Amyotrophic lateral sclerosis (ALS)

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101 Substances Researched for Amyotrophic lateral sclerosis (ALS)
NameACCKFocus
Vitamin E643Locked
Cannabinoids 1034Locked
Coenzyme Q10525Locked
Vitamin D424Locked
Vitamin B-12321Locked
Vitamin B12: methylcobalamin 321Locked
Fruit: All220Locked
Vegetables: All 220Locked
Progesterone418Locked
Testosterone318Locked
Glycoaminoglycans416Locked
Resveratrol815Locked
Antioxidant formulas313Locked
Estradiol (E(2))713Locked
Insulin-like Growth Factor (IGF-1)413Locked
Selenium213Locked
Glutathione211Locked
B-complex110Locked
Cannabis610Locked
Capsaicin110Locked
Copper110Locked
Curcumin910Locked
Omega-3 Fatty Acids110Locked
Peony110Locked
Polyunsaturated Fatty Acids (PUFAs)110Locked
Salvia miltiorrhiza110Locked
Superoxide dismutase110Locked
Traditional Chinese Medicine: JWSJZ Decoction110Locked
Turmeric110Locked
Whey110Locked
Zinc110Locked
Alpha-Lipoic Acid48Locked
Melatonin77Locked
Bee Venom46Locked
Ashwagandha35Locked
Catechin 15Locked
EGCG (Epigallocatechin gallate)35Locked
5-HTP (5-Hydroxytryptophan)14Locked
Genistein24Locked
Polyphenols44Locked
Stilbenes34Locked
Anthocyanins23Locked
Coconut Oil23Locked
Ginkgo biloba23Locked
Ginseng23Locked
Honokiol13Locked
Palmitoylethanolamide 13Locked
Rosmarinic acid23Locked
Amino Acids: Branched Chain12Locked
Arginine12Locked
Arginine-alpha-ketoglutarate (AAKG)12Locked
Astragalus12Locked
Burdock12Locked
Cannabidiol22Locked
Caprylic Acid12Locked
Carnosic Acid12Locked
Creatine12Locked
EPA (Eicosapentaenoic Acid)12Locked
Fisetin12Locked
Flavonoids22Locked
GABA (gamma-Aminobutyric Acid)12Locked
Galactooligosaccharides12Locked
Glycyrrhiza uralensis12Locked
Hesperidin22Locked
Hydrogen Water12Locked
Lignan12Locked
Medium Chain Triglycerides12Locked
Nicotinamide12Locked
Prebiotics12Locked
Pterostilbene12Locked
Pyruvate12Locked
Red Wine Extract22Locked
Rosemaric Acid12Locked
Rosemary12Locked
S-Adenosylmethionine (SAMe)12Locked
Scolopendra subspinipes mutilans12Locked
Strawberry12Locked
Wen Pi Tang12Locked
phytoestrogens12Locked
Astaxanthin11Locked
Astragaloside11Locked
Avocado11Locked
Caffeic acid phenethyl ester11Locked
Carnitine11Locked
Carotenoids11Locked
Echinacea11Locked
Endocannabinoids11Locked
Folic Acid 11Locked
Ginsenosides11Locked
Herbal Therapies (Unspecified in Abstracts)11Locked
L-Carnitine11Locked
Lemon11Locked
Myricetin11Locked
Olive11Locked
Paeonol11Locked
Panax Ginseng11Locked
Quercetin11Locked
Tauroursodeoxycholic acid11Locked
Tibetan Herbal Formula: Padma 28 11Locked
Wine11Locked
acetyl-11-keto-beta-boswellic acid11Locked
14 Problem Substances Researched for Amyotrophic lateral sclerosis (ALS)
NameACCKFocus
Pesticides532Locked
Lead425Locked
Statin Drugs220Locked
Tobacco220Locked
Lyme's Disease (Borrelia burgdorferi)515Locked
Agricultural Chemicals110Locked
L-glutamic Acid110Locked
Monosodium Glutamate (MSG)110Locked
Nicotine110Locked
Persistent organic pollutants (POPs)110Locked
Aluminum58Locked
Mercury36Locked
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)23Locked
Excitotoxins11Locked
18 Therapeutic Actions Researched for Amyotrophic lateral sclerosis (ALS)
NameACCKFocus
Acupuncture220Locked
Stem Cell Related Therapy720Locked
Exercise517Locked
Hypnosis110Locked
Meditation 110Locked
Spiritual/Religious Practice 110Locked
Therapeutic Breathing110Locked
Dietary Modification: Low Carbohydrate/Ketogenic57Locked
Dietary Modification: Vegetarian13Locked
Yoga13Locked
Electroacupuncture12Locked
Exercise: Running12Locked
Exercise: Swimming12Locked
Intermittent Hypoxia (low oxygen)12Locked
Aquatic therapy 11Locked
Dietary Modification: High-Fat/Low-Carbohydrate 11Locked
Dietary Modification: Mediterranean Diet11Locked
Mindfullness Training11Locked
4 Problematic Actions Researched for Amyotrophic lateral sclerosis (ALS)
NameACCKFocus
Electromagnetic Field Harms556Locked
Electromagnetic Radiation546Locked
Mobile Phone Radiation110Locked
Vaccination: All44Locked
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View the Evidence:
216 Abstracts with Amyotrophic lateral sclerosis (ALS) Research

[+]

A systematic review and meta-analysis off the effects of cannabinoids in Amyotrophic lateral sclerosis murine models.Dec 05, 2018

Pubmed Data : J Neurochem. 2018 Dec 6. Epub 2018 Dec 6. PMID: 30520038
Article Published Date : Dec 05, 2018
Study Type : Meta Analysis, Review
Additional Links
Substances : Cannabinoids
Diseases : Amyotrophic lateral sclerosis (ALS)
[+]

In this meta-analysis, there was an observed increased risk of amytrophic lateral sclerosis in workers occupationally exposed to extremely low frequency electromagnetic fields. Feb 01, 2018

Pubmed Data : Bioelectromagnetics. 2018 Feb ;39(2):156-163. Epub 2018 Jan 19. PMID: 29350413
Article Published Date : Feb 01, 2018
Study Type : Meta Analysis
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Neurotoxic
[+]

There is an association between occupational exposure to power frequency electromagnetic fields and amyotrophic lateral sclerosis.Feb 01, 2003

Pubmed Data : Am J Ind Med. 2003 Feb;43(2):212-20. PMID: 12541277
Article Published Date : Feb 01, 2003
Study Type : Meta Analysis
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Anti Therapeutic Actions : Electromagnetic Field Harms
[+]

"Consumption of foods high inω-3 PUFAs may help prevent or delay the onset of ALS."Jul 13, 2014

Pubmed Data : JAMA Neurol. 2014 Jul 14. Epub 2014 Jul 14. PMID: 25023276
Article Published Date : Jul 13, 2014
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Amyotrophic lateral sclerosis (ALS)
[+]

A high intake of poluunsaturated fatty acids and vitamin E is associated with a 50-60% decreased risk of developing ALS. Apr 01, 2007

Pubmed Data : J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):367-71. Epub 2006 Apr 28. PMID: 16648143
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs), Vitamin E
Diseases : Amyotrophic Lateral Sclerosis
[+]

A higher intake of food rich in antioxidants such as fruit and vegetables confer protection against the development of ALS.Dec 19, 2003

Pubmed Data : Life Sci. 2003 Dec 19;74(5):663-73. PMID: 19209004
Article Published Date : Dec 19, 2003
Study Type : Human Study
Additional Links
Substances : Fruit: All, Vegetables: All
Diseases : Amyotrophic Lateral Sclerosis
[+]

A majority of patients with amyotrophic lateral sclerosis had signs of intestinal inflammation.Aug 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Rep. 2017 Sep ;5(18). PMID: 28947596
Article Published Date : Aug 31, 2017
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Dysbiosis, Gastrointestinal Inflammation
[+]

Acupuncture treatment appears to have value on respiratory physiology parameters in amyotrophic lateral sclerosis patients: a pilot study.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:506317. Epub 2013 Sep 11. PMID: 24101939
Article Published Date : Dec 31, 2012
Study Type : Human Study
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS)
Therapeutic Actions : Acupuncture
[+]

An ALS-specific meditation programme is beneficial for the quality of life and psychological well-being of people with ALS.Mar 31, 2017

Pubmed Data : Eur J Neurol. 2017 Apr ;24(4):578-586. Epub 2017 Feb 23. PMID: 28229508
Article Published Date : Mar 31, 2017
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Quality of Life: Poor
Therapeutic Actions : Meditation
[+]

Antioxidants, carotenes, fruits, and vegetables were associated with higher ALS function.Oct 23, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JAMA Neurol. 2016 Oct 24. Epub 2016 Aug 24. PMID: 27775751
Article Published Date : Oct 23, 2016
Study Type : Human Study
Additional Links
Substances : Fruit: All, Vegetables: All
Diseases : Amyotrophic lateral sclerosis (ALS)
Pharmacological Actions : Antioxidants
Additional Keywords : Risk Reduction
[+]

Autologous bone marrow-derived stem cell therapy is safe and feasible in patients of ALS.Aug 31, 2012

Pubmed Data : Neurol India. 2012 Sep-Oct;60(5):465-9. PMID: 23135021
Article Published Date : Aug 31, 2012
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Stem Cell Related Therapy
[+]

Capsaicin may improve swallowing impairment in patients with amyotrophic lateral sclerosis.Mar 31, 2022

Pubmed Data : Acta Med Okayama. 2022 Apr ;76(2):179-186. PMID: 35503446
Article Published Date : Mar 31, 2022
Study Type : Human Study
Additional Links
Substances : Capsaicin
Diseases : Amyotrophic Lateral Sclerosis
[+]

Cigarette smoking is associated with increased risk for ALS. Jan 01, 1999

Pubmed Data : Neuroepidemiology. 1999;18(4):194-202. PMID: 10364720
Article Published Date : Jan 01, 1999
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Smoking
Problem Substances : Tobacco
Adverse Pharmacological Actions : Neurotoxic
[+]

Coenzyme Q10 levels as high as 3,000 mg a day are safe and well-tolerated in ALS patients. Dec 13, 2005

Pubmed Data : Neurology. 2005 Dec 13;65(11):1834-6. PMID: 16344537
Article Published Date : Dec 13, 2005
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Diaphragm training has value in amyotrophic lateral sclerosis.Nov 30, 2008

Pubmed Data : J Clin Neuromuscul Dis. 2008 Dec ;10(2):56-60. PMID: 19169091
Article Published Date : Nov 30, 2008
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Therapeutic Breathing
[+]

Efficacy of hypnosis-based treatment in amyotrophic lateral sclerosis: a pilot study.Dec 31, 2011

Pubmed Data : Front Psychol. 2012 ;3:465. Epub 2012 Nov 5. PMID: 23162510
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS)
Therapeutic Actions : Hypnosis
[+]

