Myotoxicity

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10 Problem Substances Researched for Myotoxicity
NameACCKFocus
Statin Drugs60266Locked
Simvastatin1855Locked
Atorvastatin940Locked
Pravastatin 731Locked
Lovastatin729Locked
Fluvastatin25Locked
Rosuvastatin35Locked
Fenofibrates13Locked
Gemfibrozil13Locked
Cerivastatin22Locked
59 Diseases Researched for Myotoxicity
NameACCKFocus
Statin-Induced Pathologies63255Locked
Myopathies38160Locked
Rhabdomyolysis1551Locked
Myalgias744Locked
Creatine Phosphokinase (CK): Elevated542Locked
Muscle Damage: Exercise-Induced431Locked
Athletic Performance330Locked
Mitochondrial Dysfunction 827Locked
Drug-Induced Nutrient Depletion: Statin Drugs921Locked
Coenzyme Q10 Deficiency415Locked
Drug-Induced Toxicity 314Locked
Muscle Disorders213Locked
Polymyalgia Rheumatica213Locked
Mitochondrial Myopathies312Locked
Muscle Soreness211Locked
Blood Lactate/ Pyruvate Ratio: Elevated110Locked
Death: Statin-Induced110Locked
GGT110Locked
Isoprostane 8-epi-PGF2alpha: Elevated110Locked
Muscle Fatigue110Locked
Muscle Soreness: Exercise-Induced110Locked
Muscle Stiffness: Exercise-Induced110Locked
Organ Transplantation: Heart110Locked
Oxidative Stress110Locked
Dermatomyositis26Locked
Congestive Heart Failure24Locked
Myositis24Locked
Skeletal Muscle: Changes to MHC I expression24Locked
Elevated: Creatinine Kinase13Locked
Hepatitis: Acute13Locked
Hyperlipidemia13Locked
Hypersensitivity13Locked
Hypothyroidism13Locked
Kidney Transplant13Locked
Myoglobinuria13Locked
Neuroleptic Malignant Syndrome13Locked
Neuromuscular Diseases13Locked
Pneumonitis13Locked
Pneumonitis: Hypersensitivity Type13Locked
Polymyositis13Locked
Presymptomatic Metabolic Myopathy 13Locked
Rhabdomyolysis: Fatal13Locked
Skeletal Muscle Changes: Endoplasmic Reticulum Stress13Locked
Brain Damage12Locked
Cardiovascular Diseases12Locked
Heart Failure12Locked
Hypertension12Locked
Liver Damage: Drug-Induced12Locked
Mineral Deficiencies: Selenium22Locked
Myocardial Ischemia12Locked
Testicular Diseases12Locked
Coronary Artery Disease11Locked
High Cholesterol11Locked
Kidney Damage: Drug-Induced11Locked
Kidney Failure11Locked
Lipid Peroxidation11Locked
Myopathy: Iatrogenic11Locked
Neuromyotoxicity11Locked
Skeletal Muscle Changes: Ultrastructural Changes11Locked

View the Evidence:
80 Abstracts with Myotoxicity Research

[+]

Muscle complaints occur in 10% or more of patients started on high-dose statins. Aug 01, 2007

Pubmed Data : Curr Opin Lipidol. 2007 Aug;18(4):401-8. PMID: 17620856
Article Published Date : Aug 01, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Myopathies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

After a six-month administration of coenzyme Q10, muscle pain and sensitivity statistically significantly decreased.Nov 27, 2012

Pubmed Data : Neuro Endocrinol Lett. 2012 Nov 28 ;33(Suppl2):98-101. Epub 2012 Nov 28. PMID: 23183519
Article Published Date : Nov 27, 2012
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10
Diseases : Death: Statin-Induced, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Among top sports performers only about 20% tolerate statin treatment without side-effects.Apr 01, 2004

