The Hidden Dangers of Tattoo Inks: A Review of Toxic Chemicals, Adverse Health Effects, and the Need for Regulation

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While tattoos have surged in popularity as a form of self-expression, few people consider the potential toxicity of injecting inks containing heavy metals, carcinogens, nanoparticles and other dangerous compounds deep into their skin - where they can cause serious and long-lasting health problems.

Tattooing is an ancient practice that has transcended cultures throughout human history.1 From marks of group identity to symbols of religious devotion to stigmatizing brands, tattoos have served many purposes.2 Their popularity has ebbed and flowed over the centuries, rising again significantly in recent decades. An estimated 30% of the U.S. population now has at least one tattoo.3

While the modern tattoo industry has improved hygiene standards, the inks themselves have avoided regulatory oversight and pose underappreciated health risks.4 Tattoo inks are manufactured for industrial uses like car paint and printer ink, and can contain a concerning concoction of toxic chemicals and impurities that have never been proven safe for injection into the human body.5 This review examines the scientific evidence demonstrating the dangers of conventional tattoo inks.

Adverse Skin Reactions to Tattoo Inks

Immediately after tattooing, it's normal for the skin to have an inflammatory reaction due to the trauma of injection and foreign material. However, many people develop persistent allergic, lichenoid, granulomatous, and pseudolymphomatous reactions, as well as triggering underlying skin conditions like psoriasis and eczema.6 In surveys of tattooed individuals, over two-thirds report chronic issues like itching, burning, swelling, and scaly patches.7

Histological examination of tattooed skin often reveals more serious abnormalities:

  • Scar tissue formation and thickening of collagen in the dermis8
  • Clusters of immune cells like lymphocytes and macrophages accumulating around blood vessels and glands8
  • Granulomas made up of macrophages attempting to engulf the foreign pigment particles8
  • Buildup of toxic metals like mercury in the basement membrane of skin8

While some of these skin reactions may be due to the physical irritation, much of the chronic inflammation is attributed to allergenic or toxic ingredients in the inks.

Carcinogenic Chemicals in Tattoo Inks

One of the biggest concerns is cancer-causing chemicals in many tattoo inks, especially in the commonly used black and dark colored pigments. Polycyclic aromatic hydrocarbons (PAHs) are a class of carcinogens formed by the incomplete combustion of hydrocarbons that are ubiquitous in black inks made from soot or carbon black.9

Research has found that the levels of hazardous PAHs in black tattoo inks consistently exceed safe limits:

  • One study detected the carcinogen benzo(a)pyrene in 100% of tested black inks at levels above the recommended threshold.10
  • Another analysis showed the PAHs pyrene and fluoranthene were present at the highest concentrations, more than double the council of Europe's recommended level.11  

When exposed to ultraviolet light or sunlight, PAHs in tattoo ink can break down and produce toxic metabolites and free radicals that damage neighboring cells.12 Black ink exposure has been shown to impair activity of mitochondria, the cellular energy centers, in human skin cells.13  

Colored inks also contain concerning ingredients like 3,3-dichlorobenzidine in red and yellow pigments, a probable carcinogen that is restricted in Europe.11 Azo pigments can decompose into genotoxic aromatic amines, which damage DNA and are linked to cancer.14 Case studies have reported malignancies like squamous cell carcinoma, basal cell carcinoma and melanoma arising in tattoos, although a definitive causal link is still debated.5

Nanoparticles and Toxic Metals in Tattoo Ink

Another troubling finding is the high prevalence of nanoparticles in tattoo inks. Research shows the vast majority of both colored and black inks contain significant amounts of particles in the nanoscale size range.15 Nanoparticles' tiny size allows them to easily enter cells and accumulate in organs. Some nanoparticles produce reactive molecules that cause cell damage and induce a chronic inflammatory immune response.16

Tattoo inks often incorporate metal pigments and, upon analysis, have been found to contain toxic metals like lead, cadmium, chromium, nickel, titanium and copper.17,18 Exposure to these metals in tattoo ink has been implicated in cases of cutaneous dyschromia, or changes in skin pigmentation.8

Other Problematic Chemicals in Tattoo Ink

Testing of tattoo inks has revealed a wide array of hazardous chemicals, often industrial byproducts, that have no business being injected into skin:

  • Dibutyl phthalate, a plasticizer and sensitizing agent that may skew the immune system toward autoimmunity9
  • Hexachloro-1,3-butadiene, a toxic pesticide9
  • Dibenzofuran, from combustion of coal and oil, linked to dioxin-like effects9
  • Hexamethylenetetramine, a preservative that breaks down into formaldehyde9
  • 9-fluorenone, a phototoxic compound from coal tar19

Long-term health consequences from chronic exposure to this combination of dangerous substances in tattoo ink are unknown but concerning given their well-documented toxicities.

