Melatonin: A Beacon of Hope for Migraine Sufferers

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For countless individuals battling the debilitating effects of migraine, the search for effective and safe preventive treatments has been a long and arduous journey. However, a glimmer of hope has emerged in the form of melatonin, a hormone naturally produced by the body that may hold the key to reducing the frequency and severity of migraine attacks.

Melatonin: A Beacon of Hope for Migraine Sufferers

Migraine, a neurological disorder characterized by intense headaches and a host of accompanying symptoms, affects a staggering 12-20% of the general population.1 For those who suffer from episodic migraine, the impact on quality of life can be profound, often leading to significant disruptions in daily activities. While preventive treatments such as beta-blockers and anticonvulsants have been the mainstay of migraine management, their effectiveness is often limited, and side effects can be a concern.2 In recent years, researchers have turned their attention to melatonin, a hormone closely tied to the body's circadian rhythms, as a potential alternative in the preventive treatment of migraine.

The Melatonin-Migraine Connection

The link between melatonin and migraine is rooted in the complex interplay of the hypothalamus, a region of the brain that plays a crucial role in the pathophysiology of migraine.3 Melatonin, secreted by the pineal gland, is a key regulator of the body's circadian rhythms and has been shown to possess a range of biological properties that may be beneficial in migraine prevention, including antioxidant effects, regulation of neurotransmitter activity, and inhibition of pain-related peptides.4

Putting Melatonin to the Test

In a recent double-blind, randomized clinical trial, researchers set out to investigate the effects of melatonin supplementation on the frequency and severity of migraine attacks.5 Sixty patients with episodic migraine were divided into two groups, with one group receiving 3 mg of melatonin daily and the other a placebo, in addition to a standard preventive medication. Over the course of two months, the melatonin group experienced a significant reduction in the frequency and duration of migraine attacks compared to the placebo group. Additionally, the melatonin group reported a decrease in the use of acute pain medications and improvements in migraine-related disability and sleep quality.

A Safe and Well-Tolerated Option

One of the most promising aspects of melatonin as a preventive treatment for migraine is its favorable safety profile. In the aforementioned study, side effects were minimal and comparable between the melatonin and placebo groups.5 This finding is consistent with previous research, which has consistently demonstrated the safety and tolerability of melatonin supplementation in migraine patients.6

Mechanisms of Action

While the exact mechanisms by which melatonin exerts its beneficial effects in migraine prevention are not fully understood, several theories have been proposed. Melatonin's antinociceptive properties, mediated through its interactions with various neurotransmitter systems, may play a role in reducing the frequency and intensity of migraine attacks.7 Additionally, melatonin's ability to regulate sleep-wake cycles and improve sleep quality may indirectly contribute to migraine prevention, as poor sleep is a well-established trigger for migraine.8


The results of this study, along with a growing body of evidence, suggest that melatonin may be a valuable addition to the arsenal of preventive treatments for episodic migraine. Its favorable safety profile, coupled with its effectiveness in reducing migraine frequency and severity, make it an attractive option for patients and healthcare providers alike. While further research is needed to fully elucidate the mechanisms underlying melatonin's benefits in migraine prevention, the future looks bright for this humble hormone in the fight against one of the most common and debilitating neurological disorders.

To learn more about the potential therapeutic applications of melatonin, visit our database on the subject here.

To learn more about natural strategies to address migraines, visit our database on the subject here.


1: Ashina M. Migraine. N Engl J Med. 2020;383:1866-76. doi: 10.1056/NEJMra1915327.

2: Jackson JL, Kuriyama A, Kuwatsuka Y, Nickoloff S, Storch D, Jackson W, et al. Beta-blockers for the prevention of headache in adults, a systematic review and meta-analysis. PLoS One. 2019;14:e0212785. doi: 10.1371/journal.pone.0212785.

3: Goadsby PJ, Holland PR, Martins-Oliveira M, Hoffmann J, Schankin C, Akerman S. Pathophysiology of Migraine: A Disorder of Sensory Processing. Physiol Rev. 2017;97:553-622. doi: 10.1152/physrev.00034.2015.

4: Tseng PT, Yang CP, Su KP, Chen TY, Wu YC, Tu YK, et al. The association between melatonin and episodic migraine: A pilot network meta-analysis of randomized controlled trials to compare the prophylactic effects with exogenous melatonin supplementation and pharmacotherapy. J Pineal Res. 2020;69:e12663. doi: 10.1111/jpi.12663.

5: Mehramiri A, Shalilahmadi D, Mohamadianinejad SE, Kouti L, Hosseinpour Y. The Effect of Melatonin on Reducing the Frequency and Severity of Migraine Attacks: A Double-Blind, Randomized Clinical Trial. Iran J Med Sci. 2024;49:313-21. doi: 10.30476/ijms.2023.97782.2965. 

6: Long R, Zhu Y, Zhou S. Therapeutic role of melatonin in migraine prophylaxis: A systematic review. Medicine (Baltimore). 2019;98:e14099. doi: 10.1097/MD.0000000000014099.

7: Srinivasan V, Lauterbach EC, Ho KY, Acuna-Castroviejo D, Zakaria R, Brzezinski A. Melatonin in antinociception: its therapeutic applications. Curr Neuropharmacol. 2012;10:167-78. doi: 10.2174/157015912800604489.

8: Kelman L, Rains JC. Headache and sleep: examination of sleep patterns and complaints in a large clinical sample of migraineurs. Headache. 2005;45:904-10. doi: 10.1111/j.1526-4610.2005.05159.x.

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