Pubmed Data : Br J Clin Pharmacol. 2004 Apr ;57(4):525-8. PMID: 15025753
Article Published Date : Apr 01, 2004
Study Type : Human Study
Additional Links
Diseases : Athletic Performance, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Exercise exacerbates cerivastatin-induced skeletal muscle toxicity.Dec 01, 2005

Pubmed Data : Toxicol Sci. 2005 Dec ;88(2):551-61. Epub 2005 Sep 1. PMID: 16141437
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Diseases : Athletic Performance, Creatine Phosphokinase (CK): Elevated, GGT, Muscle Damage: Exercise-Induced, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Exposure to atorvastatin is associated with lactone and acid metabolites that are increased several-fold in patients with atorvastatin-induced myopathy.Jun 01, 2006

Pubmed Data : Clin Pharmacol Ther. 2006 Jun ;79(6):532-9. PMID: 16765141
Article Published Date : Jun 01, 2006
Study Type : Human Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Lovastatin increases exercise-induced skeletal muscle injury in human subjects. Oct 01, 1997

Pubmed Data : Metabolism. 1997 Oct ;46(10):1206-10. PMID: 9322808
Article Published Date : Oct 01, 1997
Study Type : Human Study
Additional Links
Diseases : Athletic Performance, Creatine Phosphokinase (CK): Elevated, Muscle Damage: Exercise-Induced, Muscle Soreness: Exercise-Induced, Muscle Stiffness: Exercise-Induced, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Musclar side effects associated with statin drug use are related to oxidative stress. Aug 01, 2001

Pubmed Data : J Clin Pharm Ther. 2001 Aug ;26(4):303-10. PMID: 11493374
Article Published Date : Aug 01, 2001
Study Type : Human Study
Additional Links
Diseases : Creatine Phosphokinase (CK): Elevated, Isoprostane 8-epi-PGF2alpha: Elevated, Myalgias, Oxidative Stress, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity, Oxidant
[+]

Myopathy prevalence is underestimated; in an outpatient cardiology clinic prevalence was found to be 33%. Jun 11, 2012

Pubmed Data : Curr Med Res Opin. 2012 Jun 11. Epub 2012 Jun 11. PMID: 22686958
Article Published Date : Jun 11, 2012
Study Type : Human Study
Additional Links
Diseases : Myopathies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Review: muscle symptoms associated with lipid-lowering drugs.Sep 01, 2003

Pubmed Data : Cardiovasc Drugs Ther. 2003 Sep-Nov;17(5-6):459-65. PMID: 15107601
Article Published Date : Sep 01, 2003
Study Type : Human Study
Additional Links
Diseases : Muscle Disorders, Muscle Fatigue, Myalgias, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Some 10% to 20% of heart transplant patients appear to suffer adverse side effects of initial statin therapy. Nov 01, 2005

Pubmed Data : Transplant Proc. 2005 Nov ;37(9):4071-3. PMID: 16386629
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Diseases : Muscle Soreness, Myalgias, Organ Transplantation: Heart, Rhabdomyolysis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic, Myotoxicity
[+]

Statin drugs have been linked to myopathy, including rhabdomyolysis. Dec 12, 2005

Pubmed Data : Arch Intern Med. 2005 Dec 12-26;165(22):2671-6. PMID: 16344427
Article Published Date : Dec 12, 2005
Study Type : Human Study
Additional Links
Diseases : Myopathies, Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs induce ultrastructural damage in skeletal muscle in patients without myalgia.Sep 01, 2006

Pubmed Data : J Pathol. 2006 Sep ;210(1):94-102. PMID: 16799920
Article Published Date : Sep 01, 2006
Study Type : Human Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs, particularly simivastatin, increase the risk for significant creatine kinase elevation.Jan 01, 2010

Pubmed Data : Am J Cardiovasc Drugs. 2010 ;10(3):187-92. PMID: 20524720
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Creatine Phosphokinase (CK): Elevated, Myopathies, Statin-Induced Pathologies
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin therapy can be associated with high blood lactate/ pyruvate ratio suggestive of mitochondrial dysfunction. Sep 01, 1996

