Breast Cancer: Estrogen

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18 Substances Researched for Breast Cancer: Estrogen
NameACCKFocus
Caffeic Acid110Locked
Caffeine110Locked
Melatonin46Locked
Silibinin15Locked
Sulforaphane15Locked
Alpha-naphthoflavone14Locked
Huaier (Trametes robiniophila murr)34Locked
Vitamin C14Locked
Genistein22Locked
Jambul 12Locked
Vitamin E: Gamma-Tocopherol 12Locked
Apigenin11Locked
Betulinic acid11Locked
Black Cohosh11Locked
Pomegranate11Locked
Prunella vulgaris11Locked
Shikonin11Locked
Ursolic Acid11Locked
6 Problem Substances Researched for Breast Cancer: Estrogen
NameACCKFocus
Tamoxifen211Locked
Bisphenol A 34Locked
17beta-estradiol11Locked
Glyphosate11Locked
Glyphosate formulations11Locked
Parabens11Locked
1 Problematic Actions Researched for Breast Cancer: Estrogen
NameACCKFocus
High Bone Density11Locked

View the Evidence:
26 Abstracts with Breast Cancer: Estrogen Research

[+]

Moderate coffee intake was associated with smaller invasive primary tumors and lower proportions of ER positive tumors compared with patients with low consumption.Feb 16, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Cancer Res. 2015 Feb 17. Epub 2015 Feb 17. PMID: 25691730
Article Published Date : Feb 16, 2015
Study Type : Human Study
Additional Links
Substances : Caffeic Acid, Caffeine
Diseases : Breast Cancer, Breast Cancer: Estrogen
Pharmacological Actions : Anti-Tumor, Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Estrogen Receptor Modulators, Insulin-Like Growth Factor Inhibition/Downregulation
Additional Keywords : Dose Response, Risk Reduction
Problem Substances : Tamoxifen
[+]

Sulforaphane may prevent or treat breast cancer by reversing estrogen-induced metabolic changes or alterations in methylation.Dec 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FEBS Open Bio. 2018 Dec ;8(12):2022-2034. Epub 2018 Nov 14. PMID: 30524952
Article Published Date : Dec 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer: Estrogen
Additional Keywords : Estrogen Positive Breast Cancer, Folate, Methylation
[+]

Treatment with silibinin of ERα-positive MCF-7 cells down-regulates the expression of ERα.May 11, 2015

Pubmed Data : J Pharmacol Sci. 2015 May 12. Epub 2015 May 12. PMID: 26117209
Article Published Date : May 11, 2015
Study Type : Human In Vitro
Additional Links
Substances : Silibinin
Diseases : Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions : Apoptotic, Autophagy Up-regulation, Estrogen Receptor Modulators
[+]

Gamma tocopherol could be an effective agent for the prevention and treatment of E2-induced breast cancer.Jun 29, 2015

Pubmed Data : Cancer Prev Res (Phila). 2015 Jun 30. Epub 2015 Jun 30. PMID: 26130252
Article Published Date : Jun 29, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin E: Gamma-Tocopherol
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Chemopreventive, Nrf2 activation
[+]

Huaier extract synergizes with tamoxifen to induce autophagy and apoptosis in ER-positive breast cancer cells.Mar 22, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Mar 23. Epub 2016 Mar 23. PMID: 27027343
Article Published Date : Mar 22, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Huaier (Trametes robiniophila murr)
Diseases : Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions : Anti-metastatic, Apoptotic, Autophagy Up-regulation, Cell cycle arrest
Additional Keywords : Plant Extracts, Synergy with Tamoxifen
[+]

Melatonin could enhance the sensitivity of breast tumors to adriamycin in vivo.Dec 31, 2014

Pubmed Data : Eur J Gynaecol Oncol. 2015 ;36(2):197-202. PMID: 26050360
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Breast Cancer: estrogen receptor alpha-positive, Quality of Life: Poor
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug: Adriamycin, Significant Treatment Outcome
[+]

The jamun-diet significantly delayed the first tumor appearance by 21 days, and reduced the tumor incidence 65% vs 96% in this animal study. Mar 30, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Mar 31. Epub 2016 Mar 31. PMID: 27030099
Article Published Date : Mar 30, 2016
Study Type : Animal Study
Additional Links
Substances : Jambul
Diseases : Breast Cancer, Breast Cancer: Estrogen
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive, MicroRNA modulator
[+]

