Breast Cancer: Chemically-Induced

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35 Substances Researched for Breast Cancer: Chemically-Induced
NameACCKFocus
Isothiocyanates24Locked
Shemamruthaa24Locked
Genistein23Locked
Bael 12Locked
Berberine12Locked
Black Pepper12Locked
Crocetin12Locked
Crocin12Locked
Daisy12Locked
Dandelion 12Locked
Fig12Locked
Flavonoids12Locked
Flaxseed12Locked
Fucoidan12Locked
Garcinia kola12Locked
Honokiol12Locked
Isoflavones12Locked
Lemongrass: Essential Oil12Locked
Lignans12Locked
Mangiferin12Locked
Neem12Locked
Nigella sativa (aka Black Seed)12Locked
Nobiletin 12Locked
Tangeretin 12Locked
Taurine12Locked
Thymoquinone12Locked
Tualang Honey12Locked
White Button Mushroom 12Locked
Curcumin11Locked
Daidzein11Locked
Diallyl sulfide11Locked
Ginger11Locked
Lotus 11Locked
Pomegranate11Locked
Resveratrol11Locked
8 Problem Substances Researched for Breast Cancer: Chemically-Induced
NameACCKFocus
Bisphenol A 23Locked
Chlorpyrifos12Locked
Diethylstilbestrol (DES)11Locked
Glyphosate11Locked
Glyphosate formulations11Locked
Meat: Cooked11Locked
Parabens11Locked
Perfluorooctanoic acid (PFOA) 11Locked

View the Evidence:
36 Abstracts with Breast Cancer: Chemically-Induced Research

[+]

A fucoidan-supplemented diet can inhibit DMBA-induced tumors in rats.Oct 31, 2017

Pubmed Data : Nutr Cancer. 2017 Nov-Dec;69(8):1234-1244. Epub 2017 Oct 18. PMID: 29043842
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Chemopreventive, Immunomodulatory
[+]

Anti-estrogenic and anti-cell proliferative effect of allyl isothiocyanate in chemoprevention of chemically induced mammary carcinogenesis.Mar 19, 2019

Pubmed Data : Pathol Oncol Res. 2019 Mar 20. Epub 2019 Mar 20. PMID: 30895454
Article Published Date : Mar 19, 2019
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anti-Estrogenic, Chemopreventive
[+]

Chlorpyrifos may act as a breast cancer risk factor.Oct 01, 2018

Pubmed Data : J Steroid Biochem Mol Biol. 2018 Oct 2. Epub 2018 Oct 2. PMID: 30290214
Article Published Date : Oct 01, 2018
Study Type : Animal Study
Additional Links
Diseases : Breast Cancer: Chemically-Induced, Pesticide Toxicity
Additional Keywords : Epigenetic Modification, Risk Factors
Problem Substances : Chlorpyrifos
[+]

Crocin and crocetin showed a significant protective effect against the N-methyl-N-nitrosourea induced breast cancer in rats.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell J. 2017 Apr-Jun;19(1):94-101. Epub 2016 Dec 21. PMID: 28367420
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Crocetin, Crocin
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Dandelion root extract is effective as anticancer herbal agent.Aug 19, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2018 Aug 20. Epub 2018 Aug 20. PMID: 30126855
Article Published Date : Aug 19, 2018
Study Type : Animal Study
Additional Links
Substances : Dandelion
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Antiproliferative , Chemopreventive
[+]

Evaluating the therapeutic potential of white button mushroom (Agaricus bisporus) against DMBA-induced breast cancer.Oct 25, 2021

Pubmed Data : J Food Biochem. 2021 Oct 26:e13979. Epub 2021 Oct 26. PMID: 34698374
Article Published Date : Oct 25, 2021
Study Type : Animal Study
Additional Links
Substances : White Button Mushroom
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Chemopreventive
[+]

Fig latex could decrease tumor growth without having any adverse effect on hematological and histological factors.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2018 Jul-Aug;8(4):286-295. PMID: 30377588
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Fig
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Antiproliferative , Chemopreventive
[+]

In utero and postnatal isoflavone exposureappears to reduce the risk to develop breast cancer.Dec 20, 2011

Pubmed Data : Mol Nutr Food Res. 2011 Dec 20. Epub 2011 Dec 20. PMID: 22183799
Article Published Date : Dec 20, 2011
Study Type : Animal Study
Additional Links
Substances : Genistein, Isoflavones
Diseases : Breast Cancer: Chemically-Induced, Prenatal Chemical Exposures
Pharmacological Actions : Chemopreventive
[+]

Kolaviron could be further explored in targeting DMBA-induced mammary damage implicated in mammary carcinogenesis.Mar 20, 2021

