Results for thymoquinone

Administration of thymoquinone reduced renal fibrosis and permeability and improved oxidative stress status.

Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1203) : AC(706)
Diseases : Kidney Fibrosis : CK(268) : AC(151)
Pharmacological Actions : Anti-Fibrotic : CK(2393) : AC(1138), Antioxidants : CK(36502) : AC(15304)
Additional Keywords : Anti-Fibrotic, Antioxidants : CK(303) : AC(126), Kidney Fibrosis, thymoquinone

Forced inhibition of PDE1A expression might be a new therapeutic strategy for the management of acute lymphoblastic leukemia.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1203) : AC(706)
Diseases : Acute lymphoblastic leukemia (ALL) : CK(258) : AC(96)
Pharmacological Actions : Antineoplastic Agents : CK(2354) : AC(1570), Apoptotic : CK(9997) : AC(7738)
Additional Keywords : Acute lymphoblastic leukemia (ALL), Antineoplastic Agents : CK(78) : AC(35), Apoptotic, thymoquinone

N. sativa and thymoquinone may prove clinically useful in the treatment of diabetics and in the protection of β-cells against oxidative stress.

Article Published Date : Nov 30, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1925) : AC(498), Thymoquinone : CK(1203) : AC(706)
Diseases : Diabetes: Oxidative Stress : CK(641) : AC(247)
Pharmacological Actions : Antioxidants : CK(36502) : AC(15304), Malondialdehyde Down-regulation : CK(3135) : AC(1024), Pancreato Protective Agents : CK(575) : AC(312), Superoxide Dismutase Up-regulation : CK(2566) : AC(988)
Additional Keywords : Antioxidants : CK(303) : AC(126), Diabetes: Oxidative Stress, Nigella sativa (aka Black Seed), Phytotherapy : CK(4061) : AC(1058), Plant Extracts : CK(19293) : AC(7058), thymoquinone

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.

Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1925) : AC(498), Thymoquinone : CK(1203) : AC(706)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1308) : AC(632)
Pharmacological Actions : Chemoprotective Agents : CK(4476) : AC(1712)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone

These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.

Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1203) : AC(706)
Diseases : Inflammation : CK(16913) : AC(5775)
Pharmacological Actions : Anti-Inflammatory Agents : CK(42224) : AC(16877), Cyclooxygenase 2 Inhibitors : CK(2326) : AC(1366), Interleukin-1 beta downregulation : CK(6446) : AC(3137), Interleukin-6 Downregulation : CK(9848) : AC(3831), NF-kappaB Inhibitor : CK(6293) : AC(3650), Nitric Oxide Inhibitor : CK(715) : AC(361), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(12294) : AC(5063)
Additional Keywords : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Interleukin-1 beta downregulation, thymoquinone

Thymoquinone abolishes a number of factors known to be involved in rheumatoid arthritis pathogenesis.

Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1203) : AC(706)
Diseases : Inflammation : CK(16913) : AC(5775), Rheumatoid Arthritis : CK(2488) : AC(595)
Pharmacological Actions : Anti-Inflammatory Agents : CK(42224) : AC(16877), Antiproliferative : CK(10544) : AC(7913), Cyclooxygenase 2 Inhibitors : CK(2326) : AC(1366), Interleukin-1 beta downregulation : CK(6446) : AC(3137), NF-kappaB Inhibitor : CK(6293) : AC(3650), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(12294) : AC(5063)
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative : CK(75) : AC(61), Inflammation : CK(128) : AC(57), rheumatoid arthritis, thymoquinone

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells.

Article Published Date : Sep 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1203) : AC(706)
Diseases : Multiple Myeloma : CK(439) : AC(166)
Pharmacological Actions : Antineoplastic Agents : CK(2354) : AC(1570), Antiproliferative : CK(10544) : AC(7913), Apoptotic : CK(9997) : AC(7738), Chemosensitizer : CK(1722) : AC(1325), Interleukin-6 Downregulation : CK(9848) : AC(3831), STAT3 Inhibitor : CK(325) : AC(217)
Additional Keywords : Antineoplastic Agents : CK(78) : AC(35), Antiproliferative : CK(75) : AC(61), Apoptotic, Multiple Myeloma, thymoquinone

Thymoquinone inhibits the migration and invasion of cervical cancer cells.

Article Published Date : Dec 03, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1203) : AC(706)
Diseases : Cervical Cancer : CK(1010) : AC(619)
Pharmacological Actions : Anti-metastatic : CK(2987) : AC(2277)
Additional Keywords : Anti-metastatic, Cervical Cancer, thymoquinone

Thymoquinone is a promising agent in the treatment of head and neck cancer due to its anti-proliferative and radiosensitizing properties.

Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1203) : AC(706)
Diseases : Head and Neck Cancer : CK(823) : AC(195)
Pharmacological Actions : Antiproliferative : CK(10544) : AC(7913), Radiosensitizer : CK(384) : AC(260)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Head and Neck Cancer, Radiosensitizer, thymoquinone

Thymoquinone may be considered for topical application alone in the treatment of acute otitis externa.

Article Published Date : Dec 13, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1203) : AC(706)
Diseases : Otitis : CK(25) : AC(5)
Pharmacological Actions : Anti-Bacterial Agents : CK(4371) : AC(2085), Anti-Inflammatory Agents : CK(42224) : AC(16877)
Additional Keywords : Anti-Bacterial Agents, Anti-Inflammatory Agents, Otitis, Superiority of Natural Substances versus Drugs : CK(1918) : AC(405), thymoquinone

Thymoquinone protects against cobalt chloride-induced neurotoxicity.

Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1203) : AC(706)
Diseases : Neurodegenerative Diseases : CK(13626) : AC(4509)
Pharmacological Actions : Antioxidants : CK(36502) : AC(15304), Neuroprotective Agents : CK(21337) : AC(8465), Nrf2 activation : CK(3345) : AC(1903)
Additional Keywords : Antioxidants : CK(303) : AC(126), Cobalt, Neurodegenerative diseases, Neuroprotective Agents, Nrf2 activation, thymoquinone
Problem Substances : Cobalt : CK(21) : AC(14)

Thymoquinone use may decrease the destructive effects of methotrexate on testicular tissue of patients using this agent.

Article Published Date : Jul 31, 2011
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1203) : AC(706)
Diseases : Drug Toxicity: Methotrexate : CK(215) : AC(106), Lipid Peroxidation : CK(2130) : AC(847), Oxidative Stress : CK(15947) : AC(6229)
Pharmacological Actions : Antioxidants : CK(36502) : AC(15304)
Additional Keywords : Antioxidants : CK(303) : AC(126), Drug Toxicity: Methotrexate, Lipid Peroxidation, oxidative stress, thymoquinone

Treatment by Thymoquinone restores inflammation-induced liver fibrosis.

Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1203) : AC(706)
Diseases : Fibrosis: Liver : CK(32) : AC(13), Inflammation : CK(16913) : AC(5775), Lipopolysaccharide-Induced Toxicity : CK(3404) : AC(1979)
Pharmacological Actions : Anti-Inflammatory Agents : CK(42224) : AC(16877)
Additional Keywords : Anti-Inflammatory Agents, Fibrosis: Liver, Inflammation : CK(128) : AC(57), Lipopolysaccharide-Induced Toxicity, thymoquinone

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