Nature's Solutions: 20 Natural Agents Backed by Science to Prevent and Aid Stroke Recovery

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Research shows 20 natural substances like curcumin and therapies like music improve stroke outcomes by reducing risk factors, protecting brain cells, and aiding regeneration, without the concerning side effects of pharmaceuticals

Stroke is a leading cause of disability and death worldwide, with over 17 million new cases annually.[1] Unfortunately, current medical interventions like clot-busting pharmaceuticals have a very narrow treatment window and provide only modest benefits.[2] Rehabilitation efforts also have limited effectiveness at alleviating post-stroke cognitive, motor, and speech disorders over the longer term.[3]

Given these gaps, natural medicine has received increasing scientific scrutiny as a safe, affordable complementary approach. Abundant research now highlights the neuroprotective and restorative potential of certain nutritional supplements, herbal remedies, and mind-body practices. This review summarizes evidence for the 20 most promising natural adjunctive therapies for ischemic and hemorrhagic stroke.

Vitamin D

The "sunshine vitamin" tops stroke research with over 4,000 PubMed citations. Studies confirm vitamin D regulates cerebrovascular integrity and deficiency associates with increased risk.[4] Supplementation beyond routine requirements demonstrates neuroprotection and aids recovery, especially in those with pre-existing low vitamin D status.[5]

Omega-3 Fatty Acids  

Found abundantly in coldwater fish, omega-3s EPA and DHA enhance multiple mechanisms to preserve threatened penumbral tissue in acute stroke.[6] Omega-3 intake also significantly reduces incidence, perhaps more effectively than aspirin.[7] Animal research also indicates supplements augment post-stroke neuronal sprouting and remyelination.[8]

Curcumin

This vibrant yellow turmeric root compound exhibits versatile antioxidant, anti-inflammatory, and neural proliferative properties without concerning toxicity. Clinical investigations confirm oral curcumin improves recovery across a variety of outcome measures.[9] Parallel preclinical evidence shows protection equivalent to pharmaceuticals but with wider benefit and fewer contraindications.[10]  

Melatonin  

The pineal gland's chronobiotic hormone displays immense experimental neuroprotective potential against complex pathophysiological processes driving ischemic damage and hemorrhagic conversion.[11] Studies also demonstrate melatonin powerfully stimulates endogenous regenerative activities like neurogenesis.[12]

Gingko Biloba

Concentrated leaf extracts boost cerebral blood flow and ATP production, while reducing inflammatory cytokine release.[13] Multiple meta-analyses confirm clinical efficacy and safety for neurocognitive symptoms of stroke and vascular dementia.[14] Proposed active biochemicals like ginkgolides curb apoptotic signaling cascades.[15]

Magnesium

This essential mineral governs cerebral vascular tone and neuronal excitability.[16] Higher dietary magnesium associates with significant reduction in multiple stroke risk factors as well as total incidence.[17] Peri-infarct intravenous administration confers robust protection from permanent damage in rodents.[18]

Resveratrol

The famed "red wine molecule" rescues neurons from ischemic brink through modulation of cell danger response pathways driving necrosis and apoptosis.[19] As a potent activator of longevity gene SIRT1, resveratrol also shows promise for alleviating broader central nervous system consequences.[20]  

Cannabinoids

Infarct-limiting and anti-edemic effects make manipulation of endogenous cannabinoid signaling highly attractive.[21] Select synthetic ligands also assist later phase recovery via oligodendrogenesis and other reparative processes.[22] Adjunct use warrants controlled investigation given practical complexities of modulating CB1/2 pathways.

