Glutathione Down-Regulation

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10 Problem Substances Researched for Glutathione Down-Regulation
NameACCKFocus
Cell Phone Exposure416Locked
Thimerosal 416Locked
Mercury15Locked
Glyphosate23Locked
Aluminum oxide12Locked
Aspartame12Locked
Vaccine Adjuvants12Locked
Glyphosate formulations11Locked
Herbicide11Locked
Roundup11Locked
18 Diseases Researched for Glutathione Down-Regulation
NameACCKFocus
Oxidative Stress1747Locked
Lipid Peroxidation721Locked
DNA damage516Locked
Brain: Oxidative Stress24Locked
Radiation Induced Illness24Locked
Infertility: Male23Locked
ALT: Elevated12Locked
AST: Elevated12Locked
Brain Inflammation 12Locked
Cardiovascular Diseases12Locked
Chemically-Induced Liver Damage12Locked
Glyphosate Toxicity12Locked
Kidney Damage12Locked
Mitochondrial Dysfunction 12Locked
Mobile Phone-Induced Oxidative Stress12Locked
Puberty: Precocious12Locked
Genital Diseases: Male11Locked
Neurodegenerative Diseases11Locked

View the Evidence:
23 Abstracts with Glutathione Down-Regulation Research

[+]

Plasma level of lipid peroxides was significantly increased after 1, 2 and 4 h of exposure to radiofrequency fields of the cellular phone in standby position in volunteers.Nov 01, 2001

Pubmed Data : J Pharm Biomed Anal. 2001 Nov ;26(4):605-8. PMID: 11516912
Article Published Date : Nov 01, 2001
Study Type : Human Study
Additional Links
Diseases : Lipid Peroxidation, Oxidative Stress
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Mobile Phone Radiation
Problem Substances : Cell Phone Exposure
Adverse Pharmacological Actions : Glutathione Down-Regulation, Superoxide Dismutase Downregulation
[+]

An alternatively spliced form of methionine synthase expressed in human neuronal cells is sensitive to inhibition by thimerosal and lower GSH levels contribute to their inhibitory action.Jan 01, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:6143753. Epub 2016 Feb 18. PMID: 26989453
Article Published Date : Jan 01, 2016
Study Type : Human In Vitro
Additional Links
Problem Substances : Thimerosal
Adverse Pharmacological Actions : Glutathione Down-Regulation
[+]

These findings suggest occupational exposure to pulsed microwaves could cause genetic and cell alterations and that oxidative stress may be one of the possible mechanisms of DNA and cell damage.Jan 01, 2011

Pubmed Data : Int J Hyg Environ Health. 2011 Jan ;214(1):59-65. Epub 2010 Sep 15. PMID: 20833106
Article Published Date : Jan 01, 2011
Study Type : Human In Vitro
Additional Links
Diseases : DNA damage, Oxidative Stress
Additional Keywords : EMF, RF-EMF and Cancers
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Microwave Radiation
Adverse Pharmacological Actions : Cytotoxic, Genotoxic, Glutathione Down-Regulation, Malondialdehyde (MDA) Up-Regulation
[+]

Thimerosal induces DNA strand breaks, downregulates glutathione, and stimulates apoptosis in vitro.Feb 01, 2008

Pubmed Data : Chem Res Toxicol. 2008 Feb ;21(2):483-93. Epub 2008 Jan 16. PMID: 18197631
Article Published Date : Feb 01, 2008
Study Type : Human In Vitro
Additional Links
Diseases : DNA damage
Additional Keywords : Vaccine Research
Problem Substances : Mercury, Thimerosal
Adverse Pharmacological Actions : Apoptotic, Genotoxic, Glutathione Down-Regulation
[+]

This study reveals a similar activity of both ethylmercury and methylmercury. An ethylmercury-glutathione adduct was also identified, suggesting ethylmercury may impair glutathione activity.Apr 01, 2014

Pubmed Data : J Trace Elem Med Biol. 2014 Apr ;28(2):125-30. Epub 2014 Feb 9. PMID: 24613139
Article Published Date : Apr 01, 2014
Study Type : Human In Vitro
Additional Links
Diseases : Oxidative Stress
Additional Keywords : Vaccine Research
Problem Substances : Thimerosal
Adverse Pharmacological Actions : Glutathione Down-Regulation, Neurotoxic
[+]

