Cancers: Drug Resistant

Name	AC	CK
Curcumin	81	114
Ginsenosides	23	42
Silibinin	9	36
Flavonoids	26	32
Quercetin	23	26
Resveratrol	16	24
EGCG (Epigallocatechin gallate)	19	22
Beta-Elemene	15	20
Genistein	8	17
Sulforaphane	10	16
Wogonin	6	16
Burdock	3	13
Isoflavones	3	13
Capsaicin	3	12
Daidzein	3	12
Polyphenols	9	12
Shikonin	11	12
Berberine	8	11
Licorice	9	11
Amurensin G	2	10
Apigenin	8	10
Luteolin	8	10
Oridonin	8	10
Soy	1	10
Sumac	1	10
Tanshinone IIA	10	10
Ursolic Acid	10	10
Bufalin	6	9
Cucurbitacin B	7	9
Tangeretin	6	9
Vitamin C	8	9
Baicalein	5	8
Emodin	6	8
NAC (N-acetyl-L-cysteine)	3	8
Honokiol	5	7
Lotus	6	7
Naringenin	5	7
Parthenolide	7	7
Piperlongumine	6	7
Salvia miltiorrhiza	7	7
Artesunate	4	6
Cruciferous Vegetables	2	6
Indole-3-Carbinol	3	6
Nobiletin	4	6
Achiote	1	5
Arctigenin	5	5
Astragaloside	5	5
Betulinic acid	5	5
Gallic Acid	5	5
Ginkgo biloba	3	5
Panax Notoginseng	1	5
Paprika	4	5
Puerarin	3	5
Vitamin C: Intravenous	1	5
Asiatic Acid	4	4
Carotenoids	3	4
Catechin	3	4
Celastrol	3	4
Chrysin	4	4
Curcumol	4	4
DHA (Docosahexaenoic Acid)	4	4
Elecampane	4	4
Fisetin	3	4
Formononetin	4	4
Fucoxanthin	2	4
Ginger	4	4
Isoliquiritigenin	3	4
Kaempferol	3	4
Mulberry	4	4
Phloretin	3	4
Pterostilbene	3	4
Reishi Mushroom	4	4
Thymoquinone	3	4
Tripterygium wilfordii	3	4
Xanthohumol	3	4
beta-Carotene	2	4
Barberry	3	3
Bisdemethoxycurcumin	3	3
Caffeic Acid	3	3
Cannabinoids	2	3
Crocin	2	3
Cucurbitacin D	3	3
Deguelin	3	3
Delphinidin	2	3
Ellagic Acid	3	3
Fermented Foods and Beverages	2	3
Lycopene	2	3
Myricetin	3	3
Nordihydroguaiaretic acid (NDGA)	3	3
Paeonol	2	3
Rosemaric Acid	2	3
Rutin	3	3
Squalene	1	3
Stilbenes	2	3
Tannic Acid	2	3
Theaflavins	3	3
Thunder god vine	1	3
6-Shogaol	2	2
AHCC	1	2
Adlay	1	2
Allicin	2	2
Alpinia galanga	1	2
Andrographis	2	2
Anthocyanins	2	2
Antrodia camphorata	1	2
Asparagus	1	2
Bee Propolis	1	2
Benzyl isothiocyanate	2	2
Beta-Caryophyllene	1	2
Biochanin A	2	2
Butterfly Pea	1	2
Canthaxanthin	1	2
Carbon 60	2	2
Carvacrol	2	2
Cholesterol	1	2
Cinnamic acid	1	2
Citrus Triterpenoids	2	2
Coenzyme Q10	1	2
Cordyceps Militaris	2	2
Crocetin	2	2
EPA (Eicosapentaenoic Acid)	2	2
Glucosamine	2	2
Glycyrrhizin	2	2
Green Tea	2	2
Hesperidin	1	2
Horse Chestnut	1	2
Kefir	1	2
Lactobacillus plantarum	2	2
Lignans	1	2
