Fluoride-Free Diet Stimulates Pineal Gland Regeneration in Aged Rats

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Could your pineal gland--the "seat of the soul"--be under siege by fluoride toxicity? Startling new animal research suggests that eliminating fluoride from your diet may be the key to rejuvenating this vital but often calcified organ.

A 2019 study found that a fluoride-free diet stimulated regeneration and growth of the pineal gland in aged rats. Pineal glands of 26-month-old rats were examined after 0, 4, or 8 weeks on a fluoride-free diet. The fluoride-free diet increased the number of pinealocytes (melatonin-producing cells) and supporting cells compared to controls on a standard fluoridated diet. The findings suggest that lowering dietary fluoride exposure may help reverse the age-related decline of the pineal gland.

The pineal gland, a small endocrine organ nestled in the center of the vertebrate brain, has been a subject of fascination and reverence across cultures since ancient times. Descartes notably deemed it the "seat of the soul",1 while Eastern spiritual traditions associate it with the mystical "third eye."2 Despite its diminutive size, this pine cone shaped gland serves the critical role of secreting the sleep-regulating hormone melatonin.3 However, the pineal gland faces a formidable but little-known threat: calcification induced by fluoride toxicity.

Fluoride, a ubiquitous environmental pollutant, has been shown to accumulate in the pineal gland and contribute to its calcification.4 This calcification has been linked to a decline in pineal function and melatonin output, which may have far-reaching implications for many bodily systems.5,6 However, an intriguing new animal study published in the journal Biological Trace Element Research suggests a potential solution: a fluoride-free diet.7

In the study, researchers Mrvelj and Womble examined the effects of removing fluoride from the diet of twenty 26-month-old male rats. The aged rats had been raised on standard fluoridated food and tap water.7 A control group was sacrificed at the study's onset to establish baseline measurements. The remaining rats were divided into three groups: 4 weeks fluoride-free diet, 8 weeks fluoride-free diet, and 4 weeks fluoride-free followed by 4 weeks on 1.2 ppm fluoridated water (the maximum level allowed by the EPA).7

The results were striking. Examination of the rats' pineal glands revealed that the fluoride-free diet stimulated growth and cellular proliferation. After just 4 weeks, the fluoride-free group exhibited a 96% increase in the number of supporting cells compared to controls.7 By 8 weeks, pinealocyte (melatonin-secreting cell) numbers surged by 73%.7 In sharp contrast, pineal glands from the fluoride-treated group were indistinguishable from controls, indicating that fluoride inhibits pineal growth.7

The fact that these regenerative changes occurred in aged rats is especially noteworthy. Prior studies have documented that pineal function and melatonin output decline significantly with age, in tandem with increased pineal calcification.8,9,10 This latest research provides the first clue that this trajectory may be alterable through dietary modification.

While research on humans is still needed, this animal study has exciting implications for natural health. Dietary steps such as filtering fluoridated tap water, choosing fluoride-free dental products, and emphasizing fluoride-free foods may help protect and even heal the pineal gland. Other studies suggest that supplements like magnesium and phytate may also mitigate the effects of fluoride toxicity.11,12

In our increasingly toxic world, threats to our bodily systems abound. However, this fluoride research represents a ray of hope for all who wish to tap into the restorative potential of the "seat of the soul." By reducing fluoride intake, we may preserve the pineal gland as a vital connector to our body's innate wisdom and healing capacities. In the timeless quest for natural paths to health, this tiny but mighty gland may prove to be a crucial ally.

For more information on natural ways to mitigate Fluoride toxicity, visit our database on the subject here.

Learn more by reading: Fluoride Literally Turns the Pineal Gland to Stone, Research Suggests



1. López-Muñoz, Francisco, Jesús Boya, and Cecilio Alamo. "Neuron theory, the cornerstone of neuroscience, on the centenary of the Nobel Prize award to Santiago Ramón y Cajal." Brain research bulletin 70, no. 4-6 (2006): 391-405. https://doi.org/10.1016/j.brainresbull.2006.07.010.

2. Tiffany, Francis. "Accessing your third eye." Atlantis Rising Magazine 25 (2000): 26-28. https://archive.org/details/AtlantisRising25.

3. Reiter, Russel J. "Melatonin: the chemical expression of darkness." Molecular and cellular endocrinology 79, no. 1-3 (1991): C153-C158. https://doi.org/10.1016/0303-7207(91)90087-9.

4. Luke, Jennifer. "Fluoride deposition in the aged human pineal gland." Caries research 35, no. 2 (2001): 125-128. https://doi.org/10.1159/000047443.

5. Kunz, Dieter, Stephan Schmitz, Richard Mahlberg, Anke Mohr, Christoph Stöter, Karl-Jürgen Wolf, and Werner Martin Herrmann. "A new concept for melatonin deficit: on pineal calcification and melatonin excretion." Neuropsychopharmacology 21, no. 6 (1999): 765-772. https://doi.org/10.1016/S0893-133X(99)00069-X.

6. Tan, Dun-Xian, Xiao-Ying Xu, Xin Zhou, and Russel J. Reiter. "Pineal calcification, melatonin production, aging, associated health consequences and rejuvenation of the pineal gland." Molecules 23, no. 2 (2018): 301. https://doi.org/10.3390/molecules23020301.

7. Mrvelj, Aaron, and Mark D. Womble. "Fluoride-Free Diet Stimulates Pineal Growth in Aged Male Rats." Biological trace element research (2019): 1-8. https://doi.org/10.1007/s12011-019-01964-4.

8. Humbert, W., and P. Pévet. "The decrease of pineal melatonin production with age: causes and consequences." Annals of the New York Academy of Sciences 719, no. 1 (1994): 43-63. https://doi.org/10.1111/j.1749-6632.1994.tb56819.x.

9. Kunz, Dieter, Stephan Schmitz, Richard Mahlberg, Anke Mohr, Christoph Stöter, Karl-Jürgen Wolf, and Werner Martin Herrmann. "A new concept for melatonin deficit: on pineal calcification and melatonin excretion." Neuropsychopharmacology 21, no. 6 (1999): 765-772. https://doi.org/10.1016/S0893-133X(99)00069-X.

10. Tan, Dun-Xian, Lucien C. Manchester, Eduardo Fuentes-Broto, Sergio D. Paredes, and Russel J. Reiter. "Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity." Obesity reviews 12, no. 3 (2011): 167-188. https://doi.org/10.1111/j.1467-789X.2010.00756.x.

11. Malin, Adrienne J., Brittany N. Bose, Naima Busgang, Sonali A. Gennings, Chris Thorpy, Michael Strunin, Linda Seo, Young-Eun Kho et al. "Fluoride exposure and kidney and liver function among adolescents in the United States: NHANES, 2013–2016." Environment international 132 (2019): 105012. https://doi.org/10.1016/j.envint.2019.105012.

12. Xiong, Xiulan, Jun Liu, Wenxiu He, Tao Xia, Ping He, Xiaoming Chen, Kedi Yang, and Aiguo Wang. "Dose–effect relationship between drinking water fluoride levels and damage to liver and kidney functions in children." Environmental research 103, no. 1 (2007): 112-116. https://doi.org/10.1016/j.envres.2006.05.008.

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