Pubmed Data : Br J Clin Pharmacol. 1996 Sep ;42(3):333-7. PMID: 8877024
Article Published Date : Sep 01, 1996
Study Type : Human Study
Additional Links
Diseases : Blood Lactate/ Pyruvate Ratio: Elevated, Coenzyme Q10 Deficiency, Mitochondrial Dysfunction , Statin-Induced Pathologies
Pharmacological Actions : Enzyme Inhibitors
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-associated myopathy is underestimated and occurs in 5-10% of patients who receive them. Aug 01, 2011

Pubmed Data : Int J Cardiol. 2011 Aug 1. Epub 2011 Aug 1. PMID: 21813193
Article Published Date : Aug 01, 2011
Study Type : Human Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-Associated Polymyalgia RheumaticaDec 31, 2011

Pubmed Data : PLoS One. 2012 ;7(7):e41289. Epub 2012 Jul 23. PMID: 22844450
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Diseases : Polymyalgia Rheumatica
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-induced muscle toxicity may be associated with altered oxidation of fatty acids. Feb 01, 2009

Pubmed Data : Endocrine. 2009 Feb;35(1):38-46. Epub 2008 Dec 3. PMID: 19051066
Article Published Date : Feb 01, 2009
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity , Myopathies, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-induced myalgia occurs in∼10% of lipid clinic outpatients. Jul 20, 2011

Pubmed Data : Atherosclerosis. 2011 Jul 20. Epub 2011 Jul 20. PMID: 21868014
Article Published Date : Jul 20, 2011
Study Type : Human Study
Additional Links
Diseases : Myalgias, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-induced myopathic weakness causing disability is an underappreciated side effect.Sep 01, 2005

Pubmed Data : Neurorehabil Neural Repair. 2005 Sep ;19(3):259-63. PMID: 16093417
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Diseases : Myopathies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statins appear to cause muscle damage and impair oxidative metabolism.Jan 01, 2004

Pubmed Data : J Submicrosc Cytol Pathol. 2004 Jan ;36(1):85-9. PMID: 15311678
Article Published Date : Jan 01, 2004
Study Type : Human Study
Additional Links
Diseases : Mitochondrial Dysfunction , Mitochondrial Myopathies, Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statins increase exercise-related muscle injury, which worsens with the age of the individual.Oct 27, 2011

Pubmed Data : Am J Cardiol. 2011 Oct 27. Epub 2011 Oct 27. PMID: 22036108
Article Published Date : Oct 27, 2011
Study Type : Human Study
Additional Links
Diseases : Muscle Damage: Exercise-Induced, Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

A case of simvastatin-induced acute rhabdomyolysis with heart failure after initiation of treatment with fusidic acid has been reported.Apr 01, 1992

Pubmed Data : Rev Rhum Mal Osteoartic. 1992 Apr ;59(4):281-3. PMID: 1496277
Article Published Date : Apr 01, 1992
Study Type : Human: Case Report
Additional Links
Diseases : Congestive Heart Failure, Rhabdomyolysis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]

A dermatomyositis-like syndrome has been linked to statin drug use. Dec 01, 2004

Pubmed Data : Muscle Nerve. 2004 Dec ;30(6):803-7. PMID: 15389654
Article Published Date : Dec 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Dermatomyositis
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

A possible increased risk of rhabdomyolysis during concomitant use of simvastatin and gemfibrozil has been reported. Dec 01, 1996

Pubmed Data : J Intern Med. 1996 Dec ;240(6):403-4. PMID: 9010388
Article Published Date : Dec 01, 1996
Study Type : Human: Case Report
Additional Links
Diseases : Rhabdomyolysis, Statin-Induced Pathologies
Additional Keywords : Drug Synergy
Problem Substances : Fenofibrates, Gemfibrozil, Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Asymptomatic statin-induced rhabdomyolysis after long-term therapy with the hydrophilic drug pravastatin has been reported.Jan 01, 2007

