Ulcerogenic

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6 Problem Substances Researched for Ulcerogenic

Name	AC	CK
Alendronate (trade name Fosamax)	8	63
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	3	30
Aspirin	3	22
Naproxen	1	10
Pamidronate	1	10
Atorvastatin	1	3

11 Diseases Researched for Ulcerogenic

Name	AC	CK
Gastric Ulcer	8	57
Drug-Induced Toxicity: Gastrointestinal	2	20
Osteoporosis	2	11
Duodenal Ulcer	1	10
Esophageal Cancer	1	10
Esophageal Diseases	1	10
Esophagitis	1	10
Statin-Induced Pathologies	1	3
Aspirin-Induced Toxicity	1	2
Esophageal Ulcer	1	1
Gastric Cancer	1	1

Research Articles 10
Cumulative Knowledge Score 16
Overall Research Rating GOOD

View the Evidence:
10 Abstracts with Ulcerogenic Research

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Alendronate and naproxen are synergistic for development of gastric ulcers.Jan 08, 2001

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Pubmed Data : Arch Intern Med. 2001 Jan 8;161(1):107-10. PMID: 11146706

Article Published Date : Jan 08, 2001

Study Type : Human Study

Additional Links

Diseases : Duodenal Ulcer, Gastric Ulcer

Additional Keywords : Toxic Drug Synergy

Problem Substances : Alendronate (trade name Fosamax) , Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Ulcerogenic

[+]

Alendronate has been associated with esophageal injury in users.Dec 01, 1999

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Pubmed Data : Mod Pathol. 1999 Dec;12(12):1152-7. PMID: 10619269

Article Published Date : Dec 01, 1999

Study Type : Human Study

Additional Links

Diseases : Esophageal Cancer, Gastric Ulcer

Problem Substances : Alendronate (trade name Fosamax)

Adverse Pharmacological Actions : Ulcerogenic

[+]

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

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Pubmed Data : Aliment Pharmacol Ther. 2000 Nov;14(11):1451-7. PMID: 11069316

Article Published Date : Nov 01, 2000

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastric Ulcer, Osteoporosis

Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Gastrotoxic, Ulcerogenic

[+]

Alendronate users have an increased rate of esophageal and gastric events.Sep 01, 2000

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Pubmed Data : Pharmacoepidemiol Drug Saf. 2000 Sep;9(5):371-6. PMID: 19025842

Article Published Date : Sep 01, 2000

Study Type : Human Study

Additional Links

Diseases : Esophageal Diseases, Gastric Ulcer

Problem Substances : Alendronate (trade name Fosamax)

Adverse Pharmacological Actions : Ulcerogenic

[+]

Bisphosphonates cause mucosal injury to the upper gastrointestinal tract similar to aspirin.Aug 01, 1997

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Pubmed Data : Am J Gastroenterol. 1997 Aug;92(8):1322-5. PMID: 9260798

Article Published Date : Aug 01, 1997

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastric Ulcer

Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Pamidronate

Adverse Pharmacological Actions : Gastrotoxic, Ulcerogenic

[+]

Esophagitis associated with use of alendronate has been reported in postmenopausic patients.May 01, 2001

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Pubmed Data : Acta Gastroenterol Latinoam. 2001 May;31(2):59-63. PMID: 11471319

Article Published Date : May 01, 2001

Study Type : Human Study

Additional Links

Diseases : Esophagitis

Problem Substances : Alendronate (trade name Fosamax)

Adverse Pharmacological Actions : Corrosive, Ulcerogenic

[+]

Atorvastatin-induced severe gastric ulceration has been reported. May 28, 2005

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Pubmed Data : World J Gastroenterol. 2005 May 28 ;11(20):3159-60. PMID: 15918210

Article Published Date : May 28, 2005

Study Type : Human: Case Report

Additional Links

Diseases : Gastric Ulcer, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin

Adverse Pharmacological Actions : Ulcerogenic

[+]

Alendronate is used experimentally to induce gastric damage and lesion in rat stomachs. Oct 01, 2007

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Pubmed Data : Inflammopharmacology. 2007 Oct;15(5):196-202. PMID: 17943251

Article Published Date : Oct 01, 2007

Study Type : Animal Study

Additional Links

Diseases : Gastric Ulcer

Problem Substances : Alendronate (trade name Fosamax)

Adverse Pharmacological Actions : Ulcerogenic

[+]

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

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Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063

Article Published Date : Jan 31, 2011

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor

Problem Substances : Aspirin

Adverse Pharmacological Actions : Ulcerogenic

[+]

Alendoronate has been reported to cause esophageal ulceration.Apr 01, 2001

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Pubmed Data : Arq Gastroenterol. 2001 Apr-Jun;38(2):129-31. PMID: 11793943

Article Published Date : Apr 01, 2001

Study Type : Commentary

Additional Links

Diseases : Esophageal Ulcer, Gastric Cancer, Osteoporosis

Problem Substances : Alendronate (trade name Fosamax)

Adverse Pharmacological Actions : Ulcerogenic

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Focus Your Research

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View the Evidence: 10 Abstracts with Ulcerogenic Research

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Currently Available Sorting Options

Alendronate and naproxen are synergistic for development of gastric ulcers.Jan 08, 2001

Alendronate has been associated with esophageal injury in users.Dec 01, 1999

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

Alendronate users have an increased rate of esophageal and gastric events.Sep 01, 2000

Bisphosphonates cause mucosal injury to the upper gastrointestinal tract similar to aspirin.Aug 01, 1997

Esophagitis associated with use of alendronate has been reported in postmenopausic patients.May 01, 2001

Atorvastatin-induced severe gastric ulceration has been reported. May 28, 2005

Alendronate is used experimentally to induce gastric damage and lesion in rat stomachs. Oct 01, 2007

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

Alendoronate has been reported to cause esophageal ulceration.Apr 01, 2001

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Ulcerogenic

View the Evidence:
10 Abstracts with Ulcerogenic Research