Brain Ischemia

Name	AC	CK
Ginsenosides	12	31
Ginkgo biloba	16	29
Curcumin	15	28
Flavonoids	13	20
Resveratrol	6	20
Hydrogen Water	9	18
Cannabidiol	7	13
EGCG (Epigallocatechin gallate)	2	12
Astragaloside	7	11
Frankincense	2	11
Gastrodin	6	11
Paeoniflorin	6	11
Fiber	1	10
Policosanol	1	10
Puerarin	5	10
Rye	1	10
Wheat Grass	1	10
Whole Grains	1	10
Panax Notoginseng	4	7
Safflower	4	6
Thymoquinone	4	6
Hydrogen: Molecular	3	5
Rose	3	5
Tanshinone IIA	3	5
Cannabinoids	2	4
Carnosine	2	4
Coenzyme Q10	2	4
Coumestrol	2	4
Grape Seed Extract	2	4
Persimmon	2	4
Pomegranate	2	4
Quercetin	2	4
Apigenin	2	3
Berberine	2	3
Betulinic acid	2	3
Chrysin	2	3
Icariin	2	3
Lion's Mane (Hericium Erinaceus)	1	3
Luteolin	2	3
Lycopene	2	3
Melatonin	2	3
Polyphenols	2	3
Pomelo	1	3
Poria cocos	2	3
Theanine	2	3
Angelica	1	2
Apple Polyphenols	1	2
Astaxanthin	1	2
Astragalus	1	2
Bamboo	1	2
Biochanin A	1	2
Blueberry	1	2
Butterfly Pea	1	2
Carnitine	1	2
Celastrol	1	2
Chlorogenic Acid	1	2
Citrus naringin	1	2
Dates	1	2
Diosgenin	1	2
Diosmin	1	2
Dong Quai	1	2
Eleutherococcus senticosus	1	2
Ephedra sinica (Ma Huang)	1	2
Eriodictyol	1	2
Genistein	1	2
Geraniol	1	2
Gingerol	1	2
Ginseng	1	2
Ginseng (Korean)	1	2
Glycyrrhizin	1	2
Grapefruit peel extract	1	2
Green Tea	1	2
Lauric acid	1	2
Ligustrazine	1	2
Lithium	1	2
Magnolol	1	2
Mangiferin	1	2
Nobiletin	1	2
Noni	1	2
Okra	1	2
Oleuropein	1	2
Palmitoylethanolamide	2	2
Parthenolide	1	2
Patchouli	1	2
Perillaldehyde	1	2
Phloretin	1	2
Pine Bark Extract	1	2
Proanthocyanidins	1	2
Pterostilbene	1	2
Pycnogenol (Pine Bark)	1	2
Red Sage	1	2
Salvia divinorum	1	2
Salvia miltiorrhiza	1	2
Schisandra	1	2
Silymarin	1	2
Spikenard	1	2
Tetrahydrocurcumin	1	2
Turmeric	1	2
Ume (Japanese apricot)	1	2
Xanthohumol	1	2
Yellow Sweet Clover (Melilotus officinalis)	1	2
6-Shogaol	1	1
Arachidonic Acid	1	1
Catechin	1	1
Cinnamon	1	1
Fenugreek	1	1
Holy Basil	1	1
Isoflavones	1	1
Kudzu	1	1
Moringa oleifera	1	1
Nattokinase	1	1
Nigella sativa (aka Black Seed)	1	1
Rhodiola (Tibetan Ginseng)	1	1
Seaweed	1	1
Taurine	1	1
Tea	1	1
Vitexins	1	1
acetyl-11-keto-beta-boswellic acid	1	1

Name	AC	CK
Aspirin	1	10
Calcium Supplements	1	10
Warfarin	1	10
Toluene	1	2

Name	AC	CK
Electroacupuncture	8	16
Acupuncture	1	10
Photobiomodulation	4	7
Exercise	3	6
Infrared Light	2	4
Electrotherapy	1	3
Hyperbaric Treatment	1	2

[+]

Effect of acupuncture on ischaemic stroke in patients with rheumatoid arthritis.Feb 12, 2024

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Life Sci. 2022 Oct 1 ;306:120833. Epub 2022 Jul 23. PMID: 35882273

Article Published Date : Sep 30, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Brain Ischemia

Pharmacological Actions : Neuroprotective Agents

[+]

