Brain Injury: Traumatic

Name	AC	CK
Curcumin	10	36
Melatonin	6	27
Hydrogen Water	7	14
Delta-tetrahydrocannabinol (THC)	1	10
Vitamin D	1	10
Ashwagandha	2	6
Astaxanthin	3	6
Formononetin	3	6
Isoliquiritigenin	3	6
Tanshinone IIA	3	6
Safflower	3	5
Blueberry	2	4
Flavonoids	3	4
Resveratrol	3	4
Sinomenine	2	4
Sulforaphane	2	4
Thiamine (B-1)	2	4
Caffeic acid phenethyl ester	2	3
Cannabidiol	2	3
Myricetin	1	3
Pycnogenol (Pine Bark)	2	3
6-Shogaol	1	2
Aloe Vera	1	2
Andrographolide	1	2
Anthocyanins	1	2
Apocynin	1	2
Berberine	1	2
Beta-Elemene	1	2
Carnosic Acid	1	2
Carvacrol	1	2
Cordyceps Militaris	1	2
Crocin	1	2
Ferulic acid	1	2
Fisetin	1	2
Folate	1	2
Folic Acid	1	2
Fucoxanthin	1	2
Ginkgo biloba	1	2
Hesperidin	1	2
Honokiol	1	2
Huperzine	1	2
Hydrogen: Molecular	1	2
Jujube	1	2
Ligustrazine	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Mangiferin	1	2
NAC (N-acetyl-L-cysteine)	1	2
Omega-3 Fatty Acids	1	2
Onion	1	2
Paeoniflorin	1	2
Palmitoylethanolamide	1	2
Panax Notoginseng	1	2
Piperine	1	2
Psychedelics:All	1	2
Quercetin	1	2
Saffron	1	2
Taurine	1	2
Turkey Tail Mushroom	1	2
Ubiquinol	1	2
Wogonin	1	2
acetyl-11-keto-beta-boswellic acid	1	2
Alpha-Lipoic Acid	1	1
Antioxidant formulas	1	1
Cannabinoids	1	1
Curcuminoids	1	1
Elecampane	1	1
Ginseng (Korean)	1	1
Ginsenosides	1	1
Persimmon	1	1
Rhubarb	1	1
Tetrahydrocurcumin	1	1
beta-Carotene	1	1

Name	AC	CK	Focus
Aspirin	1	10
Clopidogrel	1	10

Name	AC	CK
Music	4	41
Photobiomodulation	5	27
Qigong	2	11
Tai Chi	2	11
Acupressure	1	10
Acupuncture	1	10
Yoga	1	10
Dietary Modification: Low Carbohydrate/Ketogenic	3	6
Hyperbaric Treatment	2	4
Light-Emitting Diodes (LEDs) Therapy	1	3
Laser Treatment	1	2
Light Therapy: Red Colored	1	1

[+]

Curcumin in the treatment of inflammation and oxidative stress responses in traumatic brain injury.Dec 31, 2023

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Pubmed Data : Front Neurol. 2024 ;15:1380353. Epub 2024 May 10. PMID: 38798711

Article Published Date : Dec 31, 2023

Study Type : Meta Analysis, Review

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Substances : Curcumin

Diseases : Brain Injury: Traumatic

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

[+]

Photobiomodulation in acute traumatic brain injury.Jan 31, 2023

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Pubmed Data : J Neurotrauma. 2023 Feb ;40(3-4):210-227. Epub 2022 Aug 30. PMID: 35698294

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Pubmed Data : Am Surg. 2014 Oct ;80(10):979-83. PMID: 25264643

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Pubmed Data : Healthcare (Basel). 2023 Aug 11 ;11(16). Epub 2023 Aug 11. PMID: 37628465

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Pubmed Data : Complement Ther Clin Pract. 2020 Apr 8 ;40:101172. Epub 2020 Apr 8. PMID: 32347208

Article Published Date : Apr 07, 2020

Study Type : Human Study

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Diseases : Brain Injury: Traumatic

