywords : Anti-Inflammatory Agents, Fibrosis: Liver, Inflammation : CK(128) : AC(57), Lipopolysaccharide-Induced Toxicity, thymoquinone

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