Ligustrazine	1	2
Lupeol	2	2
Omega-3 Fatty Acids	2	2
Paeoniflorin	2	2
Phellinus Linteus	2	2
Phenethyl isothiocyanate	2	2
Proanthocyanidins	2	2
Psychedelics:All	1	2
Rosemary	1	2
Saikosaponin	2	2
Scopoletin	1	2
Seaweed	1	2
Silymarin	2	2
Tea	1	2
Tetrahydrocurcumin	1	2
Tocotrienol: Gamma	2	2
Triptolide	2	2
Watercress	1	2
Zeaxanthin	1	2
acetyl-11-keto-beta-boswellic acid	1	2
Acerola	1	1
Agosterol A	1	1
Alpha-Lipoic Acid	1	1
Antheraxanthin	1	1
Apple: Golden Delicious	1	1
Artemisinin	1	1
Ashwagandha	1	1
Bay leaf	1	1
Bee Venom	1	1
Beet	1	1
Berbamine	1	1
Berries: All	1	1
Beta Sitosterol	1	1
Betel	1	1
Birch	1	1
Bitter Melon	1	1
Black Raspberry	1	1
Black Tea	1	1
Bryostatin 1	1	1
Caffeic acid phenethyl ester	1	1
Camptothecin	1	1
Cannabidiol	1	1
Cannabis	1	1
Capsorubin	1	1
Cardamonin	1	1
Cashew	1	1
Catechols	1	1
Chlorogenic Acid	1	1
Chokeberry	1	1
Citrus naringin	1	1
Clausena excavata	1	1
Cleistocalyx Operculatus	1	1
Coconut	1	1
Coconut Husk/Fiber	1	1
Cucurbitacin E	1	1
Curcuminoids	1	1
Dandelion	1	1
Demethoxycurcumin	1	1
Ecteinascidin 743	1	1
Euphorbia	1	1
Farnesiferol A	1	1
Fenugreek	1	1
Ferula Persica	1	1
Ferula Szowitsiana	1	1
Ferulic acid	1	1
Fish Oil	1	1
Frankincense	1	1
Fucoidan	1	1
Galbanic Acid	1	1
Garcinia hanburyi	1	1
Geraniol	1	1
Gingerol	1	1
Ginseng (Siberian)	1	1
Gold (nanoparticles)	1	1
Gotu Kola	1	1
Grape	1	1
Grape Seed Extract	1	1
Guggul	1	1
Harmine	1	1
Hedyotis corymbosa	1	1
Hedyotiscone A	1	1
Honey	1	1
Hu Zhang (Polygonum cuspidatum)	1	1
Isothiocyanates	1	1
Japanese Raisin Tree	1	1
Kava Kava	1	1
Lactoferrin	1	1
Lobelia	1	1
Loquat	1	1
Lutein	1	1
Maca	1	1
Magnolia	1	1
Magnolia grandifloris (honokiol)	1	1
Mangosteen	1	1
Melatonin	1	1
Mistletoe	1	1
Mululuza	1	1
Mustard Oil	1	1
Neem	1	1
Oat Bran	1	1
Oleanolic acid	1	1
Oleuropein	1	1
Orange	1	1
Organosulfur Compounds	1	1
Peony	1	1
Persimmon	1	1
Piceatannol	1	1
Piperidines	1	1
Piperine	1	1
Poria cocos	1	1
Progesterone	1	1
Red Sage	1	1
Saffron	1	1
Sakuranetin	1	1
Schisandra	1	1
Selenium	1	1
Sinomenine	1	1
Sipholane triterpenoids	1	1
St. Johns Wort	1	1
Syringic Acid	1	1
Thyme	1	1
Vanillin	1	1
Vinpocetine	1	1
Vitamin D	1	1
Vitamin E	1	1
Vitamin E: Gamma-tocotrienol	1	1
Vitamin E: alpha tocopherol	1	1
Welwitindolinones	1	1
Xanthones	1	1
cottonseed oil (gossypol)	1	1