Therapeutic Actions : Yoga

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Significant Treatment Outcome

[+]

W. somnifera root extract was neuroprotective and could have therapeutic potential in secondary injury and long-term sequelae of mild TBI.Jun 30, 2017

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Pubmed Data : Front Neurol. 2022 ;13:882991. Epub 2022 Jun 21. PMID: 35800078

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Diseases : Brain Injury: Traumatic

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Neuroprotective Agents

[+]

6-Shogaol treatment produced beneficial effects for TBI-induced anxiety/depression-like behaviors.Jan 10, 2022

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Pubmed Data : Nurs Outlook. 2017 Jul 1. Epub 2017 Jul 1. PMID: 28755974

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Pubmed Data : J Neurotrauma. 2019 Jul 1 ;36(13):2147-2152. Epub 2019 Mar 26. PMID: 30672378

Article Published Date : Jun 30, 2019

Study Type : Animal Study

Additional Links

Substances : Carnosic Acid

Diseases : Brain Injury: Traumatic

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, Nrf2 activation

[+]

Carvacrol decreases blood-brain barrier permeability post-diffuse traumatic brain injury.Sep 03, 2023

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Pubmed Data : Sci Rep. 2023 Sep 4 ;13(1):14546. Epub 2023 Sep 4. PMID: 37666857

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Pubmed Data : Mol Med Rep. 2015 Dec ;12(6):7985-91. Epub 2015 Oct 13. PMID: 26496827

Article Published Date : Nov 30, 2015

Study Type : Animal Study

Additional Links

Substances : Psychedelics:All

Diseases : Brain Injury: Traumatic

Pharmacological Actions : Anti-Apoptotic, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Hericium erinaceus and Coriolus versicolor modulate molecular and biochemical changes after traumatic brain injury.Jun 01, 2021

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Pubmed Data : Am J Transl Res. 2017 ;9(12):5653-5661. Epub 2017 Dec 15. PMID: 29312517

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Formononetin

Diseases : Brain Injury: Traumatic

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, MicroRNA modulator, Neuroprotective Agents

[+]

Integrated metabolomics and network pharmacology to reveal the mechanisms of hydroxysafflor yellow A against acute traumatic brain injury.Dec 31, 2020

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Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.Dec 31, 2013

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Pubmed Data : PLoS One. 2014 ;9(9):e108034. Epub 2014 Sep 24. PMID: 25251220

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Hydrogen Water

Diseases : Alzheimer's Disease, Brain Injury: Traumatic, Neurodegenerative Diseases, Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Risk Reduction

[+]

N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury.Dec 31, 2017

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Pubmed Data : Neurotox Res. 2023 Feb ;41(1):57-84. Epub 2022 Dec 28. PMID: 36576717

Article Published Date : Jan 31, 2023

Study Type : Animal Study

Additional Links

Substances : acetyl-11-keto-beta-boswellic acid, Piperine

Diseases : Brain Injury: Traumatic

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Pycnogenol preserves synaptic function after controlled cortical impact injury.Jan 31, 2016

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Pubmed Data : Exp Neurol. 2016 Feb ;276:5-12. Epub 2015 Nov 29. PMID: 26607913

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Brain Injury: Traumatic

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

[+]

Quercetin improves mitochondrial function in traumatic brain injury models.Dec 31, 2015

Pubmed Data : Acta Pharmacol Sin. 2010 Oct 18. Epub 2010 Oct 18. PMID: 20953205

Article Published Date : Oct 18, 2010

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Brain Injury: Traumatic, Traumatic Brain Injury

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Tanshinone IIA attenuates neuronal loss in mouse traumatic brain injury model.Dec 31, 2019

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Pubmed Data : Neurotherapeutics. 2010 Jan;7(1):51-61. PMID: 20129497

Article Published Date : Jan 01, 2010

Study Type : Review

Additional Links

Substances : Alpha-Lipoic Acid, Antioxidant formulas, Curcumin, Resveratrol

Diseases : Brain Injury: Traumatic, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Pharmacological Actions : Neuroprotective Agents

