Teratogenic

Name	AC	CK
Coffee	4	42
Caffeine	4	40
Wheat	3	40
Gluten	3	31
Statin Drugs	8	25
Gliadin	2	20
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	20
Retinyl palmitate	4	16
Atorvastatin	2	12
Fluoxetine (trade name Prozac)	3	12
Uranium: Depleted	2	11
Anaesthetic Gases	1	10
Angiotensin Receptor Blockers (ARBs)	1	10
Angiotensin-Converting Enzyme (ACE) Inhibitor	1	10
Antibiotics	1	10
Celecoxib	1	10
Diclofenac	1	10
Ibuprofen	1	10
Naproxen	1	10
Pesticides	1	10
Pivmecillinam	1	10
Polycyclic aromatic hydrocarbon	1	10
Radiation Exposure	1	10
Rofecoxib	1	10
Selective Serotonin Reuptake Inhibitors (SSRIs)	1	10
Tea	1	10
Tobacco Smoke: Passive	1	10
Zolpidem (trade name Ambien)	1	10
Lovastatin	3	9
Perchlorate	4	7
Glyphosate	3	6
Sodium Fluoride	3	6
Fluoride	2	4
Letrozole (trade name Femera)	2	4
Potato	2	4
Roundup (herbicide)	2	4
Zinc Chloride	2	4
Methotrexate	1	3
Arsenic	1	2
Bisphenol A	1	2
Phthalates	1	2
Retinyl Acetate	1	2
Sodium Selenate	1	2
Sodium Selenite	1	2
Solanum Species	1	2
Spirosolane	1	2
Vitamin A acetate	1	2
Vitamin A palmitate	1	2
Formaldehyde	1	1
Radioiodine 131	1	1
Simvastatin	1	1
Warfarin	1	1

Name	AC	CK
Abortion: Spontaneous	15	130
Miscarriage	13	114
Birth Defects	24	93
Prenatal Chemical Exposures	25	82
Celiac Disease	3	31
Gluten Sensitivity	2	30
Drug-Induced Toxicity	3	22
Statin-Induced Pathologies	6	21
Fetal Death	1	20
Pregnancy Complications	2	20
Infertility: Male	4	15
Infertility	3	14
Prenatal Nutrition: Prevention of Problems	3	14
Infertility: Female	2	12
Prenatal Nutrition: Health of the Offspring	2	12
Miscarriage: Recurrent	2	11
Abnormalities	1	10
Anthrax	1	10
DNA damage	1	10
Drug-Induced	1	10
Female Urogenital Diseases and Pregnancy Complications	1	10
Heart Defects: Congenital	1	10
Neural Tube Defects	1	10
Pregnancy Complications: Urinary Tract Infections	1	10
Sperm Count: Low	1	10
Sperm Quality: Low	1	10
Spina Bifida	1	10
Vaccine-induced Toxicity	1	10
Pregnancy: Environmental Exposures	3	7
Fluoride Toxicity	3	6
Neurotoxicity	1	5
Cardiomyopathy	1	3
Drug Toxicity: Methotrexate	1	3
Scoliosis	1	3
Breastfeeding Concerns: Chemical Exposure	1	2
Hepatomegaly	1	2
Huntington Disease	1	2
Infant Mortality	1	2
Microcephaly	1	2
Obsessive-Compulsive Disorder	1	2
Phthalate Toxicity	1	2
Schizophrenia	1	2
Tourette Syndrome	1	2
Female	1	1
Hypothyroidism	1	1
Low Testosterone	1	1
Prenatal Radiation Exposure	1	1
Radiation-Induced Illness: Radioiodine (Iodine-131)	1	1
Thyroid Diseases	1	1

[+]

Consumption of coffee during pregnancy was associated with a higher risk of fetal death, especially losses occurring after 20 completed weeks of gestation.Nov 15, 2005

Click here to read the entire abstract

Pubmed Data : Am J Epidemiol. 2005 Nov 15;162(10):983-90. Epub 2005 Oct 5. PMID: 16207803

Article Published Date : Nov 15, 2005

Study Type : Meta Analysis

Additional Links

Diseases : Abortion: Spontaneous, Fetal Death, Miscarriage

Problem Substances : Coffee

Adverse Pharmacological Actions : Teratogenic

[+]

Recurrent miscarriages may occur due to undiagnosed celiac disease, and may resolve after a gluten-free diet.Nov 01, 2008

Click here to read the entire abstract

Pubmed Data : Dig Dis Sci. 2008 Nov;53(11):2925-8. Epub 2008 Mar 27. PMID: 18368491

Article Published Date : Nov 01, 2008

Study Type : Meta Analysis

Additional Links

Diseases : Celiac Disease, Gluten Sensitivity

Problem Substances : Gluten, Wheat

Adverse Pharmacological Actions : Teratogenic

[+]

Birth defects are more common in pregnant women who received the anthrax vaccine during their first trimester versus later in pregnancy. Aug 15, 2008

Click here to read the entire abstract

Pubmed Data : Am J Epidemiol. 2008 Aug 15 ;168(4):434-42. Epub 2008 Jul 2. PMID: 18599489

Article Published Date : Aug 15, 2008

Study Type : Human Study

Additional Links

Diseases : Anthrax, Birth Defects, Vaccine-induced Toxicity

Anti Therapeutic Actions : Vaccination: All, Vaccination: Anthrax

Adverse Pharmacological Actions : Teratogenic

[+]

Celiac disease associated antibodies are higher in Argentine women with recurrent pregnancy loss.Mar 01, 2006

