Amyotrophic lateral sclerosis (ALS)

Name	AC	CK
Vitamin E	6	43
Cannabinoids	10	34
Coenzyme Q10	5	25
Vitamin D	4	24
Vitamin B-12	3	21
Vitamin B12: methylcobalamin	3	21
Fruit: All	2	20
Vegetables: All	2	20
Progesterone	4	18
Testosterone	3	18
Glycoaminoglycans	4	16
Antioxidant formulas	3	13
Estradiol (E(2))	7	13
Insulin-like Growth Factor (IGF-1)	4	13
Selenium	2	13
Glutathione	2	11
B-complex	1	10
Cannabis	6	10
Copper	1	10
Curcumin	9	10
Omega-3 Fatty Acids	1	10
Polyunsaturated Fatty Acids (PUFAs)	1	10
Resveratrol	7	10
Superoxide dismutase	1	10
Traditional Chinese Medicine: JWSJZ Decoction	1	10
Whey	1	10
Zinc	1	10
Alpha-Lipoic Acid	4	8
Bee Venom	4	6
Melatonin	6	6
Ashwagandha	3	5
Catechin	1	5
EGCG (Epigallocatechin gallate)	3	5
5-HTP (5-Hydroxytryptophan)	1	4
Genistein	2	4
Stilbenes	3	4
Anthocyanins	2	3
Ginkgo biloba	2	3
Palmitoylethanolamide	1	3
Polyphenols	3	3
Rosmarinic acid	2	3
Amino Acids: Branched Chain	1	2
Arginine	1	2
Arginine-alpha-ketoglutarate (AAKG)	1	2
Caprylic Acid	1	2
Carnosic Acid	1	2
Coconut Oil	1	2
Creatine	1	2
EPA (Eicosapentaenoic Acid)	1	2
Fisetin	1	2
Flavonoids	2	2
GABA (gamma-Aminobutyric Acid)	1	2
Galactooligosaccharides	1	2
Hesperidin	2	2
Medium Chain Triglycerides	1	2
Nicotinamide	1	2
Prebiotics	1	2
Pterostilbene	1	2
Pyruvate	1	2
Red Wine Extract	2	2
Rosemaric Acid	1	2
Rosemary	1	2
S-Adenosylmethionine (SAMe)	1	2
Scolopendra subspinipes mutilans	1	2
Strawberry	1	2
Wen Pi Tang	1	2
phytoestrogens	1	2
Astragaloside	1	1
Avocado	1	1
Caffeic acid phenethyl ester	1	1
Cannabidiol	1	1
Carnitine	1	1
Endocannabinoids	1	1
Folic Acid	1	1
Ginseng	1	1
Ginsenosides	1	1
Herbal Therapies (Unspecified in Abstracts)	1	1
Lemon	1	1
Olive	1	1
Panax Ginseng	1	1
Tauroursodeoxycholic acid	1	1
Tibetan Herbal Formula: Padma 28	1	1
Wine	1	1
acetyl-11-keto-beta-boswellic acid	1	1

Name	AC	CK
Pesticides	5	32
Lead	4	25
Statin Drugs	2	20
Tobacco	2	20
Lyme's Disease (Borrelia burgdorferi)	5	15
Agricultural Chemicals	1	10
L-glutamic Acid	1	10
Monosodium Glutamate (MSG)	1	10
Nicotine	1	10
Persistent organic pollutants (POPs)	1	10
Aluminum	5	8
Mercury	3	6
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	3
Excitotoxins	1	1

Name	AC	CK
Acupuncture	2	20
Stem Cell Related Therapy	7	20
Exercise	5	17
Hypnosis	1	10
Meditation	1	10
Spiritual/Religious Practice	1	10
Therapeutic Breathing	1	10
Dietary Modification: Low Carbohydrate/Ketogenic	5	7
Dietary Modification: Vegetarian	1	3
Yoga	1	3
Electroacupuncture	1	2
Exercise: Running	1	2
Exercise: Swimming	1	2
Intermittent Hypoxia (low oxygen)	1	2
Aquatic therapy	1	1
Dietary Modification: High-Fat/Low-Carbohydrate	1	1
Dietary Modification: Mediterranean Diet	1	1
Mindfullness Training	1	1

Name	AC	CK
Electromagnetic Field Harms	5	56
Electromagnetic Radiation	5	46
Mobile Phone Radiation	1	10
Vaccination: All	4	4

[+]

A systematic review and meta-analysis off the effects of cannabinoids in Amyotrophic lateral sclerosis murine models.Dec 05, 2018