50 GHz microwave radiation induces oxidative stress and DNA damage in the rat brain.Jul 01, 2009

Pubmed Data : Appl Biochem Biotechnol. 2009 Jul ;158(1):126-39. Epub 2008 Dec 17. PMID: 19089649
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress, DNA damage
Anti Therapeutic Actions : 5G Millimeter Wave Radiation, Electromagnetic Field Harms, Electromagnetic Radiation, Electromagnetic Radiation: 60 GHZ, Electromagnetic Radiation: 6-24 GHz (5G)
Adverse Pharmacological Actions : Genotoxic, Glutathione Down-Regulation, Oxidant, Superoxide Dismutase Downregulation
[+]

900 MHz pulse-modulated radiofrequency radiation induces oxidative stress in rat heart, lung, testis and liver tissues via lipid peroxidation, increased nitric oxide synthase, and antioxidant defense downregulation.Mar 01, 2011

Pubmed Data : Gen Physiol Biophys. 2011 Mar ;30(1):84-9. PMID: 21460416
Article Published Date : Mar 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Lipid Peroxidation, Oxidative Stress
Additional Keywords : Radio Frequency Electromagnetic Radiation Exposure
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Mobile Phone Radiation
Adverse Pharmacological Actions : Glutathione Down-Regulation, Malondialdehyde (MDA) Up-Regulation
[+]

Acute 60 Hz electromagnetic field exposure decreases superoxide dismutase and reduced glutathione activity in rats.Dec 01, 2010

Pubmed Data : Int J Radiat Biol. 2010 Dec ;86(12):1088-94. Epub 2010 Aug 11. PMID: 20701462
Article Published Date : Dec 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Lipid Peroxidation, Oxidative Stress
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Glutathione Down-Regulation, Superoxide Dismutase Downregulation
[+]

Aluminum nanoparticles are more neurotoxic than micrometer aluminum.Jun 01, 2018

Pubmed Data : Biol Trace Elem Res. 2018 Jun ;183(2):261-269. Epub 2017 Aug 30. PMID: 28856594
Article Published Date : Jun 01, 2018
Study Type : Animal Study
Additional Links
Diseases : Lipid Peroxidation, Mitochondrial Dysfunction , Oxidative Stress
Additional Keywords : Vaccine Research
Problem Substances : Aluminum oxide, Vaccine Adjuvants
Adverse Pharmacological Actions : Glutathione Down-Regulation, Oxidant
[+]

Animals exposed to 1.8 GHz radiofrequency field exhibit decreases in glutathione peroxidase, superoxide dismutase, and melatonin.Feb 12, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Environ Res Public Health. 2015 Feb 12 ;12(2):2071-87. Epub 2015 Feb 12. PMID: 25685954
Article Published Date : Feb 12, 2015
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress
Additional Keywords : electromagnetic fields, electromagnetic frequencies, electromagnetic radiation, EMF
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Electromagnetic Radiation: 1.8 GHz, Mobile Phone Radiation
Adverse Pharmacological Actions : Glutathione Down-Regulation, Oxidant
[+]

Exposure to electromagnetic fields far below current exposure limits results in increased biomarkers oxidative stress in rats.Jan 01, 2006

Pubmed Data : Electromagn Biol Med. 2006 ;25(3):177-88. PMID: 16954120
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress, Radiation Induced Illness
Additional Keywords : EMF
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Glutathione Down-Regulation, Malondialdehyde (MDA) Up-Regulation, Oxidant, Superoxide Dismutase Downregulation
[+]

Ginkgo biloba protects against glyphosate toxicity in mice. Aug 22, 2011

Pubmed Data : J Med Food. 2011 Aug 22. Epub 2011 Aug 22. PMID: 21859351
Article Published Date : Aug 22, 2011
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Glyphosate Toxicity
Problem Substances : Glyphosate
Adverse Pharmacological Actions : Glutathione Down-Regulation, Malondialdehyde (MDA) Up-Regulation
[+]