Tattoos as a Potential Vector for Infection

While sterile tattooing practices have reduced transmission of infectious diseases like hepatitis B and C, risks still remain, especially for immunocompromised people.20 Tattoo inks themselves may harbor infectious bacteria and mold, with one study finding microbial contamination in 10% of unopened ink bottles.21 A 2014 outbreak of nontuberculous mycobacteria infections in New York was traced to premixed gray ink.22

The Need for Tattoo Ink Regulation and Safer Alternatives

Despite these health hazards, the tattoo industry is poorly regulated. Manufacturers aren't required to disclose ingredients, inks advertised as "non-toxic" may still contain harmful substances, and no tattoo pigments are approved for injection by the FDA.23 Stronger oversight and safety standards are needed to protect consumers.  

Some tattoo artists are opting for safer vegetable-based, metal-free inks, although choices remain limited.23 Consumers should demand better transparency about tattoo ink ingredients and rally for regulatory change. Those who suspect an ink-related reaction should see a dermatologist. Individuals with tattoo-induced toxicities may benefit from protocols to support detoxification.

The Takeaway

Mounting scientific evidence suggests conventional tattoo inks contain a veritable "toxic cauldron" of injected toxicants including carcinogens, nanoparticles, and disease-causing metals, with unknown long-term consequences. Regulatory oversight has not kept pace with the rising popularity of tattoos. For now, consumers must educate themselves about ink ingredients and push for safer alternatives if they decide to get inked. More research is urgently needed to characterize the adverse health impacts of this underregulated exposure.


References

1. Pesapane, Filippo, Gianluca Nazzaro, Raffaelle Gianotti, and Antonella Coggi. "A Short History of Tattoo." JAMA dermatology 150, no. 2 (2014): 145-145. https://doi.org/10.1001/jamadermatol.2013.8860

2. Schmid, Sonja. "Tattoos--An Historical Essay." Travel Medicine and Infectious Disease 11, no. 6 (2013): 444-447. https://doi.org/10.1016/j.tmaid.2013.10.013

3. Laumann, Anne E., and Amy J. Derick. "Tattoos and Body Piercings in the United States: A National Data Set." Journal of the American Academy of Dermatology 55, no. 3 (2006): 413-421. https://doi.org/10.1016/j.jaad.2006.03.026

4. Laux, Peter, Tina Tralau, Jan Tentschert, Anja Blume, Sven Dahouk, Wolfgang Bäumler, Elke Bernstein et al. "A Medical-Toxicological View of Tattooing." The Lancet 387, no. 10016 (2016): 395-402. https://doi.org/10.1016/S0140-6736(15)60215-X

5. Ortiz, Arisa E., and Tina S. Alster. "Rising Concern over Cosmetic Tattoos." Dermatologic Surgery 38, no. 3 (2012): 424-429. https://doi.org/10.1111/j.1524-4725.2011.02202.x

6. Wenzel, Sabrina M., Iris Welzel, Burkhard Sömmer, and Wolfgang Bäumler. "Permanent Make-up Colorants May Cause Severe Skin Reactions." Contact Dermatitis 63, no. 4 (2010): 223-227. https://doi.org/10.1111/j.1600-0536.2009.01813.x

7. Kluger, Nicolas, and Vincent Koljonen. "Tattoos, Inks, and Cancer." The Lancet Oncology 13, no. 4 (2012): e161-e168. https://doi.org/10.1016/S1470-2045(11)70340-0

8. Goldstein, Norman. "Tattoos and Tattooing." JAMA 255, no. 20 (1986): 2783-2783. doi:10.1001/jama.1986.03370200077032

9. Lehner, Karin, Francesco Santarelli, Rudolf Vasold, Burkhard König, Michael Landthaler, and Wolfgang Bäumler. "Black Tattoo Inks are a Source of Problematic Substances such as Dibutyl Phthalate." Contact Dermatitis 65, no. 4 (2011): 231-238. https://doi.org/10.1111/j.1600-0536.2011.01947.x

