Results for Apple

SKN-1 is involved in combination of apple peels and blueberry extracts synergistically protecting against oxidative stress in Caenorhabditis elegans.

Article Published Date : Jun 23, 2020
Study Type : Animal Study
Additional Links
Substances : Apple, Blueberry : CK(721) : AC(250)
Diseases : Aging : CK(3728) : AC(933), Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856)
Additional Keywords : Natural Substance Synergy : CK(1094) : AC(506)

6 Health Benefits of Rutin, and Where to Find It

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Tuesday, November 22, 2022 - 15:55
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Rutin is an antioxidant and anti-inflammatory powerhouse found in a variety of delicious food that may boost your health via multiple avenues, from promoting healthy circulation to providing pain relief

Rutin is one of about 4,000 types of flavonoids that are found abundantly in plants. Also known as rutoside and vitamin P, rutin is a flavonol that acts as an active constituent in tea leaves, apples, buckwheat, most citrus fruits and passion flower, for example, with nutraceutical effects that have been valued since ancient times.[i]

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A reappraisal of traditional apple cultivars from Southern Italy as a rich source of phenols with superior antioxidant activity.

Article Published Date : Oct 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Apple
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856)
Additional Keywords : Cultivars : CK(3) : AC(3), Plant Extracts : CK(14140) : AC(5210)

Administration of a polyphenol-rich apple extract reduces the number of neoplastic lesions in mice with AOM-induced colorectal cancer.

Article Published Date : Apr 14, 2021
Study Type : Animal Study
Additional Links
Substances : Apple, Polyphenols : CK(1878) : AC(700)
Diseases : Cachexia : CK(83) : AC(29), Colorectal Cancer : CK(3666) : AC(1651)
Pharmacological Actions : Anticarcinogenic Agents : CK(1890) : AC(889), Chemopreventive : CK(5374) : AC(1717)

Among men and women with moderately elevated BP, intake of three kiwifruits was associated with lower systolic and diastolic 24-h BP compared with one apple a day.

Article Published Date : Jan 31, 2015
Study Type : Human Study
Additional Links
Substances : Apple, Kiwifruit : CK(194) : AC(48)
Diseases : Endothelial Dysfunction : CK(2115) : AC(440), Hypertension : CK(6384) : AC(950)
Pharmacological Actions : Antihypertensive Agents : CK(4527) : AC(683)

An apple oligogalactan enhances the growth inhibitory effect of 5-fluorouracil on colorectal cancer.

Article Published Date : Jun 04, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Apple
Diseases : Colorectal Cancer : CK(3666) : AC(1651)
Pharmacological Actions : Chemosensitizer : CK(1124) : AC(854)
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil : CK(151) : AC(107)

An apple peel polyphenol extract protected cells against the indomethacin-associated adverse effects in vivo.

Article Published Date : Nov 08, 2011
Study Type : Animal Study
Additional Links
Substances : Apple, Polyphenols : CK(1878) : AC(700)
Diseases : Lipid Peroxidation : CK(1632) : AC(631), Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Cytoprotective : CK(659) : AC(326)
Additional Keywords : Drug: Indomethacin : CK(43) : AC(24)
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(2825) : AC(496)

Annurca apple as a functional food for the contribution to a healthy balance of plasma cholesterol levels.

Article Published Date : Apr 30, 2017
Study Type : Human Study
Additional Links
Substances : Apple
Diseases : Cardiovascular Diseases : CK(12780) : AC(1983)
Pharmacological Actions : Anticholesteremic Agents : CK(3078) : AC(530), Cardioprotective : CK(5377) : AC(1675)

Annurca apple-rich diet restores long-term potentiation and induces behavioral modifications in aged rats.

Article Published Date : May 31, 2006
Study Type : Animal Study
Additional Links
Substances : Apple
Diseases : Aging : CK(3728) : AC(933), Anxiety : CK(3360) : AC(595)
Pharmacological Actions : Anti-Anxiety Agents : CK(2913) : AC(487), Antioxidants : CK(21528) : AC(8856)

Anthocyanin-rich apples may influence immune function compared to control apples.

Article Published Date : Mar 26, 2021
Study Type : Human Study
Additional Links
Substances : Anthocyanins : CK(938) : AC(334), Apple, Polyphenols : CK(1878) : AC(700)
Pharmacological Actions : Gastrointestinal Agents : CK(3145) : AC(843), Immunomodulatory : CK(4048) : AC(1475)

Antihyperlipidemic effects of apple peel extract in high-fat diet-induced hyperlipidemic rats.

Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Apple
Diseases : Hyperlipidemia : CK(1569) : AC(402)
Pharmacological Actions : Hypolipidemic : CK(5358) : AC(1221)

Apple consumption mediates significant gut microbial metabolic activity.

Article Published Date : Feb 25, 2020
Study Type : Human Study
Additional Links
Substances : Apple
Diseases : Hypercholesterolemia : CK(2333) : AC(408)
Pharmacological Actions : Gastrointestinal Agents : CK(3145) : AC(843)

Apple consumption reduces markers of postprandial inflammation following a high fat meal in overweight and obese adults.

Article Published Date : Jul 20, 2021
Study Type : Human Study
Additional Links
Substances : Apple
Diseases : Cardiovascular Diseases : CK(12780) : AC(1983), Inflammation : CK(9572) : AC(3089), Obesity : CK(6879) : AC(1686)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334)
Additional Keywords : Risk Reduction : CK(15144) : AC(1708)

Apple extracts can extend cellular lifespan by lowering the level of intracellular ROS and by the activation of cellular signalling pathways.

Article Published Date : Apr 04, 2017
Study Type : Animal Study
Additional Links
Substances : Apple, Apple Polyphenols : CK(175) : AC(62)
Diseases : Aging : CK(3728) : AC(933), Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672), Antioxidants : CK(21528) : AC(8856)
Additional Keywords : Plant Extracts : CK(14140) : AC(5210)

Apple intake, specifically boiled apple, might reduce the risk of coronary heart disease by inhibiting postocclusion steps, such as myocardial injury after artery occlusion.

Article Published Date : Oct 31, 2014
Study Type : Animal Study
Additional Links
Substances : Apple
Diseases : Atherosclerosis : CK(1390) : AC(487), Cardiovascular Diseases : CK(12780) : AC(1983), Myocardial Ischemia : CK(528) : AC(256)
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672), Anti-atherogenic : CK(348) : AC(120), Cardioprotective : CK(5377) : AC(1675)
Additional Keywords : Plant Extracts : CK(14140) : AC(5210)

Apple peel flavonoid fraction 4 suppresses breast cancer cell growth by cytostatic and cytotoxic mechanisms.

Article Published Date : Sep 12, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apple, Flavonoids : CK(2352) : AC(870)
Diseases : Breast Cancer : CK(6327) : AC(2272), Breast Cancer: Triple Negative : CK(708) : AC(466)
Pharmacological Actions : Anti-metastatic : CK(1972) : AC(1481), Antiproliferative : CK(6801) : AC(5032)

Apple phenolic extracts ameliorate lead-induced cognitive impairment and depression- and anxiety-like behavior.

Article Published Date : Feb 14, 2022
Study Type : Animal Study
Additional Links
Substances : Apple
Diseases : Anxiety : CK(3360) : AC(595), Cognitive Decline/Dysfunction : CK(3236) : AC(654), Depression : CK(6233) : AC(1096)
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672), Anti-Inflammatory Agents : CK(20859) : AC(8334), Antioxidants : CK(21528) : AC(8856), Interleukin-1 beta downregulation : CK(3041) : AC(1567), MicroRNA modulator : CK(1023) : AC(618), Neuroprotective Agents : CK(10404) : AC(4396), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(6736) : AC(2815)
Problem Substances : Lead : CK(526) : AC(162)

Apple phenolic extracts strongly inhibit α-glucosidase activity.

Article Published Date : Jul 12, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apple
Diseases : Diabetes Mellitus: Type 2 : CK(8552) : AC(1714), Hyperglycemia : CK(1494) : AC(453)
Pharmacological Actions : Alpha-glucosidase inhibitor : CK(274) : AC(201), Antioxidants : CK(21528) : AC(8856)
Additional Keywords : Plant Extracts : CK(14140) : AC(5210)

Apple phlorizin attenuates oxidative stress in Drosophila melanogaster.

Article Published Date : Feb 28, 2019
Study Type : Insect Study
Additional Links
Substances : Apple, Flavonoids : CK(2352) : AC(870)
Diseases : Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Nrf2 activation : CK(1584) : AC(916)

Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis.