Long term consumption of aspartame causes liver injury and oxidative stress in the rat liver.Jun 01, 2011

Pubmed Data : Food Chem Toxicol. 2011 Jun ;49(6):1203-7. Epub 2011 Mar 3. PMID: 21376768
Article Published Date : Jun 01, 2011
Study Type : Animal Study
Additional Links
Diseases : ALT: Elevated, AST: Elevated, Chemically-Induced Liver Damage, Oxidative Stress
Problem Substances : Aspartame
Adverse Pharmacological Actions : Glutathione Down-Regulation, Hepatotoxic, Oxidant
[+]

Long-term exposure to PEMF can lead to oxidative damage of the liver and spleen.Dec 01, 2015

Pubmed Data : Wien Klin Wochenschr. 2015 Dec ;127(23-24):959-62. Epub 2015 Apr 25. PMID: 25910613
Article Published Date : Dec 01, 2015
Study Type : Animal Study
Additional Links
Diseases : Mobile Phone-Induced Oxidative Stress, Radiation Induced Illness
Additional Keywords : EMF
Adverse Pharmacological Actions : Glutathione Down-Regulation, Hepatotoxic, Malondialdehyde (MDA) Up-Regulation, Oxidant
[+]

Olive leaf extract reduces oxidative stress and oxidative stress-related glucose metabolism disruption induced by 2.45 GHz Wi-Fi signals.Nov 01, 2013

Pubmed Data : Environ Toxicol Pharmacol. 2013 Nov ;36(3):826-34. Epub 2013 Aug 3. PMID: 23994945
Article Published Date : Nov 01, 2013
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Glutathione Peroxidase 1 (GPx1) Up-Regulation, Superoxide Dismutase Up-regulation
Additional Keywords : electromagnetic fields, electromagnetic frequencies, electromagnetic radiation, EMF, Plant Extracts, Radio Frequency Electromagnetic Radiation Exposure, Wireless Technology
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Electromagnetic Radiation: 2.4 GHz, Microwave Radiation, Mobile Phone Radiation
Problem Substances : Cell Phone Exposure
Adverse Pharmacological Actions : Glutathione Down-Regulation, Malondialdehyde (MDA) Up-Regulation
[+]

One month of mobile phone radiation induces oxidative stress in the rat brain as demonstrated by elevated TBARS, reduced glutathione activity, and down-regulated antioxidant activity overall.Jan 01, 2014

Pubmed Data : Bratisl Lek Listy. 2014 ;115(5):260-6. PMID: 25174055
Article Published Date : Jan 01, 2014
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress, Oxidative Stress
Additional Keywords : electromagnetic fields, electromagnetic frequencies, electromagnetic radiation, EMF
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Mobile Phone Radiation
Adverse Pharmacological Actions : Glutathione Down-Regulation, Oxidant
[+]

Rats born to mothers exposed to Wi-Fi and cell phone electromagnetic fields exhibit elevated oxidative stress in kidneys and testes and may cause precocious puberty.Dec 01, 2013

Pubmed Data : Biol Trace Elem Res. 2013 Dec ;156(1-3):221-9. Epub 2013 Oct 8. PMID: 24101576
Article Published Date : Dec 01, 2013
Study Type : Animal Study
Additional Links
Diseases : Kidney Damage, Lipid Peroxidation, Oxidative Stress, Puberty: Precocious
Additional Keywords : Cell Phones, electromagnetic fields, electromagnetic frequencies, electromagnetic radiation, EMF, Pregnancy, Pregnancy And Fetal Growth, Radio Frequency Electromagnetic Radiation Exposure, Wi-Fi Devices, Wireless Technology
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Electromagnetic Radiation: 1.8 GHz, Electromagnetic Radiation: 2.4 GHz, Mobile Phone Radiation, Wi-Fi Radiation
Problem Substances : Cell Phone Exposure
Adverse Pharmacological Actions : Endocrine Disruptor: Testes, Glutathione Down-Regulation, Oxidant, Renotoxic
[+]

Rats exposed to mobile phone radiation in utero have elevated biomarkers of oxidative stress and histopathological changes in heart tissue.Jan 01, 2015