Efficacy of mecasin for treatment of amyotrophic lateral sclerosis.Oct 27, 2023

Pubmed Data : J Ethnopharmacol. 2023 Oct 28 ;315:116670. Epub 2023 May 29. PMID: 37257710
Article Published Date : Oct 27, 2023
Study Type : Human Study
Additional Links
Substances : Peony, Salvia miltiorrhiza, Turmeric
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Existential well-being, as well as spirituality issues, perceived by SALS patients seems to be directly related with quality of life, severity of mood disturbance and burden experienced by their caregivers.Feb 28, 2011

Pubmed Data : Amyotroph Lateral Scler. 2011 Mar ;12(2):105-8. Epub 2010 Jul 26. PMID: 20653520
Article Published Date : Feb 28, 2011
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Spiritual/Religious Practice
[+]

Free testosterone is significantly decreased in ALS, indicating that supplementation with testosterone may have a therapeutic role in ALS treatment. Mar 15, 2002

Pubmed Data : J Neurol Sci. 2002 Mar 15;195(1):67-70. PMID: 11867076
Article Published Date : Mar 15, 2002
Study Type : Human Study
Additional Links
Substances : Testosterone
Diseases : Amyotrophic Lateral Sclerosis
[+]

Glutamate levels may contribute to the pathogenesis of ALS.Feb 01, 2010

Pubmed Data : Acta Neurol Scand. 2010 Feb;121(2):120-6. Epub 2009 Oct 5. PMID: 19804473
Article Published Date : Feb 01, 2010
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Problem Substances : L-glutamic Acid, Monosodium Glutamate (MSG)
Adverse Pharmacological Actions : Excitotoxic
[+]

High homocysteine levels are associated with neurodegenerative conditions such as Parkinson's disease, ALS and progressive supranuclear palsy.Jul 01, 2010

Pubmed Data : Dement Geriatr Cogn Disord. 2010 Jul;29(6):553-9. Epub 2010 Jul 3. PMID: 20606437
Article Published Date : Jul 01, 2010
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Hyperhomocysteinemia, Parkinson's Disease, Supranuclear Palsy: Progressive
Additional Keywords : Diseases that are Linked
[+]

High homocysteine levels may be associated with the pathogenesis of neurological disorders.Jan 01, 2010

Pubmed Data : Front Biosci (Schol Ed). 2010;2:359-72. Epub 2010 Jan 1. PMID: 20036953
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Substances : B-complex
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Epilepsy, High Homocysteine, Hyperhomocysteinemia, Multiple Sclerosis, Parkinson's Disease, Stroke
Additional Keywords : Diseases that are Linked
[+]

High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis.Feb 12, 2019

Pubmed Data : J Neurol Neurosurg Psychiatry. 2019 Feb 13. Epub 2019 Feb 13. PMID: 30760645
Article Published Date : Feb 12, 2019
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Pesticide Toxicity
Additional Keywords : Increased Risk
Problem Substances : Persistent organic pollutants (POPs), Pesticides
[+]

In ALS patients, we report that a severe vitamin D deficiency accelerates the rate of decline and were associated with a marked shorter life expectancy.Apr 30, 2014

Pubmed Data : Neurobiol Aging. 2014 May ;35(5):1198-205. Epub 2013 Nov 13. PMID: 24378089
Article Published Date : Apr 30, 2014
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Amyotrophic lateral sclerosis (ALS), Vitamin D Deficiency
Pharmacological Actions : Neuroprotective Agents
[+]

It is possible that lesions suggestive of Amyotrophic Lateral Sclerosis may be attributed to celiac disease. Mar 01, 2007

Pubmed Data : BJU Int. 2007 Mar;99(3):619-22. Epub 2006 Nov 28. PMID: 19910450
Article Published Date : Mar 01, 2007
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Autoimmune Diseases, Celiac Disease
[+]

JWSJZ decoction may be a safe treatment for ALS, and may have delayed the development of ALS.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:347525. Epub 2013 Sep 5. PMID: 24093046
Article Published Date : Dec 31, 2012
Study Type : Human Study
Additional Links
Substances : Traditional Chinese Medicine: JWSJZ Decoction
Diseases : Amyotrophic lateral sclerosis (ALS)
[+]

Lead exposure is a risk factor for amyotrophic lateral sclerosis.Jan 01, 2005

Pubmed Data : Neurodegener Dis. 2005;2(3-4):195-201. PMID: 16909025
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Problem Substances : Lead
[+]

Methylcobalamin may prevent muscle wasting in amyotrophic lateral sclerosis.Dec 01, 1998

Pubmed Data : Muscle Nerve. 1998 Dec;21(12):1775-8. PMID: 9843082
Article Published Date : Dec 01, 1998
Study Type : Human Study
Additional Links
Substances : Vitamin B12: methylcobalamin , Vitamin B-12
Diseases : Amyotrophic Lateral Sclerosis
[+]

Occupational exposures to agricultural chemicals is associated with increased risk for ALS. Jun 15, 1997

Pubmed Data : Am J Epidemiol. 1997 Jun 15;145(12):1076-88. PMID: 9199537
Article Published Date : Jun 15, 1997
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Problem Substances : Agricultural Chemicals, Pesticides
Adverse Pharmacological Actions : Neurotoxic
[+]

Pesticide exposure is associated with an increased risk of amyotrophic lateral sclerosis.Jan 01, 2010

Pubmed Data : Ann Ist Super Sanita. 2010;46(3):284-7. PMID: 20847462
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Problem Substances : Pesticides
Adverse Pharmacological Actions : Neurotoxic
[+]

Progesterone levels correlate positively with survival and prognosis in ALS patients.Jan 01, 2011

Pubmed Data : Acta Neurol Scand. 2011 Jan;123(1):60-7. PMID: 20545634
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Substances : Progesterone
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Selenium, glutathione, copper/zinc and superoxide dismutase may have therapeutic value in ALS. Jan 01, 1995

Pubmed Data : Scand J Rheumatol. 1995;24(2):85-93. PMID: 9726810
Article Published Date : Jan 01, 1995
Study Type : Human Study
Additional Links
Substances : Antioxidant formulas, Copper, Glutathione, Selenium, Superoxide dismutase, Zinc
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Calcium Channel Blockers
[+]

Serum vitamin E levels have a protective effect on ALS risk.Apr 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Amyotroph Lateral Scler Frontotemporal Degener. 2013 May ;14(4):246-51. Epub 2013 Jan 4. PMID: 23286756
Article Published Date : Apr 30, 2013
Study Type : Human Study
Additional Links
Substances : Vitamin E
Diseases : Amyotrophic Lateral Sclerosis
[+]

Significant neurological improvement in two patients with amyotrophic lateral sclerosis after 4 weeks of treatment with acupuncture injection point therapy using enercel.Nov 30, 2011

Pubmed Data : J Acupunct Meridian Stud. 2011 Dec ;4(4):257-61. Epub 2011 Oct 19. PMID: 22196509
Article Published Date : Nov 30, 2011
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Acupuncture
Additional Keywords : Plant Extracts
[+]

Statin drug use may be linked to neuromuscular diseases and an amyotrophic lateral sclerosis-like syndrome. Jan 01, 2007

Pubmed Data : Drug Saf. 2007;30(6):515-25. PMID: 17536877
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Neuromuscular Diseases
Problem Substances : Statin Drugs
[+]

Statin drugs may cause ALS-like neurodegeneration in susceptible individuals.Jan 01, 2009

Pubmed Data : Drug Saf. 2009;32(8):649-61. PMID: 19591530
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases, Oxidative Stress
Problem Substances : Statin Drugs
[+]

Suboptimal vitamin D levels are frequently found in ALS patients (81%). Oct 31, 2013

Pubmed Data : J Clin Neurosci. 2013 Nov ;20(11):1550-3. Epub 2013 Jun 29. PMID: 23815870
Article Published Date : Oct 31, 2013
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Amyotrophic Lateral Sclerosis, Vitamin D Deficiency
[+]

There is an association between blood lead and the risk of amyotrophic lateral sclerosis.May 15, 2010

Pubmed Data : Am J Epidemiol. 2010 May 15;171(10):1126-33. Epub 2010 Apr 20. PMID: 20406759
Article Published Date : May 15, 2010
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Lead Poisoning
Problem Substances : Lead
[+]

There is increased mitochondrial oxidative damage in patients with sporadic amyotrophic lateral sclerosisApr 15, 2008

Pubmed Data : J Neurol Sci. 2008 Apr 15;267(1-2):66-9. Epub 2007 Oct 24. PMID: 17961597
Article Published Date : Apr 15, 2008
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10
Diseases : Amyotrophic Lateral Sclerosis, Mitochondrial Diseases, Oxidative Stress
Additional Keywords : Diseases that are Linked
[+]

These results strengthen the positive association between amyotrophic lateral sclerosis and extremely-low electromagnetic field exposure.Jan 01, 2017

Pubmed Data : Occup Environ Med. 2017 08 ;74(8):578-585. Epub 2017 Mar 29. PMID: 28356332
Article Published Date : Jan 01, 2017
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Neurotoxic
[+]

These results suggest a possible association between residential UHF-EMF exposure and amyotrophic lateral sclerosis.Jun 10, 2019

Pubmed Data : Environ Res. 2019 Jun 11 ;176:108525. Epub 2019 Jun 11. PMID: 31226626
Article Published Date : Jun 10, 2019
Study Type : Human Study
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS)
Additional Keywords : Increased Risk
Anti Therapeutic Actions : Electromagnetic Radiation, Mobile Phone Radiation
[+]

This data provides new evidence that exposure to short-term air pollution may increase the risk of acute exacerbation of ALS.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Int. 2019 02 ;123:467-475. Epub 2019 Jan 5. PMID: 30622072
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Air Pollution Linked Toxicity, Amyotrophic Lateral Sclerosis
Additional Keywords : Increased Risk
[+]

Tobacco consumption is associated with increased risk for ALS. Jan 15, 2000

Pubmed Data : Am J Epidemiol. 2000 Jan 15;151(2):156-63. PMID: 10645818
Article Published Date : Jan 15, 2000
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Nicotine/Tobacco Toxicity , Smoking
Problem Substances : Nicotine, Tobacco
Adverse Pharmacological Actions : Neurotoxic
[+]

Treadmill ambulation is feasible, tolerated and safe for patients for amyotrophic lateral sclerosis.Dec 01, 2010

Pubmed Data : Arch Phys Med Rehabil. 2010 Dec;91(12):1920-9. PMID: 21112435
Article Published Date : Dec 01, 2010
Study Type : Human Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Exercise
[+]

Vitamin B12 as methylcobalamin significantly prolongs survival time in Amyotrophic Lateral Sclerosis. Oct 01, 2007

Pubmed Data : Brain Nerve. 2007 Oct;59(10):1141-7. PMID: 17969354
Article Published Date : Oct 01, 2007
Study Type : Human Study
Additional Links
Substances : Vitamin B12: methylcobalamin , Vitamin B-12
Diseases : Amyotrophic Lateral Sclerosis
[+]