Pomelo peel essential oil ameliorates cerebral ischemia-reperfusion injury.Dec 31, 2021

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Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:8279851. Epub 2022 May 5. PMID: 35571242

Article Published Date : Dec 31, 2021

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Pubmed Data : Curr Eye Res. 2005 Jul;30(7):583-91. PMID: 17882954

Article Published Date : Jul 01, 2005

Study Type : Animal Study

Additional Links

Substances : Red Sage

Diseases : Brain Ischemia, Cerebral Ischemia, Stroke, Stroke: Attenuation/Recovery

Pharmacological Actions : Neuritogenic

Additional Keywords : Nerve Regeneration, Regenerative Substances, Stroke: Recovery

[+]

A. esculentus flowers protects against transient cerebral ischemia-reperfusion injury.Dec 31, 2017

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Betulinic acid protects against cerebral ischemia-reperfusion injury.Apr 29, 2011

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Pubmed Data : Nitric Oxide. 2011 Apr 30 ;24(3):132-8. Epub 2011 Feb 1. PMID: 21292018

Article Published Date : Apr 29, 2011

Study Type : Animal Study

Additional Links

Substances : Betulinic acid

Diseases : Brain: Oxidative Stress, Brain Ischemia

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nitric Oxide Inhibitor

[+]

Bilobalide protects against neuronal death in global brain ischemia.Aug 31, 2002

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Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2002 Sep ;48(6):663-9. PMID: 12396077

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Pubmed Data : Neurochem Res. 2008 Jun;33(6):1036-43. Epub 2008 Jan 18. PMID: 18204970

Article Published Date : Jun 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Brain Ischemia, Cerebral Ischemia, Cerebral Stroke, Middle Cerebral Artery Occlusion (MCAO), Stroke: Attenuation/Recovery , Stroke: Prevention

[+]

Curcumin ameliorates white matter injury after ischemic stroke.Dec 31, 2020

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Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:1552127. Epub 2021 Sep 30. PMID: 34630845

Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats.Jun 13, 2011

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Pubmed Data : J Ethnopharmacol. 2011 Jun 14 ;136(1):117-22. Epub 2011 Apr 16. PMID: 21527331

Article Published Date : Jun 13, 2011

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Brain Ischemia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care.Mar 31, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Phytother Res. 2005 Feb;19(2):167-9. PMID: 15852490

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Pubmed Data : Brain Res Bull. 2012 Feb 10 ;87(2-3):193-8. Epub 2011 Nov 12. PMID: 22100334

Article Published Date : Feb 09, 2012

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Brain Ischemia, Stroke

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

[+]

F. mume is potentially an effective therapeutic for the treatment of vascular dementia.Dec 31, 2014

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Pubmed Data : BMC Complement Altern Med. 2015 ;15:125. Epub 2015 Apr 22. PMID: 25898017

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Pubmed Data : Neuroreport. 2024 Jul 1 ;35(10):664-672. Epub 2024 May 16. PMID: 38813905

Article Published Date : Jun 30, 2024

Study Type : Animal Study

Additional Links

Substances : Gastrodin

Diseases : Brain Ischemia, Stroke

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Anti-Inflammatory Agents, Brain-derived neurotrophic factor modulator, Interleukin-6 Downregulation

[+]

Gastrodin improves cognitive dysfunction and decreases oxidative stress in vascular dementia rats induced by chronic ischemia.Dec 31, 2014

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Pubmed Data : Chem Biol Drug Des. 2023 Sep ;102(3):523-535. Epub 2023 Apr 28. PMID: 37118873

Article Published Date : Aug 31, 2023

Study Type : Animal Study

Additional Links

Substances : Geraniol

Diseases : Brain Ischemia, Oxidative Stress, Stroke

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Ginkgetin attenuates cerebral ischemia-reperfusion induced autophagy and cell death.Sep 29, 2019

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Pubmed Data : Biosci Rep. 2019 Sep 30 ;39(9). Epub 2019 Sep 6. PMID: 31420372

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Pubmed Data : Oncotarget. 2017 Jul 4 ;8(27):44682-44693. PMID: 28591721

Article Published Date : Jul 03, 2017

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Brain Ischemia, Stroke

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

[+]

Ginkgolide K protects SH‑SY5Y cells against oxygen‑glucose deprivation‑induced injury by inhibiting the p38 and JNK signaling pathways.Aug 31, 2018

