Ulcerogenic

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6 Problem Substances Researched for Ulcerogenic
NameACCKFocus
Alendronate (trade name Fosamax) 863Locked
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)330Locked
Aspirin 322Locked
Naproxen110Locked
Pamidronate110Locked
Atorvastatin13Locked
11 Diseases Researched for Ulcerogenic
NameACCKFocus
Gastric Ulcer857Locked
Drug-Induced Toxicity: Gastrointestinal220Locked
Osteoporosis211Locked
Duodenal Ulcer110Locked
Esophageal Cancer110Locked
Esophageal Diseases110Locked
Esophagitis110Locked
Statin-Induced Pathologies13Locked
Aspirin-Induced Toxicity 12Locked
Esophageal Ulcer11Locked
Gastric Cancer11Locked

View the Evidence:
10 Abstracts with Ulcerogenic Research

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Alendronate and naproxen are synergistic for development of gastric ulcers.Jan 08, 2001

Pubmed Data : Arch Intern Med. 2001 Jan 8;161(1):107-10. PMID: 11146706
Article Published Date : Jan 08, 2001
Study Type : Human Study
Additional Links
Diseases : Duodenal Ulcer, Gastric Ulcer
Additional Keywords : Toxic Drug Synergy
Problem Substances : Alendronate (trade name Fosamax) , Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse Pharmacological Actions : Ulcerogenic
[+]

Alendronate has been associated with esophageal injury in users.Dec 01, 1999

Pubmed Data : Mod Pathol. 1999 Dec;12(12):1152-7. PMID: 10619269
Article Published Date : Dec 01, 1999
Study Type : Human Study
Additional Links
Diseases : Esophageal Cancer, Gastric Ulcer
Problem Substances : Alendronate (trade name Fosamax)
Adverse Pharmacological Actions : Ulcerogenic
[+]

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

Pubmed Data : Aliment Pharmacol Ther. 2000 Nov;14(11):1451-7. PMID: 11069316
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastric Ulcer, Osteoporosis
Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse Pharmacological Actions : Gastrotoxic, Ulcerogenic
[+]

Alendronate users have an increased rate of esophageal and gastric events.Sep 01, 2000

Pubmed Data : Pharmacoepidemiol Drug Saf. 2000 Sep;9(5):371-6. PMID: 19025842
Article Published Date : Sep 01, 2000
Study Type : Human Study
Additional Links
Diseases : Esophageal Diseases, Gastric Ulcer
Problem Substances : Alendronate (trade name Fosamax)
Adverse Pharmacological Actions : Ulcerogenic
[+]

Bisphosphonates cause mucosal injury to the upper gastrointestinal tract similar to aspirin.Aug 01, 1997

Pubmed Data : Am J Gastroenterol. 1997 Aug;92(8):1322-5. PMID: 9260798
Article Published Date : Aug 01, 1997
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastric Ulcer
Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Pamidronate
Adverse Pharmacological Actions : Gastrotoxic, Ulcerogenic
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Esophagitis associated with use of alendronate has been reported in postmenopausic patients.May 01, 2001

Pubmed Data : Acta Gastroenterol Latinoam. 2001 May;31(2):59-63. PMID: 11471319
Article Published Date : May 01, 2001
Study Type : Human Study
Additional Links
Diseases : Esophagitis
Problem Substances : Alendronate (trade name Fosamax)
Adverse Pharmacological Actions : Corrosive, Ulcerogenic
[+]

Atorvastatin-induced severe gastric ulceration has been reported. May 28, 2005

Pubmed Data : World J Gastroenterol. 2005 May 28 ;11(20):3159-60. PMID: 15918210
Article Published Date : May 28, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Gastric Ulcer, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Ulcerogenic
[+]

Alendronate is used experimentally to induce gastric damage and lesion in rat stomachs. Oct 01, 2007

Pubmed Data : Inflammopharmacology. 2007 Oct;15(5):196-202. PMID: 17943251
Article Published Date : Oct 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Gastric Ulcer
Problem Substances : Alendronate (trade name Fosamax)
Adverse Pharmacological Actions : Ulcerogenic
[+]

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063
Article Published Date : Jan 31, 2011
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
Problem Substances : Aspirin
Adverse Pharmacological Actions : Ulcerogenic
[+]

Alendoronate has been reported to cause esophageal ulceration.Apr 01, 2001

Pubmed Data : Arq Gastroenterol. 2001 Apr-Jun;38(2):129-31. PMID: 11793943
Article Published Date : Apr 01, 2001
Study Type : Commentary
Additional Links
Diseases : Esophageal Ulcer, Gastric Cancer, Osteoporosis
Problem Substances : Alendronate (trade name Fosamax)
Adverse Pharmacological Actions : Ulcerogenic

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