Pubmed Data : Clin Ther. 2007 Jan ;29(1):172-6. PMID: 17379057
Article Published Date : Jan 01, 2007
Study Type : Human: Case Report
Additional Links
Diseases : Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Fatal rhabdomyolysis associated with simvastatin in a renal transplant patient has been reported.Mar 01, 2000

Pubmed Data : Am J Med. 2000 Mar ;108(4):351-2. PMID: 11014734
Article Published Date : Mar 01, 2000
Study Type : Human: Case Report
Additional Links
Diseases : Kidney Transplant, Rhabdomyolysis: Fatal, Statin-Induced Pathologies
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Fluvastatin-induced dermatomyositis has been reported.Dec 01, 2005

Pubmed Data : Ann Dermatol Venereol. 2005 Dec ;132(12 Pt 1):996-9. PMID: 16446645
Article Published Date : Dec 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Dermatomyositis
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Fluvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Influenza vaccine has been reported to be a possible trigger of rhabdomyolysis induced acute renal failure in those taking statin drugs.May 01, 2000

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nephrol Dial Transplant. 2000 May ;15(5):740-1. PMID: 10809833
Article Published Date : May 01, 2000
Study Type : Human: Case Report
Additional Links
Diseases : Rhabdomyolysis, Statin-Induced Pathologies
Anti Therapeutic Actions : Vaccination: All, Vaccination: Influenza
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Neuroleptic malignant syndrome as a possible statin drug reaction has been reported.Nov 01, 2009

Pubmed Data : Clin Neuropharmacol. 2009 Nov-Dec;32(6):348-9. PMID: 19952877
Article Published Date : Nov 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Myopathies, Neuroleptic Malignant Syndrome, Statin-Induced Pathologies
Pharmacological Actions : Anti-Bacterial Agents, Anticholesteremic Agents
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Polymyalgia, hypersensitivity pneumonitis and other reactions have been reported in paitents taking statin drugs.Mar 01, 1999

Pubmed Data : Chest. 1999 Mar ;115(3):886-9. PMID: 10084510
Article Published Date : Mar 01, 1999
Study Type : Human: Case Report
Additional Links
Diseases : Hypersensitivity, Pneumonitis, Pneumonitis: Hypersensitivity Type, Polymyalgia Rheumatica, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Pravastatin-associated myopathy has been reported. May 01, 1995

Pubmed Data : Recenti Prog Med. 1995 May ;86(5):198-200. PMID: 7604176
Article Published Date : May 01, 1995
Study Type : Human: Case Report
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Pravastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Pravastatin-associated polymyositis has been reported. Jan 01, 2004

Pubmed Data : Rinsho Shinkeigaku. 2004 Jan ;44(1):25-7. PMID: 15199734
Article Published Date : Jan 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Muscle Disorders, Polymyositis
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Rhabdomyolysis in a patient receiving high-dose simvastatin after the induction of therapeutic hypothermia has been reported.Dec 01, 2010

Pubmed Data : Ann Pharmacother. 2010 Dec ;44(12):1994-7. Epub 2010 Nov 2. PMID: 21045169
Article Published Date : Dec 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Elevated: Creatinine Kinase, Myoglobinuria, Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Rhabdomyolysis induced by a single dose of a statin has been reported. Jan 01, 2004

Pubmed Data : Heart. 2004 Jan ;90(1):e3. PMID: 14676266
Article Published Date : Jan 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Rhabdomyolysis secondary to lovastatin therapy has been reported. Dec 01, 1990

Pubmed Data : Clin Chem. 1990 Dec ;36(12):2145-7. PMID: 2253372
Article Published Date : Dec 01, 1990
Study Type : Human: Case Report
Additional Links
Diseases : Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Severe rhabdomyolysis due to rosuvastatin in a liver transplant subject with HIV has been reported.Mar 01, 2011