[+]

Protective effects of curcumin against traumatic brain injury.Sep 30, 2022

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Progesterone attenuates adverse neurologic and morphologic changes following traumatic brain injury in rats.May 01, 2007

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Pubmed Data : Exp Neurol. 2007 May;205(1):145-53. Epub 2007 Feb 12. PMID: 17362936

Article Published Date : May 01, 2007

Additional Links

Diseases : Brain Injury: Traumatic

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View the Evidence: 127 Abstracts with Brain Injury: Traumatic Research

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Curcumin in the treatment of inflammation and oxidative stress responses in traumatic brain injury.Dec 31, 2023

Photobiomodulation in acute traumatic brain injury.Jan 31, 2023

The role of music therapy in traumatic brain injury.Oct 28, 2020

There is evidence that melatonin treatment after traumatic brain injury significantly improves both behavioural outcomes and pathological outcomes.Jun 13, 2018

A positive THC screen is associated with decreased mortality in adult patients sustaining traumatic brain injury.Sep 30, 2014

A Qigong exercise intervention programme may improve mood and self-esteem for individuals with traumatic brain injury. Jul 01, 2009

Acupressure appears to improve memory as a non-pharmacological intervention for traumatic brain injury.Oct 27, 2010

Effect of acupuncture on recovery of consciousness in patients with acute traumatic brain injury.Aug 10, 2023

Neurologic music therapy improves executive function and emotional adjustment in traumatic brain injury rehabilitation.Jul 01, 2009

The effect of music therapy on physiological parameters of patients with traumatic brain injury.Jul 31, 2020

There is high mortality rate associated with aspirin or clopidogrel or both in elderly patients who have head trauma resulting in intracranial hemmorhage. Oct 01, 2008

Vitamin D deficiency is common in patients after TBI and associated with impaired cognitive function and more severe depressive symptoms.Feb 26, 2016

Yoga led to significant improvements in balance, mobility, and self-reported occupational performance in adults with chronic brain injury.Apr 07, 2020

W. somnifera root extract was neuroprotective and could have therapeutic potential in secondary injury and long-term sequelae of mild TBI.Jun 30, 2017

Myricetin suppresses traumatic brain injury-induced inflammatory response.Dec 19, 2023

Two cases of improved cognitive function After transcranial, light-emitting diode treatments in chronic, traumatic brain injury.Dec 23, 2010

Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury Aug 31, 2020

40 Hz blue LED Relieves the gamma oscillations changes caused by traumatic brain injury.Dec 31, 2021

6-Shogaol treatment produced beneficial effects for TBI-induced anxiety/depression-like behaviors.Jan 10, 2022

A curcumin derivative restores membrane homeostasis disrupted after brain trauma.Nov 01, 2010

A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury.Dec 31, 2020

Administering ubiquinol 30 min before traumatic brain injury significantly affected cerebral gene expression profiles.Jun 30, 2017

Administration of palmitoylethanolamide protects the neurovascular unit and reduces secondary injury after traumatic brain injury.Oct 31, 2012

Aloin protects against blood-brain barrier damage after traumatic brain injury in mice.May 31, 2020

Andrographolide alleviates acute brain injury. Dec 31, 2017

Apocynin has a protective role in a rat model of traumatic brain injury.Aug 06, 2017

Astaxanthin improves cognitive performance in mice following mild traumatic brain injury.Dec 30, 2016

Astaxanthin provides neuroprotection in an experimental model of traumatic brain injury.Dec 31, 2020

Astaxanthin reduces traumatic brain injury-related injury in brain tissue.Dec 31, 2015

Beneficial effects of hydrogen gas in a rat model of traumatic brain injury.Sep 30, 2010

Berberine protects secondary injury in mice with traumatic brain injury. Jul 18, 2018

Bone mesenchymal stem cell exosomes exert a neuroprotective effect by inhibiting early neuroinflammation.Dec 31, 2018

