Brain Hypoxia

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20 Substances Researched for Brain Hypoxia
NameACCKFocus
Pomegranate24Locked
Curcumin23Locked
Flavonoids13Locked
Huperzine23Locked
Bacopa12Locked
Carnosine12Locked
Ephedra sinica (Ma Huang)12Locked
Green Tea12Locked
L-arginine12Locked
P-Coumaric Acid12Locked
Paeoniflorin12Locked
Purslane12Locked
Resveratrol12Locked
Sulforaphane22Locked
Tribulus12Locked
Astragaloside11Locked
Cordyceps sinensis11Locked
Ferulic acid11Locked
Ginsenosides11Locked
Puerarin11Locked

View the Evidence:
24 Abstracts with Brain Hypoxia Research

[+]

DMT can increase survival and alleviate cellular stress in hypoxic environments.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2016 ;10:423. Epub 2016 Sep 14. PMID: 27683542
Article Published Date : Dec 31, 2015
Study Type : Human In Vitro
Additional Links
Diseases : Brain: Oxidative Stress, Brain Hypoxia, Brain Ischemia
Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Neuroprotective Agents
[+]

An extract of Bacopa monnieri restored the memory in CoCl2-hypoxia mimetic mice.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:347978. Epub 2015 Aug 27. PMID: 26413121
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Bacopa
Diseases : Brain Hypoxia, Cognitive Decline/Dysfunction, Memory Disorders, Memory Loss
Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
Additional Keywords : Gene Expression Regulation, Plant Extracts
[+]

Curcumin intervention effectively reversed the Fas/FasL-mediated apoptosis and hypoxia-hypercapnia brain edema.May 31, 2015

Pubmed Data : Am J Med Sci. 2015 Jun ;349(6):521-5. PMID: 25867253
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Brain Hypoxia, Hypercapnia
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Ephedrine, a compound found within Ephedra, can enhance spatiral orientation and memory abilities of hypoxic-ischemic brain injured rats. Aug 01, 2007

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2007 Aug;32(16):1684-7. PMID: 18027668
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Substances : Ephedra sinica (Ma Huang)
Diseases : Brain Hypoxia, Brain Ischemia
[+]

Green tea polyphenols attenuate behavioral and oxidative responses to intermittent hypoxia. May 15, 2008

Pubmed Data : Am J Respir Crit Care Med. 2008 May 15;177(10):1135-41. Epub 2008 Feb 14. PMID: 18276944
Article Published Date : May 15, 2008
Study Type : Animal Study
Additional Links
Substances : Green Tea
Diseases : Brain Hypoxia, Hypoxia, Sleep Apnea: Central
[+]

Huperzine A attenuates cognitive deficits and brain injury after hypoxia-ischemic brain damage in neonatal rats. Jan 01, 2003

Pubmed Data : Zhonghua Er Ke Za Zhi. 2003 Jan;41(1):42-5. PMID: 14761327
Article Published Date : Jan 01, 2003
Study Type : Animal Study
Additional Links
Substances : Huperzine
Diseases : Brain Hypoxia
[+]

L-arginine and carnosine combination could effectively protect against hypoxia-induced neurotoxicity.Oct 21, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Oct 22. Epub 2019 Oct 22. PMID: 31641819
Article Published Date : Oct 21, 2019
Study Type : Animal Study
Additional Links
Substances : Carnosine, L-arginine
Diseases : Brain Hypoxia
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substance Synergy
[+]

Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury.May 31, 2005

Pubmed Data : Pediatr Res. 2005 Jun ;57(6):858-64. Epub 2005 Mar 17. PMID: 15774834
Article Published Date : May 31, 2005
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Brain Hypoxia, Brain Ischemia
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Phytotherapy
[+]

Paeoniflorin supplementation has potent protective efficiency against neonatal hypoxia/ischemia-induced brain injury.Feb 28, 2021

Pubmed Data : Korean J Physiol Pharmacol. 2021 Mar 1 ;25(2):97-109. PMID: 33602880
Article Published Date : Feb 28, 2021
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Brain: Oxidative Stress, Brain Hypoxia, Brain Injury: Traumatic
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Pinocembrin can act as a potential therapeutic strategy for intermittent hypoxia-induced neuroinflammation.Nov 10, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2020 Nov 11 ;17(1):337. Epub 2020 Nov 11. PMID: 33176803
Article Published Date : Nov 10, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Brain Hypoxia, Brain Inflammation , Sleep Apnea: Obstructive
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury.Dec 31, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dev Neurosci. 2007 ;29(4-5):363-72. PMID: 17762204
Article Published Date : Dec 31, 2006
Study Type : Animal Study
Additional Links
Substances : Pomegranate, Resveratrol
Diseases : Brain Hypoxia, Brain Ischemia
Pharmacological Actions : Antioxidants, Apoptotic, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Prophylactic effect and mechanism of p-coumaric acid against hypoxic cerebral edema in mice.Dec 31, 2018