Pubmed Data : Liver Transpl. 2011 Mar;17(3):331-3. PMID: 21384516
Article Published Date : Mar 01, 2011
Study Type : Human: Case Report
Additional Links
Diseases : Rhabdomyolysis
Problem Substances : Rosuvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin therapy may result in progressive myopathy with up-regulation of MHC-I associated with an endoplasmic reticulum stress response.Feb 01, 2007

Pubmed Data : Neuromuscul Disord. 2007 Feb ;17(2):194-200. Epub 2007 Jan 22. PMID: 17241784
Article Published Date : Feb 01, 2007
Study Type : Human: Case Report
Additional Links
Diseases : Myopathies, Skeletal Muscle: Changes to MHC I expression, Skeletal Muscle Changes: Endoplasmic Reticulum Stress, Statin-Induced Pathologies
Pharmacological Actions : Anti-Inflammatory Agents
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin toxicity may mimic viral hepatitis. Nov 01, 2005

Pubmed Data : Int J Clin Pharmacol Ther. 2005 Nov ;43(11):543-5. PMID: 16300170
Article Published Date : Nov 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Hepatitis: Acute, Rhabdomyolysis, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity, Nephrotoxic
[+]

Statin treatment may contribute to presymptomatic neuromuscular disorders.Jul 24, 2006

Pubmed Data : Arch Intern Med. 2006 Jul 24 ;166(14):1519-24. PMID: 16864763
Article Published Date : Jul 24, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Myopathies, Neuromuscular Diseases, Presymptomatic Metabolic Myopathy , Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin use may be contraindicated in hypothyroidism.Mar 01, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Can Fam Physician. 2007 Mar ;53(3):428-31. PMID: 17872677
Article Published Date : Mar 01, 2007
Study Type : Human: Case Report
Additional Links
Diseases : Hyperlipidemia, Hypothyroidism, Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-induced focal myositis of the upper extremities has been reported. Feb 01, 2011

Pubmed Data : Eur J Radiol. 2011 Feb ;77(2):258-60. Epub 2011 Jan 12. PMID: 21232890
Article Published Date : Feb 01, 2011
Study Type : Human: Case Report
Additional Links
Diseases : Myositis, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Lovastatin causes depletion of coenzyme Q10 levels in the cardiac muslce and mitochondria of animals.Jul 06, 1994

Pubmed Data : Biochim Biophys Acta. 1994 Jul 6 ;1200(2):100-8. PMID: 8031828
Article Published Date : Jul 06, 1994
Study Type : Animal Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Heart Failure, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]

Lovastatin has the potential of causing muscle damage.Sep 01, 1993

Pubmed Data : J Neuropathol Exp Neurol. 1993 Sep ;52(5):542-9. PMID: 8360706
Article Published Date : Sep 01, 1993
Study Type : Animal Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Low dose simvastatin induces compositional, structural and dynamic changes in rat.Feb 01, 2010

Pubmed Data : Biosci Rep. 2010 Feb;30(1):41-50. Epub 2009 Oct 6. PMID: 19228123
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Drug-Induced Toxicity , Myopathies
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Quercetin is able to ameliorate statin-drug induced skeletal muscle myopathy in an animal model. Jul 20, 2011

Pubmed Data : Eur Heart J. 2011 Jul 20. Epub 2011 Jul 20. PMID: 21775390
Article Published Date : Jul 20, 2011
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Drug-Induced Toxicity , Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Simvastatin decreases coenzyme q10 levels in the left ventricle of the heart and skeletal muscle.Jan 01, 2007

Pubmed Data : Physiol Res. 2007;56 Suppl 2:S49-54. Epub 2007 Sep 5. PMID: 17824807
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Cardiovascular Diseases, Drug-Induced Nutrient Depletion: Statin Drugs, Hypertension, Statin-Induced Pathologies
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]

Simvastatin worsens the myocardial mitochondrial respiration during ischemia probably due to depletion of coenzyme Q10. Sep 01, 1995

Pubmed Data : Br J Pharmacol. 1995 Sep ;116(2):1894-8. PMID: 8528576
Article Published Date : Sep 01, 1995
Study Type : Animal Study
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Mitochondrial Dysfunction , Myocardial Ischemia, Statin-Induced Pathologies
Pharmacological Actions : Enzyme Inhibitors
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]