Pubmed Data : Anticancer Agents Med Chem. 2021 Mar 21. Epub 2021 Mar 21. PMID: 34225638
Article Published Date : Mar 20, 2021
Study Type : Animal Study
Additional Links
Substances : Garcinia kola
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Lemongrass extract (essential oil) exhibits chemopreventive properties against chemically-induced alterations in mammary tissue. Nov 14, 2011

Pubmed Data : J Med Food. 2011 Nov 14. Epub 2011 Nov 14. PMID: 22082069
Article Published Date : Nov 14, 2011
Study Type : Animal Study
Additional Links
Substances : Lemongrass: Essential Oil
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Chemopreventive
[+]

Mangiferin suppressed DMBA-induced mammary carcinogenesis.Dec 31, 2020

Pubmed Data : J Environ Pathol Toxicol Oncol. 2021 ;40(2):1-9. PMID: 33822512
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, Antiproliferative , Apoptotic, Chemopreventive, NF-kappaB Inhibitor
[+]

Nobiletin has an anticell proliferative effect on DMBA-induced mammary cancer.Dec 31, 2019

Pubmed Data : J Environ Pathol Toxicol Oncol. 2020 ;39(1):13-21. PMID: 32479009
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Antiproliferative
[+]

Piper nigrum extract had a low toxicity and a potent anti-tumor effect on mammary tumorigenesis in rats.Oct 27, 2015

Pubmed Data : Cancer Prev Res (Phila). 2015 Oct 28. Epub 2015 Oct 28. PMID: 26511488
Article Published Date : Oct 27, 2015
Study Type : Animal Study
Additional Links
Substances : Black Pepper
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic
Additional Keywords : Plant Extracts
[+]

Regular consumption of neem oil prevents chemically induced breast cancer.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:2031460. Epub 2019 Apr 7. PMID: 31080481
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Shemamruthaa possesses significant anticancer effect through its role in attenuation of LPO, prevention of membrane damage and restoring membrane integrity.Nov 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Med. 2013 Dec ;6(12):925-33. PMID: 24144022
Article Published Date : Nov 30, 2013
Study Type : Animal Study
Additional Links
Substances : Shemamruthaa
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemopreventive
Additional Keywords : Plant Extracts
[+]

Tangeretin specifically regulates cellular metabolic energy fluxes in DMBA-induced breast cancer.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomed Res. 2016 Mar ;30(2):134-141. Epub 2016 Feb 26. PMID: 28276668
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Tangeretin
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Chemotherapeutic
[+]

Taxifolin inhibits 7,12-dimethylbenz(a)anthracene-induced breast carcinogenesis.Dec 31, 2017

Pubmed Data : Pharmacogn Mag. 2018 Jan ;13(Suppl 4):S749-S755. Epub 2018 Jan 31. PMID: 29491628
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents
[+]

The administration of taurine significantly reduced the DMBA-induced breast cancer rate from 80% to 40% in rats.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2016 Feb ;36(2):533-43. PMID: 26851007
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Substances : Taurine
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

The herbal preparation Shemamruthaa had antiproliferative and apoptotic effects on chemically induced breast cancer.Sep 30, 2015

Pubmed Data : J Evid Based Complementary Altern Med. 2015 Oct ;20(4):259-68. Epub 2015 Apr 17. PMID: 25888591
Article Published Date : Sep 30, 2015
Study Type : Animal Study
Additional Links
Substances : Shemamruthaa
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

The result suggests that allyl isothiocyanate has anti-inflammatory potential to prevent DMBA- and MNU-induced mammary carcinogenesis.Dec 31, 2017

Pubmed Data : Breast Cancer. 2018 Jan ;25(1):50-59. Epub 2017 May 13. PMID: 28501931
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Therapeutic effect of Aegle marmelos fruit extract against DMBA induced breast cancer.Jan 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2020 10 22 ;10(1):18016. Epub 2020 Oct 22. PMID: 33093498
Article Published Date : Jan 21, 2020
Study Type : Animal Study
Additional Links
Substances : Bael
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Antiproliferative , Chemopreventive
Additional Keywords : Phytotherapy, Plant Extracts
[+]

These findings demonstrate the preventive role of berberine against DMBA induced mammary carcinoma.May 21, 2017

Pubmed Data : Biomed Pharmacother. 2017 May 22 ;92:207-214. Epub 2017 May 22. PMID: 28544934
Article Published Date : May 21, 2017
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results of this study support the chemopreventive feature of honokiol in breast cancer.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:320. Epub 2017 May 31. PMID: 28620301
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Honokiol
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