Click here to read the entire abstract

Pubmed Data : Am J Reprod Immunol. 2006 Mar;55(3):201-7. PMID: 16451354

Article Published Date : Mar 01, 2006

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous, Miscarriage: Recurrent

Problem Substances : Gliadin, Wheat

Adverse Pharmacological Actions : Teratogenic

[+]

Coffee drinking early in pregnancy is associated with an increased risk of abortion.Aug 01, 1998

Click here to read the entire abstract

Pubmed Data : Hum Reprod. 1998 Aug;13(8):2286-91. PMID: 9756312

Article Published Date : Aug 01, 1998

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous, Miscarriage

Problem Substances : Coffee

Adverse Pharmacological Actions : Teratogenic

[+]

Environmental tobacco smoke increases the risk of spontaneous abortion.Sep 01, 2006

Click here to read the entire abstract

Pubmed Data : Epidemiology. 2006 Sep;17(5):500-5. PMID: 16837826

Article Published Date : Sep 01, 2006

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous, Miscarriage

Problem Substances : Tobacco Smoke: Passive

Adverse Pharmacological Actions : Teratogenic

[+]

Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial.Jul 11, 2014

Click here to read the entire abstract

Pubmed Data : Reprod Biol Endocrinol. 2014 Jul 12 ;12(1):65. Epub 2014 Jul 12. PMID: 25016482

Article Published Date : Jul 11, 2014

Study Type : Human Study

Additional Links

Diseases : Birth Defects, Infertility: Male, Sperm Count: Low, Sperm Quality: Low

Problem Substances : Atorvastatin

Adverse Pharmacological Actions : Teratogenic

[+]

Heavy caffeine consumption (especially when there is nausea) during pregnancy may increase the risk of spontaneous abortion.May 01, 1991

Click here to read the entire abstract

Pubmed Data : Epidemiology. 1991 May;2(3):168-74. PMID: 2054397

Article Published Date : May 01, 1991

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous, Miscarriage

Problem Substances : Caffeine

Adverse Pharmacological Actions : Teratogenic

[+]

High dietary intake of preformed vitamin A appears to be teratogenic. Among the babies born to women who took more than 10,000 IU of preformed vitamin A per day in the form of supplements, we estimate that about 1 infant in 57 had a malformation attributaNov 23, 1995

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : N Engl J Med. 1995 Nov 23 ;333(21):1369-73. PMID: 7477116

Article Published Date : Nov 23, 1995

Study Type : Human Study

Additional Links

Substances : Vitamin A

Diseases : Abnormalities, Birth Defects, Drug-Induced, Prenatal Nutrition: Prevention of Problems

Problem Substances : Retinyl palmitate

Adverse Pharmacological Actions : Teratogenic

[+]

Human epidemiological evidence is consistent with increased risk of birth defects in offspring of persons exposed to depleted uranium.Jan 01, 2005

Click here to read the entire abstract

Pubmed Data : Environ Health. 2005;4:17. Epub 2005 Aug 26. PMID: 16124873

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Diseases : Birth Defects

Problem Substances : Uranium: Depleted

Adverse Pharmacological Actions : Teratogenic

[+]

Increased risk of adverse pregnancy outcomes in women receiving zolpidem during pregnancy.Sep 01, 2010

Click here to read the entire abstract

Pubmed Data : Clin Pharmacol Ther. 2010 Sep;88(3):369-74. Epub 2010 Aug 4. PMID: 20686480

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Diseases : Pregnancy Complications, Prenatal Chemical Exposures

Problem Substances : Zolpidem (trade name Ambien)

Adverse Pharmacological Actions : Teratogenic

[+]

Maternal caffeine consumption has been linked to neural tube defects.Nov 01, 2009

Click here to read the entire abstract

Pubmed Data : Birth Defects Res A Clin Mol Teratol. 2009 Nov;85(11):879-89. PMID: 19711421

Article Published Date : Nov 01, 2009

Study Type : Human Study

Additional Links

Diseases : Neural Tube Defects, Prenatal Nutrition: Health of the Offspring, Spina Bifida

Problem Substances : Caffeine

Adverse Pharmacological Actions : Teratogenic

[+]

Maternal caffeine consumption is associated with an increased risk of spontaneous abortion.May 01, 1996

Click here to read the entire abstract

Pubmed Data : Epidemiology. 1996 May;7(3):250-5. PMID: 8728437

Article Published Date : May 01, 1996

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous, Miscarriage

Problem Substances : Caffeine, Coffee, Tea

Adverse Pharmacological Actions : Teratogenic

[+]

Maternal exposure to occupational hazards associated with radiation, pesticides and anesthetic gases (e.g. veterinary practice) is associated with an increased risk of spontaneous abortions.Nov 01, 2008

Click here to read the entire abstract

Pubmed Data : Occup Environ Med. 2008 Nov;65(11):719-25. Epub 2008 Apr 3. PMID: 18388114

Article Published Date : Nov 01, 2008

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous, Miscarriage

Problem Substances : Anaesthetic Gases, Pesticides, Radiation Exposure

Adverse Pharmacological Actions : Teratogenic

[+]

Newborns exposed in utero to SSRIs, have a twofold higher risk of mild nonsyndromic heart defects than unexposed infants.Oct 01, 2009

Click here to read the entire abstract

Pubmed Data : Birth Defects Res A Clin Mol Teratol. 2009 Oct;85(10):837-41. PMID: 19691085

