Results for thymoquinone

Administration of thymoquinone reduced renal fibrosis and permeability and improved oxidative stress status.

Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Kidney Fibrosis : CK(248) : AC(140)
Pharmacological Actions : Anti-Fibrotic : CK(2223) : AC(1061), Antioxidants : CK(34770) : AC(14593)
Additional Keywords : Anti-Fibrotic, Antioxidants : CK(303) : AC(126), Kidney Fibrosis, thymoquinone

Forced inhibition of PDE1A expression might be a new therapeutic strategy for the management of acute lymphoblastic leukemia.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Acute lymphoblastic leukemia (ALL) : CK(258) : AC(96)
Pharmacological Actions : Antineoplastic Agents : CK(2266) : AC(1496), Apoptotic : CK(9642) : AC(7425)
Additional Keywords : Acute lymphoblastic leukemia (ALL), Antineoplastic Agents : CK(78) : AC(35), Apoptotic, thymoquinone

N. sativa and thymoquinone may prove clinically useful in the treatment of diabetics and in the protection of β-cells against oxidative stress.

Article Published Date : Nov 30, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1912) : AC(494), Thymoquinone : CK(1178) : AC(692)
Diseases : Diabetes: Oxidative Stress : CK(637) : AC(245)
Pharmacological Actions : Antioxidants : CK(34770) : AC(14593), Malondialdehyde Down-regulation : CK(3064) : AC(997), Pancreato Protective Agents : CK(563) : AC(303), Superoxide Dismutase Up-regulation : CK(2448) : AC(940)
Additional Keywords : Antioxidants : CK(303) : AC(126), Diabetes: Oxidative Stress, Nigella sativa (aka Black Seed), Phytotherapy : CK(4008) : AC(1035), Plant Extracts : CK(18803) : AC(6805), thymoquinone

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.

Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1912) : AC(494), Thymoquinone : CK(1178) : AC(692)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1259) : AC(604)
Pharmacological Actions : Chemoprotective Agents : CK(4318) : AC(1630)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone

These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.

Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Inflammation : CK(16191) : AC(5533)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39952) : AC(15959), Cyclooxygenase 2 Inhibitors : CK(2270) : AC(1331), Interleukin-1 beta downregulation : CK(6096) : AC(2958), Interleukin-6 Downregulation : CK(9404) : AC(3637), NF-kappaB Inhibitor : CK(5981) : AC(3482), Nitric Oxide Inhibitor : CK(705) : AC(356), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11757) : AC(4833)
Additional Keywords : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Interleukin-1 beta downregulation, thymoquinone

Thymoquinone abolishes a number of factors known to be involved in rheumatoid arthritis pathogenesis.

Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Inflammation : CK(16191) : AC(5533), Rheumatoid Arthritis : CK(2334) : AC(564)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39952) : AC(15959), Antiproliferative : CK(10087) : AC(7550), Cyclooxygenase 2 Inhibitors : CK(2270) : AC(1331), Interleukin-1 beta downregulation : CK(6096) : AC(2958), NF-kappaB Inhibitor : CK(5981) : AC(3482), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11757) : AC(4833)
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative : CK(75) : AC(61), Inflammation : CK(128) : AC(57), rheumatoid arthritis, thymoquinone

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells.

Article Published Date : Sep 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Multiple Myeloma : CK(426) : AC(162)
Pharmacological Actions : Antineoplastic Agents : CK(2266) : AC(1496), Antiproliferative : CK(10087) : AC(7550), Apoptotic : CK(9642) : AC(7425), Chemosensitizer : CK(1668) : AC(1279), Interleukin-6 Downregulation : CK(9404) : AC(3637), STAT3 Inhibitor : CK(322) : AC(216)
Additional Keywords : Antineoplastic Agents : CK(78) : AC(35), Antiproliferative : CK(75) : AC(61), Apoptotic, Multiple Myeloma, thymoquinone

Thymoquinone inhibits the migration and invasion of cervical cancer cells.

Article Published Date : Dec 03, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Cervical Cancer : CK(983) : AC(602)
Pharmacological Actions : Anti-metastatic : CK(2884) : AC(2193)
Additional Keywords : Anti-metastatic, Cervical Cancer, thymoquinone

Thymoquinone is a promising agent in the treatment of head and neck cancer due to its anti-proliferative and radiosensitizing properties.

Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Head and Neck Cancer : CK(800) : AC(191)
Pharmacological Actions : Antiproliferative : CK(10087) : AC(7550), Radiosensitizer : CK(372) : AC(247)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Head and Neck Cancer, Radiosensitizer, thymoquinone

Thymoquinone may be considered for topical application alone in the treatment of acute otitis externa.

Article Published Date : Dec 13, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Otitis : CK(25) : AC(5)
Pharmacological Actions : Anti-Bacterial Agents : CK(4270) : AC(2008), Anti-Inflammatory Agents : CK(39952) : AC(15959)
Additional Keywords : Anti-Bacterial Agents, Anti-Inflammatory Agents, Otitis, Superiority of Natural Substances versus Drugs : CK(1901) : AC(400), thymoquinone

Thymoquinone protects against cobalt chloride-induced neurotoxicity.

Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Neurodegenerative Diseases : CK(13142) : AC(4310)
Pharmacological Actions : Antioxidants : CK(34770) : AC(14593), Neuroprotective Agents : CK(20214) : AC(8013), Nrf2 activation : CK(3165) : AC(1799)
Additional Keywords : Antioxidants : CK(303) : AC(126), Cobalt, Neurodegenerative diseases, Neuroprotective Agents, Nrf2 activation, thymoquinone
Problem Substances : Cobalt : CK(21) : AC(14)

Thymoquinone use may decrease the destructive effects of methotrexate on testicular tissue of patients using this agent.

Article Published Date : Jul 31, 2011
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Drug Toxicity: Methotrexate : CK(198) : AC(102), Lipid Peroxidation : CK(2062) : AC(809), Oxidative Stress : CK(14896) : AC(5781)
Pharmacological Actions : Antioxidants : CK(34770) : AC(14593)
Additional Keywords : Antioxidants : CK(303) : AC(126), Drug Toxicity: Methotrexate, Lipid Peroxidation, oxidative stress, thymoquinone

Treatment by Thymoquinone restores inflammation-induced liver fibrosis.

Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Fibrosis: Liver : CK(32) : AC(13), Inflammation : CK(16191) : AC(5533), Lipopolysaccharide-Induced Toxicity : CK(3249) : AC(1886)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39952) : AC(15959)
Additional Keywords : Anti-Inflammatory Agents, Fibrosis: Liver, Inflammation : CK(128) : AC(57), Lipopolysaccharide-Induced Toxicity, thymoquinone

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