Name	AC	CK
Doxorubicin	3	9
Nicotine	5	5
Adrenaline	3	4
Bisphenol A	4	4
Fluorouracil (5-FU or f5U)	2	4
Cisplatin	2	3
Carboplatin	1	2
Phthalates	2	2
Tamoxifen	2	2
Chemotherapy	1	1
Glyphosate	1	1
Herceptin	1	1

Name	AC	CK
Cryotherapy	1	3
Photobiomodulation	2	2
Light-Emitting Diodes (LEDs) Therapy	1	1
Photodynamic therapy	1	1

Name	AC	CK
Chemotherapy	4	6
Stress	3	4
Radiotherapy	2	3
Surgical Procedures	1	2

[+]

Epstein-Barr virus infection may confer multidrug resistance to breast cancer cells. Sep 20, 1997

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Pubmed Data : Lancet. 1997 Sep 20;350(9081):863-4. PMID: 16378986

Article Published Date : Sep 20, 1997

Study Type : Human Study

Additional Links

Diseases : Breast Cancer, Cancers: Multi-Drug Resistant, Epstein-Barr Virus Infections

Additional Keywords : Diseases that are Linked

[+]

Fermented soy therapy may have therapeutic value in treating platinum-resistant ovarian cancer. Jan 01, 2006

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Pubmed Data : Gynecol Oncol. 2006 Jan;100(1):205-9. Epub 2005 Sep 19. PMID: 16171852

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : Daidzein, Genistein, Isoflavones, Soy

Diseases : Cancers: Drug Resistant, Ovarian Cancer

Additional Keywords : Drug: Doxorubicin

[+]

Ginsenoside Rg3 could be used as a new regimen to delay acquired resistance of epidermal growth factor receptor-tyrosine kinase inhibitors.Oct 24, 2016

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Pubmed Data : Oncotarget. 2014 Mar 30 ;5(6):1621-34. PMID: 24742583

Article Published Date : Mar 29, 2014

Study Type : Human In Vitro

Additional Links

Substances : Cruciferous Vegetables, Sulforaphane

Diseases : Cancers: Drug Resistant, Pancreatic Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemotherapeutic

Additional Keywords : Cancer Stem Cells, Dietary Concentrations

[+]

Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.Jul 31, 2012

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Pubmed Data : Biochem Pharmacol. 2012 Aug 1 ;84(3):402-10. Epub 2012 Mar 29. PMID: 22483777

Article Published Date : Jul 31, 2012

Study Type : Human In Vitro

Additional Links

Substances : Amurensin G

Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)

Pharmacological Actions : Apoptotic, Chemosensitizer

Additional Keywords : Cancer Stem Cells, Gene Expression Regulation, Natural Substance Synergy

[+]

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

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Pubmed Data : Mol Pharmacol. 2010 Nov ;78(5):855-64. Epub 2010 Aug 16. PMID: 20713551

Article Published Date : Oct 31, 2010

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Amurensin G

Diseases : Breast Cancer: Drug Resistant, Cancers: Drug Resistant

Pharmacological Actions : Chemosensitizer

Additional Keywords : Gene Expression Regulation, Natural Substance/Drug Synergy, Plant Extracts

Problem Substances : Doxorubicin

[+]

Capsaicin inhibits 5-FU-induced autophagy and rendering Cholangiocarcinoma cells more susceptible to 5-FU-induced apoptosis.Dec 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(5):e0121538. Epub 2015 May 1. PMID: 25933112

Article Published Date : Dec 31, 2014

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Capsaicin

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Cholangiocarcinoma

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Autophagy Inhibitors, Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

[+]

Ginsenoside-Rb1 targets chemotherapy-resistant ovarian cancer stem cells.Nov 03, 2016

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Pubmed Data : Oncotarget. 2016 Nov 4. Epub 2016 Aug 4. PMID: 27825116

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Pubmed Data : Antioxid Redox Signal. 2010 Oct 1 ;13(7):987-97. PMID: 20170403

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Pubmed Data : Biomed Pharmacother. 2024 Oct ;179:117415. Epub 2024 Sep 11. PMID: 39265236

Article Published Date : Sep 30, 2024

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Baicalein

Diseases : Cancers: Drug Resistant, Cervical Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Cholesterol inhibition enhances antitumor response of gilteritinib in lung cancer cells.Sep 29, 2024

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Pubmed Data : Thorac Cancer. 2023 Feb ;14(4):371-380. Epub 2022 Dec 16. PMID: 36525508

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Pubmed Data : J Adv Res. 2022 Sep 24. Epub 2022 Sep 24. PMID: 36167294

Article Published Date : Sep 23, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Breast Cancer, Cancers: Multi-Drug Resistant

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Tumor Microenvironment

[+]