Article Published Date : Feb 14, 2020
Study Type : Animal Study
Additional Links
Substances : Apple
Diseases : Colitis : CK(840) : AC(406), Colorectal Cancer : CK(3666) : AC(1651)
Pharmacological Actions : Chemopreventive : CK(5374) : AC(1717), Gastrointestinal Agents : CK(3145) : AC(843)
Additional Keywords : Polysaccharides : CK(625) : AC(392), Risk Reduction : CK(15144) : AC(1708)

Apple pomace extract as a sustainable food ingredient.

Article Published Date : Jun 20, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apple
Diseases : Lipopolysaccharide-Induced Toxicity : CK(1764) : AC(1073), Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Antioxidants : CK(21528) : AC(8856)

Apple products and whole apple consumers had lower BMI z-scores than non-consumers:

Article Published Date : May 13, 2015
Study Type : Human Study
Additional Links
Substances : Apple
Diseases : Obesity : CK(6879) : AC(1686)
Additional Keywords : Risk Reduction : CK(15144) : AC(1708)

Apple, red grape and cinnamon have potential to inhibit of lipase, α-amylase and α-glucosidase digestive enzymes.

Article Published Date : Apr 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Apple, Cinnamon : CK(406) : AC(150), Grape : CK(4560) : AC(1322)
Diseases : Hyperglycemia : CK(1494) : AC(453)
Pharmacological Actions : Alpha-amylase inhibitor : CK(175) : AC(110), Alpha-glucosidase inhibitor : CK(274) : AC(201)

Apples can induce substantial changes in microbiota composition and metabolic activity in vitro.

Article Published Date : May 23, 2017
Study Type : In Vitro Study
Additional Links
Substances : Apple
Pharmacological Actions : Gastrointestinal Agents : CK(3145) : AC(843)
Additional Keywords : Microbiota : CK(1256) : AC(346)

Beneficial anti-platelet and anti-inflammatory properties of Irish apple juice and cider bioactives.

Article Published Date : Feb 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Apple, Fermented Foods and Beverages : CK(2588) : AC(607)
Diseases : Cardiovascular Diseases : CK(12780) : AC(1983), Inflammation : CK(9572) : AC(3089)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Anti-Platelet : CK(137) : AC(47), Cardioprotective : CK(5377) : AC(1675)

Boost Your Cardiometabolic Health With 5 Delicious Treats

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Tuesday, December 6, 2022 - 16:03
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Choosing foods that are good for you doesn't have to be a chore. These five foods are as tasty as they are beneficial for improving your cardiometabolic health

Only 6.8% of U.S. adults have optimal cardiometabolic health, which means the remaining 93.2% do not, instead belonging to the majority whose cardiometabolic health has been "poor and worsening" since 2000.[i]

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Boysenberry and apple juice concentrate reduced acute lung inflammation.

Article Published Date : Feb 28, 2021
Study Type : Animal Study
Additional Links
Substances : Apple, Berries: All : CK(3814) : AC(1087)
Diseases : Asthma : CK(2488) : AC(486), Lung Inflammation : CK(11) : AC(6)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334)

Characterization of juice fermented with Lactobacillus plantarum EM and its cholesterol-lowering effects on rats fed a high-fat and high-cholesterol diet.

Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Apple, Cabbage : CK(83) : AC(24), Fermented Foods and Beverages : CK(2588) : AC(607), Lactobacillus plantarum : CK(674) : AC(194)
Diseases : Hypercholesterolemia : CK(2333) : AC(408)
Pharmacological Actions : Anticholesteremic Agents : CK(3078) : AC(530)

Chemopreventive potential of apple pulp callus against colorectal cancer cell proliferation and tumorigenesis.

Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apple
Diseases : Colorectal Cancer : CK(3666) : AC(1651)
Pharmacological Actions : Chemopreventive : CK(5374) : AC(1717)

Chlorogenic acid has anxiolytic effects coupled with antioxidant activity.

Article Published Date : Nov 14, 2007
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Apple, Cherry: All Varieties : CK(367) : AC(74), Chlorogenic Acid : CK(299) : AC(113), Plum : CK(98) : AC(33)
Diseases : Anxiety : CK(3360) : AC(595), Neurodegenerative Diseases : CK(8689) : AC(2653), Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Anti-Anxiety Agents : CK(2913) : AC(487), Antioxidants : CK(21528) : AC(8856)
Additional Keywords : Plant Extracts : CK(14140) : AC(5210)

Cloudy apple juice fermented by lactobacillus prevents obesity.