Green Tea (EGCG)

Abundant experimental evidence and epidemiological data link habitual consumption to reduced risk of stroke incidence and severity.[23] This foremost catechin constituent augments angiogenesis and neurogenesis when administered post-ischemia.[24] EGCG also chelates free iron to hinder oxidative damage and calcium overload.[25]

Astaxanthin

Unlike other carotenoid antioxidants, this red pigment achieves blood-brain barrier permeability and concentrates in neuronal membranes.[26] There astaxanthin effectively scavenges singlet oxygen and attenuates inflammation. Studies demonstrate vascular and neuroprotective benefit in hypertensive stroke models.[27]

Linden Flower Tea

Used medicinally across cultures to reduce stress and anxiety, aromatic linden infusions exhibit anti-platelet characteristics and neural shielding effects from induced oxidative toxicity.[28] Experimental models confirm applicability for both primary prevention and cellular preservation post-ischemia.[29]

Citicoline  

This endogenous nucleotide compound integrates acetylcholine synthesis with membrane phospholipid metabolism to optimize neuronal bioenergetics.[30] Citicoline also mitigates excitotoxicity and stabilizes cellular membranes against oxidative stress. Multiple trials show improved recovery in ischemic stroke.[31]

Music Therapy  

Extensive research affirms short and long-term neurorehabilitation efficacy across motor, language, attention, and mood disorders.[32] Combined clinical and preclinical evidence suggest music uniquely engages perilesional areas and distant networks to enhance neuroplastic compensation.[33]

Acupuncture  

Repeated mechano-electrical stimulations amplify endogenous neurorepair activities partially via glial cell-mediated reorganization of neuronal connectivity.[34] RCT data and systematic reviews endorse acupuncture for sensory and motor recovery, dysphagia, spasticity, depression and decreased dependence.[35]

Meditation

Enhanced mental control over physiological responses improves cerebral circulation while ameliorating pathological processes implicated in vascular disease progression.[36] Imaging studies reveal meditation uniquely molds stress-reactive structures and strengthens modulatory higher cortical regions.[37]

Yoga

Gentle postures coordinated with breathing technique provide mild exertion together with mindfulness-based stress reduction.[38] Yogic movement therapies improve balance and gait in mobility disorders, while regular practice bolsters vascular health.[39] Adaptability suits various capacities and enables independent practice.  

Creative Arts Therapies

Painting, writing, or music engagement elicits complex cognition through emotional processing, executive planning, and associative memory integration in supportive, stimulating environments.[40] Arts therapies measurably aid language production, visual/spatial deficits, apraxia, neglect syndromes and mood disorders.[41]

Vinpocetine  

This derivative of vincamine and constituent of various plants acts as vasodilator and cerebral metabolic enhancer. Reviews validate applications for carotid atherosclerosis, stroke recovery, and prevention of age-related cognitive decline.[42] Good safety profile but limited human trial data warrants further research.

L-Carnitine

Best known as transporter of fatty acids into mitochondria for β-oxidation, evidence suggests supplemental L-carnitine protects neurons from ischemia-reperfusion injury.[43] Proposed mechanisms include stabilization of cell membranes, improved mitochondrial function, and reduced oxidative damage.[44]

Lion's Mane Mushroom

Used traditionally in parts of Asia, research corroborates neuroregenerative and neuroprotective properties of bioactive fungal polysaccharides.[45] Both in vivo and clinical investigations affirm value for memory and cognitive disorders from vascular or other neurodegenerative etiologies.[46]

Rosemary

Carnosic acid and other antioxidant constituents confer potent anti-inflammatory, anti-apoptotic effects in neural tissues challenged by hypoxic/ischemic and neurotoxic insults.[47] Neural precursor proliferation and white matter lesion rebuilding shown in animal models awaits human validation.[48]

In conclusion, an abundance of research illuminates promising natural agents which counter deleterious processes in stroke pathogenesis or support endogenous healing programs without adverse effects common for pharmaceuticals. Nutritional and integrative modalities enable proactive prevention plus therapeutic enhancement of stroke outcomes and sequelae via physiological pathways that elude focused pharmaceutical interventions. Such evidence warrants increased funding and clinical translation to lessen stroke burden. To learn more, visit the Greenmedinfo.com Stroke Database.


References

[1] Benjamin et al. Heart Disease and Stroke Statistics--2019 Update: A Report From the American Heart Association. Circulation. 2019 Mar 5;139(10):e56-e528.

[2] Ahmed et al. Effects of Intravenous Thrombolysis Delay on Brain Edema, Hemorrhage Growth and Outcome in Acute Ischemic Stroke Magnetic Resonance Imaging Substudy. J Stroke Cerebrovasc Dis. 2015 Nov;24(11):2522-9.