Vitamin E intake decreases the risk of amyotrophic lateral sclerosis: a pooled analysis of data from 5 prospective cohort studies..Mar 14, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Epidemiol. 2011 Mar 15 ;173(6):595-602. Epub 2011 Feb 18. PMID: 21335424
Article Published Date : Mar 14, 2011
Study Type : Human Study
Additional Links
Substances : Vitamin E
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Antioxidants
[+]

Vitamin E supplementation may contribute to preventing amyotrophic lateral sclerosis. Jan 01, 2005

Pubmed Data : Ann Neurol. 2005 Jan;57(1):104-10. PMID: 15529299
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Substances : Vitamin E
Diseases : Amyotrophic Lateral Sclerosis
[+]

Whey protein improves the condition of patients with amyotrophic lateral sclerosis.Apr 01, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arq Neuropsiquiatr. 2010 Apr;68(2):263-8. PMID: 20464297
Article Published Date : Apr 01, 2010
Study Type : Human Study
Additional Links
Substances : Whey
Diseases : Amyotrophic Lateral Sclerosis
[+]

50-Hz magnetic field affects iron homeostasis in vitro.Jan 01, 2019

Pubmed Data : Int J Radiat Biol. 2019 03 ;95(3):368-377. Epub 2019 Jan 4. PMID: 30513241
Article Published Date : Jan 01, 2019
Study Type : Human In Vitro
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Oxidant
[+]

Fungal infection in neural tissue of patients with amyotrophic lateral sclerosis.Nov 30, 2017

Pubmed Data : Neurobiol Dis. 2017 Dec ;108:249-260. Epub 2017 Sep 6. PMID: 28888971
Article Published Date : Nov 30, 2017
Study Type : Human In Vitro
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Fungus Diseases
[+]

Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.Sep 01, 2007

Pubmed Data : Curr Alzheimer Res. 2007 Sep ;4(4):403-11. PMID: 17908043
Article Published Date : Sep 01, 2007
Study Type : Human In Vitro
Additional Links
Substances : Catechin
Diseases : Amyotrophic Lateral Sclerosis, Huntington Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Regenerative
Additional Keywords : Nerve Regeneration
[+]

Resveratrol's neural protective effects for the injured embryoid body and cerebral organoid.Jul 11, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Pharmacol Toxicol. 2022 Jul 12 ;23(1):47. Epub 2022 Jul 12. PMID: 35820950
Article Published Date : Jul 11, 2022
Study Type : Human In Vitro
Additional Links
Substances : Resveratrol
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Alpha-lipoic acid, selenium, vitamins, micronutrients and a vegetarian diet combined with DMPS led to complete recovery from ALS in this case report. Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Complement Med Res. 2017 ;24(3):175-181. Epub 2017 Jun 12. PMID: 28641283
Article Published Date : Dec 31, 2016
Study Type : Human: Case Report
Additional Links
Substances : Alpha-Lipoic Acid, Selenium
Diseases : Amyotrophic lateral sclerosis (ALS)
Therapeutic Actions : Dietary Modification: Vegetarian
Additional Keywords : Significant Treatment Outcome
Problem Substances : Mercury
[+]

ALS untangled No. 17:"when ALS is lyme".Aug 31, 2012

Pubmed Data : Amyotroph Lateral Scler. 2012 Sep ;13(5):487-91. Epub 2012 Aug 8. PMID: 22873562
Article Published Date : Aug 31, 2012
Study Type : Human: Case Report
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Problem Substances : Lyme's Disease (Borrelia burgdorferi)
[+]

Cannabis use is not uncommon in ALS patients who reported significant benefits from its use.Mar 01, 2004

Pubmed Data : Am J Hosp Palliat Care. 2004 Mar-Apr;21(2):95-104. PMID: 15055508
Article Published Date : Mar 01, 2004
Study Type : Human: Case Report
Additional Links
Substances : Cannabis
Diseases : Amyotrophic Lateral Sclerosis
[+]

Honokiol showed promising preclinical potential as a multiple target drug for Amyotrophic lateral sclerosis treatment.Jan 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharm Sin B. 2023 Feb ;13(2):577-597. Epub 2022 Aug 10. PMID: 36873166
Article Published Date : Jan 31, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Immunologic reactivity against Borrelia burgdorferi in patients with motor neuron disease.Apr 30, 1990

Pubmed Data : Arch Neurol. 1990 May ;47(5):586-94. PMID: 2334308
Article Published Date : Apr 30, 1990
Study Type : Human: Case Report
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Problem Substances : Lyme's Disease (Borrelia burgdorferi)
[+]

Iyengar yoga therapy has been found a usefl intervention for cramp management in individuals with amyotrophic lateral sclerosis: case study. Mar 31, 2014

Pubmed Data : J Altern Complement Med. 2014 Apr ;20(4):322-6. Epub 2013 Nov 28. PMID: 24286340
Article Published Date : Mar 31, 2014
Study Type : Human: Case Report
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS)
Therapeutic Actions : Yoga
[+]

Lead toxicitity may be associated with ALS. May 01, 1998

Pubmed Data : Rev Neurol (Paris). 1998 May;154(4):345-7. PMID: 9773065
Article Published Date : May 01, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Bulbar palsy
Problem Substances : Lead
Adverse Pharmacological Actions : Neurotoxic
[+]

Lyme Disease -Induced Polyradiculopathy Mimicking Amyotrophic Lateral Sclerosis: Case Report. Jan 06, 2014

Pubmed Data : Int J Neurosci. 2014 Jan 7. Epub 2014 Jan 7. PMID: 24397499
Article Published Date : Jan 06, 2014
Study Type : Human: Case Report
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS), Guillain-Barre Syndrome
Problem Substances : Lyme's Disease (Borrelia burgdorferi)
[+]

Lyme Disease -Induced Polyradiculopathy Mimicking Amyotrophic Lateral Sclerosis: Case Report. Jan 06, 2014

Pubmed Data : Int J Neurosci. 2014 Jan 7. Epub 2014 Jan 7. PMID: 24397499
Article Published Date : Jan 06, 2014
Study Type : Human: Case Report
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS), Guillain-Barre Syndrome
Problem Substances : Lyme's Disease (Borrelia burgdorferi)
[+]

Palmitoylethanolamide treatment led to an improved clinical picture.Oct 31, 2012

Pubmed Data : CNS Neurol Disord Drug Targets. 2012 Nov 1 ;11(7):933-6. PMID: 22998138
Article Published Date : Oct 31, 2012
Study Type : Human: Case Report
Additional Links
Substances : Palmitoylethanolamide
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

[ALS-like sequelae in chronic neuroborreliosis].Dec 31, 1994

Pubmed Data : Wien Med Wochenschr. 1995 ;145(7-8):186-8. PMID: 7610670
Article Published Date : Dec 31, 1994
Study Type : Human: Case Report
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Problem Substances : Lyme's Disease (Borrelia burgdorferi)
[+]

"Galactooligosaccharide improves the animal survival and alleviates motor neuron death in SOD1G93A mouse model of amyotrophic lateral sclerosis."Aug 28, 2013

Pubmed Data : Neuroscience. 2013 Aug 29 ;246:281-90. Epub 2013 May 11. PMID: 23673277
Article Published Date : Aug 28, 2013
Study Type : Animal Study
Additional Links
Substances : Galactooligosaccharides, Prebiotics
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Apoptotic, Superoxide Dismutase Up-regulation
[+]

7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis.Apr 29, 2014

Pubmed Data : Neurosci Lett. 2014 Apr 30 ;566:286-91. Epub 2014 Mar 15. PMID: 24637017
Article Published Date : Apr 29, 2014
Study Type : Animal Study
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS)
[+]

A cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis.Aug 07, 2006

Pubmed Data : Eur J Pharmacol. 2006 Aug 7;542(1-3):100-5. Epub 2006 May 20. PMID: 16781706
Article Published Date : Aug 07, 2006
Study Type : Animal Study
Additional Links
Substances : Cannabinoids
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

A ketogenic diet in combination with nutritrional supplementation has remarkable therapeutic properties in a rodent model of ALS. Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(7):e103526. Epub 2014 Jul 25. PMID: 25061944
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Arginine-alpha-ketoglutarate (AAKG), Coenzyme Q10, GABA (gamma-Aminobutyric Acid), Medium Chain Triglycerides
Diseases : Amyotrophic lateral sclerosis (ALS)
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Aluminium may cause severe motor neuron damage in rat spinal cord resembling amyotrophic lateral sclerosis.Mar 31, 1999

Pubmed Data : Acta Histochem. 1999 Apr ;101(2):193-201. PMID: 10335362
Article Published Date : Mar 31, 1999
Study Type : Animal Study
Additional Links
Diseases : Aluminum Toxicity , Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Motor Neuron Disease
Additional Keywords : aluminum, aluminum toxicity, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Motor Neuron Disease
Problem Substances : Aluminum
[+]

Anthocyanins have significant potential as therapeutic agents in a preclinical model of Amyotrophic lateral sclerosis.Mar 08, 2017

Pubmed Data : Nutr Neurosci. 2017 Mar 9:1-13. Epub 2017 Mar 9. PMID: 28276271
Article Published Date : Mar 08, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins, Strawberry
Diseases : Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Plant Extracts, Risk Reduction, Significant Treatment Outcome
[+]

Anti-inflammatory effects of a novel herbal extract in the muscle and spinal cord of an Amyotrophic lateral sclerosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2021 ;15:743705. Epub 2021 Nov 11. PMID: 34858128
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Astragalus, Ginseng, Glycyrrhiza uralensis
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Ashwagandha treatment reversed the cytoplasmic mislocalization of hTDP-43 in spinal motor neurons and in brain.Dec 06, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neurotherapeutics. 2016 Dec 7. Epub 2016 Dec 7. PMID: 27928708
Article Published Date : Dec 06, 2016
Study Type : Transgenic Animal Study
Additional Links
Substances : Ashwagandha
Diseases : Amyotrophic lateral sclerosis (ALS), Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Bee venom attenuates neuroinflammatory events and extends survival in amyotrophic lateral sclerosis models.Dec 31, 2009

Pubmed Data : J Neuroinflammation. 2010 ;7:69. Epub 2010 Oct 15. PMID: 20950451
Article Published Date : Dec 31, 2009
Study Type : Animal Study
Additional Links
Substances : Bee Venom
Diseases : Amyotrophic Lateral Sclerosis
[+]

Bee venom combined with acupuncture was more effective at reducing inflammation and increasing immune responses.Jul 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxins (Basel). 2015 Aug ;7(8):2835-44. Epub 2015 Jul 29. PMID: 26230709
Article Published Date : Jul 31, 2015
Study Type : Transgenic Animal Study
Additional Links
Substances : Bee Venom
Diseases : Amyotrophic lateral sclerosis (ALS)
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