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[+]

Glycyrrhizin attenuates hypoxic-ischemic brain damage by inhibiting ferroptosis and neuroinflammation.Dec 31, 2021

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Isoginkgetin attenuates endoplasmic reticulum stress-induced autophagy of brain after ischemic reperfusion injury.Nov 16, 2021

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Pubmed Data : Bioengineered. 2021 Nov 17. Epub 2021 Nov 17. PMID: 34787074

Article Published Date : Nov 16, 2021

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Ginkgo biloba

Diseases : Brain Ischemia

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents

[+]

Korean ginseng tea has a cerebroprotective effect against global and focal models of ischemia in rats.Oct 03, 2005

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Pubmed Data : J Ethnopharmacol. 2005 Oct 3;101(1-3):299-307. PMID: 15970412

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Neuroprotective Agents, NF-kappaB Inhibitor

Additional Keywords : MicroRNA-21

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:1330928. Epub 2022 Nov 15. PMID: 36425058

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Pubmed Data : Dev Neurosci. 2007 ;29(4-5):363-72. PMID: 17762204

Article Published Date : Dec 31, 2006

Study Type : Animal Study

Additional Links

Substances : Pomegranate, Resveratrol

Diseases : Brain Hypoxia, Brain Ischemia

Pharmacological Actions : Antioxidants, Apoptotic, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Pre-conditioning with transcranial low-level light therapy reduces neuroinflammation and protects blood-brain barrier after focal cerebral ischemia.Dec 31, 2015

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Pubmed Data : Restor Neurol Neurosci. 2016 ;34(2):201-14. PMID: 26889965

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Diseases : Brain Inflammation , Brain Ischemia

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Present study concludes that Melilotus officinalis extract ameliorates apoptosis of brain tissues in cerebral ischemia.Apr 30, 2017

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Pubmed Data : Biomed Pharmacother. 2017 May ;89:1346-1352. Epub 2017 Mar 18. PMID: 28320101

Article Published Date : Apr 30, 2017

Study Type : Animal Study

Additional Links

Substances : Yellow Sweet Clover (Melilotus officinalis)

Diseases : Brain Ischemia, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Pretreatment of grape seed proanthocyanidin extract exerts neuroprotective effect in murine model of neonatal hypoxic-ischemic brain injury.May 29, 2019

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Pubmed Data : Cell Mol Neurobiol. 2019 May 30. Epub 2019 May 30. PMID: 31147852

Pubmed Data : J Infect Dis. 1997 Oct;176(4):1072-5. PMID: 20655115

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Pubmed Data : Stroke. 2010 Dec ;41(12):2956-64. PMID: 21115947

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Pubmed Data : Cancer Res. 2008 Jul 1;68(13):5345-54. PMID: 17705146

Article Published Date : Jul 01, 2008

Study Type : Animal Study

Additional Links

Substances : Theanine

Diseases : Brain Ischemia, Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

[+]

Therapeutic potential of novel twin compounds containing tetramethylpyrazine and carnitine substructures in experimental ischemic stroke.Dec 31, 2016

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B. sernata and AKBA reduce neuronal cell death induced by OGSD and this neuroprotective effect is mediated via attenuation of oxidative stress.Apr 30, 2017

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Pubmed Data : Acta Pol Pharm. 2017 May ;74(3):911-920. PMID: 29513961

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Pubmed Data : Neurochem Int. 2013 Nov ;63(5):522-32. Epub 2013 Sep 4. PMID: 24012531

Neuroprotection of hydroxysafflor yellow A in experimental cerebral ischemia/reperfusion injury.Mar 31, 2019

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Pubmed Data : Mol Med Rep. 2019 Apr ;19(4):3009-3020. Epub 2019 Feb 15. PMID: 30816517

Article Published Date : Mar 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Safflower

Diseases : Brain: Oxidative Stress, Brain Ischemia

Pharmacological Actions : Neuroprotective Agents

[+]

Neuroprotective effect of Ginkgolide K against H2O2-induced PC12 cell cytotoxicity by ameliorating mitochondrial dysfunction and oxidative stress.Dec 31, 2013

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Pubmed Data : Biol Pharm Bull. 2014 ;37(2):217-25. Epub 2013 Nov 12. PMID: 24225258