Vitamin C and alpha-naphthoflavone prevent estrogen-induced mammary tumors and decrease oxidative stress in female rats.Jul 01, 2009

Pubmed Data : Carcinogenesis. 2009 Jul ;30(7):1202-8. Epub 2009 Apr 30. PMID: 19406931
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Alpha-naphthoflavone, Vitamin C
Diseases : Breast Cancer: Estrogen, Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions : Antioxidants, Chemopreventive
[+]

"Genistein, a soy phytoestrogen, prevents the growth of BG-1 ovarian cancer cells induced by 17β-estradiol or bisphenol A via the inhibition of cell cycle progression."Nov 28, 2012

Pubmed Data : Int J Oncol. 2012 Nov 29. Epub 2012 Nov 29. PMID: 23229410
Article Published Date : Nov 28, 2012
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Bisphenol-A Toxicity, Breast Cancer: Estrogen, Ovarian Cancer, Ovarian Cancer: Estrogen Induced
Pharmacological Actions : Cell cycle arrest
Problem Substances : 17beta-estradiol, Bisphenol A
[+]

"Molecular mechanisms of melatonin's inhibitory actions on breast cancers."Sep 24, 2012

Pubmed Data : Cell Mol Life Sci. 2012 Sep 25. Epub 2012 Sep 25. PMID: 23007844
Article Published Date : Sep 24, 2012
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Breast Cancer, Breast Cancer: Estrogen
[+]

"Parabens detection in different zones of the human breast: consideration of source and implications of findings."May 01, 2012

Pubmed Data : J Appl Toxicol. 2012 May ;32(5):305-9. Epub 2012 Mar 7. PMID: 22408000
Article Published Date : May 01, 2012
Study Type : Review
Additional Links
Diseases : Breast Cancer, Breast Cancer: Estrogen
Problem Substances : Parabens
[+]

Antineoplaston A10 inhibits estradiol stimulated cell growth. Oct 01, 1993

Pubmed Data : J Steroid Biochem Mol Biol. 1993 Oct ;46(4):451-62. PMID: 8217876
Article Published Date : Oct 01, 1993
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer: Estrogen
Pharmacological Actions : Antiproliferative
[+]

Apigenin was found to be an effective phytoestrogen that strongly inhibited the growth of breast cancer cells, including HER2-positive ones.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Naturae. 2015 Jul-Sep;7(3):133-9. PMID: 26483970
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive, Breast Cancer: HER-2 Overexpressed
Pharmacological Actions : Antiproliferative , Cytotoxic
[+]

Betulinic acid and ursolic acid have potential use as therapeutic agents against estrogen-dependent tumors.Aug 21, 2014

Pubmed Data : Biochem Biophys Res Commun. 2014 Aug 22 ;451(2):282-7. Epub 2014 Aug 1. PMID: 25088993
Article Published Date : Aug 21, 2014
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid, Prunella vulgaris, Ursolic Acid
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive, Prostate Cancer
Pharmacological Actions : Estrogen Receptor Modulators
[+]

Black cohosh could be considered a candidate co-treatment agent of estrogen-dependent tumors.May 24, 2016

Pubmed Data : Gynecol Endocrinol. 2016 May 25:1-4. Epub 2016 May 25. PMID: 27223250
Article Published Date : May 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : Black Cohosh
Diseases : Breast Cancer: Estrogen
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

BPA at environmentally relevant doses reduces the efficacy of chemotherapeutic agents doxorubicin, cisplatin, and vinblastine.Jan 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2009 Feb ;117(2):175-80. Epub 2008 Oct 8. PMID: 19270784
Article Published Date : Jan 31, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Estrogen Receptor Modulators
Additional Keywords : Drug: Cisplatin, Drug: Doxorubicin, Drug: Vinblastine
Problem Substances : Bisphenol A
Adverse Pharmacological Actions : Chemoresistance upregulation
[+]

Chronic oxidative stress can convert estrogen-dependent nonaggressive breast cancer cells into estrogen-independent aggressive form potentially by epigenetic mechanism.Jul 25, 2015

Pubmed Data : Breast Cancer Res Treat. 2015 Jul 26. Epub 2015 Jul 26. PMID: 26208486
Article Published Date : Jul 25, 2015
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive, Oxidative Stress
Additional Keywords : Epigenetic Modification In Cancer, Increased Risk
[+]