Article Published Date : Oct 01, 2009

Study Type : Human Study

Additional Links

Diseases : Heart Defects: Congenital, Prenatal Chemical Exposures

Problem Substances : Fluoxetine (trade name Prozac) , Selective Serotonin Reuptake Inhibitors (SSRIs)

Adverse Pharmacological Actions : Teratogenic

[+]

Risk documentation occured in only 20% of women age 15-45 prescribed a medication known to contribute to birth defects. May 01, 2011

Click here to read the entire abstract

Pubmed Data : J Am Board Fam Med. 2011 May-Jun;24(3):262-71. PMID: 21551398

Article Published Date : May 01, 2011

Study Type : Human Study

Additional Links

Diseases : Birth Defects, Drug-Induced Toxicity , Statin-Induced Pathologies

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor , Angiotensin Receptor Blockers (ARBs), Statin Drugs

Adverse Pharmacological Actions : Teratogenic

[+]

Taking non-aspirin NSAIDs in early pregnancy doubles the risk of miscarriage. Jan 01, 2011

Click here to read the entire abstract

Pubmed Data : BMJ. 2011 ;343:d5769. Epub 2011 Sep 9. PMID: 21908536

Article Published Date : Jan 01, 2011

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous, Drug-Induced Toxicity , Miscarriage

Pharmacological Actions : Teratogens

Problem Substances : Celecoxib, Diclofenac, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Rofecoxib

Adverse Pharmacological Actions : Teratogenic

[+]

The ingestion of caffeine may increase the risk of an early spontaneous abortion among non-smoking women carrying fetuses with normal karyotypes.Dec 21, 2000

Click here to read the entire abstract

Pubmed Data : N Engl J Med. 2000 Dec 21;343(25):1839-45. PMID: 11117975

Article Published Date : Dec 21, 2000

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous, Miscarriage

Problem Substances : Caffeine

Adverse Pharmacological Actions : Teratogenic

[+]

Transplacental polycyclic aromatic hydrocarbons exposure to the fetus is compromising fetal development.Jun 01, 1999

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 1999 Jun;107 Suppl 3:451-60. PMID: 10346993

Article Published Date : Jun 01, 1999

Study Type : Human Study

Additional Links

Diseases : DNA damage, Prenatal Chemical Exposures

Problem Substances : Polycyclic aromatic hydrocarbon

Adverse Pharmacological Actions : Teratogenic

[+]

Unexplained infertility in women may be due to celiac disease.Jun 01, 2007

Click here to read the entire abstract

Pubmed Data : Minerva Med. 2007 Jun;98(3):217-9. PMID: 17592443

Article Published Date : Jun 01, 2007

Study Type : Human Study

Additional Links

Diseases : Celiac Disease, Gluten Sensitivity, Infertility, Infertility: Female

Problem Substances : Gliadin, Gluten, Wheat

Adverse Pharmacological Actions : Teratogenic

[+]

Use of non-steroidal anti-inflammatory drugs during pregnancy is associated with increased risk of miscarriage.Feb 03, 2001

Click here to read the entire abstract

Pubmed Data : BMJ. 2001 Feb 3;322(7281):266-70. PMID: 11157526

Article Published Date : Feb 03, 2001

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous, Miscarriage

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Teratogenic

[+]

Use of pivmecillinam (antibiotic) is associated with an increased risk of miscarriage.Apr 01, 2008

Click here to read the entire abstract

Pubmed Data : APMIS. 2008 Apr;116(4):278-83. PMID: 18397462

Article Published Date : Apr 01, 2008

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous, Female Urogenital Diseases and Pregnancy Complications, Miscarriage, Pregnancy Complications, Pregnancy Complications: Urinary Tract Infections, Prenatal Chemical Exposures

Additional Keywords : Antibiotic Use in Pregnancy

Problem Substances : Antibiotics, Pivmecillinam

Adverse Pharmacological Actions : Teratogenic

[+]

Lovastatin exhibits toxicity in human fetal brain cells.Jan 01, 1995

Click here to read the entire abstract

Pubmed Data : Neurotoxicol Teratol. 1995 Jan-Feb;17(1):31-9. PMID: 7708017

Article Published Date : Jan 01, 1995

Study Type : Human In Vitro

Additional Links

Diseases : Abortion: Spontaneous, Birth Defects, Neurotoxicity, Prenatal Chemical Exposures

Pharmacological Actions : Antiproliferative

Problem Substances : Lovastatin

Adverse Pharmacological Actions : Neurotoxic, Teratogenic

[+]

Central nervous system and limb anomalies have been reported in first-trimester statin exposure.Apr 08, 2004

Click here to read the entire abstract

Pubmed Data : N Engl J Med. 2004 Apr 8 ;350(15):1579-82. PMID: 15071140

Article Published Date : Apr 08, 2004

Study Type : Human: Case Report

Additional Links

Diseases : Birth Defects, Pregnancy: Environmental Exposures, Statin-Induced Pathologies

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Teratogenic

[+]

Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly has been reported. Jun 30, 2005

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : N Engl J Med. 2005 Jun 30 ;352(26):2759. PMID: 15987932

Article Published Date : Jun 30, 2005

Study Type : Human: Case Report

Additional Links

Diseases : Birth Defects, Pregnancy: Environmental Exposures, Statin-Induced Pathologies

Problem Substances : Lovastatin, Statin Drugs

Adverse Pharmacological Actions : Teratogenic

[+]

High-dose methotrexate during pregnancy is associated malformations. Oct 01, 2010