Tangeretin synergizes with 5-fluorouracil to induce autophagy through MicroRNA-21 in colorectal cancer cells.Dec 31, 2021

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Pubmed Data : Am J Chin Med. 2022 ;50(6):1681-1701. Epub 2022 Jul 15. PMID: 35848125

Drug-induced expression of EpCAM contributes to therapy resistance in esophageal adenocarcinoma.Nov 30, 2018

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Pubmed Data : Cell Oncol (Dordr). 2018 Dec ;41(6):651-662. Epub 2018 Aug 16. PMID: 30116994

Article Published Date : Nov 30, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Cancers: Drug Resistant, Esophageal Cancer

Additional Keywords : Cancer Stem Cells, Risk Factors

Problem Substances : Cisplatin, Doxorubicin, Fluorouracil (5-FU or f5U)

[+]

EGCG enhances 5FU sensitivity in chemoresistant colorectal cancer by targeting cancer stem cells.Mar 28, 2016

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Pubmed Data : Toxicol In Vitro. 2019 Sep 5 ;61:104642. Epub 2019 Sep 5. PMID: 31493543

Article Published Date : Sep 04, 2019

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Pubmed Data : Arch Pharm (Weinheim). 2024 Jun 29:e2400261. Epub 2024 Jun 29. PMID: 38943449

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Pubmed Data : J Ginseng Res. 2022 May ;46(3):418-425. Epub 2021 Jul 14. PMID: 35600776

Article Published Date : Apr 30, 2022

Study Type : Animal Study

Additional Links

Substances : Artesunate, Ginsenosides

Diseases : Cancers: Drug Resistant, Liver Cancer

Pharmacological Actions : Chemosensitizer, STAT3 Inhibitor

Additional Keywords : Chemothapeutic Synergy: Sorafenib

[+]

Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter.Feb 29, 2020

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Pubmed Data : J Ginseng Res. 2020 Mar ;44(2):247-257. Epub 2018 Nov 8. PMID: 32148406

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Pubmed Data : Tumour Biol. 2015 Jun 23. Epub 2015 Jun 23. PMID: 26099723

Article Published Date : Jun 22, 2015

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Cancers: Drug Resistant, Ehrlich carcinoma

Pharmacological Actions : Vascular Endothelial Growth Factor Inhibitors

Problem Substances : Doxorubicin

[+]

Indole-3 carbinol reverses multidrug resistant melanoma in vivo. Feb 01, 1996

Pubmed Data : Int J Oncol. 2017 Nov ;51(5):1383-1394. Epub 2017 Sep 22. PMID: 29048624

Article Published Date : Oct 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Licorice

Diseases : Cancers: Drug Resistant, Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation

Additional Keywords : Plant Extracts

[+]

Luteolin could restore sensitivity of oxaliplatin resistant cell lines to chemotherapeutic drugs.Dec 31, 2013

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Pubmed Data : J Exp Clin Cancer Res. 2017 12 22 ;36(1):190. Epub 2017 Dec 22. PMID: 29273065

Article Published Date : Jan 21, 2017

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Drug Resistant, Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

[+]

Puerarin enhances the anti-tumor effect of cisplatin on drug-resistant A549 cancer.Dec 31, 2019

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[+]

Oridonin induces apoptosis and reverses drug resistance in cisplatin resistant human gastric cancer cells.Jul 31, 2017

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Pubmed Data : Curr Pharm Des. 2012 Feb 28. Epub 2012 Feb 28. PMID: 22390767

Article Published Date : Feb 28, 2012

Study Type : Review

Additional Links

Diseases : Brain Cancer Stem Cells, Breast Cancer Stem Cells, Cancer Stem Cells, Cancers: Multi-Drug Resistant, Colon Cancer Stem Cells

[+]

"Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein."Dec 31, 2010

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Pubmed Data : Nutr Cancer. 2011 ;63(7):1095-103. Epub 2011 Sep 20. PMID: 21932983

Article Published Date : Dec 31, 2010

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin

Diseases : Cancers: Drug Resistant, Chemotherapy-Induced Toxicity: Cisplatin, Gastric Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer, NF-kappaB Inhibitor

[+]

"Evolutionary malignant resistance of cells to damaging factors as common biological defence mechanism in neoplastic development."Sep 01, 2000