Branched chain amino acids may have a therapeutic role in ALS. Mar 31, 2011

Pubmed Data : Mol Nutr Food Res. 2011 Apr ;55(4):541-52. Epub 2011 Jan 5. PMID: 21462321
Article Published Date : Mar 31, 2011
Study Type : Animal Study
Additional Links
Substances : Amino Acids: Branched Chain
Diseases : Amyotrophic Lateral Sclerosis
[+]

Cannabinol may have therapeutic value in ameliorating symptoms in ALS. Sep 01, 2005

Pubmed Data : Amyotroph Lateral Scler Other Motor Neuron Disord. 2005 Sep;6(3):182-4. PMID: 16183560
Article Published Date : Sep 01, 2005
Study Type : Animal Study
Additional Links
Substances : Cannabinoids , Cannabis
Diseases : Amyotrophic Lateral Sclerosis
[+]

Cannabis contains a number of compounds which may have therapeutic value in delaying the progression of ALS. Mar 01, 2004

Pubmed Data : Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Mar;5(1):33-9. PMID: 15204022
Article Published Date : Mar 01, 2004
Study Type : Animal Study
Additional Links
Substances : Cannabinoids , Cannabis
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Cannabis may provide support as a novel disease-modifying therapy in ALS.Aug 31, 2014

Pubmed Data : CNS Neurosci Ther. 2014 Sep ;20(9):809-15. Epub 2014 Apr 7. PMID: 24703394
Article Published Date : Aug 31, 2014
Study Type : Transgenic Animal Study
Additional Links
Substances : Cannabinoids
Diseases : Amyotrophic lateral sclerosis (ALS)
[+]

Caprylic triglyceride as a novel therapeutic approach to effectively improve the performance and attenuate the symptoms due to the motor neuron loss in ALS disease.Dec 31, 2011

Pubmed Data : PLoS One. 2012 ;7(11):e49191. Epub 2012 Nov 7. PMID: 23145119
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Caprylic Acid
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Superoxide Dismutase Up-regulation
[+]

Co-administration of IGF-I and glycosaminoglycans greatly delays motor neuron disease in the mouse model.Apr 01, 2002

Pubmed Data : J Neurochem. 2002 Apr;81(1):194-202. PMID: 12067233
Article Published Date : Apr 01, 2002
Study Type : Animal Study
Additional Links
Substances : Glycoaminoglycans, Insulin-like Growth Factor (IGF-1)
Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Coenzyme Q10 demonstrated significant therapeutic effects in transgenic mouse model of ALS and Huntington's disease. Apr 01, 2002

Pubmed Data : Free Radic Res. 2002 Apr;36(4):455-60. PMID: 12069110
Article Published Date : Apr 01, 2002
Study Type : Transgenic Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Amyotrophic Lateral Sclerosis, Huntington Disease, Neurodegenerative Diseases
[+]

Creatine in mouse models of neurodegeneration and aging.Apr 30, 2011

Pubmed Data : Amino Acids. 2011 May ;40(5):1297-303. Epub 2011 Mar 10. PMID: 21390530
Article Published Date : Apr 30, 2011
Study Type : Animal Study
Additional Links
Substances : Creatine
Diseases : Aging, Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases
[+]

Curcumin has anti-apoptotic properties in a transgenic amyotrophic lateral sclerosis mice.May 31, 2005

Pubmed Data : J Neurochem. 2005 Jun ;93(5):1087-98. PMID: 15934930
Article Published Date : May 31, 2005
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, NF-kappaB Inhibitor
[+]

Dietary supplementation with S-adenosyl methionine delays the onset of motor neuron pathology in a murine model of amyotrophic lateral sclerosis.Feb 28, 2010

Pubmed Data : Neuromolecular Med. 2010 Mar ;12(1):86-97. Epub 2009 Sep 16. PMID: 19757209
Article Published Date : Feb 28, 2010
Study Type : Animal Study
Additional Links
Substances : S-Adenosylmethionine (SAMe)
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Superoxide Dismutase Up-regulation
[+]

EGCG has multifunctional therapeutic effects in the mouse model of ALSOct 01, 2006

Pubmed Data : Neurochem Res. 2006 Oct;31(10):1263-9. Epub 2006 Oct 5. PMID: 17021948
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Amyotrophic Lateral Sclerosis
[+]

EGCG may provide a potential therapeutic candidate for ALS as a disease-modifying agent. Oct 01, 2007

Pubmed Data : Biomed Res. 2007 Oct;28(5):261-6. PMID: 16356650
Article Published Date : Oct 01, 2007
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Amyotrophic Lateral Sclerosis
[+]

Electroacupuncture alleviates motor dysfunction by regulating neuromuscular junction disruption and neuronal degeneration.Sep 30, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Brain Res Bull. 2024 Oct 1 ;216:111036. Epub 2024 Jul 29. PMID: 39084570
Article Published Date : Sep 30, 2024
Study Type : Animal Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : anti-inflammatory, Neuroprotective Agents
[+]

Electroacupuncture reduces neuroinflammatory responses in symptomatic amyotrophic lateral sclerosis model.May 31, 2010

Pubmed Data : J Neuroimmunol. 2010 Jun ;223(1-2):84-91. Epub 2010 May 10. PMID: 20460191
Article Published Date : May 31, 2010
Study Type : Animal Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Electroacupuncture
[+]

Estradiol slows neurodegeneration in a female mouse experimental model of amyotrophic lateral sclerosis.May 15, 2008

Pubmed Data : J Neurol Sci. 2008 May 15;268(1-2):40-7. Epub 2007 Dec 4. PMID: 18054961
Article Published Date : May 15, 2008
Study Type : Animal Study
Additional Links
Substances : Estradiol (E(2))
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Extremely high dose vitamin D attenuates a feature of ALS, but not disease outcomes; also toxic to female mice. Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(2):e30243. Epub 2013 Feb 6. PMID: 23405058
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Amyotrophic Lateral Sclerosis
[+]

Female sex hormones such as estradiol and exercise have a possible neuroprotective role in female patients with ALS. Apr 01, 2009

Pubmed Data : Med Hypotheses. 2009 Apr;72(4):434-43. Epub 2009 Jan 19. PMID: 14561497
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Estradiol (E(2))
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Exercise
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Gender Differences
[+]

Fisetin exerts antioxidant and neuroprotective effects in multiple mutant hsod1 models of amyotrophic lateral sclerosis.Mar 16, 2018

Pubmed Data : Neuroscience. 2018 Mar 17. Epub 2018 Mar 17. PMID: 29559385
Article Published Date : Mar 16, 2018
Study Type : In Vitro Study, Transgenic Animal Study
Additional Links
Substances : Fisetin
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Genistein could be a promising treatment for human amyotrophic lateral sclerosis.Jul 17, 2019

Pubmed Data : J Neuroimmune Pharmacol. 2019 Jul 18. Epub 2019 Jul 18. PMID: 31321663
Article Published Date : Jul 17, 2019
Study Type : Transgenic Animal Study
Additional Links
Substances : Genistein
Diseases : Amyotrophic lateral sclerosis (ALS)
Pharmacological Actions : Neuroprotective Agents
[+]

Genistein is neuroprotective in murine models of familial amyotrophic lateral sclerosis and stroke.May 19, 1999

Pubmed Data : Biochem Biophys Res Commun. 1999 May 19;258(3):685-8. PMID: 10329446
Article Published Date : May 19, 1999
Study Type : Animal Study
Additional Links
Substances : Genistein, phytoestrogens
Diseases : Amyotrophic Lateral Sclerosis, Stroke, Stroke: Attenuation/Recovery
Pharmacological Actions : Neuroprotective Agents
[+]

Gingko biloba has a gender-specific neuroprotective effect in a transgenic mouse model of ALS. Aug 01, 2001

Pubmed Data : J Mol Neurosci. 2001 Aug;17(1):89-96. PMID: 11665866
Article Published Date : Aug 01, 2001
Study Type : Transgenic Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Amyotrophic Lateral Sclerosis
[+]

Glycoaminoglycans have neurotrophic and neuroregenerative effects in a mouse model of motor neuron disease.Mar 01, 1998

Pubmed Data : J Neurosci Res. 1998 Mar 1;51(5):559-62. PMID: 9511999
Article Published Date : Mar 01, 1998
Study Type : Animal Study
Additional Links
Substances : Glycoaminoglycans
Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Pharmacological Actions : Neuritogenic, Neuroprotective Agents
[+]

Glycosaminoglycans boost insulin-like growth factor-I-promoted neuroprotection, indicating their potential value in motor neuron disease and peripheral neuropathies.Jan 01, 1999

Pubmed Data : Neuroscience. 1999;93(2):565-72. PMID: 10465440
Article Published Date : Jan 01, 1999
Study Type : Animal Study
Additional Links
Substances : Glycoaminoglycans, Insulin-like Growth Factor (IGF-1)
Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Peripheral Neuropathies
Pharmacological Actions : Apoptotic, Neuroprotective Agents
Additional Keywords : Drug Synergy
[+]

Glycosaminoglycans co-administration enhance insulin-like growth factor-I neuroprotective and neuroregenerative activity in traumatic and genetic models of motor neuron disease.Jul 01, 2000

Pubmed Data : Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):339-46. PMID: 10817918
Article Published Date : Jul 01, 2000
Study Type : Animal Study
Additional Links
Substances : Glycoaminoglycans, Insulin-like Growth Factor (IGF-1)
Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Pharmacological Actions : Neuroprotective Agents, Neurorestorative
Additional Keywords : Natural Substance Synergy
[+]

Inhalation experiments in rats and primates show deposition of Hg in spinal cord following single high-dose short-time exposure.Jul 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Basic Clin Pharmacol Toxicol. 2012 Aug ;111(2):126-32. Epub 2012 Mar 17. PMID: 22364490
Article Published Date : Jul 31, 2012
Study Type : Animal Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases
Problem Substances : Mercury
[+]

L-arginine has potent in vitro and in vivo neuroprotective properties and may be a candidate for therapeutic trials in ALS.Jul 10, 2009

Pubmed Data : Biochem Biophys Res Commun. 2009 Jul 10;384(4):524-9. Epub 2009 May 8. PMID: 19427829
Article Published Date : Jul 10, 2009
Study Type : Animal Study
Additional Links
Substances : Arginine
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Lead may contribute to the pathogenesis of nervous system diseases by stimulating the production of autoantibodies against neural proteins including myelin basic protein.Dec 01, 1994

Pubmed Data : Environ Health Perspect. 1994 Dec;102(12):1052-6. PMID: 7536156
Article Published Date : Dec 01, 1994
Study Type : Animal Study
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Lead Poisoning, Multiple Sclerosis
Problem Substances : Lead
Adverse Pharmacological Actions : Immunotoxic, Interleukin-6 up-regulation
[+]

Light therapy and supplementary Riboflavin in the SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.Dec 31, 2008