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Pubmed Data : J Neurochem. 2018 Dec 6. Epub 2018 Dec 6. PMID: 30520038

Article Published Date : Dec 05, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Cannabinoids

Diseases : Amyotrophic lateral sclerosis (ALS)

[+]

In this meta-analysis, there was an observed increased risk of amytrophic lateral sclerosis in workers occupationally exposed to extremely low frequency electromagnetic fields. Feb 01, 2018

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Pubmed Data : Bioelectromagnetics. 2018 Feb ;39(2):156-163. Epub 2018 Jan 19. PMID: 29350413

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Pubmed Data : Eur J Neurol. 2017 Apr ;24(4):578-586. Epub 2017 Feb 23. PMID: 28229508

Article Published Date : Mar 31, 2017

Study Type : Human Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis, Quality of Life: Poor

Therapeutic Actions : Meditation

[+]

Antioxidants, carotenes, fruits, and vegetables were associated with higher ALS function.Oct 23, 2016

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Pubmed Data : JAMA Neurol. 2016 Oct 24. Epub 2016 Aug 24. PMID: 27775751

Article Published Date : Oct 23, 2016

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Pubmed Data : Neurology. 2005 Dec 13;65(11):1834-6. PMID: 16344537

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Epidemiol. 2011 Mar 15 ;173(6):595-602. Epub 2011 Feb 18. PMID: 21335424

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Pubmed Data : Int J Radiat Biol. 2019 03 ;95(3):368-377. Epub 2019 Jan 4. PMID: 30513241

Article Published Date : Jan 01, 2019

Study Type : Human In Vitro

Additional Links

Diseases : Amyotrophic Lateral Sclerosis

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation

Adverse Pharmacological Actions : Oxidant

[+]

Fungal infection in neural tissue of patients with amyotrophic lateral sclerosis.Nov 30, 2017

Article Published Date : Dec 31, 2016

Study Type : Human: Case Report

[ALS-like sequelae in chronic neuroborreliosis].Dec 31, 1994

A ketogenic diet in combination with nutritrional supplementation has remarkable therapeutic properties in a rodent model of ALS. Dec 31, 2013

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Pubmed Data : Neuromolecular Med. 2010 Mar ;12(1):86-97. Epub 2009 Sep 16. PMID: 19757209

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Pubmed Data : PLoS One. 2013 ;8(2):e30243. Epub 2013 Feb 6. PMID: 23405058

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Vitamin D

Diseases : Amyotrophic Lateral Sclerosis

[+]

Female sex hormones such as estradiol and exercise have a possible neuroprotective role in female patients with ALS. Apr 01, 2009

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Pubmed Data : Med Hypotheses. 2009 Apr;72(4):434-43. Epub 2009 Jan 19. PMID: 14561497

Article Published Date : Apr 01, 2009

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Pubmed Data : Neuroscience. 1999;93(2):565-72. PMID: 10465440

Article Published Date : Jan 01, 1999

Study Type : Animal Study

Additional Links

Substances : Glycoaminoglycans, Insulin-like Growth Factor (IGF-1)

Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Peripheral Neuropathies

Pharmacological Actions : Apoptotic, Neuroprotective Agents

Additional Keywords : Drug Synergy

[+]

Glycosaminoglycans co-administration enhance insulin-like growth factor-I neuroprotective and neuroregenerative activity in traumatic and genetic models of motor neuron disease.Jul 01, 2000

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Pubmed Data : Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):339-46. PMID: 10817918

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Pubmed Data : Stem Cells Transl Med. 2013 Mar ;2(3):167-74. Epub 2013 Feb 14. PMID: 23413376

Article Published Date : Feb 28, 2013

Study Type : Animal Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis

Therapeutic Actions : Stem Cell Related Therapy

Pharmacological Actions : Superoxide Dismutase Up-regulation

[+]

Neuroprotection comparison of rosmarinic acid and carnosic acid in primary cultures of cerebellar granule neurons.Nov 12, 2018

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Pubmed Data : Neurobiol Dis. 2002 Dec;11(3):457-68. PMID: 12586554

Article Published Date : Dec 01, 2002

Study Type : Animal Study

Additional Links

Substances : Progesterone

Diseases : Amyotrophic Lateral Sclerosis

Pharmacological Actions : Neuroprotective Agents

[+]

Protective effects of Withania somnifera extract in a model of amyotrophic lateral sclerosis.Oct 31, 2018

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Pubmed Data : J Neurosci Res. 2010 Mar ;88(4):896-904. PMID: 19798750

