Brain: Microglial Activation

Name	AC	CK
Curcumin	12	15
Resveratrol	6	9
Cannabidiol	4	7
Cannabinoids	4	6
Ginsenosides	5	6
Paeoniflorin	3	5
Sulforaphane	3	5
Blueberry	2	4
Chinese Skullcap	2	4
Ginkgo biloba	3	4
Diosgenin	1	3
Fucoidan	3	3
Ketone Bodies	3	3
Luteolin	3	3
Quercetin	2	3
Cannabis	1	2
Coenzyme Q10	1	2
Emodin	1	2
Estradiol (E(2))	1	2
Fish Oil	1	2
Flavonoids	2	2
Gardenia	1	2
Gastrodin	2	2
Ginger	1	2
Glucosamine	1	2
Paeonol	2	2
Pomegranate	1	2
Reishi Mushroom	1	2
Sesamin	1	2
Spirulina	1	2
Stilbenes	1	2
Valerian	1	2
Vitamin D	1	2
Acacia catechu	1	1
Achillea fragrantissima	1	1
Agrimony	1	1
Apigenin	1	1
B-complex	1	1
Barley	1	1
Bee Venom	1	1
Beta-Caryophyllene	1	1
Butterbur	1	1
Catechols	1	1
Dandelion	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Eriodictyol	1	1
Fisetin	1	1
Genistein	1	1
Grapefruit	1	1
Green Tea	1	1
Isoflavones	1	1
Knema laurina	1	1
Lauric acid	1	1
Lignans	1	1
Matairesinol	1	1
Myricetin	1	1
Oleuropein	1	1
Omega-3 Fatty Acids	1	1
Phlorotannins	1	1
Piceatannol	1	1
Polyphenols	1	1
Punicalagin	1	1
Pycnogenol (Pine Bark)	1	1
Toona sinensis	1	1
Vanillin	1	1
Walnut	1	1

Name	AC	CK
Cell Phone Exposure	1	5
Bisphenol A	1	2
Mercury	2	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2
Polystyrene nanoparticles	1	2
Aluminum	1	1
Fluoride	1	1
Lectins	1	1
Pesticides	1	1
Sodium Fluoride	1	1
Wheat Germ Agglutinin (WGA)	1	1

Name	AC	CK
Dietary Modification: Low Carbohydrate/Ketogenic	2	12
Electroacupuncture	2	4
Photobiomodulation	1	2
Exercise	1	1

Name	AC	CK
Electromagnetic Field Harms	5	13
Electromagnetic Radiation	5	13
Electromagnetic Radiation: 1.8 GHz	1	5
Microwave Radiation	1	5
Mobile Phone Radiation	1	5
Electromagnetic Radiation: 2.4 GHz	1	2
Western Diet	1	2
Vaccination: All	1	1

[+]

Chronic consumption of proton pump inhibitors may increase the risk for Alzheimer disease.Apr 01, 2010

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Pubmed Data : J Clin Pharm Ther. 2010 Apr;35(2):125-6. PMID: 20456731

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2025 ;16:1462699. Epub 2025 Jan 23. PMID: 39917617

Article Published Date : Dec 31, 2024

Study Type : Human Study

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Diseases : Brain: Microglial Activation, Drug Addiction

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Anti-Inflammatory Agents

[+]

1800 MHz radiofrequency fields stimulates pro-inflammatory responses in microglia and astrocytes in vitro.Jan 01, 2014

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Pubmed Data : PLoS One. 2014 ;9(9):e108318. Epub 2014 Oct 2. PMID: 25275372

Article Published Date : Jan 01, 2014

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Pubmed Data : Sci Rep. 2016 Feb 18 ;6:21568. Epub 2016 Feb 18. PMID: 26888450

Article Published Date : Feb 17, 2016

Study Type : Animal Study

Additional Links

Diseases : Aging, Brain: Microglial Activation

Anti Therapeutic Actions : Western Diet

[+]

Curcumin and CoQ10 independently as well as in combination ameliorate chronic hyperalgesia in sickle mice.Nov 05, 2015