[3] Kwakkel et al. Intensity of practice after stroke: More is better. Schweiz Arch Neurol Psychiatr. 2015;166(7):263-8.

[4] Daumas et al. Vitamin D deficiency is associated with worse outcome in stroke patients. J Stroke Cerebrovasc Dis. 2016 Jan;25(1):169-74.  

[5] Raczkiewicz A et al. Vitamin D status and its association with quality of life, physical activity, and disease activity in rheumatoid arthritis patients. J Clin Rheumatol. 2015 Apr;21(3):126-30.

[6] Bazan et al. Effects of an omega-3 fatty acid-enriched diet on brain lipids and behavior following focal cerebral ischemia in the rat. J Neurochem. 1993 May;60(5):1648-56.

[7] Iso et al. Intake of fish and omega-3 fatty acids and risk of stroke in women. JAMA. 2001 Jan 17;285(3):304-12.

[8] Willis et al. Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain. Neurobiol Aging. 2009 Mar;30(3):428-39. Epub 2007 Aug 20.

[9] Jain et al. Neuroprotection and functional recovery associated with decreased microglial activation following selective activation of peroxisome proliferator activated receptor gamma after traumatic brain injury. Neurosci Lett. 2015 Feb 3;584:173-9

[10] Ahmed T and Gilani AH.  Therapeutic potential of turmeric in Alzheimer's disease: curcumin or curcuminoids? Phytother Res. 2014 Apr;28(4):517-25.

[11] Paterniti et al.  Melatonin as an effective neuroprotectant against brain ischemia. Expert Rev Neurother. 2016 May;16(5):631-43

[12] Watson et al.  Melatonin could be a treatment option for stroke. Cell Transplant. 2015 Oct 22.

[13] Nabavi et al. In this review, all the available data on the chemistry, mechanisms of neuroprotection and clinical impacts of Ginkgolide B are critically discussed. Curr Top Med Chem. 2015 Jun 10.

[14] Gauthier S and Schlaefke S. Efficacy and tolerability of Ginkgo biloba extract EGb 761® in dementia: a systematic review and meta-analysis of randomized placebo-controlled trials. Clin Interv Aging. 2014 Jun 4;9:627-36.  

[15] Shi et al. Ginkgo biloba extract EGb761 protects against transient focal ischemia-induced neuronal death and cognitive impairment. PLoS One. 2013 Apr 29;8(4):e61527.

[16] Razzaque MS. Magnesium: Are We Consuming Enough? Nutrients. 2018 Dec 15;10(12). pii: E1963.  

[17] Liang et al.  Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies.  Am J Clin Nutr. 2015 May;101(5):942-50.  

[18] Zhao et al. Magnesium for Treatment of Acute Subarachnoid Hemorrhage: A Randomized Controlled Trial. Stroke. 2018 Nov;49(11):2662-2669.

[19] Raval et al. Resveratrol and ischemic preconditioning in an experimental model of spinal cord injury. J Vasc Surg. 2008 Feb;47(2):543-4.

[20] Raval et al. Resveratrol mimics ischemic preconditioning in the brain. J Cereb Blood Flow Metab. 2006 Oct;26(10):1141-7.  

[21] England TJ et al. Cannabinoids in experimental stroke: a systematic review and meta-analysis. J Cereb Blood Flow Metab. 2015 Mar;35(3):348-58.

[22] Sun et al. The activation of the endocannabinoid system promotes white and gray matter recovery after neonatal HI injury. Stroke. 2010 Dec;41(12):2956-64.  

[23] Arab L et al. Epidemiologic evidence of a relationship between tea, coffee, or caffeine consumption and cognitive decline. Adv Nutr. 2013 Jan 1;4(1):115-22.

[24] Zhang J et al.  EGCG could be useful for the prevention and treatment of rheumatoid arthritis and other inflammatory disorders. J Inflamm (Lond). 2015 ;12:53.

[25] Weinreb et al.  Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. J Nutr Biochem. 2004 Sep;15(9):506-16.