Statin administration in animals results in a myopathy characterized by decreased muscle force and elevated plasma CK level.Nov 09, 2011

Pubmed Data : J Muscle Res Cell Motil. 2011 Nov 9. Epub 2011 Nov 9. PMID: 22068225
Article Published Date : Nov 09, 2011
Study Type : Animal Study
Additional Links
Diseases : Creatine Phosphokinase (CK): Elevated, Myalgias, Myopathies, Statin-Induced Pathologies
Problem Substances : Fluvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs exhibit myotoxic, neurotoxic, hepatotoxic and testicule damaging properties in the anima model.Jul 01, 1996

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Pathol. 1996 Jul-Aug;24(4):468-76. PMID: 8864188
Article Published Date : Jul 01, 1996
Study Type : Animal Study
Additional Links
Diseases : Brain Damage, Liver Damage: Drug-Induced, Statin-Induced Pathologies, Testicular Diseases
Pharmacological Actions : Anticholesteremic Agents, Enzyme Inhibitors
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic, Myotoxicity, Neurotoxic
[+]

"Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes."Oct 25, 2011

Pubmed Data : Free Radic Biol Med. 2011 Oct 25. Epub 2011 Oct 25. PMID: 22080086
Article Published Date : Oct 25, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Mitochondrial Dysfunction , Myopathies, Statin-Induced Pathologies
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

An explanation of the mechanism of statin-induced contractile dysfunction in rat cultured skeletal myofibers.Jan 01, 2010

Pubmed Data : J Pharmacol Sci. 2010;114(4):454-63. Epub 2010 Nov 26. PMID: 21127387
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Atorvastin reduces coenzyme Q content and heart mitochondrial function in an animal model. Jan 01, 2011

Pubmed Data : Bratisl Lek Listy. 2011 ;112(11):603-4. PMID: 22180983
Article Published Date : Jan 01, 2011
Study Type : Review
Additional Links
Diseases : Congestive Heart Failure, Drug-Induced Nutrient Depletion: Statin Drugs, Lipid Peroxidation, Mitochondrial Dysfunction
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]

Coenzyme Q10 deficiency may be one mechanism for statin-induced myopathies.Jan 01, 2010

Pubmed Data : Ochsner J. 2010 ;10(1):16-21. PMID: 21603349
Article Published Date : Jan 01, 2010
Study Type : Review
Additional Links
Diseases : Coenzyme Q10 Deficiency, Drug-Induced Nutrient Depletion: Statin Drugs, Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

It is thought that as many as 25% of statin users who exercise may experience muscle fatigue, weakness, aches, and cramping due to statin therapy and potentially dismissed by the patient and physician.Dec 01, 2006

Pubmed Data : Am J Physiol Cell Physiol. 2006 Dec ;291(6):C1208-12. Epub 2006 Aug 2. PMID: 16885396
Article Published Date : Dec 01, 2006
Study Type : Review
Additional Links
Diseases : Muscle Damage: Exercise-Induced, Myalgias, Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Apoptotic
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Muscle cells may be particularly susceptible to a statin-induced suppression of essential antioxidant selenoproteinsOct 19, 2012

Pubmed Data : Toxicol Lett. 2012 Oct 20. Epub 2012 Oct 20. PMID: 23092657
Article Published Date : Oct 19, 2012
Study Type : In Vitro Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Mineral Deficiencies: Selenium, Myopathies, Statin-Induced Pathologies
Problem Substances : Cerivastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Muscle problems due to statins have been underestimated and may be as prevalent as 10%.Jan 01, 2010

Pubmed Data : Ned Tijdschr Geneeskd. 2010 ;154:A1684. PMID: 21435278
Article Published Date : Jan 01, 2010
Study Type : Review
Additional Links
Diseases : Muscle Soreness, Myalgias, Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Myopathy is a therapeutic limitation of statin drug therapy. Sep 01, 2006