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Pubmed Data : Planta Med. 2007 Jun ;73(7):650-4. Epub 2007 Jun 22. PMID: 17583824

Pubmed Data : Med Hypotheses. 1999 Oct;53(4):290-9. PMID: 10608263

Article Published Date : Oct 01, 1999

Study Type : Review

Additional Links

Substances : Taurine

Diseases : Angina Pectoris, Brain Ischemia, Cerebral Ischemia, Intermittent Claudication, Ischemic Disorders

[+]

The neuroprotective mechanisms of ginkgolides and bilobalide in cerebral ischemic injury.Dec 20, 2019

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Pubmed Data : Mol Med. 2019 Dec 21 ;25(1):57. Epub 2019 Dec 21. PMID: 31864312

View the Evidence: 237 Abstracts with Brain Ischemia Research

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Aspirin adversely effects cerebral blood flow in vivo, which may explain why research has shown it may increase the risk of ischemic stroke. Jul 01, 1999

Effect of acupuncture on ischaemic stroke in patients with rheumatoid arthritis.Feb 12, 2024

Epigallocatechin gallate could potentially be used as a supplement of traditional rt-PA treatment among stroke patients.Dec 08, 2016

Evidence shows that calcium supplementation may elevate brain lesions in this study. Jun 30, 2014

Functional improvement and immune-inflammatory cytokines profile of ischaemic stroke patients after treatment with boswellic acids.Nov 30, 2019

Ginsenoside-Rd may be of some benefit in acute ischaemic stroke.Apr 30, 2009

In this large cohort of older patients with atrial fibrillation, they observed the highest rate of ischemic stroke in the first 30 days after warfarin initiation.Mar 31, 2015

Policosanol administered to patients suffering ischemic stroke treated with aspirin and vitamins showed good results on neurological outcomes and recurrent events.Sep 01, 2005

Resveratrol may positively modulate cerebral blood flow variables.Jun 01, 2010

This finding provides further evidence to support the health benefits of whole-grain consumption.Dec 31, 2018

DMT can increase survival and alleviate cellular stress in hypoxic environments.Dec 31, 2015

A case report of chronic pain associated with severe cerebral ischemia treated with spinal cord stimulation. Jun 01, 2007

Bilobalide prevents ischemia-induced edema formation in vitro and in vivo.Jan 04, 2007

Erinacine A attenuates glutamate transporter 1 downregulation and protects against ischemic brain injury.Sep 30, 2022

Pomelo peel essential oil ameliorates cerebral ischemia-reperfusion injury.Dec 31, 2021

2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside treatment promoted angiogenesis and recovery from ischemia/reperfusion-induced brain injury.Apr 30, 2017

6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries.Jul 14, 2020

A compound found within Red Sage, salvianolic acid B, alleviates brain damage and reverses some motor function loss in a rat model of stroke. Jul 01, 2005

A. esculentus flowers protects against transient cerebral ischemia-reperfusion injury.Dec 31, 2017

Angelica sinensis exerts angiogenic and anti-apoptotic effects against cerebral ischemia-reperfusion injury.Dec 31, 2016

Apigenin protects the brain against ischemia/reperfusion injury.Dec 31, 2017

Astaxanthin reduces ischemic brain injury in adult rats. Jun 01, 2009

Astragalin alleviates cerebral ischemia-reperfusion injury by improving anti-oxidant and anti-inflammatory activities.Apr 20, 2020

Astragaloside IV ameliorates cerebral ischemia-reperfusion injury.Oct 11, 2022

Astragaloside IV may alleviate hypoxic-ischemic brain damage.Mar 31, 2021

Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain.Dec 27, 2020

Bamboo has anti-apoptic and neuroprotective effects and may be useful for ischemic injury. Apr 21, 2010

Berberine exhibits neuroprotective qualities against ischemic brain damage in stroke modelsDec 05, 2008

Betulinic acid protects against cerebral ischemia-reperfusion injury.Apr 29, 2011

Bilobalide protects against neuronal death in global brain ischemia.Aug 31, 2002

Biochanin A has been shown to have neuroprotective effects in cerebral ischemia/reperfusion.Jan 14, 2015

Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function.Sep 30, 2012

Cannabidiol has a neuroprotective property in newborn rodent hypoxic ischemic insult.Sep 26, 2016