Pubmed Data : Lasers Surg Med. 2009 Jan ;41(1):52-9. PMID: 19143012
Article Published Date : Dec 31, 2008
Study Type : Transgenic Animal Study
Additional Links
Substances : Riboflavin (Vitamin B-2)
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation
[+]

Linking respiratory chain uncoupling to amyotrophic lateral sclerosis implies potential treatment with herbal extracts containing genipin.Feb 28, 2013

Pubmed Data : Med Hypotheses. 2013 Mar ;80(3):327. Epub 2012 Dec 21. PMID: 23265356
Article Published Date : Feb 28, 2013
Study Type : Animal Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Intermittent Hypoxia (low oxygen), Stem Cell Related Therapy
Additional Keywords : Plant Extracts
[+]

Lipoic acid significantly improves survival time in a transgenic mouse model of ALSApr 01, 2001

Pubmed Data : Exp Neurol. 2001 Apr;168(2):419-24. PMID: 11259130
Article Published Date : Apr 01, 2001
Study Type : Transgenic Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Amyotrophic Lateral Sclerosis
[+]

Moderate exercise delays the motor performance decline in a transgenic model of ALS.Feb 08, 2010

Pubmed Data : Brain Res. 2010 Feb 8;1313:192-201. Epub 2009 Dec 5. PMID: 19968977
Article Published Date : Feb 08, 2010
Study Type : Transgenic Animal Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Exercise
Pharmacological Actions : Neuroprotective Agents
[+]

Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis.Feb 28, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Stem Cells Transl Med. 2013 Mar ;2(3):167-74. Epub 2013 Feb 14. PMID: 23413376
Article Published Date : Feb 28, 2013
Study Type : Animal Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Stem Cell Related Therapy
Pharmacological Actions : Superoxide Dismutase Up-regulation
[+]

Neuroprotection comparison of rosmarinic acid and carnosic acid in primary cultures of cerebellar granule neurons.Nov 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Nov 13 ;23(11). Epub 2018 Nov 13. PMID: 30428519
Article Published Date : Nov 12, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosmarinic acid
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

Nicotinamide riboside and pterostilbene cooperatively delay motor neuron failure.Nov 09, 2020

Pubmed Data : Mol Neurobiol. 2020 Nov 10. Epub 2020 Nov 10. PMID: 33174130
Article Published Date : Nov 09, 2020
Study Type : Animal Study
Additional Links
Substances : Nicotinamide, Pterostilbene
Diseases : Amyotrophic lateral sclerosis (ALS)
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Non-invasive assessment of disease progression and neuroprotective effects of dietary coconut oil supplementation in the Amyotrophic lateral sclerosis.Sep 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuroimage Clin. 2018 Sep 19 ;20:1092-1105. Epub 2018 Sep 19. PMID: 30368196
Article Published Date : Sep 18, 2018
Study Type : Animal Study
Additional Links
Substances : Coconut Oil
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Pathology reduction and motor behavior improvement associated with ultrasound-mediated delivery of arctiin to the motor cortex.Aug 28, 2024

Pubmed Data : Ultrasonics. 2024 Aug 29 ;144:107449. Epub 2024 Aug 29. PMID: 39217855
Article Published Date : Aug 28, 2024
Study Type : Animal Study
Additional Links
Substances : Burdock, Lignan
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Progesterone has neuroprotective properties in a mouse model of spinal cord motor neuron degeneration disease.Dec 01, 2002

Pubmed Data : Neurobiol Dis. 2002 Dec;11(3):457-68. PMID: 12586554
Article Published Date : Dec 01, 2002
Study Type : Animal Study
Additional Links
Substances : Progesterone
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Protective effects of Withania somnifera extract in a model of amyotrophic lateral sclerosis.Oct 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Neurol. 2018 Nov ;309:193-204. Epub 2018 Aug 19. PMID: 30134145
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ashwagandha
Diseases : Amyotrophic lateral sclerosis (ALS)
Pharmacological Actions : Neuroprotective Agents
[+]

Pyruvate slows disease progression in a transgenic mouse model of ALS.Feb 21, 2007

Pubmed Data : Neurosci Lett. 2007 Feb 21;413(3):265-9. Epub 2006 Dec 13. PMID: 17174029
Article Published Date : Feb 21, 2007
Study Type : Transgenic Animal Study
Additional Links
Substances : Pyruvate
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Resveratrol Ameliorates Motor Neuron Degeneration and Improves Survival in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2014 ;2014:483501. Epub 2014 Jun 26. PMID: 25057490
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Amyotrophic lateral sclerosis (ALS)
[+]

Resveratrol improves motoneuron function and extends survival in SOD1(G93A) ALS mice.Mar 31, 2014

Pubmed Data : Neurotherapeutics. 2014 Apr ;11(2):419-32. PMID: 24414863
Article Published Date : Mar 31, 2014
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Amyotrophic lateral sclerosis (ALS)
[+]

Resveratrol upregulated heat shock proteins and extended the survival of in a mouse model of ALS. Nov 04, 2012

Pubmed Data : Brain Res. 2012 Nov 5 ;1483:112-7. Epub 2012 Sep 19. PMID: 23000195
Article Published Date : Nov 04, 2012
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Antioxidants, Heat Shock Protein Inducer, Superoxide Dismutase Up-regulation
[+]

Rosmarinic acid has therapeutic value in motor dysfunction and life span in a mouse model of familial amyotrophic lateral sclerosis.Feb 28, 2010

Pubmed Data : J Neurosci Res. 2010 Mar ;88(4):896-904. PMID: 19798750
Article Published Date : Feb 28, 2010
Study Type : Animal Study
Additional Links
Substances : Rosemaric Acid, Rosemary
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation
Additional Keywords : Phytotherapy
[+]

Running and swimming prevent the deregulation of the BDNF/TrkB neurotrophic signalling at the neuromuscular junction in amyotrophic lateral sclerosis.Oct 22, 2019

Pubmed Data : Cell Mol Life Sci. 2019 Oct 23. Epub 2019 Oct 23. PMID: 31646358
Article Published Date : Oct 22, 2019
Study Type : Animal Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Exercise, Exercise: Running, Exercise: Swimming
Pharmacological Actions : Neuroprotective Agents
[+]

Scolopendra subspinipes mutilans attenuates neuroinflammation in a mouse model of ALS. Dec 31, 2012

Pubmed Data : J Neuroinflammation. 2013 ;10:131. Epub 2013 Oct 29. PMID: 24168240
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Scolopendra subspinipes mutilans
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Superoxide Dismutase Up-regulation
[+]

Stem cell factor-activated bone marrow ameliorates amyotrophic lateral sclerosis by promoting protective microglial migration.Jun 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurosci Res. 2014 Jul ;92(7):856-69. PMID: 24936617
Article Published Date : Jun 30, 2014
Study Type : Animal Study
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS)
Therapeutic Actions : Stem Cell Related Therapy
[+]

Steroid hormones may have neuroprotective properties in ALS. Jun 01, 2001

Pubmed Data : Cell Mol Neurobiol. 2001 Jun;21(3):237-54. PMID: 11569536
Article Published Date : Jun 01, 2001
Study Type : Animal Study
Additional Links
Substances : Estradiol (E(2)), Progesterone, Testosterone
Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Systemic treatment with adipose-derived mesenchymal stem cells ameliorates clinical and pathological features in the amyotrophic lateral sclerosis murine model.May 27, 2013

Pubmed Data : Neuroscience. 2013 May 28 ;248C:333-343. Epub 2013 May 28. PMID: 23727509
Article Published Date : May 27, 2013
Study Type : Transgenic Animal Study
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS)
Therapeutic Actions : Stem Cell Related Therapy
[+]

Testosterone may have neuroprotective properties.Nov 13, 2009

Pubmed Data : Neurosci Lett. 2009 Nov 13;465(2):123-7. Epub 2009 Sep 6. PMID: 19735695
Article Published Date : Nov 13, 2009
Study Type : Animal Study
Additional Links
Substances : Testosterone
Diseases : Amyotrophic Lateral Sclerosis, Brain Damage, Motor Neuron Disease
Pharmacological Actions : Neuroprotective Agents
[+]

The CB2 cannabinoid agonist AM-1241 prolongs survival (56%) in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset.Jul 01, 2005

Pubmed Data : Curr Eye Res. 2005 Jul;30(7):583-91. PMID: 17241118
Article Published Date : Jul 01, 2005
Study Type : Animal Study
Additional Links
Substances : Cannabinoids
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

The Chinese Herbal Formula: Wen-Pi-Tang delays the onset and progression of ALS. Mar 01, 2009

Pubmed Data : Biol Pharm Bull. 2009 Mar;32(3):382-8. PMID: 19252282
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Wen Pi Tang
Diseases : Amyotrophic Lateral Sclerosis
[+]

The ketogenic diet was neuroprotective and anti-inflammatory against MPTP-neurotoxicity.Sep 30, 2010

Pubmed Data : J Mol Neurosci. 2010 Oct ;42(2):145-53. Epub 2010 Mar 24. PMID: 20333481
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Brain: Microglial Activation, Parkinson's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(4):e61626. Epub 2013 Apr 19. PMID: 23620776
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : EPA (Eicosapentaenoic Acid)
Diseases : Amyotrophic Lateral Sclerosis, Lipid Peroxidation
Pharmacological Actions : Superoxide Dismutase Up-regulation
[+]

The progression of ALS is associated with oxygen radical-induced lipid peroxidative damage, indicating that antioxidant therapy may be useful. Jul 01, 1998

Pubmed Data : J Neurosci Res. 1998 Jul 1;53(1):66-77. PMID: 9670993
Article Published Date : Jul 01, 1998
Study Type : Animal Study
Additional Links
Substances : Antioxidant formulas, Vitamin E
Diseases : Amyotrophic Lateral Sclerosis, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

The serotonin precurser 5-HTP improves locomotor function and survival in a mouse model of ALS.Sep 01, 2003

Pubmed Data : Amyotroph Lateral Scler Other Motor Neuron Disord. 2003 Sep;4(3):171-6. PMID: 14527871
Article Published Date : Sep 01, 2003
Study Type : Animal Study
Additional Links
Substances : 5-HTP (5-Hydroxytryptophan)
Diseases : Amyotrophic Lateral Sclerosis, Lou Gehrig Disease
[+]

Treatment with estradiol (E2) may also delay disease progression of post-menopausal women with ALS.Sep 17, 2004

Pubmed Data : Brain Res. 2004 Sep 17;1021(1):128-31. PMID: 15328040
Article Published Date : Sep 17, 2004
Study Type : Animal Study
Additional Links
Substances : Estradiol (E(2))
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Treatment with hydrogen-rich saline delays disease progression in a mouse model of Amyotrophic lateral sclerosis.Mar 31, 2016

