Breast Cancer: BRCA1

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6 Substances Researched for Breast Cancer: BRCA1
NameACCKFocus
Alcohol 110Locked
Selenium110Locked
Indole-3-Carbinol22Locked
Cucurbitacin B 11Locked
Genistein11Locked
Resveratrol11Locked
4 Problem Substances Researched for Breast Cancer: BRCA1
NameACCKFocus
Oral Contraceptives110Locked
Simian virus 40 (SV40)110Locked
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)12Locked
Epstein-Barr Virus11Locked
1 Therapeutic Actions Researched for Breast Cancer: BRCA1
NameACCKFocus
Exercise110Locked

View the Evidence:
11 Abstracts with Breast Cancer: BRCA1 Research

[+]

Alcohol consumption is not a risk factor for breast cancer among women with a BRCA1 or BRCA2 mutation. May 31, 2015

Pubmed Data : Breast Cancer Res Treat. 2015 Jun ;151(2):435-41. Epub 2015 May 3. PMID: 25935583
Article Published Date : May 31, 2015
Study Type : Human Study
Additional Links
Substances : Alcohol
Diseases : BRCA1/BRCA2: Prevalence, Breast Cancer: BRCA1
Additional Keywords : BRCA Gene
[+]

Oral selenium is a good candidate for chemoprevention in women who carry a mutation in the BRCA1 gene.Apr 30, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2005 May ;14(5):1302-6. PMID: 15894690
Article Published Date : Apr 30, 2005
Study Type : Human Study
Additional Links
Substances : Selenium
Diseases : Breast Cancer: BRCA1, DNA damage
Pharmacological Actions : Antioxidants, Chemopreventive, Genoprotective
Additional Keywords : Risk Reduction, Sodium Selenite, Supplementation
[+]

Prolonged periods of sedentary behavior are associated with significantly lower BRCA1 mRNA expression.Nov 01, 2015

Pubmed Data : Cancer Prev Res (Phila). 2015 Nov 2. Epub 2015 Nov 2. PMID: 26526989
Article Published Date : Nov 01, 2015
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: BRCA1, Sitting Sickness
Therapeutic Actions : Exercise
Additional Keywords : Gene Expression Regulation, Risk Factors
[+]

Simian virus 40 is found at far higher rates in breast tumors and probably contributes to pathogenesis in those tumors.Jan 01, 2009

Pubmed Data : Breast Cancer Res Treat. 2009 Jan;113(1):43-58. Epub 2008 Jan 18. PMID: 18205041
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: BRCA1, Cancer Metastasis
Additional Keywords : Oncoviruses
Problem Substances : Simian virus 40 (SV40)
[+]

The onset of BC in this population can be influenced by reproductive factors such as the number of pregnancies and the use of oral contraceptives.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Genet Genomic Med. 2016 Mar ;4(2):172-7. Epub 2015 Dec 10. PMID: 27066510
Article Published Date : Feb 29, 2016
Study Type : Human Study
Additional Links
Diseases : BRCA1/BRCA2: Prevalence, Breast Cancer: BRCA1
Additional Keywords : Risk Factors
Problem Substances : Oral Contraceptives
[+]

Gestational exposure to the AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin induces BRCA-1 promoter hypermethylation and reduces BRCA-1 expression in mammary tissue of rat offspring: Preventive effects of resveratrol.Oct 16, 2013

Pubmed Data : Mol Carcinog. 2013 Oct 17. Epub 2013 Oct 17. PMID: 24136580
Article Published Date : Oct 16, 2013
Study Type : Animal Study
Additional Links
Diseases : Breast Cancer: BRCA1, Fetal Origin of Adult Disease
Problem Substances : 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
[+]

BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.Feb 12, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Cancer. 2006 Feb 13 ;94(3):407-26. PMID: 16434996
Article Published Date : Feb 12, 2006
Study Type : In Vitro Study
Additional Links
Substances : Genistein, Indole-3-Carbinol
Diseases : Breast Cancer, Breast Cancer: BRCA1, Prostate Cancer
Pharmacological Actions : Chemopreventive, Estrogen Receptor Modulators
[+]

Epstein-Barr virus-specific methylation of human genes in gastric cancer cells.Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Infect Agent Cancer. 2010 ;5:27. Epub 2010 Dec 31. PMID: 21194482
Article Published Date : Dec 31, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer: BRCA1, Gastric Cancer
Problem Substances : Epstein-Barr Virus
[+]

Resveratrol may prevent epigenetic silencing of the BRCA-1 gene by the aromatic hydrocarbon receptor in human breast cancer cells.Sep 01, 2010

Pubmed Data : J Nutr. 2010 Sep;140(9):1607-14. Epub 2010 Jul 14. PMID: 20631324
Article Published Date : Sep 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Breast Cancer, Breast Cancer: BRCA1, DNA damage
Pharmacological Actions : Anticarcinogenic Agents, Estrogen Receptor Modulators
Additional Keywords : Epigenetic Modification, Stilbenes
[+]

Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes.Dec 31, 1999

Pubmed Data : J Mol Med (Berl). 2000 ;78(3):155-65. PMID: 10868478
Article Published Date : Dec 31, 1999
Study Type : In Vitro Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Breast Cancer, Breast Cancer: BRCA1, Cancer Metastasis, Lung Cancer
Pharmacological Actions : Anticarcinogenic Agents
[+]

Survivin could be an important target of cucurbitacin B in BRCA1 defective breast cancer cells.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(2):e55732. Epub 2013 Feb 5. PMID: 23393598
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Breast Cancer, Breast Cancer: BRCA1
Pharmacological Actions : Anti-metastatic, Antiproliferative , P21 Activation, Survivin Down-Regulation
Additional Keywords : BRCA Gene

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Breast Cancer: BRCA1 Related Articles

Is BRCA ("Breast Cancer Gene") A Death Sentence?
Written by Sayer Ji, Founder
What we think we know about the BRCA (Breast Cancer Susceptibility Associated) genes causing cancer is patently false, according to a new meta-analysis on the extant literature on the subject of these gene variations on breast cancer survival prognosis.
Ovarian Cancer: What We Think We Know May Harm Us
Written by Sayer Ji, Founder
What do we really know about ovarian cancer risk and the 'gene mutations' considered largely responsible for increasing it? The answer is quite surprising and opens up the possibility for a radical change in how we diagnosis and treat the most lethal gynecological cancer in existence.
Angelina Jolie, BRCA Gene, Preventive Cancer Surgery
Written by Dr. Jeffrey Dach, MD
Angelina Jolie's story in a New York Times Op Ed revealed the celebrity underwent not only a bilateral prophylactic mastectomy about two years ago, but also more recently, a bilateral oophorectomy.
The “Deadly Breast Cancer Gene” Is A Myth, Lancet Study Confirms
Written by Sayer Ji, Founder
A powerful new Lancet study reveals that the so-called breast cancer susceptibility genes -- BRCA 1 and BRCA 2 -- do not, in fact, cause breast cancer. Jolie's prophylactic mastectomy, for instance, was for naught.

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