The progression of ALS is associated with oxygen radical-induced lipid peroxidative damage, indicating that antioxidant therapy may be useful. Jul 01, 1998

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Pubmed Data : J Neurosci Res. 1998 Jul 1;53(1):66-77. PMID: 9670993

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Pubmed Data : PLoS One. 2015 ;10(5):e0126355. Epub 2015 May 28. PMID: 26020962

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Vitamin D

Diseases : Amyotrophic lateral sclerosis (ALS), Vitamin D Deficiency

Additional Keywords : Risk Factors

[+]

α-Lipoic acid attenuates oxidative stress and neurotoxicity in a Drosophila model and NSC34 cell line of amyotrophic lateral sclerosis.May 25, 2018

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Pubmed Data : Brain Res Bull. 2018 May 26 ;140:299-310. Epub 2018 May 26. PMID: 29842900

Pubmed Data : Arch Toxicol. 2017 Feb ;91(2):549-599. Epub 2016 Oct 8. PMID: 27722929

Article Published Date : Jan 31, 2017

Study Type : Review

Additional Links

Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Asthma, Attention Deficit Hyperactivity Disorder, Autism, Birth Defects, Bronchitis, Infertility, Obesity, Parkinson's Disease, Pesticide Toxicity

Additional Keywords : Risk Factors

Problem Substances : Pesticides

Adverse Pharmacological Actions : Neurotoxic

[+]

A review of experimental research on herbal compounds in amyotrophic lateral sclerosis.Dec 31, 2013

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Pubmed Data : Phytother Res. 2014 Jan ;28(1):9-21. Epub 2013 Mar 21. PMID: 23519768

Article Published Date : Dec 31, 2013

Study Type : Review

Additional Links

Substances : Herbal Therapies (Unspecified in Abstracts)

Diseases : Amyotrophic Lateral Sclerosis

Additional Keywords : Plant Extracts

[+]

Acetyl-11-keto-beta boswellic acid mediated neuroprotection in methyl mercury-induced experimental model of ALS.May 31, 2021

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Pubmed Data : Neurochem Res. 2021 Jun 1. Epub 2021 Jun 1. PMID: 34075522

Article Published Date : May 31, 2021

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Pubmed Data : Antioxidants (Basel). 2019 Aug 22 ;8(9). Epub 2019 Aug 22. PMID: 31443476

Article Published Date : Aug 21, 2019

Study Type : Review

Additional Links

Substances : Anthocyanins

Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases, Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Antioxidant and anti-inflammatory effects of citrus flavonoid hesperetin.Jul 09, 2020

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Pubmed Data : Antioxidants (Basel). 2020 Jul 10 ;9(7). Epub 2020 Jul 10. PMID: 32664395

Cultivating stem cells for treating amyotrophic lateral sclerosis.Dec 25, 2012

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Pubmed Data : Neuropharmacology. 2008 Jun;54(7):1112-9. Epub 2008 Mar 16. PMID: 18436268

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis, Inflammation

Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Neuroprotective Agents, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ginseng and its constituents have potential merits in the treatment of cerebral disorders.Dec 31, 2015

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Pubmed Data : Am J Respir Crit Care Med. 2013 Mar 1 ;187(5):535-42. Epub 2012 Dec 6. PMID: 23220913

Article Published Date : Feb 28, 2013

Study Type : Review

Additional Links

Diseases : Amyotrophic Lateral Sclerosis

Therapeutic Actions : Stem Cell Related Therapy

Pharmacological Actions : Superoxide Dismutase Up-regulation

[+]

It has been suggested that where it is legal to do so, marijuana should be considered in the pharmacological management of ALS.Jul 01, 2001

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Pubmed Data : Toxicol Appl Pharmacol. 2011 Mar 15;251(3):217-25. Epub 2011 Jan 13. PMID: 21237187

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Pubmed Data : Antioxidants (Basel). 2021 Apr 25 ;10(5). Epub 2021 Apr 25. PMID: 33923111

Article Published Date : Apr 24, 2021

Study Type : In Vitro Study

Additional Links

Substances : Lemon

Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Nutritional interventions may be therapeutic in the treatment of amyotrophic lateral sclerosis.Dec 01, 2009

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Pubmed Data : Clin Nutr. 2009 Dec;28(6):604-17. Epub 2009 Sep 25. PMID: 19782443

Article Published Date : Dec 01, 2009

Study Type : Commentary

Additional Links

Substances : Alpha-Lipoic Acid, Carnitine, Coenzyme Q10, EGCG (Epigallocatechin gallate), Folic Acid , Ginkgo biloba, Melatonin, Red Wine Extract, Vitamin E