Pubmed Data : Neurochem Res. 2016 Apr ;41(4):770-8. Epub 2015 Nov 4. PMID: 26537817
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Amyotrophic Lateral Sclerosis, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Vitamin D deficiency exacerbates disease pathophysiology in the G93A mouse model of ALS.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(5):e0126355. Epub 2015 May 28. PMID: 26020962
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Amyotrophic lateral sclerosis (ALS), Vitamin D Deficiency
Additional Keywords : Risk Factors
[+]

α-Lipoic acid attenuates oxidative stress and neurotoxicity in a Drosophila model and NSC34 cell line of amyotrophic lateral sclerosis.May 25, 2018

Pubmed Data : Brain Res Bull. 2018 May 26 ;140:299-310. Epub 2018 May 26. PMID: 29842900
Article Published Date : May 25, 2018
Study Type : Insect Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Amyotrophic lateral sclerosis (ALS)
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

7,8-Dihydroxyflavone may have value in ALS. Aug 31, 2013

Pubmed Data : Mol Cell Neurosci. 2013 Sep ;56:18-28. Epub 2013 Mar 14. PMID: 23500004
Article Published Date : Aug 31, 2013
Study Type : In Vitro Study
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS)
Pharmacological Actions : Neuroprotective Agents
[+]

A brief literature review of low-level laser therapy for treating amyotrophic lateral sclerosis and confirmation of its effectiveness.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicine (Taipei). 2024 ;14(1):1-9. Epub 2024 Mar 1. PMID: 38533300
Article Published Date : Dec 31, 2023
Study Type : Review
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Photobiomodulation
[+]

A dietary reduction in glutathione precursors, e.g. glutamate, cysteine and sulfite, as well as glutathionine supplementation may benefit patients with ALS Nov 01, 2008

Pubmed Data : J Altern Complement Med. 2008 Nov;14(9):1159-64. PMID: 18973429
Article Published Date : Nov 01, 2008
Study Type : Commentary
Additional Links
Substances : Glutathione
Diseases : Amyotrophic Lateral Sclerosis
[+]

A review and update of human exposure and toxicity of pesticides. Jan 31, 2017

Pubmed Data : Arch Toxicol. 2017 Feb ;91(2):549-599. Epub 2016 Oct 8. PMID: 27722929
Article Published Date : Jan 31, 2017
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Asthma, Attention Deficit Hyperactivity Disorder, Autism, Birth Defects, Bronchitis, Infertility, Obesity, Parkinson's Disease, Pesticide Toxicity
Additional Keywords : Risk Factors
Problem Substances : Pesticides
Adverse Pharmacological Actions : Neurotoxic
[+]

A review of experimental research on herbal compounds in amyotrophic lateral sclerosis.Dec 31, 2013

Pubmed Data : Phytother Res. 2014 Jan ;28(1):9-21. Epub 2013 Mar 21. PMID: 23519768
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Substances : Herbal Therapies (Unspecified in Abstracts)
Diseases : Amyotrophic Lateral Sclerosis
Additional Keywords : Plant Extracts
[+]

A review on preventive role of ketogenic diet (KD) in CNS disorders from the gut microbiota perspective.Feb 22, 2021

Pubmed Data : Rev Neurosci. 2021 Feb 23 ;32(2):143-157. Epub 2020 Oct 19. PMID: 33070123
Article Published Date : Feb 22, 2021
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Anxiety, Autism Spectrum Disorders, Central Nervous System Diseases, Depression, Epilepsy, Multiple Sclerosis, Parkinson's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Gut-brain Axis
[+]

Acetyl-11-keto-beta boswellic acid mediated neuroprotection in methyl mercury-induced experimental model of ALS.May 31, 2021

Pubmed Data : Neurochem Res. 2021 Jun 1. Epub 2021 Jun 1. PMID: 34075522
Article Published Date : May 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : acetyl-11-keto-beta-boswellic acid
Diseases : Amyotrophic Lateral Sclerosis, Mercury Poisoning
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Methylmercury, Remyelination
Problem Substances : Mercury
[+]

Agents modulating cannabinoid receptors or endocannabinoid tone provide promising therapeutic opportunities in the treatment of inflammatory neurodegenerative disorders of the CNS.Jun 30, 2010

Pubmed Data : Exp Neurol. 2010 Jul ;224(1):92-102. Epub 2010 Mar 29. PMID: 20353778
Article Published Date : Jun 30, 2010
Study Type : Review
Additional Links
Substances : Cannabinoids
Diseases : Amyotrophic Lateral Sclerosis, Inflammation, Multiple Sclerosis, Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

Aluminum is implicated in Alzheimer's, ALS, and parkinsonism-dementia. Its accumulation occurs primarily in infants and children with immature or impaired renal function.Jun 01, 1990

Pubmed Data : Clin Lab Med. 1990 Jun ;10(2):403-22. PMID: 2197055
Article Published Date : Jun 01, 1990
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Kidney Failure: Chronic, Parkinson's Disease
Anti Therapeutic Actions : Vaccination: All
Problem Substances : Aluminum
Adverse Pharmacological Actions : Bioaccumulator, Nephrotoxic, Neurotoxic
[+]

Anthocyanins and their metabolites as therapeutic agents for neurodegenerative disease.Aug 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Aug 22 ;8(9). Epub 2019 Aug 22. PMID: 31443476
Article Published Date : Aug 21, 2019
Study Type : Review
Additional Links
Substances : Anthocyanins
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Antioxidant and anti-inflammatory effects of citrus flavonoid hesperetin.Jul 09, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Jul 10 ;9(7). Epub 2020 Jul 10. PMID: 32664395
Article Published Date : Jul 09, 2020
Study Type : Review
Additional Links
Substances : Hesperidin
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Aquatherapy for neurodegenerative disorders.Dec 31, 2013

Pubmed Data : J Huntingtons Dis. 2014 ;3(1):5-11. PMID: 25062761
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS), Multiple Sclerosis, Neurodegenerative Diseases
Therapeutic Actions : Aquatic therapy , Exercise
[+]

Astragaloside IV and echinacoside benefit neuronal properties via direct effects and through upregulation of SOD1 astrocyte function in vitro.Nov 19, 2020

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 Nov 20. Epub 2020 Nov 20. PMID: 33219470
Article Published Date : Nov 19, 2020
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Bee venom may have therapeutic value in ALS. Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:368196. Epub 2011 Aug 28. PMID: 21904562
Article Published Date : Dec 31, 2011
Study Type : Review
Additional Links
Substances : Bee Venom
Diseases : Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases
[+]

Bee venom shows value in a cell model of ALS. Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2013 ;13:179. Epub 2013 Jul 18. PMID: 23866691
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Bee Venom
Diseases : Amyotrophic lateral sclerosis (ALS)
[+]

Benefits of curcumin in brain disorders.Aug 31, 2019

Pubmed Data : Biofactors. 2019 Sep ;45(5):666-689. Epub 2019 Jun 11. PMID: 31185140
Article Published Date : Aug 31, 2019
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Anxiety, Autism Spectrum Disorders, Dementia, Depression, disease, Huntington Disease, Multiple Sclerosis, Parkinson's Disease, Stroke
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Benefits of the neurogenic potential of melatonin for treating neurological and neuropsychiatric disorders.Mar 01, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2023 Mar 2 ;24(5). Epub 2023 Mar 2. PMID: 36902233
Article Published Date : Mar 01, 2023
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Amyotrophic Lateral Sclerosis, Dementia, Epilepsy, Psychiatric Disorders, Schizophrenia, Traumatic Brain Injury
Pharmacological Actions : Neurogenesis, Neuroprotective Agents
[+]

Bisdemethoxycurcumin, a novel potent polyphenolic compound, effectively inhibits the formation of amyloid aggregates in ALS-associated hSOD1 mutant (L38R).Nov 30, 2024

Pubmed Data : Int J Biol Macromol. 2024 Dec ;282(Pt 2):136701. Epub 2024 Oct 24. PMID: 39461630
Article Published Date : Nov 30, 2024
Study Type : In Vitro Study
Additional Links
Substances : Bisdemethoxycurcumin
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Cannabidiol and neurodegeneration: from molecular mechanisms to clinical benefits. Jul 02, 2024

Pubmed Data : Ageing Res Rev. 2024 Jul 3:102386. Epub 2024 Jul 3. PMID: 38969143
Article Published Date : Jul 02, 2024
Study Type : Review
Additional Links
Substances : Cannabidiol
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Huntington Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Cannabidiol modulates genes linked with amyotrophic lateral sclerosis.Oct 06, 2016

Pubmed Data : J Cell Biochem. 2016 Oct 7. Epub 2016 Aug 7. PMID: 27714895
Article Published Date : Oct 06, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Amyotrophic lateral sclerosis (ALS)
Additional Keywords : Gene Expression Regulation
[+]

Cannabis has potential therapeutic value in the treatment of amyotrophic lateral sclerosis.Aug 01, 2010

Pubmed Data : Am J Hosp Palliat Care. 2010 Aug;27(5):347-56. Epub 2010 May 3. PMID: 20439484
Article Published Date : Aug 01, 2010
Study Type : Review
Additional Links
Substances : Cannabinoids , Cannabis
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, Antioxidants, Neuroprotective Agents
[+]

Cellular mechanisms of melatonin: Insight from neurodegenerative diseases. Jan 06, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2020 08 7 ;10(8). Epub 2020 Aug 7. PMID: 32784556
Article Published Date : Jan 06, 2020
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Huntington Disease, Multiple Sclerosis, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Cultivating stem cells for treating amyotrophic lateral sclerosis.Dec 25, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Stem Cells. 2012 Dec 26 ;4(12):117-9. PMID: 23516096
Article Published Date : Dec 25, 2012
Study Type : Review
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS)
Therapeutic Actions : Stem Cell Related Therapy
[+]

Curcumin abolishes mutant TDP-43 induced excitability in a motoneuron-like cellular model of ALS.Jul 10, 2014

Pubmed Data : Neuroscience. 2014 Jul 11 ;272:141-53. Epub 2014 Apr 29. PMID: 24785678
Article Published Date : Jul 10, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Amyotrophic lateral sclerosis (ALS)
[+]

Curcumin exhibits potential therapeutic properties in a cell model of ALS. Jan 31, 2014

Pubmed Data : Mol Neurobiol. 2014 Feb ;49(1):368-79. Epub 2013 Aug 10. PMID: 23934646
Article Published Date : Jan 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Amyotrophic lateral sclerosis (ALS)
[+]

Curcumin shows therapeutic value in a cell model of ALS. Nov 30, 2012

Pubmed Data : Brain Res Bull. 2012 Dec 1 ;89(5-6):185-90. Epub 2012 Sep 15. PMID: 22986236
Article Published Date : Nov 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Amyotrophic lateral sclerosis (ALS)
[+]

Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Nanomedicine. 2019 ;14:4449-4460. Epub 2019 Jun 17. PMID: 31417253
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Central Nervous System Diseases, Epilepsy, Huntington Disease, Multiple Sclerosis, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Curcumins promote monocytic gene expression related toβ-amyloid and superoxide dismutase clearance.Dec 31, 2011