Click here to read the entire abstract

Pubmed Data : Prescrire Int. 2010 Oct;19(109):212-3. PMID: 21180376

Article Published Date : Oct 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Birth Defects, Cardiomyopathy, Drug Toxicity: Methotrexate, Prenatal Chemical Exposures, Scoliosis

Problem Substances : Methotrexate

Adverse Pharmacological Actions : Teratogenic

[+]

"According to US EPA, 2,4-D in agricultural scenarios may be up to three times higher than the NOEC values for teratogenic effects reported in this study. "Aug 01, 2011

Click here to read the entire abstract

Pubmed Data : Environ Toxicol. 2011 Aug ;26(4):373-81. Epub 2010 Jan 28. PMID: 20112415

Article Published Date : Aug 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Birth Defects

Adverse Pharmacological Actions : Teratogenic

[+]

"Teratogenic effects of chronic ingestion of high levels of vitamin A (retinyl acetate) in cats."Feb 01, 2003

Click here to read the entire abstract

Pubmed Data : J Anim Physiol Anim Nutr (Berl). 2003 Feb ;87(1-2):42-51. PMID: 14511148

Article Published Date : Feb 01, 2003

Study Type : Animal Study

Additional Links

Diseases : Birth Defects

Problem Substances : Retinyl Acetate

Adverse Pharmacological Actions : Teratogenic

[+]

A two-generational reproductive study of zinc chloride in rats demonstrates it causes significant pathological changes in a wide range of tissues.May 01, 2007

Click here to read the entire abstract

Pubmed Data : J Environ Sci Health B. 2007 May;42(4):403-15. PMID: 17474020

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Problem Substances : Zinc Chloride

Adverse Pharmacological Actions : Cytotoxic, Genotoxic, Teratogenic

[+]

Adverse effects were observed as a result of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice.Jan 01, 2003

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2003 Jan ;41(1):61-71. PMID: 12453729

Article Published Date : Jan 01, 2003

Study Type : Animal Study

Additional Links

Substances : Eggplant, Potato, Solanum Species, Tomato

Diseases : Birth Defects, Hepatomegaly, Infertility, Miscarriage

Adverse Pharmacological Actions : Abortive, Teratogenic

[+]

Aloe vera protects against fluoride-induced teratogenic effects during pre- and postnatal development in mice.Aug 31, 2022

Click here to read the entire abstract

Pubmed Data : Environ Sci Pollut Res Int. 2022 Sep ;29(42):63577-63587. Epub 2022 Apr 23. PMID: 35460489

Article Published Date : Aug 31, 2022

Study Type : Animal Study

Additional Links

Substances : Aloe Vera

Diseases : Fluoride Toxicity , Prenatal Chemical Exposures

Problem Substances : Sodium Fluoride

Adverse Pharmacological Actions : Teratogenic

[+]

Coffee intake during pregnancy should be limited since it produces significant and long-lasting teratopharmacological and behavioral alterations in the offspring.Jan 01, 1996

Click here to read the entire abstract

Pubmed Data : Acta Physiol Pharmacol Bulg. 1996 ;22(2):51-61. PMID: 9465968

Article Published Date : Jan 01, 1996

Study Type : Animal Study

Additional Links

Substances : Coffee

Diseases : Prenatal Chemical Exposures, Prenatal Nutrition: Health of the Offspring, Prenatal Nutrition: Prevention of Problems

Problem Substances : Coffee

Adverse Pharmacological Actions : Teratogenic

[+]

Developmental exposure to perchlorate alters synaptic transmission in hippocampus of the adult rat.Jun 01, 2008

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 2008 Jun;116(6):752-60. PMID: 18560531

Article Published Date : Jun 01, 2008

Study Type : Animal Study

Additional Links

Diseases : Prenatal Chemical Exposures

Problem Substances : Perchlorate

Adverse Pharmacological Actions : Teratogenic

[+]

Drugs targeting cholesterol synthesis are embryo lethal in mice and likely contribute to birth defects in humans. Feb 01, 2011

Click here to read the entire abstract

Pubmed Data : Drug Metab Rev. 2011 Feb ;43(1):69-90. PMID: 21247357

Article Published Date : Feb 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Birth Defects, Infant Mortality , Statin-Induced Pathologies

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Teratogenic

[+]

Environmentally relevant concentrations of ammonium perchlorate inhibit thyroid function and alter sex ratios in developing Xenopus laevis.Mar 01, 2002

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Chem. 2002 Mar;21(3):590-7. PMID: 11878472

Article Published Date : Mar 01, 2002

Study Type : Animal Study

Additional Links

Problem Substances : Perchlorate

Adverse Pharmacological Actions : Mutagenic, Teratogenic

[+]

Fluoride exposure over several generations results in adverse histopathological and biochemical changes in lung tissue. Nov 01, 2003

Click here to read the entire abstract

Pubmed Data : J Appl Toxicol. 2003 Nov-Dec;23(6):437-46. PMID: 14635268

Article Published Date : Nov 01, 2003

Study Type : Animal Study

Additional Links

Diseases : Fluoride Toxicity

Problem Substances : Fluoride, Sodium Fluoride

Adverse Pharmacological Actions : Teratogenic

[+]

Gestational exposure to doses of letrozole that are equal to or lower than the daily recommended human dose has toxic effects on prenatal development in rats.Aug 01, 2008

Click here to read the entire abstract

Pubmed Data : Hum Reprod. 2008 Aug;23(8):1719-23. Epub 2008 May 15. PMID: 18487213