These results reveal the capability of TPHE to induce apoptosis in LA7-induced tumours in rats.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2015 ;36(3):988-1003. Epub 2015 Jun 15. PMID: 26087920
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Daisy
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Chemopreventive
Additional Keywords : Selective Antiproliferation
[+]

Thymoquinone and black cumin seed (Nigella sativa) oil exert a protective effect against breast carcinogens.Mar 15, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Med Sci. 2015 Mar 16 ;11(1):220-9. Epub 2013 Feb 28. PMID: 25861310
Article Published Date : Mar 15, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Plant Extracts
[+]

Treatment with SDG normalized several biomarkers in mammary gland tissue, dysplasia, cell number, and expression of several genes that had been altered by carcinogen.May 25, 2015

Pubmed Data : Nutr Cancer. 2015 May 26:1-8. Epub 2015 May 26. PMID: 26010915
Article Published Date : May 25, 2015
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Lignans
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative
Additional Keywords : Dietary Modification, Gene Expression Regulation
[+]

Tualang Honey exerted positive modulation effects on DMBA-induced breast cancers in rats in this preliminary study.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2013 ;14(4):2249-54. PMID: 23725121
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Tualang Honey
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Significant Treatment Outcome
[+]

A ternary mixture of common chemicals perturbs benign human breast epithelial cells more than the same chemicals do individually.Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Sci. 2018 Sep 1 ;165(1):131-144. PMID: 29846718
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Bisphenol Toxicity, Breast Cancer: Chemically-Induced
Additional Keywords : Synergistic Toxicity
Problem Substances : Bisphenol A , Parabens, Perfluorooctanoic acid (PFOA)
[+]

Curcumin significantly inhibited PhIP-induced DNA adduct formation and DNA double stand breaks with a concomitant decrease in reactive oxygen species production.Aug 27, 2015

Pubmed Data : Cancer Lett. 2015 Aug 28 ;365(1):122-31. Epub 2015 May 21. PMID: 26004342
Article Published Date : Aug 27, 2015
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer: Chemically-Induced, DNA damage
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Dietary Modification, Gene Expression Regulation, Risk Reduction
Problem Substances : Meat: Cooked
[+]

Diallyl sulfide in vitro has beneficial effects as a chemopreventive agent due to its ability to inhibit DNA damage produced by estrogenic chemicals similar to diethylstilbestrol.Nov 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Steroids. 2014 Dec ;92:96-100. Epub 2014 Sep 30. PMID: 25278253
Article Published Date : Nov 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Diallyl sulfide
Diseases : Breast Cancer: Chemically-Induced, DNA damage
Pharmacological Actions : Chemopreventive, Genoprotective
Problem Substances : Diethylstilbestrol (DES)
[+]

Genistein and daidzein, in combination, protect against chemically-induced mammary carcinogenesis. Jan 01, 2011

Pubmed Data : Afr J Tradit Complement Altern Med. 2011 ;8(2):91-7. Epub 2010 Dec 30. PMID: 22238489
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Genistein
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Chemopreventive
[+]

Glyphosate induces human breast cancer cells growth via estrogen receptors.Jun 07, 2013

Pubmed Data : Food Chem Toxicol. 2013 Jun 8. Epub 2013 Jun 8. PMID: 23756170
Article Published Date : Jun 07, 2013
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced, Breast Cancer: estrogen receptor alpha-positive
Problem Substances : Glyphosate, Glyphosate formulations
Adverse Pharmacological Actions : Carcinogenic, Estrogenic
[+]

Neferine inhibits 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis.Dec 31, 2020

Pubmed Data : J Environ Pathol Toxicol Oncol. 2021 ;40(3):51-61. PMID: 34587404
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Resveratrol and curcumin synergistically caused apoptosis in cigarette smoke induced breast cancer cells. Aug 31, 2015

Pubmed Data : Int J Biochem Cell Biol. 2015 Sep ;66:75-84. Epub 2015 Jul 23. PMID: 26212257
Article Published Date : Aug 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Resveratrol
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Apoptotic
Additional Keywords : Natural Substance Synergy
[+]

Several pomegranate phytochemicals exhibited synergistic effects in suppressing growth of tumor cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2015;20(12):22315-22328. Epub 2015 Dec 12. PMID: 26703530
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclin D1 Down-Regulation, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Natural Substance Synergy
[+]

Zingerone induced caspase-dependent apoptosis in MCF-7 cells and prevents 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis.Sep 01, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Sep 2:e22387. Epub 2019 Sep 2. PMID: 31476248
Article Published Date : Sep 01, 2019
Study Type : In Vitro Study
Additional Links
Substances : Ginger
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive

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