Diseases : Amyotrophic Lateral Sclerosis

[+]

Paeonol exhibits neuroprotective activity via a carrier-mediated transport system.Jul 17, 2022

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Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases.Dec 31, 2007

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Pubmed Data : CNS Neurosci Ther. 2008 ;14(3):234-47. Epub 2008 Jul 29. PMID: 18684235

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Pubmed Data : Int J Mol Sci. 2019 Jun 22 ;20(12). Epub 2019 Jun 22. PMID: 31234550

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View the Evidence: 199 Abstracts with Amyotrophic lateral sclerosis (ALS) Research

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A systematic review and meta-analysis off the effects of cannabinoids in Amyotrophic lateral sclerosis murine models.Dec 05, 2018

In this meta-analysis, there was an observed increased risk of amytrophic lateral sclerosis in workers occupationally exposed to extremely low frequency electromagnetic fields. Feb 01, 2018

There is an association between occupational exposure to power frequency electromagnetic fields and amyotrophic lateral sclerosis.Feb 01, 2003

"Consumption of foods high inω-3 PUFAs may help prevent or delay the onset of ALS."Jul 13, 2014

A high intake of poluunsaturated fatty acids and vitamin E is associated with a 50-60% decreased risk of developing ALS. Apr 01, 2007

A higher intake of food rich in antioxidants such as fruit and vegetables confer protection against the development of ALS.Dec 19, 2003

A majority of patients with amyotrophic lateral sclerosis had signs of intestinal inflammation.Aug 31, 2017

Acupuncture treatment appears to have value on respiratory physiology parameters in amyotrophic lateral sclerosis patients: a pilot study.Dec 31, 2012

An ALS-specific meditation programme is beneficial for the quality of life and psychological well-being of people with ALS.Mar 31, 2017

Antioxidants, carotenes, fruits, and vegetables were associated with higher ALS function.Oct 23, 2016

Autologous bone marrow-derived stem cell therapy is safe and feasible in patients of ALS.Aug 31, 2012

Capsaicin may improve swallowing impairment in patients with amyotrophic lateral sclerosis.Mar 31, 2022

Cigarette smoking is associated with increased risk for ALS. Jan 01, 1999

Coenzyme Q10 levels as high as 3,000 mg a day are safe and well-tolerated in ALS patients. Dec 13, 2005

Diaphragm training has value in amyotrophic lateral sclerosis.Nov 30, 2008

Efficacy of hypnosis-based treatment in amyotrophic lateral sclerosis: a pilot study.Dec 31, 2011

Existential well-being, as well as spirituality issues, perceived by SALS patients seems to be directly related with quality of life, severity of mood disturbance and burden experienced by their caregivers.Feb 28, 2011

Free testosterone is significantly decreased in ALS, indicating that supplementation with testosterone may have a therapeutic role in ALS treatment. Mar 15, 2002

Glutamate levels may contribute to the pathogenesis of ALS.Feb 01, 2010

High homocysteine levels are associated with neurodegenerative conditions such as Parkinson's disease, ALS and progressive supranuclear palsy.Jul 01, 2010

High homocysteine levels may be associated with the pathogenesis of neurological disorders.Jan 01, 2010

High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis.Feb 12, 2019

In ALS patients, we report that a severe vitamin D deficiency accelerates the rate of decline and were associated with a marked shorter life expectancy.Apr 30, 2014

It is possible that lesions suggestive of Amyotrophic Lateral Sclerosis may be attributed to celiac disease. Mar 01, 2007

JWSJZ decoction may be a safe treatment for ALS, and may have delayed the development of ALS.Dec 31, 2012

Lead exposure is a risk factor for amyotrophic lateral sclerosis.Jan 01, 2005

Methylcobalamin may prevent muscle wasting in amyotrophic lateral sclerosis.Dec 01, 1998

Occupational exposures to agricultural chemicals is associated with increased risk for ALS. Jun 15, 1997

Pesticide exposure is associated with an increased risk of amyotrophic lateral sclerosis.Jan 01, 2010

Progesterone levels correlate positively with survival and prognosis in ALS patients.Jan 01, 2011

Selenium, glutathione, copper/zinc and superoxide dismutase may have therapeutic value in ALS. Jan 01, 1995

Serum vitamin E levels have a protective effect on ALS risk.Apr 30, 2013

Significant neurological improvement in two patients with amyotrophic lateral sclerosis after 4 weeks of treatment with acupuncture injection point therapy using enercel.Nov 30, 2011