Article Published Date : Aug 01, 2008

Study Type : Animal Study

Additional Links

Diseases : Birth Defects, Drug-Induced Toxicity , Prenatal Chemical Exposures

Problem Substances : Letrozole (trade name Femera)

Adverse Pharmacological Actions : Embryotoxic, Teratogenic

[+]

Glyphosate-based herbicides produce teratogenic (birth defect causing) effects including microcephaly in vertebrates by impairing retinoic acid signaling. Oct 17, 2010

Click here to read the entire abstract

Pubmed Data : Chem Res Toxicol. 2010 Oct 18 ;23(10):1586-95. Epub 2010 Aug 9. PMID: 20695457

Article Published Date : Oct 17, 2010

Study Type : Animal Study

Additional Links

Diseases : Microcephaly

Problem Substances : Glyphosate, Roundup (herbicide)

Adverse Pharmacological Actions : Teratogenic

[+]

High dose vitamin A palmitate results in fused carpal bone defects in rat fetuses.Jun 01, 2010

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2010 Jun;29(6):439-50. Epub 2010 Mar 17. PMID: 20237176

Article Published Date : Jun 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Birth Defects, Prenatal Chemical Exposures

Problem Substances : Vitamin A palmitate

Adverse Pharmacological Actions : Teratogenic

[+]

Letrozole has a toxic effect on the embryos of rats. Nov 01, 2009

Click here to read the entire abstract

Pubmed Data : Hum Reprod. 2009 Nov;24(11):2688-92. Epub 2009 Jul 27. PMID: 19638353

Article Published Date : Nov 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Abortion: Spontaneous, Birth Defects, Prenatal Chemical Exposures

Problem Substances : Letrozole (trade name Femera)

Adverse Pharmacological Actions : Embryotoxic, Teratogenic

[+]

Low doses of vitamin A (retinyl acetate) result in defects in offspring of animals and perhaps humans when consumed during the early gestational period.Oct 01, 2000

Click here to read the entire abstract

Pubmed Data : Teratology. 2000 Oct;62(4):214-26. PMID: 10992263

Article Published Date : Oct 01, 2000

Study Type : Animal Study

Additional Links

Diseases : Birth Defects

Problem Substances : Vitamin A acetate

Adverse Pharmacological Actions : Teratogenic

[+]

Low levels of selenium, fluoride and arsenic are toxic to rat embryos.Mar 30, 1999

Click here to read the entire abstract

Pubmed Data : Wei Sheng Yan Jiu. 1999 Mar 30;28(2):74-6. PMID: 11939006

Article Published Date : Mar 30, 1999

Study Type : Animal Study

Additional Links

Diseases : Birth Defects, Prenatal Chemical Exposures

Additional Keywords : Drug Synergy

Problem Substances : Arsenic, Fluoride, Sodium Selenate, Sodium Selenite

Adverse Pharmacological Actions : Teratogenic

[+]

Maternal exposure to agrochemicals (such as glyphosate) during pregnancy induces a variety of functional abnormalities in the specific activity of the enzymes in the studied organs of the pregnant rats and their fetuses.Mar 01, 2001

Click here to read the entire abstract

Pubmed Data : Environ Res. 2001 Mar ;85(3):226-31. PMID: 11237511

Article Published Date : Mar 01, 2001

Study Type : Animal Study

Additional Links

Diseases : Prenatal Chemical Exposures

Problem Substances : Glyphosate

Adverse Pharmacological Actions : Endocrine Disruptor, Teratogenic

[+]

Perchlorate induces hermaphroditism in threespine sticklebacks.Aug 01, 2006

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Chem. 2006 Aug;25(8):2087-96. PMID: 16916028

Article Published Date : Aug 01, 2006

Study Type : Animal Study

Additional Links

Problem Substances : Perchlorate

Adverse Pharmacological Actions : Endocrine Disruptor, Teratogenic

[+]

Phthalate esters with long-term low-dose exposure may pose male reproductive toxicity in humans.Feb 28, 2017

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2017 Mar ;101:94-104. Epub 2017 Jan 12. PMID: 28089693

Article Published Date : Feb 28, 2017

Study Type : Animal Study

Additional Links

Diseases : Infertility: Male, Phthalate Toxicity

Problem Substances : Phthalates

Adverse Pharmacological Actions : Teratogenic

[+]

Pre- and postnatal toxicity of the HMG-CoA reductase inhibitor atorvastatin in rats.Dec 31, 1997

Click here to read the entire abstract

Pubmed Data : Toxicol Sci. 1998 Jan ;41(1):88-99. PMID: 9520344

Article Published Date : Dec 31, 1997

Study Type : Animal Study

Additional Links

Diseases : Infertility, Infertility: Female, Infertility: Male

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Teratogenic

[+]

Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life.May 31, 2009

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Health Perspect. 2009 Jun ;117(6):879-85. Epub 2009 Jan 15. PMID: 19590677

Article Published Date : May 31, 2009

Study Type : Animal Study

Additional Links

Diseases : Prenatal Chemical Exposures

Pharmacological Actions : Teratogens

Additional Keywords : Multi-Generational Effects

Problem Substances : Bisphenol A

Adverse Pharmacological Actions : Carcinogenic, Teratogenic

[+]

Retinyl (retinol) palmitate feeding results in abnormal development and abnormalities in the embryos of mice.Apr 01, 2003