Pubmed Data : Respir Physiol Neurobiol. 2019 02 ;260:95-104. Epub 2018 Nov 14. PMID: 30447305
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Brain: Oxidative Stress, Brain Hypoxia, Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, Prophylactic Agents
[+]

Protective effect of resveratrol against hypoxia-induced neural oxidative stress.Jul 22, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pers Med. 2022 Jul 23 ;12(8). Epub 2022 Jul 23. PMID: 35893296
Article Published Date : Jul 22, 2022
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Brain Hypoxia, Neurodegenerative Diseases
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Purslane (P. olecracea) attenuates hypoxia in nerve tissues. Jan 01, 2007

Pubmed Data : Asia Pac J Clin Nutr. 2007;16 Suppl 1:227-33. PMID: 17392109
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Purslane
Diseases : Brain Hypoxia, Hypoxia: Brain
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Tribulus terrestris can decrease the apoptosis induced by hypoxia and reoxygenation. Jan 01, 2008

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2008 Jan;6(1):45-50. PMID: 18184546
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Tribulus
Diseases : Brain Hypoxia, Hypoxia: Brain
Pharmacological Actions : Neuroprotective Agents
[+]

A Cordyceps sinensis extract reduced the amount of hypoxia-induced inflammatory cytokines and transcription factors on par with the normoxic control.Dec 31, 2014

Pubmed Data : Int J Med Mushrooms. 2015 ;17(9):829-40. PMID: 26756295
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Cordyceps sinensis
Diseases : Brain Hypoxia, Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Astragaloside IV reduces the hypoxia-induced injury in PC-12 cells.Sep 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 Oct ;106:419-425. Epub 2018 Jul 11. PMID: 29990829
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Brain Hypoxia
Pharmacological Actions : MicroRNA modulator, Neuroprotective Agents
[+]

Curcumin protects against adverse changes associated with neuronal hypoxia. Jan 01, 2003

Pubmed Data : Asia Pac J Clin Nutr. 2003;12(1):50-60. PMID: 18461445
Article Published Date : Jan 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Brain Hypoxia
Pharmacological Actions : Neuroprotective Agents
[+]

Ferulic acid could reduce the oxidative stress induced by hypoxia in PC12 cells.Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2015 May ;18(5):478-84. PMID: 26124934
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ferulic acid
Diseases : Brain Hypoxia, Oxidative Stress
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Huperzine A protects against brain oxygen-glucose deprivation-induced injury. Feb 20, 2007

Pubmed Data : FEBS Lett. 2007 Feb 20;581(4):596-602. Epub 2007 Jan 18. PMID: 17257593
Article Published Date : Feb 20, 2007
Study Type : In Vitro Study
Additional Links
Substances : Huperzine
Diseases : Brain Hypoxia, Brain Inflammation , Hypoxia
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Puerarin attenuates hypoxia-resulted damages in neural stem cells by up-regulating microRNA-214.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):2746-2753. PMID: 31282213
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Brain Hypoxia
Pharmacological Actions : MicroRNA modulator, Neuroprotective Agents
[+]

Sulforaphane protects astrocytes (brain cells) against oxidative stress and delayed death caused by oxygen and glucose deprivation.Apr 15, 2009

Pubmed Data : Glia. 2009 Apr 15;57(6):645-56. PMID: 18942756
Article Published Date : Apr 15, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Hypoxia, Cerebral Ischemia, Hypoglycemia, Hypoxia, Oxidative Stress
Pharmacological Actions : Antioxidants, Apoptotic, Neuroprotective Agents
[+]

Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation.May 01, 2010

Pubmed Data : J Neurosci Res. 2010 May 1;88(6):1355-63. PMID: 19998483
Article Published Date : May 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Damage, Brain Hypoxia, Brain Injury: Hippocampal Damage, Hypoglycemia, Hypoxia, Oxidative Stress
Pharmacological Actions : Neuroprotective Agents
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The results indicate that the activation of the GABA(A) receptor is correlated with the neuroprotective mechanisms of ginsenoside Rb3.Jan 26, 2011

Pubmed Data : J Ethnopharmacol. 2011 Jan 27 ;133(2):914-6. Epub 2010 Oct 20. PMID: 20969942
Article Published Date : Jan 26, 2011
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Brain Hypoxia
Pharmacological Actions : Neuroprotective Agents

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