Article Published Date : Mar 16, 2021
Study Type : Animal Study
Additional Links
Substances : Apple, Fermented Foods and Beverages : CK(2588) : AC(607)
Diseases : Obesity : CK(6879) : AC(1686)
Pharmacological Actions : Gastrointestinal Agents : CK(3145) : AC(843), Hypolipidemic : CK(5358) : AC(1221)
Additional Keywords : Anti-Obesity Agents : CK(2925) : AC(774)

Cloudy apple juice potentiates hepatoprotection during experimental liver injury.

Article Published Date : Aug 20, 2019
Study Type : Animal Study
Additional Links
Substances : Apple
Diseases : Chemically-Induced Liver Damage : CK(1565) : AC(721)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926), Hepatoprotective : CK(5098) : AC(2264)

Combination of apple peel and blueberry extracts synergistically induced lifespan extension via DAF-16 in Caenorhabditis elegans.

Article Published Date : Jul 21, 2020
Study Type : Animal Study
Additional Links
Substances : Apple, Blueberry : CK(721) : AC(250)
Diseases : Aging : CK(3728) : AC(933)
Additional Keywords : Gene Expression Regulation : CK(1141) : AC(501)

Combining thermotherapy with cryotherapy for efficient eradication of apple stem grooving virus from infected in-vitro-cultured apple shoots.

Article Published Date : Jul 31, 2018
Study Type : In Vitro Study, Plant Study
Additional Links
Substances : Apple
Therapeutic Actions : Cryotherapy : CK(10) : AC(1)
Additional Keywords : Plant Disease

Consumption of apple-boysenberry beverage decreased the proliferation of test strains of A. naeslundii and S. mutans.

Article Published Date : Apr 25, 2017
Study Type : Human Study
Additional Links
Substances : Apple, Berries: All : CK(3814) : AC(1087)
Diseases : Steptococcus Mutans Infections : CK(301) : AC(100)
Pharmacological Actions : Anti-Bacterial Agents : CK(2894) : AC(1251)
Additional Keywords : Biofilm : CK(99) : AC(71)

Consumption of apples in different forms can cause weight loss in overweight.

Article Published Date : Apr 08, 2018
Study Type : Review
Additional Links
Substances : Apple
Diseases : Obesity : CK(6879) : AC(1686)
Additional Keywords : Anti-Obesity Agents : CK(2925) : AC(774)

Crude whole apple extract has considerable anti-cariogenic effect on S. mutans.

Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Apple
Diseases : Dental Caries : CK(574) : AC(98), Steptococcus Mutans Infections : CK(301) : AC(100)
Pharmacological Actions : Antimicrobial : CK(1209) : AC(582)
Additional Keywords : Plant Extracts : CK(14140) : AC(5210)

Dietary flavonoid intake at midlife and healthy aging in women.

Article Published Date : Nov 30, 2014
Study Type : Human Study
Additional Links
Substances : Apple, Berries: All : CK(3814) : AC(1087), Flavonoids : CK(2352) : AC(870), Onion : CK(420) : AC(124), Orange : CK(345) : AC(71)
Diseases : Aging : CK(3728) : AC(933), Cancers: All : CK(28241) : AC(10590), Cardiovascular Diseases : CK(12780) : AC(1983), Diabetes Mellitus: Type 2 : CK(8552) : AC(1714), Hypertension : CK(6384) : AC(950), Stroke : CK(2862) : AC(421)
Additional Keywords : Risk Reduction : CK(15144) : AC(1708)

Dihydrochalcone-derived polyphenols from tea crab apple (Malus hupehensis) and their inhibitory effects on α-glucosidase in vitro.

Article Published Date : May 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apple
Pharmacological Actions : Alpha-glucosidase inhibitor : CK(274) : AC(201)

Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris).

Article Published Date : Feb 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Apple, Vitamin C : CK(4687) : AC(1149)

Effect of anti-obesity and antioxidant activity through the additional consumption of peel from 'Fuji' pre-washed apple.

Article Published Date : Feb 08, 2022
Study Type : In Vitro Study
Additional Links
Substances : Apple
Diseases : Obesity : CK(6879) : AC(1686)
Pharmacological Actions : Hypolipidemic : CK(5358) : AC(1221)
Additional Keywords : Anti-Obesity Agents : CK(2925) : AC(774)

Effects of fermented beverage in subjects with metabolic syndrome.