Carnosine protects against cerebral ischemic injury by inhibiting matrix-metalloproteinases.Jul 12, 2021

Celastrol protects against cerebral ischemia/reperfusion injury.Dec 31, 2021

Cerebral ischemia was protected by oleuropein.Sep 18, 2018

Chlorogenic acid ameliorates memory loss and hippocampal cell death after transient global ischemia.Aug 21, 2019

Chronic low dose lithium treatment exhibits neuroprotection in transient focal cerebral ischemia. May 01, 2003

Chrysin prevents cognitive and hippocampal long-term potentiation deficits and inflammation in rat with cerebral hypoperfusion and reperfusion injury.May 31, 2019

Clitoria ternatea L. root extract ameliorated the cognitive and hippocampal long-term potentiation deficits induced by chronic cerebral hypoperfusion.Oct 04, 2018

Components of Astragalus and Panax notoginseng could strengthen the protective effects on cerebral ischemia injury.Dec 31, 2014

CoQ10 is a robust neuroprotective agent against ischemia-reperfusion brain injury in ratsSep 13, 2015

Coumestrol has neuroprotective effects before and after global cerebral ischemia in female rats.Sep 19, 2012

Coumestrol treatment has potential benefits for either prevention or therapeutics use against cerebral ischemia in males.Feb 28, 2014

Curcumin (from Turmeric) has a protective effect against Middle Cerebral Artery Occlusion (MCAO)Jun 01, 2008

Curcumin ameliorates white matter injury after ischemic stroke.Dec 31, 2020

Curcumin can ameliorate cerebral pathological changes in the event of ischemic brain injury.Jun 01, 2009

Curcumin exhibits neuroprotective properties when given 4h post-ischemia in the rat thromboembolic stroke models.Nov 21, 2008

Curcumin has a neuroprotective effect in hypoxia ischemia brain tissue injury. Apr 01, 2009

Curcumin has a neuroprotective effect in in middle cerebral artery occlusion induced focal cerebral ischemia in rats.Jan 09, 2004

Curcumin has a neuroprotective effect on focal cerebral ischemic rats by preventing blood-brain barrier damage.Jan 01, 2010

Curcumin has neuroprotective effect on transient focal cerebral ischemia in rats.Sep 10, 2008

Curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus.May 01, 2006

Curcumin protects against ischaemia/reperfusion insult in rat forebrain.Sep 01, 2002

Curcumin protects rat brains against focal ischemia.Jul 28, 2009

Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia.Dec 31, 2016

Diosgenin attenuates the brain injury induced by transient focal cerebral ischemia-reperfusion.Dec 31, 2015

Diosmin protects against cerebral ischemia/reperfusion injury.May 29, 2014

Dose-finding study of phototherapy on stroke outcome in a rabbit model of ischemic stroke.Sep 05, 2016

Effect of 2-week naringin supplementation on neurogenesis and BDNF levels in ischemia-reperfusion model.Mar 07, 2024

Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats.Jun 13, 2011

Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care.Mar 31, 2023

EGCG could be coadministered with rt-PA, to extend its therapeutic window in treating acute brain ischemia.Mar 31, 2016

Electroacupuncture alleviates neurological function via activating the Yap-OPA1 axis and mitochondrial fusion in rats with cerebral ischemia.Nov 24, 2023

Electroacupuncture can alleviate learning and memory impairment in cerebral ischemia-reperfusion.Apr 24, 2024

Electroacupuncture can up-regulate the expression of angiogenesis-related factors in middle cerebral artery occlusion.Oct 24, 2019

Electroacupuncture improves cognitive impairment after ischemic stroke.Nov 30, 2024

Electroacupuncture of scalp acupoint alleviates cerebral ischemic inflammatory injury.Feb 24, 2024

Electroacupuncture pre-treatment is effective in improving cerebral ischemia-reperfusion injury in animals.Dec 24, 2019

Electroacupuncture reduces inflammatory damage following cerebral ischemia-reperfusion.Sep 01, 2024

Eleutherococcus has a neuroprotective effect by inhibiting inflammation and microglial activation in brain ischemia.Feb 01, 2005

Ephedrine, a compound found within Ephedra, can enhance spatiral orientation and memory abilities of hypoxic-ischemic brain injured rats. Aug 01, 2007

Brain Ischemia

View the Evidence:
237 Abstracts with Brain Ischemia Research