Pubmed Data : Electromagn Biol Med. 2015 ;34(4):390-7. Epub 2014 Aug 28. PMID: 25166431
Article Published Date : Jan 01, 2015
Study Type : Animal Study
Additional Links
Diseases : Cardiovascular Diseases, Oxidative Stress
Additional Keywords : cardiovascular health, electromagnetic fields, electromagnetic frequencies, Electromagnetic Hypersensitivity, electromagnetic radiation, EMF, Pregnancy, Pregnancy And Fetal Growth
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Mobile Phone Radiation
Problem Substances : Cell Phone Exposure
Adverse Pharmacological Actions : Apoptotic, Glutathione Down-Regulation, Malondialdehyde (MDA) Up-Regulation, Oxidant
[+]

These results suggest that direct chronic exposure to mobile phone caused severe biochemical and histopathological changes in the rat brain.Jan 12, 2016

Pubmed Data : J Chem Neuroanat. 2016 12 ;78:10-19. Epub 2016 Jul 26. PMID: 27474378
Article Published Date : Jan 12, 2016
Study Type : Animal Study
Additional Links
Diseases : Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Electromagnetic Radiation: 1.8 GHz
Adverse Pharmacological Actions : Apoptotic, Glutathione Down-Regulation, Inflammatory, Malondialdehyde (MDA) Up-Regulation, Neurotoxic, Superoxide Dismutase Downregulation
[+]

This study demonstrates the pro-inflammatory, pro-oxidant, and genotoxic effects of microwave radiation in rat brains.Dec 01, 2015

Pubmed Data : Neurotoxicology. 2015 Dec ;51:158-65. Epub 2015 Oct 25. PMID: 26511840
Article Published Date : Dec 01, 2015
Study Type : Animal Study
Additional Links
Diseases : Brain Inflammation , DNA damage, Oxidative Stress
Anti Therapeutic Actions : Microwave Radiation
Adverse Pharmacological Actions : Glutathione Down-Regulation, Inflammatory, Interleukin-6 up-regulation, Malondialdehyde (MDA) Up-Regulation, Oxidant, Tumor necrosis factorα (TNFα) up-regulation
[+]

Wi-Fi radiation leads to DNA damage in rat testes.Apr 01, 2013

Pubmed Data : J Pediatr Urol. 2013 Apr ;9(2):223-9. Epub 2012 Mar 30. PMID: 22465825
Article Published Date : Apr 01, 2013
Study Type : Animal Study
Additional Links
Diseases : DNA damage, Infertility: Male, Oxidative Stress
Additional Keywords : Radio Frequency Electromagnetic Radiation Exposure, Wireless Technology
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Electromagnetic Radiation: 1.8 GHz, Electromagnetic Radiation: 2.4 GHz, Wi-Fi Radiation
Adverse Pharmacological Actions : Glutathione Down-Regulation, Malondialdehyde (MDA) Up-Regulation
[+]

Mercury and thimerosal inhibit methionine synthase which interferes with the production of glutathione.Jan 01, 2014

Pubmed Data : Rev Environ Contam Toxicol. 2014 ;229:1-18. PMID: 24515807
Article Published Date : Jan 01, 2014
Study Type : Review
Additional Links
Diseases : Lipid Peroxidation, Neurodegenerative Diseases
Anti Therapeutic Actions : Vaccination: All
Problem Substances : Thimerosal
Adverse Pharmacological Actions : Glutathione Down-Regulation
[+]

Roundup Disrupted Male Reproductive Functions By Triggering Calcium-Mediated Cell Death In Rat Testis And Sertoli Cells.Jun 28, 2013

Pubmed Data : Free Radic Biol Med. 2013 Jun 29. Epub 2013 Jun 29. PMID: 23820267
Article Published Date : Jun 28, 2013
Study Type : In Vitro Study
Additional Links
Diseases : Genital Diseases: Male, Infertility: Male, Oxidative Stress
Problem Substances : Glyphosate, Glyphosate formulations, Herbicide, Roundup
Adverse Pharmacological Actions : Glutathione Down-Regulation, Glutathione S-transferase Inducer (xenobiotic)

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