Pubmed Data : Neurodegener Dis. 2012 ;10(1-4):274-6. Epub 2011 Dec 7. PMID: 22156608
Article Published Date : Dec 31, 2011
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Superoxide Dismutase Up-regulation
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Discovery of natural compounds as nonpeptidyl inhibitors is a significant transition towards feasible drug development for neurodegenerative disorders.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:379817. Epub 2015 May 4. PMID: 26064904
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Rosmarinic acid
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Huntington Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Nonpeptidyl Inhibitors
[+]

Effects of curcumin on microglial cells.Jun 30, 2019

Pubmed Data : Neurotox Res. 2019 Jul ;36(1):12-26. Epub 2019 Apr 4. PMID: 30949950
Article Published Date : Jun 30, 2019
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Brain: Microglial Activation, Brain Inflammation , Multiple Sclerosis, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Neuroprotective Agents
[+]

Effects of ketogenic diet on neuroinflammation in neurodegenerative diseases.Jul 10, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging Dis. 2022 Jul 11 ;13(4):1146-1165. Epub 2022 Jul 11. PMID: 35855338
Article Published Date : Jul 10, 2022
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Brain Inflammation , Parkinson's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Effects of natural antioxidants in neurodegenerative disease.Dec 31, 2011

Pubmed Data : Nutr Neurosci. 2012 Jan ;15(1):1-9. PMID: 22305647
Article Published Date : Dec 31, 2011
Study Type : Review
Additional Links
Substances : Antioxidant formulas, Polyphenols
Diseases : Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Effects of Panax ginseng in Neurodegenerative Diseases.Sep 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2012 Oct ;36(4):342-53. PMID: 23717136
Article Published Date : Sep 30, 2012
Study Type : Review
Additional Links
Substances : Panax Ginseng
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Huntington Disease, Multiple Sclerosis, Neurodegenerative Diseases
[+]

Estradiol may play a role in the neuroprotection of spinal astrocytes in amyotrophic lateral sclerosis patients.Nov 01, 2005

Pubmed Data : Neurobiol Dis. 2005 Nov;20(2):461-70. PMID: 15893467
Article Published Date : Nov 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Estradiol (E(2))
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Estrogen Receptor Modulators, Neuroprotective Agents
[+]

Estradiol protects spinal motor neurons from excitotoxic insults in vitro, and may have application as a treatment for ALS.Nov 09, 2000

Pubmed Data : Neuroreport. 2000 Nov 9;11(16):3493-7. PMID: 11095506
Article Published Date : Nov 09, 2000
Study Type : In Vitro Study
Additional Links
Substances : Estradiol (E(2))
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Estrogen may have therapeutic value in the treatment of amyotrophic lateral sclerosis and spinal cord injury.Feb 01, 2011

Pubmed Data : J Endocrinol. 2011 Feb;208(2):171-82. Epub 2010 Nov 10. PMID: 21068071
Article Published Date : Feb 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Estradiol (E(2))
Diseases : Amyotrophic Lateral Sclerosis, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Excitotoxins (e.g. aspartame, glutamate) may play a significant role in the degeneration in ALS.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Neuropathol. 2013 Jan ;125(1):95-109. Epub 2012 Nov 13. PMID: 23143228
Article Published Date : Dec 31, 2012
Study Type : Review
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Problem Substances : Excitotoxins
[+]

Folic acid protects motor neurons against the increased homocysteine, inflammation and programmed cell death.Jun 01, 2008

Pubmed Data : Neuropharmacology. 2008 Jun;54(7):1112-9. Epub 2008 Mar 16. PMID: 18436268
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Inflammation
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Neuroprotective Agents, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginseng and its constituents have potential merits in the treatment of cerebral disorders.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:2614742. Epub 2016 Aug 18. PMID: 27630732
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Ginseng, Ginsenosides
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Central Nervous System Diseases, Huntington Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review.Jun 15, 2022

Pubmed Data : Crit Rev Food Sci Nutr. 2022 Jun 16:1-66. Epub 2022 Jun 16. PMID: 35708049
Article Published Date : Jun 15, 2022
Study Type : Review
Additional Links
Substances : Astaxanthin
Diseases : Aging, Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Atherosclerosis, Breast Cancer, Chronic Obstructive Pulmonary Disease, Colon Cancer, Diabetic Nephropathy, Diabetic Retinopathy, Lung Cancer, Macular Degeneration, Multiple Sclerosis, Neurodegenerative Diseases, Nonalcoholic fatty liver disease (NAFLD), Osteoarthritis, Osteoporosis, Parkinson's Disease, Prostate Cancer, Stroke
Pharmacological Actions : Hepatoprotective, Neuroprotective Agents, Renoprotective
[+]

Hesperidin and THSG might be potential lead compound to design inhibitors of mutant SOD1 for ALS therapy.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2014 ;2014:156276. Epub 2014 May 18. PMID: 24963318
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Substances : Hesperidin
Diseases : Amyotrophic lateral sclerosis (ALS)
[+]

High-fat and ketogenic diets may have value in treating amyotrophic lateral sclerosis.Jul 31, 2013

Pubmed Data : J Child Neurol. 2013 Aug ;28(8):989-92. Epub 2013 May 10. PMID: 23666040
Article Published Date : Jul 31, 2013
Study Type : Review
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Dietary Modification: High-Fat/Low-Carbohydrate , Dietary Modification: Low Carbohydrate/Ketogenic
[+]

IGF-I prevents glutamate-induced motor neuron programmed cell death.Jan 15, 2009

Pubmed Data : Food Chem Toxicol. 2009 Jan 15. PMID: 15193297
Article Published Date : Jan 15, 2009
Study Type : In Vitro Study
Additional Links
Substances : Insulin-like Growth Factor (IGF-1)
Diseases : Amyotrophic Lateral Sclerosis, Excitotoxicity
Pharmacological Actions : Apoptotic, Neuroprotective Agents
[+]

Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis.Feb 28, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Respir Crit Care Med. 2013 Mar 1 ;187(5):535-42. Epub 2012 Dec 6. PMID: 23220913
Article Published Date : Feb 28, 2013
Study Type : Review
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Stem Cell Related Therapy
Pharmacological Actions : Superoxide Dismutase Up-regulation
[+]

It has been suggested that where it is legal to do so, marijuana should be considered in the pharmacological management of ALS.Jul 01, 2001

Pubmed Data : Am J Hosp Palliat Care. 2001 Jul-Aug;18(4):264-70. PMID: 11467101
Article Published Date : Jul 01, 2001
Study Type : Review
Additional Links
Substances : Cannabis
Diseases : Amyotrophic Lateral Sclerosis
[+]

Ketogenic effect of coconut oil in ALS patients.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2024 ;11:1429498. Epub 2024 Jul 17. PMID: 39086545
Article Published Date : Dec 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Coconut Oil
Diseases : Amyotrophic lateral sclerosis (ALS)
Pharmacological Actions : Neuroprotective Agents
[+]

L-carnitine in the treatment of psychiatric and neurological manifestations.Apr 19, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2024 Apr 20 ;16(8). Epub 2024 Apr 20. PMID: 38674921
Article Published Date : Apr 19, 2024
Study Type : Review
Additional Links
Substances : L-Carnitine
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Carpal Tunnel Syndrome, Depression, Migraines, Neurological Conditions, Stroke
[+]

Mangiferin activates the nuclear factor erythroid 2-related factor pathway to protect SOD1-G93A induced NSC-34 motor neurons from oxidative stress.Sep 30, 2024

Pubmed Data : J Biochem Mol Toxicol. 2024 Oct ;38(10):e23849. PMID: 39264833
Article Published Date : Sep 30, 2024
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin
Diseases : Amyotrophic Lateral Sclerosis, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Mediterranean diet, brain and muscle: Olive polyphenols and resveratrol protection in neurodegenerative and neuromuscular disorders.May 02, 2021

Pubmed Data : Curr Med Chem. 2021 May 3. Epub 2021 May 3. PMID: 33949928
Article Published Date : May 02, 2021
Study Type : Review
Additional Links
Substances : Olive, Polyphenols, Resveratrol
Diseases : Amyotrophic Lateral Sclerosis, Duchenne's Muscular Dystrophy, Muscle Atrophy , Neuromuscular Diseases
Therapeutic Actions : Dietary Modification: Mediterranean Diet
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Melatonin is selectively taken up by mitochondrial membranes which prevents oxidative stress induced mitochondrial dysfunction.Jun 17, 2015

Pubmed Data : Rejuvenation Res. 2015 Jun 18. Epub 2015 Jun 18. PMID: 26087000
Article Published Date : Jun 17, 2015
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Huntington Disease, Mitochondrial Dysfunction , Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Mitochondrial Metabolism
[+]

Melatonin normalizes markers of oxidative stress to control values in a mouse model of ALS. Nov 01, 2006

Pubmed Data : J Pineal Res. 2006 Nov;41(4):313-23. PMID: 17014688
Article Published Date : Nov 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Amyotrophic Lateral Sclerosis
[+]

Melatonin supplementation may have a therapeutic role in neurodegenerative disorders.Dec 31, 2013

Pubmed Data : Front Biosci (Landmark Ed). 2014 ;19:429-46. Epub 2014 Jan 1. PMID: 24389194
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases, Parkinson's Disease
[+]

Melatonin: A review of its potential functions and effects on neurological diseases.Nov 08, 2019

Pubmed Data : Rev Neurol (Paris). 2019 Nov 9. Epub 2019 Nov 9. PMID: 31718830
Article Published Date : Nov 08, 2019
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Epilepsy, Headache, Huntington Disease, Multiple Sclerosis, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents, Prophylactic Agents
[+]

Methyl Vitamin B12 rescues a motor neuron-like cell line from homocysteine-mediated cell death.Mar 15, 2011

Pubmed Data : Toxicol Appl Pharmacol. 2011 Mar 15;251(3):217-25. Epub 2011 Jan 13. PMID: 21237187
Article Published Date : Mar 15, 2011
Study Type : In Vitro Study
Additional Links
Substances : Vitamin B12: methylcobalamin , Vitamin B-12
Diseases : Amyotrophic Lateral Sclerosis, High Homocysteine, Neuroblastoma
Pharmacological Actions : Neuroprotective Agents
[+]

Mindfulness training has been suggested to be of value to ALS patients and their caregivers. Mar 31, 2014

Pubmed Data : J Altern Complement Med. 2014 Apr ;20(4):272-5. Epub 2013 Dec 11. PMID: 24328393
Article Published Date : Mar 31, 2014
Study Type : Commentary
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS)
Therapeutic Actions : Mindfullness Training
[+]

Myricetin: A potent anti-amyloidogenic polyphenol against superoxide dismutase 1 aggregation.Jul 04, 2023