Genistein derivatives inhibit estrogen receptor alpha-positive breast cancer.May 15, 2011

Pubmed Data : Cancer Biol Ther. 2011 May 15 ;11(10):883-92. Epub 2011 May 15. PMID: 21389782
Article Published Date : May 15, 2011
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions : Antiproliferative , Apoptotic, Estrogen Receptor Modulators
Additional Keywords : Estrogen Receptor Beta
[+]

Glyphosate induces human breast cancer cells growth via estrogen receptors.Jun 07, 2013

Pubmed Data : Food Chem Toxicol. 2013 Jun 8. Epub 2013 Jun 8. PMID: 23756170
Article Published Date : Jun 07, 2013
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced, Breast Cancer: estrogen receptor alpha-positive
Problem Substances : Glyphosate, Glyphosate formulations
Adverse Pharmacological Actions : Carcinogenic, Estrogenic
[+]

Huaier can induce cell apoptosis in both ER-positive and ER-negative breast cancer cell lines.Oct 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Sci. 2010 Nov ;101(11):2375-83. PMID: 20718753
Article Published Date : Oct 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Huaier (Trametes robiniophila murr)
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Huaier extract is a novel estrogen receptor modulator and is a promising drug for the prevention and treatment of ERα-positive human breast cancers.Jun 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2013 Jul ;43(1):321-8. Epub 2013 May 20. PMID: 23686317
Article Published Date : Jun 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Huaier (Trametes robiniophila murr)
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions : Antiproliferative , Chemopreventive, Estrogen Receptor Modulators, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Individuals with certain diseases such as obesity, diabetes, estrogen receptor-positive breast or endometrial cancer have greater bone density than healthy individuals,Mar 01, 2012

Pubmed Data : Endocrinol Nutr. 2012 Mar ;59(3):207-14. Epub 2012 Feb 9. PMID: 22325788
Article Published Date : Mar 01, 2012
Study Type : Review
Additional Links
Diseases : Breast Cancer: Estrogen, Diabetes, Endometrial Cancer, Obesity
Anti Therapeutic Actions : High Bone Density
[+]

Melatonin down-regulates estrogen production in endothelial cells via its anti-aromatase activity.Feb 27, 2013

Pubmed Data : Oncol Rep. 2013 Feb 28. Epub 2013 Feb 28. PMID: 23450505
Article Published Date : Feb 27, 2013
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Breast Cancer, Breast Cancer: Estrogen, Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions : Aromatase Inhibitors
[+]

Melatonin may exert oncostatic effects against breast cancer by downregulating VEGF factor, therefore reducing the number of estrogen-producing cells and the process of angiogenesis.Aug 15, 2012

Pubmed Data : J Pineal Res. 2012 Aug 16. Epub 2012 Aug 16. PMID: 23013414
Article Published Date : Aug 15, 2012
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Breast Cancer: Estrogen
Pharmacological Actions : Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Inhibitors
[+]

Shikonin has been suggested as a good candidate for the induction of cell death in ER+ breast cancer.Sep 18, 2017

Pubmed Data : Anticancer Agents Med Chem. 2017 Sep 19. Epub 2017 Sep 19. PMID: 28933271
Article Published Date : Sep 18, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions : Apoptotic
[+]

This review analyses plausible mechanisms of Punica in preventing the progression of breast cancer by acting at various steps of carcinogenesis.Apr 08, 2015

Pubmed Data : Biofactors. 2015 Apr 9. Epub 2015 Apr 9. PMID: 25857627
Article Published Date : Apr 08, 2015
Study Type : Review
Additional Links
Substances : Pomegranate
Diseases : Breast Cancer, Breast Cancer: Estrogen, Breast Cancer: Metastatic
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Chemopreventive, Chemotherapeutic
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Tamoxifen

Copyright: rob3000 / 123RF Stock Photo

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Flaxseed Helps Prevent And Kill Breast Cancer, Meta-Analysis Reveals
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As we edge closer to Breast Cancer Awareness month, a timely new meta-analysis proves that the consumption of flaxseed prevents and kills breast cancer.
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We are now increasingly being exposed to an emerging class of “metalloestrogens” in our food, supplements and environment with the potential to add to the estrogenic burden of the human breast.

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