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Ginsenoside Rg3 attenuates microglia activation following systemic lipopolysaccharide treatment in mice.Dec 31, 2011

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Pubmed Data : Biol Pharm Bull. 2012 ;35(9):1546-52. PMID: 22975507

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Pubmed Data : J Biol Regul Homeost Agents. 2019 Jul-Aug;33(4):1051-1062. PMID: 31392878

Article Published Date : Jul 01, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Brain: Microglial Activation

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation

Adverse Pharmacological Actions : Inflammatory, Neurotoxic

[+]

Quercetin hinders microglial activation to alleviate neurotoxicity.May 24, 2021

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Pubmed Data : Eur J Pharmacol. 2008 Jun 24;588(1):106-13. Epub 2008 Apr 18. PMID: 18499097

Article Published Date : Jun 24, 2008

Study Type : In Vitro Study

Additional Links

Substances : Acacia catechu, Catechols

Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Neurodegenerative Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Enzyme Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Certain natural compounds could help minimize the neuro- aspects of long covid.Feb 21, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cells. 2023 Feb 22 ;12(5). Epub 2023 Feb 22. PMID: 36899824

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Pubmed Data : Cell Mol Neurobiol. 2014 Jan ;34(1):31-42. Epub 2013 Sep 13. PMID: 24030360

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol, Cannabinoids , Delta-tetrahydrocannabinol (THC), Lignans

Diseases : Brain: Microglial Activation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Neuroprotective Agents

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Knema laurina (Black wild nutmeg) has a high anti-inflammatory and neuroprotective effect and promotes neurogenesis if given hours after stroke like injury.Jan 03, 2009

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Pubmed Data : J Neuroimmunol. 2009 Jan 3 ;206(1-2):91-9. Epub 2008 Nov 22. PMID: 19028400

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Pubmed Data : FEBS J. 2020 Sep 27. Epub 2020 Sep 27. PMID: 32981207

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Pharmacol Res. 2006 Dec ;54(6):461-7. Epub 2006 Sep 28. PMID: 17067811

Article Published Date : Nov 30, 2006

Study Type : In Vitro Study

Additional Links

Substances : Piceatannol

Diseases : Brain: Microglial Activation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

Pycnogenol may be developed as a therapeutic agent for the treatment of neuroinflammatory diseases.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Glia. 2018 Feb ;66(2):256-278. Epub 2017 Oct 23. PMID: 29058362

Article Published Date : Jan 31, 2018

Study Type : Review

Additional Links

Substances : Ketone Bodies

Diseases : Brain: Microglial Activation, Depression

Pharmacological Actions : Antidepressive Agents, Histone deacetylase inhibitor

[+]

The plant extracts curcumin, quercetin, green tea, balcalein, and luteolin offer protection and promote healing of neurological tissues Jan 01, 2012

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Pubmed Data : Surg Neurol Int. 2012 ;3:19. Epub 2012 Feb 15. PMID: 22439110

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Pubmed Data : Mol Biosyst. 2015 Nov ;11(11):2915-24. PMID: 26256823

Article Published Date : Oct 31, 2015

Study Type : In Vitro Study

Additional Links

Diseases : Brain: Microglial Activation, Pesticide Toxicity

Problem Substances : Pesticides

Adverse Pharmacological Actions : Inflammatory, Neurotoxic

[+]

This study suggests that excitotoxicity may be the central mechanism of autism spectrum disorders and that excitotoxins like aluminum, fluoride, and mercury may exacerbate excitotoxicity.Jan 01, 2009

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Pubmed Data : Curr Med Chem. 2009 ;16(2):157-70. PMID: 19149568

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View the Evidence: 118 Abstracts with Brain: Microglial Activation Research

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Chronic consumption of proton pump inhibitors may increase the risk for Alzheimer disease.Apr 01, 2010

Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism.Aug 14, 2010

These results indicate excessive microglial activation in multiple brain regions in young adult subjects with ASD.Dec 31, 2012