Statin drug use may be linked to neuromuscular diseases and an amyotrophic lateral sclerosis-like syndrome. Jan 01, 2007

Statin drugs may cause ALS-like neurodegeneration in susceptible individuals.Jan 01, 2009

Suboptimal vitamin D levels are frequently found in ALS patients (81%). Oct 31, 2013

There is an association between blood lead and the risk of amyotrophic lateral sclerosis.May 15, 2010

There is increased mitochondrial oxidative damage in patients with sporadic amyotrophic lateral sclerosisApr 15, 2008

These results strengthen the positive association between amyotrophic lateral sclerosis and extremely-low electromagnetic field exposure.Jan 01, 2017

These results suggest a possible association between residential UHF-EMF exposure and amyotrophic lateral sclerosis.Jun 10, 2019

This data provides new evidence that exposure to short-term air pollution may increase the risk of acute exacerbation of ALS.Dec 31, 2018

Tobacco consumption is associated with increased risk for ALS. Jan 15, 2000

Treadmill ambulation is feasible, tolerated and safe for patients for amyotrophic lateral sclerosis.Dec 01, 2010

Vitamin B12 as methylcobalamin significantly prolongs survival time in Amyotrophic Lateral Sclerosis. Oct 01, 2007

Vitamin E intake decreases the risk of amyotrophic lateral sclerosis: a pooled analysis of data from 5 prospective cohort studies..Mar 14, 2011

Vitamin E supplementation may contribute to preventing amyotrophic lateral sclerosis. Jan 01, 2005

Whey protein improves the condition of patients with amyotrophic lateral sclerosis.Apr 01, 2010

50-Hz magnetic field affects iron homeostasis in vitro.Jan 01, 2019

Fungal infection in neural tissue of patients with amyotrophic lateral sclerosis.Nov 30, 2017

Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.Sep 01, 2007

Resveratrol's neural protective effects for the injured embryoid body and cerebral organoid.Jul 11, 2022

Alpha-lipoic acid, selenium, vitamins, micronutrients and a vegetarian diet combined with DMPS led to complete recovery from ALS in this case report. Dec 31, 2016

ALS untangled No. 17:"when ALS is lyme".Aug 31, 2012

Cannabis use is not uncommon in ALS patients who reported significant benefits from its use.Mar 01, 2004

Immunologic reactivity against Borrelia burgdorferi in patients with motor neuron disease.Apr 30, 1990

Iyengar yoga therapy has been found a usefl intervention for cramp management in individuals with amyotrophic lateral sclerosis: case study. Mar 31, 2014

Lead toxicitity may be associated with ALS. May 01, 1998

Lyme Disease -Induced Polyradiculopathy Mimicking Amyotrophic Lateral Sclerosis: Case Report. Jan 06, 2014

Lyme Disease -Induced Polyradiculopathy Mimicking Amyotrophic Lateral Sclerosis: Case Report. Jan 06, 2014

Palmitoylethanolamide treatment led to an improved clinical picture.Oct 31, 2012

[ALS-like sequelae in chronic neuroborreliosis].Dec 31, 1994

"Galactooligosaccharide improves the animal survival and alleviates motor neuron death in SOD1G93A mouse model of amyotrophic lateral sclerosis."Aug 28, 2013

7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis.Apr 29, 2014

A cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis.Aug 07, 2006

A ketogenic diet in combination with nutritrional supplementation has remarkable therapeutic properties in a rodent model of ALS. Dec 31, 2013

Aluminium may cause severe motor neuron damage in rat spinal cord resembling amyotrophic lateral sclerosis.Mar 31, 1999

Anthocyanins have significant potential as therapeutic agents in a preclinical model of Amyotrophic lateral sclerosis.Mar 08, 2017

Anti-inflammatory effects of a novel herbal extract in the muscle and spinal cord of an Amyotrophic lateral sclerosis.Dec 31, 2020

Ashwagandha treatment reversed the cytoplasmic mislocalization of hTDP-43 in spinal motor neurons and in brain.Dec 06, 2016

Bee venom attenuates neuroinflammatory events and extends survival in amyotrophic lateral sclerosis models.Dec 31, 2009

Bee venom combined with acupuncture was more effective at reducing inflammation and increasing immune responses.Jul 31, 2015

Branched chain amino acids may have a therapeutic role in ALS. Mar 31, 2011

Amyotrophic lateral sclerosis (ALS)

View the Evidence:
199 Abstracts with Amyotrophic lateral sclerosis (ALS) Research