Click here to read the entire abstract

Pubmed Data : Biol Pharm Bull. 2003 Apr;26(4):553-6. PMID: 12673043

Article Published Date : Apr 01, 2003

Study Type : Animal Study

Additional Links

Diseases : Prenatal Chemical Exposures

Problem Substances : Retinyl palmitate

Adverse Pharmacological Actions : Teratogenic

[+]

Retinyl palmitate exhibits teratrogenic properties. Dec 01, 2009

Click here to read the entire abstract

Pubmed Data : Indian J Exp Biol. 2009 Dec ;47(12):949-54. PMID: 20329697

Article Published Date : Dec 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Birth Defects, Prenatal Chemical Exposures

Problem Substances : Retinyl palmitate

Adverse Pharmacological Actions : Teratogenic

[+]

Retinyl palmitate induces malformations in the embryos of pregnant rats.Sep 01, 1996

Click here to read the entire abstract

Pubmed Data : Pharmacol Toxicol. 1996 Sep;79(3):131-5. PMID: 8884871

Article Published Date : Sep 01, 1996

Study Type : Animal Study

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Diseases : Birth Defects, Prenatal Chemical Exposures

Problem Substances : Retinyl palmitate

Adverse Pharmacological Actions : Teratogenic

[+]

Sodium flouride exposure during pregnancy may interfere with normal development and increase the risk of neurological and psychiatric disorders in adulthood.Jun 01, 2010

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2010 Jun;14(6):507-12. PMID: 20712257

Article Published Date : Jun 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Fluoride Toxicity , Huntington Disease, Obsessive-Compulsive Disorder, Prenatal Chemical Exposures, Schizophrenia, Tourette Syndrome

Problem Substances : Sodium Fluoride

Adverse Pharmacological Actions : Genotoxic, Teratogenic

[+]

Spirosolane-containing Solanum species are capable of inducing congenital craniofacial malformations.Jan 01, 1990

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Pubmed Data : Toxicon. 1990 ;28(8):873-84. PMID: 2080514

Article Published Date : Jan 01, 1990

Study Type : Animal Study

Additional Links

Substances : Potato, Solanum Species

Diseases : Birth Defects

Problem Substances : Potato, Solanum Species, Spirosolane

Adverse Pharmacological Actions : Teratogenic

[+]

Sprouted potato may contain glycoalkaloids which could be teratogenic.Feb 01, 1993

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Pubmed Data : Zhonghua Fu Chan Ke Za Zhi. 1993 Feb;28(2):73-5, 121-2. PMID: 8344084

Article Published Date : Feb 01, 1993

Study Type : Animal Study

Additional Links

Diseases : Prenatal Nutrition: Prevention of Problems

Problem Substances : Potato

Adverse Pharmacological Actions : Teratogenic

[+]

Statin drugs cause early embryo lethality in animals. Oct 31, 2003

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Pubmed Data : J Biol Chem. 2003 Oct 31 ;278(44):42936-41. Epub 2003 Aug 14. PMID: 12920113

Article Published Date : Oct 31, 2003

Study Type : Animal Study

Additional Links

Diseases : Birth Defects

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Teratogenic

[+]

Statin drugs have been shown to cause adverse effects in pregnant rats and their offspring, including fetal death. Oct 17, 2011

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Pubmed Data : Birth Defects Res B Dev Reprod Toxicol. 2011 Oct 17. Epub 2011 Oct 17. PMID: 22006546

Article Published Date : Oct 17, 2011

Study Type : Animal Study

Additional Links

Diseases : Abortion: Spontaneous, Birth Defects, Statin-Induced Pathologies

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Teratogenic

[+]

The glyphosate herbicide Roundup exhibits teratogenic potential in rats. Apr 30, 2003

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Pubmed Data : Toxicol Lett. 2003 Apr 30;142(1-2):45-52. PMID: 12765238

Article Published Date : Apr 30, 2003

Study Type : Animal Study

Additional Links

Diseases : Prenatal Chemical Exposures

Problem Substances : Glyphosate, Roundup (herbicide)

Adverse Pharmacological Actions : Endocrine Disruptor, Teratogenic

[+]

Zinc chloride exposure results in developmental and reproductive toxicities. Oct 25, 2010

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Pubmed Data : Reprod Toxicol. 2010 Oct 25. Epub 2010 Oct 25. PMID: 20977935

Article Published Date : Oct 25, 2010

Study Type : Animal Study

Additional Links

Diseases : Breastfeeding Concerns: Chemical Exposure, Prenatal Chemical Exposures

Problem Substances : Zinc Chloride

Adverse Pharmacological Actions : Teratogenic

[+]

Depleted uranium has genotoxic, carcinogenic and mutagenic properties.Jun 01, 2001

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Pubmed Data : Toxicol Ind Health. 2001 Jun;17(5-10):180-91. PMID: 12539863

Article Published Date : Jun 01, 2001

Study Type : Review

Additional Links

Diseases : Infertility: Male

Problem Substances : Uranium: Depleted

Adverse Pharmacological Actions : Cardiotoxic, Genotoxic, Teratogenic

[+]

Fetal exposure to radioiodine may result in major malformations, thyroid dysfunction, miscarriage, death and thyroid cancer later in life.Jan 17, 2011

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Pubmed Data : Endocr Pract. 2011 Jan 17:1-10. Epub 2011 Jan 17. PMID: 21247851

Article Published Date : Jan 17, 2011

Study Type : Review

Additional Links

Diseases : Birth Defects, Miscarriage, Prenatal Radiation Exposure, Radiation-Induced Illness: Radioiodine (Iodine-131), Thyroid Diseases