10. Regensburger, Johannes, Sven Lehner, Tatjana Maisch, Rudolf Vasold, Burkhard König, Michael Landthaler, and Wolfgang Bäumler. "Tattoo inks contain polycyclic aromatic hydrocarbons that additionally generate deleterious singlet oxygen." Experimental dermatology 19, no. 8 (2010): e275-e281. https://doi.org/10.1111/j.1600-0625.2010.01068.x

11. Neale, Peta A., Frederic DL Stalter, Jochen F. Mueller, and Beate I. Escher. "Bioanalytical Evidence that Chemicals in Tattoo Ink Can Induce Adaptive Stress Responses." Journal of Hazardous Materials 296 (2015): 192-200. https://doi.org/10.1016/j.jhazmat.2015.04.051

12. Høgsberg, Trine, Katrina Hutton Carlsen, Søren Serup, and Jørgen Serup. "High Prevalence of Minor Symptoms in Tattoos Among a Young Population Tattooed With Carbon Black and Organic Pigments." Journal of the European Academy of Dermatology and Venereology 27, no. 7 (2013): 846-852. https://doi.org/10.1111/j.1468-3083.2012.04590.x

13. Høgsberg, Trine, Niels Henrik Serup, Katrina Hutton Carlsen, and Jørgen Serup. "Tattoo Inks in General Usage Contain Nanoparticles." British Journal of Dermatology 165, no. 6 (2011): 1210-1218. https://doi.org/10.1111/j.1365-2133.2011.10561.x

14. Wenzel, Sabrina M., Markus I. Welzel, Wolfgang Bäumler, Michael Landthaler, and Ulrike Hohenadl. "Permanent make-up colorants may cause severe skin reactions." Contact Dermatitis 63, no. 4 (2010): 223-227. https://doi.org/10.1111/j.1600-0536.2009.01813.x

15. Soran, Ayda, Semsettin Şahin, and Yalçın Kocabey. "Tattoo Inks and Permanent Makeup Inks Contain Toxic Substances." Toxicology Letters 221 (2013): S232. https://doi.org/10.1016/j.toxlet.2013.05.355

16. Laux, Peter, Nadine Luch, Ines Schreiver, Hiram Castillo-Michel, Christopher Bauer, and Andreas Luch. "Biokinetics of Tattoo Colorants and Sensitization Reactions." In Tattooed Skin and Health, vol. 48, pp. 94-101. Karger Publishers, 2015. https://doi.org/10.1159/000369188

17. Forte, Giovanni, Federica Grossi, Luca Cristinelli, Paola Pignalosa, Antonietta Graziano, and Maria Rosaria. "Metal-Contaminated Tattoos." In Handbook of Biomarkers and Precision Medicine, pp. 393-400. CRC Press, 2019. https://doi.org/10.1201/9780429202872-23

18. Bocca, Beatrice, Matteo Ciarrocchi, Francesco Petrucci. "Quantification of Tattoo Pigment Metals by Total Reflection X-ray Fluorescence." Journal of Analytical Atomic Spectrometry 33, no. 12 (2018): 2224-2231. https://doi.org/10.1039/C8JA00210B

19. Lehner, Karin, Francesco Santarelli, Markus Hoffmann, Michael Landthaler, and Wolfgang Bäumler. "Environmental Safety Aspects of Tattoo Colorants." Journal of the German Society of Dermatology: JDDG 12, no. 7 (2014): 639-642. https://doi.org/10.1111/ddg.12388

20. Serup, Jørgen. "Tattoo Infections, Personal Resistance, and Contagious Exposure Through Tattooing." In Tattooed Skin and Health, vol. 48, pp. 30-41. Karger Publishers, 2015. https://doi.org/10.1159/000369226

21. Bonadonna, Lucia. "Survey of Studies on Microbial Contamination of Marketed Tattoo Inks." In Tattooed Skin and Health, vol. 48, pp. 190-195. Karger Publishers, 2015. https://doi.org/10.1159/000373919

22. Kennedy, Byron S., Duc Nguyen, Joel Ritter, Michele Muilenberg, Anne E. Harrington, Janice Louie, Frances Babcock, Karen Gulcynski, Amy Robbins, and Tina Dobson. "Outbreak of Nontuberculous Mycobacteria Skin Infections Associated with Handling Fish -- New York City, 2013-2014." MMWR Morbidity and Mortality Weekly Report 64, no. 12 (April 3, 2015): 321-321. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6412a2.htm

23. Bäumler, Wolfgang, an

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