Lipogenesis Up-Regulation

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3 Problem Substances Researched for Lipogenesis Up-Regulation

Name	AC	CK	Focus
Fructose	6	10
Insulin	1	2
Trans Fatty Acids	1	1

12 Diseases Researched for Lipogenesis Up-Regulation

Name	AC	CK	Focus
Fructose-Induced Toxicity	5	9
Fatty Liver	5	8
Liver Stress: Fructose-Induced	4	8
Nonalcoholic fatty liver disease (NAFLD)	5	8
Metabolic Syndrome X	2	4
Diabetes Mellitus: Type 2	2	3
Insulin Resistance	2	3
Triglycerides: Elevated	2	3
Endotoxemia	1	2
Hyperglycemia	1	2
Inflammation	1	2
Obesity	1	1

Research Articles 7
Cumulative Knowledge Score 11
Overall Research Rating GOOD

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7 Abstracts with Lipogenesis Up-Regulation Research

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A high fructose diet may contribute to the development of fatty liver, gluconeogenesis up-regulation and inflammation. May 01, 2010

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Pubmed Data : Endocrinology. 2010 May;151(5):2040-9. Epub 2010 Mar 8. PMID: 20211973

Article Published Date : May 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Fatty Liver, Fructose-Induced Toxicity , Hyperglycemia, Inflammation, Liver Stress: Fructose-Induced, Triglycerides: Elevated

Problem Substances : Insulin

Adverse Pharmacological Actions : Dyslipidemic, Gluconeogenesis Up-Regulation, Inflammatory, Lipogenesis Up-Regulation

[+]

Fructose induces gluconeogenesis and lipogenesis which may result in adverse metabolic changes.Mar 01, 2011

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Pubmed Data : J Endocrinol. 2011 Mar;208(3):273-83. Epub 2011 Jan 6. PMID: 21212096

Article Published Date : Mar 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Diabetes Mellitus: Type 2, Insulin Resistance, Metabolic Syndrome X

Problem Substances : Fructose

Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance, Gluconeogenesis Up-Regulation, Lipogenesis Up-Regulation, SIRT1 Modulator

[+]

Lactobaccilus casei Shirota protects from fructose-induced fatty liver in an animal model. Jun 26, 2012

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Pubmed Data : J Nutr Biochem. 2012 Jun 27. Epub 2012 Jun 27. PMID: 22749137

Article Published Date : Jun 26, 2012

Study Type : Animal Study

Additional Links

Substances : Lactobacillus casei: Shirota

Diseases : Fructose-Induced Toxicity , Liver Stress: Fructose-Induced, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Problem Substances : Fructose

Adverse Pharmacological Actions : Hepatotoxic, Lipogenesis Up-Regulation

[+]

Loss of intestinal Serotonin reuptake transporter (SERT) is a critical factor in fructose-induced impairment of intestinal barrier function and subsequently the development of steatosis.Mar 01, 2010

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Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G335-44. Epub 2009 Aug 27. PMID: 19713474

Article Published Date : Mar 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Endotoxemia, Fatty Liver, Fructose-Induced Toxicity , Liver Stress: Fructose-Induced, Nonalcoholic fatty liver disease (NAFLD)

Problem Substances : Fructose

Adverse Pharmacological Actions : Hepatotoxic, Lipogenesis Up-Regulation

[+]

Rats fed fructose-enriched diets have characteristics of nonalcoholic hepatic steatosis.Nov 01, 2009

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Pubmed Data : J Nutr. 2009 Nov;139(11):2067-71. Epub 2009 Sep 23. PMID: 19776184

Article Published Date : Nov 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Fatty Liver, Fructose-Induced Toxicity , Liver Stress: Fructose-Induced, Metabolic Syndrome X, Nonalcoholic fatty liver disease (NAFLD)

Problem Substances : Fructose

Adverse Pharmacological Actions : Hepatotoxic, Lipogenesis Up-Regulation

[+]

Dietary fructose may promote the development of nonalcoholic fatty liver disease, which in and of itself,can result in hepatic insulin resistance, a key feature of type 2 diabetes mellitus.Feb 01, 2011

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Pubmed Data : Trends Endocrinol Metab. 2011 Feb;22(2):60-5. Epub 2010 Nov 9. PMID: 21067942

Article Published Date : Feb 01, 2011

Study Type : Review

Additional Links

Diseases : Diabetes Mellitus: Type 2, Fatty Liver, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD), Obesity

Problem Substances : Fructose

Adverse Pharmacological Actions : Lipogenesis Up-Regulation

[+]

Fructose, trans-fatty acids and saturated fats may increase intrahepatic triglyceride levels independent of total calorie intake, resulting in nonalcoholic fatty liver disease. Mar 01, 2010

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Pubmed Data : Curr Opin Gastroenterol. 2010 Mar;26(2):160-4. PMID: 20010099

Article Published Date : Mar 01, 2010

Study Type : Review

Additional Links

Diseases : Fatty Liver, Fructose-Induced Toxicity , Nonalcoholic fatty liver disease (NAFLD), Triglycerides: Elevated

Problem Substances : Fructose, Trans Fatty Acids

Adverse Pharmacological Actions : Hepatotoxic, Lipogenesis Up-Regulation

Research Articles 7
Cumulative Knowledge Score 11
Overall Research Rating GOOD

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