Carnosic acid improves outcome after repetitive mild traumatic brain injury.Jun 30, 2019

Carvacrol decreases blood-brain barrier permeability post-diffuse traumatic brain injury.Sep 03, 2023

Curcumin attenuates cerebral edema following traumatic brain injury in mice.Feb 01, 2010

Curcumin has a neuroprotective effect in brain trauma. Jul 21, 2009

Curcumin treatment significantly improved the neurological status evaluated during 2 weeks after brain injury.Aug 31, 2013

Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury.Jan 09, 2020

Dietary blueberry supplementation has a beneficial effect in mitigating the acute aspects of the traumatic brain injury pathology.May 20, 2019

Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition.Feb 01, 2006

Effect of hydrogen-rich water on the chondriosome damage and cytokines in brain tissue of rats with traumatic brain injury.Mar 31, 2018

Expression of VEGF and GFAP in a rat model of traumatic brain injury treated with honokiol.Mar 04, 2019

Fisetin alleviates oxidative stress after traumatic brain injury.May 21, 2018

Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.Apr 30, 2010

Formononetin mediates the promising anti-traumatic brain injury effects against neurocyte damage.Mar 14, 2014

Fucoxanthin provides neuroprotection in models of traumatic brain injury.Apr 20, 2017

Ginkgolide B reduces neuronal cell apoptosis in the traumatic rat brain.Nov 30, 2012

Harmine may exert neuroprotective effects by synergistically reducing excitotoxicity and inflammation following traumatic brain injury.Nov 30, 2015

Hericium erinaceus and Coriolus versicolor modulate molecular and biochemical changes after traumatic brain injury.Jun 01, 2021

Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury.Nov 14, 2018

Huperzine A alleviates neuroinflammation, oxidative stress and improves cognitive function after repetitive traumatic brain injury.Jan 11, 2017

Hydrogen rich water could exert a neuroprotective effect against traumatic brain injury and attenuate inflammation.Apr 14, 2016

Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury.Aug 31, 2012

Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway.Jul 31, 2018

Hydrogen-rich water has beneficial effects on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury.Apr 30, 2016

Hydrogen-rich water promote CD34+ cells home to the site of injured tissue in rats with traumatic brain injury.Feb 28, 2017

Hydroxysafﬂor yellow A exerts antioxidant effects in a rat model of traumatic brain injury.Sep 30, 2016

Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury.Dec 31, 2016

Integrated metabolomics and network pharmacology to reveal the mechanisms of hydroxysafflor yellow A against acute traumatic brain injury.Dec 31, 2020

Isoliquiritigenin attenuates neuroinflammation in traumatic brain injury.Dec 31, 2018

Isoliquiritigenin protects against blood brain barrier damage and inhibits the secretion of pro-inflammatory cytokines in mice after traumatic brain injury.Nov 30, 2018

Isoliquiritigenin provides protection and attenuates oxidative stress-induced injuries after traumatic brain injury.Nov 30, 2018

Ketogenic Diet as a potential treatment for traumatic brain injury in mice.Dec 06, 2021

Ketogenic diet protects myelin and axons in diffuse axonal injury.Jan 22, 2021

Low-level Laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits.Apr 01, 2007

Mangiferin attenuates blast-induced traumatic brain injuryApr 24, 2017

Melatonin restores KCC2 expression, inhibits neuronal apoptosis and attenuates secondary brain injury after traumatic brain injury.May 08, 2016

Melatonin supplementation has protective effect on oxidative stress and antioxidant redox system in the cerebral cortex and blood.May 31, 2014

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.Dec 31, 2013

N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury.Dec 31, 2017

Neuroprotective effect of formononetin against traumatic brain injury.Sep 30, 2018

Neuroprotective effects of Vaccinium myrtillus on damage-related brain injury.Dec 31, 2022

Brain Injury: Traumatic

View the Evidence:
127 Abstracts with Brain Injury: Traumatic Research