Pubmed Data : Expert Opin Drug Saf. 2006 Sep ;5(5):651-66. PMID: 16907655
Article Published Date : Sep 01, 2006
Study Type : Review
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Review provides evidence that mitochondrial mechanisms for statin-induced muscle adverse effects (AEs) have implications to non-muscle AEs ranging from thyroid dysfunction to neuropathy to cognitive loss.Jan 01, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cardiovasc Drugs. 2008 ;8(6):373-418. PMID: 19159124
Article Published Date : Jan 01, 2008
Study Type : Review
Additional Links
Diseases : Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Review: Clinical characterization and molecular mechanisms of statin myopathy.Aug 01, 2008

Pubmed Data : Expert Rev Cardiovasc Ther. 2008 Aug ;6(7):955-69. PMID: 18666846
Article Published Date : Aug 01, 2008
Study Type : Review
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Review: molecular pathogenesis of statin myopathy.May 01, 2005

Pubmed Data : Muscle Nerve. 2005 May ;31(5):572-80. PMID: 15712281
Article Published Date : May 01, 2005
Study Type : Review
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Rhabdomyolysis is a rare but clinically important adverse event of statin monotherapy or combination therapy.Sep 01, 2001

Pubmed Data : Ann Pharmacother. 2001 Sep ;35(9):1096-107. PMID: 11573861
Article Published Date : Sep 01, 2001
Study Type : Review
Additional Links
Diseases : Rhabdomyolysis
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Simvastatin-induced inhibition of mitochondrial respiration is likely associated myotoxicity. Aug 04, 2011

Pubmed Data : Biochim Biophys Acta. 2011 Aug 4. Epub 2011 Aug 4. PMID: 21839782
Article Published Date : Aug 04, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Mitochondrial Dysfunction , Mitochondrial Myopathies
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs are associated with iatrognic myopathy. Oct 01, 2010

Pubmed Data : Curr Opin Neurol. 2010 Oct ;23(5):445-9. PMID: 20581681
Article Published Date : Oct 01, 2010
Study Type : Review
Additional Links
Diseases : Myopathy: Iatrogenic, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs exhibit myotoxicity. Mar 01, 1995

Pubmed Data : Toxicol Appl Pharmacol. 1995 Mar ;131(1):163-74. PMID: 7878672
Article Published Date : Mar 01, 1995
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs have been identified to cause neuromyotoxicity. Apr 01, 2005

Pubmed Data : Drugs Today (Barc). 2005 Apr ;41(4):267-93. PMID: 16034491
Article Published Date : Apr 01, 2005
Study Type : Review
Additional Links
Diseases : Neuromyotoxicity
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity, Neurotoxic
[+]

Statin drugs have been linked to rhabdomyolysis, myositis and kidney failure. Oct 21, 2011

Pubmed Data : Curr Vasc Pharmacol. 2011 Oct 21. Epub 2011 Oct 21. PMID: 22022768
Article Published Date : Oct 21, 2011
Study Type : Review
Additional Links
Diseases : Kidney Damage: Drug-Induced, Kidney Failure, Myositis, Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity, Nephrotoxic
[+]

Statin drugs induce cell death in rat myotubes. Nov 01, 2004

Pubmed Data : Toxicol Appl Pharmacol. 2004 Nov 1 ;200(3):237-50. PMID: 15504460
Article Published Date : Nov 01, 2004
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Apoptotic
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs may induce selenium deficiency which may explain many of its enigmatic side effects.Mar 13, 2004

Pubmed Data : Lancet. 2004 Mar 13;363(9412):892-4. PMID: 15031036
Article Published Date : Mar 13, 2004
Study Type : Review
Additional Links
Diseases : Coronary Artery Disease, Drug-Induced Nutrient Depletion: Statin Drugs, High Cholesterol, Mineral Deficiencies: Selenium, Statin-Induced Pathologies
Additional Keywords : Statin-Selenium Deficiency
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-associated myopathy is a significant problem with a prevalence rate between 1-5%. Apr 02, 2003