This succinct analysis offers evidence of the enormous potential of a KD to treat drug addiction through the inhibition of microglial activation.Dec 31, 2024

1800 MHz radiofrequency fields stimulates pro-inflammatory responses in microglia and astrocytes in vitro.Jan 01, 2014

Diosgenin prevents microglial activation and protects dopaminergic neurons from lipopolysaccharide-induced neural damage.Sep 25, 2021

Resveratrol inhibits activation of microglia after stroke.Jan 30, 2023

"Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine."Jun 30, 2012

2.45 GHz EMF exposure can initiate the activation of rat microglia cells and STAT3 signalling involves in EMF-induced microglial activation.Jan 01, 2010

2.45 GHz radiation exposure resulted in decreased protein kinase C activity in the hippocampus and increase in glial cell count in exposed rats.Jan 01, 2006

A compound in Chinese skullcap known as baicalein reduces the inflammatory process in a rodent model of diabetic retinopathyMay 01, 2009

Acute exposure to 900-MHz microwaves induces glial reactivity and biochemical modifications in the rat brain.Dec 01, 2004

Bisphenol A exposure induces increased microglia and microglial related factors in the murine embryonic dorsal telencephalon and hypothalamus.Feb 28, 2018

Blueberry attenuates microglial activation in the brain suggesting it may attenuate age-induced inflammation. Dec 14, 2009

Blueberry treatment administered before and/or after lipopolysaccharide stimulation attenuates inflammation and oxidative stress.Jan 31, 2023

Cannabidiol has a neuroprotective effect in endotoxin-induced uveitis. Jan 01, 2008

Cannabidiol inhibits symptoms of multiple sclerosis-like disease in mice. Mar 30, 2011

Cannabinoids demonstrated antinociceptive effects in this mouse model of diabetic peripheral neuropathy.Mar 16, 2010

Cannabinoids may have therapeutic value in neurodegenerative conditions by preventing and/or reducing neuroinflammation. Feb 22, 2007

Chinese skullcap (Scutellaria baicalensis) significantly improves functional recovery from spinal cord injury in rats by inhibiting inflammation and oxidative stress after injury.Aug 01, 2009

Chronic consumption of a western diet induces robust glial activation in aging mice.Feb 17, 2016

Curcumin and CoQ10 independently as well as in combination ameliorate chronic hyperalgesia in sickle mice.Nov 05, 2015

Curcumin protects pre-oligodendrocytes from activated microglia, indicating it may play a role in protecting against preterm periventricular leukomalacia (PVL).Jun 21, 2010

Effect of electroacupuncture at fengchi on facial allodynia, microglial activation, and microglia-neuron interaction in a rat model of migraine.Aug 17, 2022

Electroacupuncture pre-treatment alleviates sepsis-induced brain injury by inhibition of microglial activation and attenuation of inflammation.Oct 18, 2016

Emodin relieves morphine-stimulated BV2 microglial activation and inflammation.May 14, 2024

Fish oil consumption may play an important role in modulating microglial/macrophage response and ameliorating the Alzheimer's disease pathology.Dec 31, 2018

Genipin, a compound found within gardenia fruit, inhibits microglial activation in a mouse model of brain inflammation. Feb 01, 2010

Ginger inhibits micoglial cell activiation associated with brain inflammation. Jun 01, 2009

Ginkgolide B protects against ischemic strokeAug 31, 2016

Ginsenoside Rg3 attenuates microglia activation following systemic lipopolysaccharide treatment in mice.Dec 31, 2011

Glucosamine exerts a neuroprotective effect via suppression of inflammation in rat brain ischemia/reperfusion injury.Nov 15, 2010

Paeoniflorin protects against ischemia-induced brain damages in rats.Dec 31, 2011

Photobiomodulation may alleviate neuroinflammation and lymphocyte activation.Jun 06, 2024

Polystyrene nanoplastics penetrate across the blood-brain barrier and induce activation of microglia in the brain of mice.Jun 30, 2022

Pomegranate polyphenols and extract inhibit nuclear factor of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease.Apr 30, 2013