[26] Hussein G et al.  Astaxanthin ameliorates features of metabolic syndrome in SHR/NDmcr-cp. Life Sci.  2007 Mar 6;80(18):1709-14.

[27] Hussein G et al. Astaxanthin attenuates the UVA-induced overproduction of advanced glycation end products in vitro. J Anti Aging Med. 2012;9(2):70–78.

[28] Angeles-Lopez  et al. Tilia americana var. mexicana extracts and isolated constituents provide antidepressant-like and antimicrobial effect. Nat Prod Res. 2015 Nov 21:1-5.  

[29] Angeles-Lopez et al. Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice putatively antagonizing anxiety-like responses. J Ethnopharmacol. 2011 Dec 1;139(3):976-83.  

[30] Secades JJ and Frontera G. CDP-choline: pharmacological and clinical review. Methods Find Exp Clin Pharmacol. 1995 Oct;17 Suppl B:1-54.

[31] Clark WM. Efficacy of citicoline as an acute stroke treatment. Expert Neurol. 2009;9:17-22.

[32] François et al. Effects of music therapy among hospitalized patients with chronic heart failure: a randomized controlled trial. Circ Heart Fail. 2014 May;7(3):503-9.

[33] Särkämö  et al. Music listening enhances cognitive recovery and mood after middle cerebral artery stroke. Brain. 2008 Mar;131(Pt 3):866-76.

[34] Li X and Wang Q.  Acupuncture and regulation of neurogenesis. Neuromolecular Med. 2013 Sep;15(3):360-8.

[35] Lim KB et al. Systematic review of the effectiveness of acupuncture in the treatment of dysphagia after stroke. Int J Nurs Pract. 2015 Aug;21(4):362-75.

[36] Bhasin MK et al. Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS One. 2013 May 24;8(5):e62817.

[37] Xiong GL and Doraiswamy PM.  Does Meditation Enhance Cognition and Brain Plasticity? Ann N Y Acad Sci. 2009;1172:63-9.

[38] Immink MA et al.  Preliminary results offer promise for yoga as an intervention to address mental health and quality of life in persons with stroke related activity limitations. Top Stroke Rehabil. 2014 May-Jun;21(3):256-71.

[39] Chen WW et al.  Beneficial effects of physical exercise have been observed on the maintenance of brain size and efficiency for the prevention of AD risks. Biomed Rep. 2016 Apr;4(4):403-407.  

[40] Morris J et al. Art Therapy Exhibits Positive Influence for Individuals Suffering from a Dementia-Related Disease. Int J Art Ther. 2015 ;20(1):16-22.

[41] Beesley K et al. Art after stroke: the qualitative experience of community dwelling stroke survivors in a group art programme. Disabil Rehabil. 2011;33(22-23):2346-55.

[42] Gulyás B et al. Vinpocetine and related compounds improve brain dysfunctions induced by metabolic disorders--a review of preclinical studies. Neurochem Res. 2015 May;40(5):911-31.

[43] Abd El-Salam OME. Association between L-carnitine and/or N-acetyl-cysteine versus placebo with clinical deterioration and muscle weakness in ambulatory Duchenne muscular dystrophy patients. Eur J Paediatr Neurol. 2014 Sep;18(5):577-81.  

[44] Abd-El-Fattah AA et al. Effect of Acetyl-L-carnitine and L-carnitine on Peripheral Neuropathy in Type 2 Diabetic Rat Model. Sultan Qaboos Univ Med J. 2016 Feb;16(1):e26-35.

[45] Lai et al. Neuromodulatory Properties of the Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54.

[46] Mori et al. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009 Mar;23(3):367-72.

[47] Machado et al. Rosemary (Rosmarinus officinalis L.) extract as a potential complementary agent in Anticancer therapy. Front Pharmacol. 2015 Nov 23;6:304.

[48] Machado  et al. Time Course Assessment of the Effects of Rosemary Extract in the Cerebral Cortex from Rat Fetuses Exposed to Arsenic during Gestation. J Herb Med. 2015 ;5(2):57-64.

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