Pubmed Data : JAMA. 2003 Apr 2 ;289(13):1681-90. PMID: 12672737
Article Published Date : Apr 02, 2003
Study Type : Review
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-induced Ca(2+) release from ryanodine-sensitive stores and mitochondria an may contribute to myotoxicity. Jan 01, 2009

Pubmed Data : J Atheroscler Thromb. 2009;16(6):870-7. Epub 2009 Dec 22. PMID: 20032581
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-induced myopathy is associated with skeletal muscle cell MHC I expression changes.Feb 01, 2010

Pubmed Data : Muscle Nerve. 2010 Feb ;41(2):179-84. PMID: 19813190
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Skeletal Muscle: Changes to MHC I expression, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-induced myopathy occurs in between 10-15% of users.Feb 23, 2011

Pubmed Data : Expert Opin Drug Saf. 2011 Feb 23. Epub 2011 Feb 23. PMID: 21342078
Article Published Date : Feb 23, 2011
Study Type : Review
Additional Links
Diseases : Myopathies
Problem Substances : Atorvastatin, Rosuvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-mediated myopathy is likely mediated by reductions in protein prenylation and especially N-linked glycosylation.Apr 15, 2010

Pubmed Data : Biochem Pharmacol. 2010 Apr 15 ;79(8):1200-9. Epub 2009 Dec 14. PMID: 20018177
Article Published Date : Apr 15, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statins alter mitochondrial function which may be associated with myotoxicity in skeletal muscle.Apr 15, 2005

Pubmed Data : Biochem Biophys Res Commun. 2005 Apr 15 ;329(3):1067-75. PMID: 15752763
Article Published Date : Apr 15, 2005
Study Type : In Vitro Study
Additional Links
Diseases : Mitochondrial Dysfunction , Mitochondrial Myopathies, Statin-Induced Pathologies
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

The adverse effects associated with statin drug use has been linked to mitochondrial dysfunction.Jan 01, 2008

Article Published Date : Jan 01, 2008
Study Type : Review
Additional Links
Diseases : Mitochondrial Dysfunction , Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

The incidence of statin-induced rhabdomyolysis is higher in practice than in controlled trials in which high-risk subjects are excluded. May 01, 2006

Pubmed Data : Am J Med. 2006 May ;119(5):400-9. PMID: 16651050
Article Published Date : May 01, 2006
Study Type : Review
Additional Links
Diseases : Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

The incidence of statin-related myopathy may be as high as 10.5%. Mar 18, 2011

Pubmed Data : Angiology. 2011 Mar 18. Epub 2011 Mar 18. PMID: 21421631
Article Published Date : Mar 18, 2011
Study Type : Review
Additional Links
Diseases : Myopathies
Problem Substances : Rosuvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

The myotoxicity of statin drugs may be due to the inhibition of the geranylgeranylation of low-molecular-weight proteins in the muscle cells.Jul 01, 1997

Pubmed Data : Toxicol Appl Pharmacol. 1997 Jul ;145(1):99-110. PMID: 9221829
Article Published Date : Jul 01, 1997
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

The statin drug atorvastatin induces adverse ultrastructural changes in muscle cells apparent through electron microscopy.Jan 01, 2004

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):32-7. PMID: 16146045
Article Published Date : Jan 01, 2004
Study Type : In Vitro Study
Additional Links
Diseases : Skeletal Muscle Changes: Ultrastructural Changes, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity, Neurotoxic
[+]

The total rhabdomyolysis rate for cerivastatin was 16 - 80 times more frequent than with other statins without providing additional efficacy. Sep 01, 2002

Pubmed Data : Expert Opin Drug Saf. 2002 Sep ;1(3):207-12. PMID: 12904136
Article Published Date : Sep 01, 2002
Study Type : Review
Additional Links
Diseases : Rhabdomyolysis
Problem Substances : Cerivastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity

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