Problem Substances : Radioiodine 131

Adverse Pharmacological Actions : Carcinogenic, Teratogenic

[+]

Fluoxetine exhibits embrytoxicity.Dec 19, 2008

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Pubmed Data : Life Sci. 2008 Dec 19;83(25-26):871-7. Epub 2008 Oct 28. PMID: 18996131

Article Published Date : Dec 19, 2008

Study Type : In Vitro Study

Additional Links

Diseases : Prenatal Chemical Exposures

Problem Substances : Fluoxetine (trade name Prozac)

Adverse Pharmacological Actions : Teratogenic

[+]

Fluoxetine may adversely affect fetal neural development.Sep 20, 2010

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Pubmed Data : J Neurosci Res. 2010 Sep 20. Epub 2010 Sep 20. PMID: 20857517

Article Published Date : Sep 20, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Prenatal Chemical Exposures

Problem Substances : Fluoxetine (trade name Prozac)

Adverse Pharmacological Actions : Teratogenic

[+]

Formaldehyde adducts may induce mitochondrial dysfunction.Jul 01, 2001

Click here to read the entire abstract

Pubmed Data : Arch Environ Health. 2001 Jul-Aug;56(4):300-11. PMID: 11572272

Article Published Date : Jul 01, 2001

Study Type : Review

Additional Links

Diseases : Female

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Formaldehyde

Adverse Pharmacological Actions : Teratogenic

[+]

Perchlorate has significant potential to adversely affect neurodevelopment in the developing fetus.May 10, 2006

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Pubmed Data : Anal Chim Acta. 2006 May 10;567(1):4-12. Epub 2006 Mar 27. PMID: 17723372

Article Published Date : May 10, 2006

Study Type : Commentary

Additional Links

Diseases : Hypothyroidism, Prenatal Chemical Exposures

Problem Substances : Perchlorate

Adverse Pharmacological Actions : Teratogenic

[+]

Recurrent miscarriages may be due to undiagnosed celiac disease.Feb 01, 2000

Click here to read the entire abstract

Pubmed Data : Recenti Prog Med. 2000 Feb;91(2):72-5. PMID: 10748651

Article Published Date : Feb 01, 2000

Study Type : Review

Additional Links

Diseases : Abortion: Spontaneous, Celiac Disease, Miscarriage, Miscarriage: Recurrent

Problem Substances : Gluten

Adverse Pharmacological Actions : Teratogenic

[+]

Simvastatin suppresses human testicular testosterone synthesis.Apr 01, 1991

Click here to read the entire abstract

Pubmed Data : J Steroid Biochem Mol Biol. 1991 Apr ;38(4):465-8. PMID: 2031860

Article Published Date : Apr 01, 1991

Study Type : In Vitro Study

Additional Links

Diseases : Low Testosterone, Pregnancy: Environmental Exposures, Statin-Induced Pathologies

Problem Substances : Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Endocrine Disruptor, Teratogenic

[+]

Warfarin and lovastatin exhibit embryotoxic potential.Aug 01, 2010

Click here to read the entire abstract

Pubmed Data : Reprod Toxicol. 2010 Aug;30(1):121-30. Epub 2010 May 20. PMID: 20493250

Article Published Date : Aug 01, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Prenatal Chemical Exposures

Problem Substances : Lovastatin, Warfarin

Adverse Pharmacological Actions : Embryotoxic, Teratogenic

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View the Evidence: 66 Abstracts with Teratogenic Research

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Consumption of coffee during pregnancy was associated with a higher risk of fetal death, especially losses occurring after 20 completed weeks of gestation.Nov 15, 2005

Recurrent miscarriages may occur due to undiagnosed celiac disease, and may resolve after a gluten-free diet.Nov 01, 2008

Birth defects are more common in pregnant women who received the anthrax vaccine during their first trimester versus later in pregnancy. Aug 15, 2008

Celiac disease associated antibodies are higher in Argentine women with recurrent pregnancy loss.Mar 01, 2006

Coffee drinking early in pregnancy is associated with an increased risk of abortion.Aug 01, 1998

Environmental tobacco smoke increases the risk of spontaneous abortion.Sep 01, 2006

Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial.Jul 11, 2014

Heavy caffeine consumption (especially when there is nausea) during pregnancy may increase the risk of spontaneous abortion.May 01, 1991

High dietary intake of preformed vitamin A appears to be teratogenic. Among the babies born to women who took more than 10,000 IU of preformed vitamin A per day in the form of supplements, we estimate that about 1 infant in 57 had a malformation attributaNov 23, 1995

Human epidemiological evidence is consistent with increased risk of birth defects in offspring of persons exposed to depleted uranium.Jan 01, 2005

Increased risk of adverse pregnancy outcomes in women receiving zolpidem during pregnancy.Sep 01, 2010

Maternal caffeine consumption has been linked to neural tube defects.Nov 01, 2009

Maternal caffeine consumption is associated with an increased risk of spontaneous abortion.May 01, 1996

Maternal exposure to occupational hazards associated with radiation, pesticides and anesthetic gases (e.g. veterinary practice) is associated with an increased risk of spontaneous abortions.Nov 01, 2008

Newborns exposed in utero to SSRIs, have a twofold higher risk of mild nonsyndromic heart defects than unexposed infants.Oct 01, 2009

Risk documentation occured in only 20% of women age 15-45 prescribed a medication known to contribute to birth defects. May 01, 2011