Pulsed electromagnetic fields induce microglia polarization and inflammation in the brain.Jul 01, 2019

Quercetin hinders microglial activation to alleviate neurotoxicity.May 24, 2021

Reishi (Ganoderma lucidum) Protects Dopaminergic Neuron Degeneration Through Inhibition of Microglial Activation.Jul 16, 2009

Resveratrol reduces infection-related neuroinflammation and deficits in working memory in aged mice.Dec 01, 2009

Selective suppression of microglial activation by paeoniflorin attenuates morphine tolerance.Jul 31, 2015

Sesamin protects against neurotoxicity via inhibition of microglial activation under high glucose circumstances.Jul 03, 2022

Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation.Jan 01, 2010

Sulforaphane suppresses LPS-induced inflammation in primary rat microglia, indicating it may have a therapeutic role in reducing brain inflammation.Jun 01, 2010

The ketogenic diet was neuroprotective and anti-inflammatory against MPTP-neurotoxicity.Sep 30, 2010

There is evidence that estradiol may have neuroprotective properties. Jan 01, 2011

This study provides additional evidence for a microglial activation component in schizophrenia.Jan 01, 2014

Turmeric extract exhibits anti-Alzheimer properties.Aug 30, 2011

Valerian root extracts has protective effects against ischemic injury in the hippocampal pyramidal neurons.May 31, 2015

Vitamin D markedly reduces angiotensin II and ameliorates overactivation of NADPH in the brain.Jan 01, 2019

"Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells."Jul 31, 2011

Achillea fragrantissima possesses anti-neuroinflammatory activities for prevention or treatment of neurodegenerative diseases.Dec 31, 2010

Agrimony has an inhibitory effect on lipopolysaccharide-induced nitric oxide and proinflammatory cytokine production in microglial cells, indicating it may be of use in treating brain inflammation. Feb 01, 2010

Animal studies demonstrate a link between maternal immune activation and autism spectrum disorder in offspring.Jan 01, 2018

Anti-apoptotic and anti-inflammatory properties of grapefruit integroPectin on human microglial HMC3 cell line.Feb 17, 2024

Anti-inflammatory effect of ginsenoside Rg5 in lipopolysaccharide-stimulated BV2 microglial cells.May 07, 2013

Anti-inflammatory effects of ginsenoside-Rh2 inhibits LPS-induced activation of microglia and overproduction of inflammatory mediators.Apr 30, 2016

Apigenin and luteolin have anti-inflammatory effects and may have neuroprotective/disease-modifying properties in various neurodegenerative disorders, including Alzheimer's disease (AD).Jan 01, 2008

Bee venom and its major component melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated microglia.Jan 01, 2010

Butterbur (P. hybridus) exhibits ant-inflammatory activity in rat microglial (brain) cells. Jan 01, 2005

Catechols have anti-inflammatory effects in lipopolysaccharide-stimulated microglia cells, inhibiting neurotoxicity. Jun 24, 2008

Certain natural compounds could help minimize the neuro- aspects of long covid.Feb 21, 2023

Compound K is a promising agent for prevention and the treatment of cerebral ischemia and other neuroinflammatory disorders.Mar 31, 2012

Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia.Oct 01, 2007

Curcumin inhibits lipopolysaccharide-activated primary microglia.Jan 01, 2009

Curcumin protects against cerebral ischemia-induced neuronal cell death.Oct 01, 2005

Curcumin protects dopaminergic neuron against lipopolysaccharide induced neurotoxicity. Oct 01, 2008

Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression associated with inflammation.Mar 01, 2004

Curcumin suppresses the inflammatory response of brain microglial cells.Dec 01, 2003

D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and BV-2 cells.Feb 28, 2023

Dandelion inhibits inflammation in rat astrocytes, indicating it may have antiinflammatory activity in the central nervous system. Aug 01, 2000

Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses in microglia cells.Mar 01, 2010

Brain: Microglial Activation

View the Evidence:
118 Abstracts with Brain: Microglial Activation Research