Pubmed Data : ACS Chem Neurosci. 2023 Jul 5 ;14(13):2461-2475. Epub 2023 Jun 14. PMID: 37314311
Article Published Date : Jul 04, 2023
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Neuroprotective potential of caffeic acid phenethyl ester in CNS disorders.Jun 07, 2021

Pubmed Data : Curr Neuropharmacol. 2021 Jun 8. Epub 2021 Jun 8. PMID: 34102977
Article Published Date : Jun 07, 2021
Study Type : Review
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Anxiety, Brain Injury: Traumatic, Depression, Epilepsy, Huntington Disease, Parkinson's Disease, Stroke
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

New neuroprotective effect of lemon integroPectin on neuronal cellular model.Apr 24, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2021 Apr 25 ;10(5). Epub 2021 Apr 25. PMID: 33923111
Article Published Date : Apr 24, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lemon
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Nutritional interventions may be therapeutic in the treatment of amyotrophic lateral sclerosis.Dec 01, 2009

Pubmed Data : Clin Nutr. 2009 Dec;28(6):604-17. Epub 2009 Sep 25. PMID: 19782443
Article Published Date : Dec 01, 2009
Study Type : Commentary
Additional Links
Substances : Alpha-Lipoic Acid, Carnitine, Coenzyme Q10, EGCG (Epigallocatechin gallate), Folic Acid , Ginkgo biloba, Melatonin, Red Wine Extract, Vitamin E
Diseases : Amyotrophic Lateral Sclerosis
[+]

Paeonol exhibits neuroprotective activity via a carrier-mediated transport system.Jul 17, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2022 Jul 18 ;11(7). Epub 2022 Jul 18. PMID: 35883881
Article Published Date : Jul 17, 2022
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Amyotrophic lateral sclerosis (ALS)
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Pesticides and human chronic diseases: evidences, mechanisms, and perspectives.Apr 14, 2013

Pubmed Data : Toxicol Appl Pharmacol. 2013 Apr 15 ;268(2):157-77. Epub 2013 Feb 9. PMID: 23402800
Article Published Date : Apr 14, 2013
Study Type : Review
Additional Links
Diseases : Abnormalities, Amyotrophic Lateral Sclerosis, Drug-Induced, Oxidative Stress
Additional Keywords : Epigenetic Modification
Problem Substances : Pesticides
[+]

Polyphenols and stem cells for neuroregeneration in Parkinson's disease and Amyotrophic lateral sclerosis.Dec 31, 2021

Pubmed Data : Curr Pharm Des. 2022 ;28(10):806-828. PMID: 34781865
Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Polyphenols
Diseases : Amyotrophic Lateral Sclerosis, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Nerve Regeneration
[+]

Progesterone has neuroprotective properties in traumatic central nervous system and motor neuron degeneration.Jul 01, 2009

Pubmed Data : Front Neuroendocrinol. 2009 Jul;30(2):173-87. Epub 2009 Mar 24. PMID: 19318112
Article Published Date : Jul 01, 2009
Study Type : Review
Additional Links
Substances : Progesterone
Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Motor Neuron Disease: Amyotrophic Lateral Sclerosis, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Quercetin activates the Sestrin2/AMPK/SIRT1 axis to improve amyotrophic lateral sclerosis.Apr 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2023 May ;161:114515. Epub 2023 Mar 11. PMID: 36913894
Article Published Date : Apr 30, 2023
Study Type : Review
Additional Links
Substances : Quercetin
Diseases : Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Resveratrol has a protective effect in a cell model of amyotrophic lateral sclerosis.Oct 09, 2011

Pubmed Data : Neurosci Lett. 2011 Oct 10 ;503(3):250-5. Epub 2011 Aug 27. PMID: 21896316
Article Published Date : Oct 09, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Apoptotic, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Resveratrol's therapeutic properties in neurodegenerative conditions may be due to its gene protective and regulatory as well as antioxidant properties.Jun 01, 2008

Pubmed Data : Neuropharmacology. 2008 Jun;54(7):1112-9. Epub 2008 Mar 16. PMID: 15956815
Article Published Date : Jun 01, 2008
Study Type : Review
Additional Links
Substances : Flavonoids, Polyphenols, Red Wine Extract, Resveratrol, Wine
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Brain Inflammation , Neurodegenerative Diseases, Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Stilbenes
[+]

Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases.Dec 31, 2007

Pubmed Data : CNS Neurosci Ther. 2008 ;14(3):234-47. Epub 2008 Jul 29. PMID: 18684235
Article Published Date : Dec 31, 2007
Study Type : Review
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Huntington Disease, Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

Role of the gut microbiota in the development of various neurological diseases.Jul 20, 2019

Pubmed Data : Neurologia. 2019 Jul 21. Epub 2019 Jul 21. PMID: 31340904
Article Published Date : Jul 20, 2019
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Dysbiosis, Multiple Sclerosis, Neuromyelitis Optica, Parkinson's Disease
Additional Keywords : Gut-brain Axis
[+]

Tauroursodeoxycholic acid (TUDCA) may have therapeutic value in neurodegenerative illnesses. Apr 30, 2014

Pubmed Data : Glob Adv Health Med. 2014 May ;3(3):58-69. PMID: 24891994
Article Published Date : Apr 30, 2014
Study Type : Review
Additional Links
Substances : Tauroursodeoxycholic acid
Diseases : Amyotrophic lateral sclerosis (ALS), Huntington Disease, Multiple Sclerosis, Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic
[+]

The critical review results indicate that compounds in avocado are unique antioxidants, and thus may be promising as effective neuropreventive agents.Dec 31, 2015

Pubmed Data : Adv Neurobiol. 2016 ;12:337-54. PMID: 27651262
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Avocado
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Huntington Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Avocado, Huntington Disease, Neurodegenerative diseases, Parkinson's disease
[+]

The endocannabinoid system may play a valuable role in the development of treatment options for amyotrophic lateral sclerosis.Jan 01, 2008

Pubmed Data : Curr Pharm Des. 2008;14(23):2306-16. PMID: 18781981
Article Published Date : Jan 01, 2008
Study Type : Review
Additional Links
Substances : Cannabinoids
Diseases : Amyotrophic Lateral Sclerosis, Endocannabinoid Disorders, Endocannabinoid System
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Diseases that are Linked
[+]

The findings of this study add evidence to an association between magnetic field exposure and dementia.Jan 01, 2006

Pubmed Data : Soz Praventivmed. 2006 ;51(4):210-20. PMID: 17193783
Article Published Date : Jan 01, 2006
Study Type : Review
Additional Links
Diseases : Motor Neuron Disease, Neurodegenerative Diseases
Additional Keywords : Radio Frequency Electromagnetic Radiation Exposure
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Neurotoxic
[+]

The herbal preparation Padma® 28 protects against neurotoxicity in PC12 cells.Apr 30, 2011

Pubmed Data : Phytother Res. 2011 May ;25(5):740-3. Epub 2011 Mar 17. PMID: 21413090
Article Published Date : Apr 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Tibetan Herbal Formula: Padma 28
Diseases : Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

The ketogenic diet may have therapeutic value in neuromuscular and neurodegenerative Diseases.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2014 ;2014:474296. Epub 2014 Jul 3. PMID: 25101284
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Mitochondrial Diseases, Neurodegenerative Diseases, Parkinson's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet may have value in ALS. Jun 30, 2011

Pubmed Data : Neurol Neurochir Pol. 2011 Jul-Aug;45(4):370-8. PMID: 22101998
Article Published Date : Jun 30, 2011
Study Type : Review
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The neuroprotective potential of carotenoids in vitro and in vivo.Jul 20, 2021

Pubmed Data : Phytomedicine. 2021 Jul 21 ;91:153676. Epub 2021 Jul 21. PMID: 34339943
Article Published Date : Jul 20, 2021
Study Type : Review
Additional Links
Substances : Carotenoids
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Huntington Disease, Parkinson's Disease, Stroke
Pharmacological Actions : Neuroprotective Agents
[+]

The potential of flavonoids for the treatment of neurodegenerative diseases.Jun 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Jun 22 ;20(12). Epub 2019 Jun 22. PMID: 31234550
Article Published Date : Jun 21, 2019
Study Type : Review
Additional Links
Substances : Flavonoids
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, disease, Huntington Disease, Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

The review concludes the results of recent studies on Ashwagandha suggesting its extensive potential as neuroprotective in various brain disorders.Apr 15, 2020

Pubmed Data : J Ethnopharmacol. 2020 Apr 16 ;257:112876. Epub 2020 Apr 16. PMID: 32305638
Article Published Date : Apr 15, 2020
Study Type : Review
Additional Links
Substances : Ashwagandha
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Attention Deficit Disorder with Hyperactivity, Autism Spectrum Disorders, Depression, Huntington Disease, Parkinson's Disease, Schizophrenia
Pharmacological Actions : Neuroprotective Agents
[+]

The role of the intestinal microbiota in neurodegenerative diseases.Aug 12, 2018

Pubmed Data : Neurochem Int. 2018 Aug 13. Epub 2018 Aug 13. PMID: 30114473
Article Published Date : Aug 12, 2018
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Autism Spectrum Disorders, Brain Inflammation , Dysbiosis, Neurodegenerative Diseases, Parkinson's Disease
[+]

Therapeutic potential and molecular mechanisms of echinacoside in neurodegenerative diseases.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:841110. Epub 2022 Feb 4. PMID: 35185590
Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Echinacea
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

This review describes the cellular metabolism of aluminum ions and how they relate to neurodegeneration.Mar 01, 1986

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 1986 Mar ;65:363-441. PMID: 2940082
Article Published Date : Mar 01, 1986
Study Type : Review
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Brain Inflammation
Anti Therapeutic Actions : Vaccination: All
Problem Substances : Aluminum
[+]

This review describes the cellular metabolism of aluminum ions and how they relate to neurodegeneration.Mar 01, 1986

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 1986 Mar ;65:363-441. PMID: 2940082
Article Published Date : Mar 01, 1986
Study Type : Review
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Brain Inflammation
Anti Therapeutic Actions : Vaccination: All
Problem Substances : Aluminum
[+]

This review describes the cellular metabolism of aluminum ions and how they relate to neurodegeneration.Mar 01, 1986

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 1986 Mar ;65:363-441. PMID: 2940082
Article Published Date : Mar 01, 1986
Study Type : Review
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Brain Inflammation
Anti Therapeutic Actions : Vaccination: All
Problem Substances : Aluminum
[+]

This review discusses the potential of cannabinoid therapeutics as disease-modifying or symptom control agents for slowing disease progression in MS and ALS.Dec 31, 2014

Pubmed Data : Handb Exp Pharmacol. 2015 ;231:213-31. PMID: 26408162
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Cannabinoids , Cannabis, Endocannabinoids
Diseases : Amyotrophic lateral sclerosis (ALS), Multiple Sclerosis
Pharmacological Actions : Neuroprotective Agents

Copyright: rob3000 / 123RF Stock Photo

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