Taking non-aspirin NSAIDs in early pregnancy doubles the risk of miscarriage. Jan 01, 2011

The ingestion of caffeine may increase the risk of an early spontaneous abortion among non-smoking women carrying fetuses with normal karyotypes.Dec 21, 2000

Transplacental polycyclic aromatic hydrocarbons exposure to the fetus is compromising fetal development.Jun 01, 1999

Unexplained infertility in women may be due to celiac disease.Jun 01, 2007

Use of non-steroidal anti-inflammatory drugs during pregnancy is associated with increased risk of miscarriage.Feb 03, 2001

Use of pivmecillinam (antibiotic) is associated with an increased risk of miscarriage.Apr 01, 2008

Lovastatin exhibits toxicity in human fetal brain cells.Jan 01, 1995

Central nervous system and limb anomalies have been reported in first-trimester statin exposure.Apr 08, 2004

Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly has been reported. Jun 30, 2005

High-dose methotrexate during pregnancy is associated malformations. Oct 01, 2010

"According to US EPA, 2,4-D in agricultural scenarios may be up to three times higher than the NOEC values for teratogenic effects reported in this study. "Aug 01, 2011

"Teratogenic effects of chronic ingestion of high levels of vitamin A (retinyl acetate) in cats."Feb 01, 2003

A two-generational reproductive study of zinc chloride in rats demonstrates it causes significant pathological changes in a wide range of tissues.May 01, 2007

Adverse effects were observed as a result of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice.Jan 01, 2003

Aloe vera protects against fluoride-induced teratogenic effects during pre- and postnatal development in mice.Aug 31, 2022

Coffee intake during pregnancy should be limited since it produces significant and long-lasting teratopharmacological and behavioral alterations in the offspring.Jan 01, 1996

Developmental exposure to perchlorate alters synaptic transmission in hippocampus of the adult rat.Jun 01, 2008

Drugs targeting cholesterol synthesis are embryo lethal in mice and likely contribute to birth defects in humans. Feb 01, 2011

Environmentally relevant concentrations of ammonium perchlorate inhibit thyroid function and alter sex ratios in developing Xenopus laevis.Mar 01, 2002

Fluoride exposure over several generations results in adverse histopathological and biochemical changes in lung tissue. Nov 01, 2003

Gestational exposure to doses of letrozole that are equal to or lower than the daily recommended human dose has toxic effects on prenatal development in rats.Aug 01, 2008

Glyphosate-based herbicides produce teratogenic (birth defect causing) effects including microcephaly in vertebrates by impairing retinoic acid signaling. Oct 17, 2010

High dose vitamin A palmitate results in fused carpal bone defects in rat fetuses.Jun 01, 2010

Letrozole has a toxic effect on the embryos of rats. Nov 01, 2009

Low doses of vitamin A (retinyl acetate) result in defects in offspring of animals and perhaps humans when consumed during the early gestational period.Oct 01, 2000

Low levels of selenium, fluoride and arsenic are toxic to rat embryos.Mar 30, 1999

Maternal exposure to agrochemicals (such as glyphosate) during pregnancy induces a variety of functional abnormalities in the specific activity of the enzymes in the studied organs of the pregnant rats and their fetuses.Mar 01, 2001

Perchlorate induces hermaphroditism in threespine sticklebacks.Aug 01, 2006

Phthalate esters with long-term low-dose exposure may pose male reproductive toxicity in humans.Feb 28, 2017

Pre- and postnatal toxicity of the HMG-CoA reductase inhibitor atorvastatin in rats.Dec 31, 1997

Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life.May 31, 2009

Retinyl (retinol) palmitate feeding results in abnormal development and abnormalities in the embryos of mice.Apr 01, 2003

Retinyl palmitate exhibits teratrogenic properties. Dec 01, 2009

Retinyl palmitate induces malformations in the embryos of pregnant rats.Sep 01, 1996

Sodium flouride exposure during pregnancy may interfere with normal development and increase the risk of neurological and psychiatric disorders in adulthood.Jun 01, 2010

Spirosolane-containing Solanum species are capable of inducing congenital craniofacial malformations.Jan 01, 1990

Sprouted potato may contain glycoalkaloids which could be teratogenic.Feb 01, 1993

Statin drugs cause early embryo lethality in animals. Oct 31, 2003

Statin drugs have been shown to cause adverse effects in pregnant rats and their offspring, including fetal death. Oct 17, 2011

The glyphosate herbicide Roundup exhibits teratogenic potential in rats. Apr 30, 2003

Zinc chloride exposure results in developmental and reproductive toxicities. Oct 25, 2010

Depleted uranium has genotoxic, carcinogenic and mutagenic properties.Jun 01, 2001

Fetal exposure to radioiodine may result in major malformations, thyroid dysfunction, miscarriage, death and thyroid cancer later in life.Jan 17, 2011

Fluoxetine exhibits embrytoxicity.Dec 19, 2008

Fluoxetine may adversely affect fetal neural development.Sep 20, 2010

Formaldehyde adducts may induce mitochondrial dysfunction.Jul 01, 2001

Perchlorate has significant potential to adversely affect neurodevelopment in the developing fetus.May 10, 2006

Recurrent miscarriages may be due to undiagnosed celiac disease.Feb 01, 2000

Simvastatin suppresses human testicular testosterone synthesis.Apr 01, 1991

Warfarin and lovastatin exhibit embryotoxic potential.Aug 01, 2010

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View the Evidence:
66 Abstracts with Teratogenic Research