Article Published Date : Mar 30, 2021
Study Type : Human Study
Additional Links
Substances : Apple, Fermented Foods and Beverages : CK(2588) : AC(607), Kale : CK(63) : AC(8), Vinegar : CK(149) : AC(42)
Diseases : Metabolic Syndrome X : CK(2073) : AC(376)
Pharmacological Actions : Alpha-glucosidase inhibitor : CK(274) : AC(201), Enzyme Inhibitors: Pancreatic Lipase : CK(46) : AC(19)

Enhanced antioxidant activity for apple juice fermented with Lactobacillus plantarum ATCC14917.

Article Published Date : Dec 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Apple, Fermented Foods and Beverages : CK(2588) : AC(607), Lactobacillus plantarum : CK(674) : AC(194)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856)
Problem Substances : Fructose : CK(458) : AC(133)

Five Top Uses for Apple Cider Vinegar

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Friday, July 9, 2021 - 16:28
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Learn five health benefits you can get from apple cider vinegar, used since time immemorial for a range of therapies, from wound healing to shedding excess pounds

There isn't a shortage of stories around the therapeutic effects of apple cider vinegar (ACV), from weight management to disease prevention and treatment. This popular home remedy has also been used for hundreds of years in the kitchen as a cooking ingredient.

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FOOD AS INFORMATION: Living Water, Epigenetic Pathways, and the Wisdom of the Ancestral Diet

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Wednesday, February 8, 2023 - 14:11
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Food delivers powerful healing properties that scientists have spent decades analyzing in detail.

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Fruit and berry extracts could inhibit cancer cell proliferation in vitro.

Article Published Date : Nov 30, 2004
Study Type : In Vitro Study
Additional Links
Substances : Apple, Black Currant : CK(351) : AC(70), Blueberry : CK(721) : AC(250), Cherry: All Varieties : CK(367) : AC(74), Chokeberry : CK(375) : AC(120), Lingonberry : CK(54) : AC(22), Plum : CK(98) : AC(33), Raspberry : CK(156) : AC(80), Rose Hips : CK(85) : AC(23), Sea buckthorn : CK(245) : AC(88)
Diseases : Breast Cancer : CK(6327) : AC(2272), Cancers, Colon Cancer : CK(1493) : AC(954)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Antiproliferative : CK(6801) : AC(5032)
Additional Keywords : Natural Substance Synergy : CK(1094) : AC(506), Plant Extracts : CK(14140) : AC(5210)

Grape or apple juices have protective effects in bone tissue of rats exposed to cadmium.

Article Published Date : Mar 25, 2018
Study Type : Animal Study
Additional Links
Substances : Apple, Grape : CK(4560) : AC(1322)
Diseases : Cadmium Poisoning : CK(306) : AC(152)
Pharmacological Actions : Osteoprotective : CK(971) : AC(351)
Problem Substances : Cadmium : CK(383) : AC(148)

Healthiest Foods That Are in Season in the Spring

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Tuesday, June 8, 2021 - 12:37
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Revel in the seasonal colors and tastes of spring with these five fresh picks with distinct health and disease-fighting benefits

Blossom by blossom, spring is upon us. And with one of our favorite seasons comes fruits and vegetables that have climbed the top of the list with their time-tested, science-backed health benefits. Springtime offers fruits and vegetables in a rainbow of colors, including apples, apricots, avocados, bananas, broccoli, carrots, celery, kale, kiwifruit, lemons, peas, rhubarb, strawberries and so many more.

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Healthiest Produce That's in Season in September

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Friday, September 24, 2021 - 13:44
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These seven nutrient-packed fruits and vegetables are just in time for your fall-season plans for optimal health and well-being

As the fall season rolls around we're reminded of cool weather, the richest earth colors and the start of another school year. September is also a great time to enjoy the healthiest fruits and vegetables from nature. Keep a list of the freshest produce available in this season and have a look at their unique benefits.

1. Apples: Anticancer Potential

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Hepatoprotective effects of standardized extracts from an ancient Italian apple variety against carbon tetrachloride.

Article Published Date : Apr 14, 2020
Study Type : Animal Study
Additional Links
Substances : Apple
Diseases : Chemically-Induced Liver Damage : CK(1565) : AC(721)
Pharmacological Actions : Hepatoprotective : CK(5098) : AC(2264)

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