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Pubmed Data : J Exp Clin Cancer Res. 2000 Sep ;19(3):335-48. PMID: 11144527

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Pubmed Data : Int J Mol Med. 2019 Sep ;44(3):1026-1038. Epub 2019 Jul 8. PMID: 31524219

Article Published Date : Aug 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Elecampane

Diseases : Cancers: Drug Resistant, Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Gemcitabine

[+]

Alantolactone induces apoptosis in chronic myelogenous leukemia sensitive or resistant to imatinib.Aug 31, 2013

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Pubmed Data : Apoptosis. 2013 Sep ;18(9):1060-70. PMID: 23613107

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Pubmed Data : Cell Physiol Biochem. 2020 Aug 19 ;54(4):748-766. PMID: 32809300

Article Published Date : Aug 18, 2020

Study Type : In Vitro Study

Additional Links

Substances : Allicin

Diseases : Cancers: Drug Resistant, Lung Cancer

Pharmacological Actions : Apoptotic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor

[+]

Allyl isothiocyanate is a potential antiproliferative compound that modulates gene expression according to the tumor cell TP53 genotype.Dec 31, 2014

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Pubmed Data : Mutat Res. 2015 Jan ;771:29-35. Epub 2014 Dec 11. PMID: 25771977

Anti-cancer effects of alpha lipoic acid, cisplatin and paclitaxel combination in the OVCAR-3 ovarian adenocarcinoma cell line.Apr 04, 2024

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Pubmed Data : Mol Biol Rep. 2024 Apr 5 ;51(1):485. Epub 2024 Apr 5. PMID: 38578399

[+]

Apigenin induces apoptosis and counteracts cisplatin-induced chemoresistance via Mcl-1 in ovarian cancer cells.Jul 31, 2020

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Pubmed Data : Exp Ther Med. 2020 Aug ;20(2):1329-1336. Epub 2020 Jun 11. PMID: 32742367

Article Published Date : Jul 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Cancers: Drug Resistant, Ovarian Cancer

Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Apigenin inhibits antiestrogen-resistant breast cancer cell growth. Nov 01, 2006

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Pubmed Data : J Pineal Res. 2006 Nov;41(4):358-62. PMID: 18645020

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Pubmed Data : Blood Cells Mol Dis. 2002 Mar-Apr;28(2):160-8. PMID: 12064912

Article Published Date : Mar 01, 2002

Study Type : In Vitro Study

Additional Links

Substances : Artesunate, Bufalin

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Leukemia

Pharmacological Actions : Antiproliferative , Chemosensitizer

[+]

Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation.Oct 31, 2022

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Pubmed Data : Biomed Pharmacother. 2022 Nov ;155:113705. Epub 2022 Oct 7. PMID: 36271541

Article Published Date : Oct 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Artesunate

Diseases : Cancers: Drug Resistant, Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antiproliferative , Chemosensitizer

[+]

Asiatic acid re-sensitizes multidrug-resistant A549/DDP cells to cisplatin.Dec 31, 2021

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Pubmed Data : J Cell Physiol. 2018 Aug 26. Epub 2018 Aug 26. PMID: 30146689

Article Published Date : Aug 25, 2018

Study Type : In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Breast Cancer, Cancers: Drug Resistant

Pharmacological Actions : Chemosensitizer

Additional Keywords : Drug: Taxol, Natural Substance/Drug Synergy

[+]

Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib.Mar 31, 2017

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Pubmed Data : Tumour Biol. 2017 Apr ;39(4):1010428317697555. PMID: 28443459

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Pubmed Data : Eur J Med Res. 2024 Jul 26 ;29(1):387. Epub 2024 Jul 26. PMID: 39061086

Article Published Date : Jul 25, 2024

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Cancers: Drug Resistant, Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Bayberry leaves proanthocyanidin could be a valuable resource of natural compounds for cancer treatment.Dec 31, 2017

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Pubmed Data : Prostate. 2024 Feb ;84(2):131-147. Epub 2023 Oct 12. PMID: 37828768

Article Published Date : Jan 31, 2024

Study Type : In Vitro Study

Additional Links

Substances : Berbamine

Diseases : Cancers: Drug Resistant, Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Cancer Stem Cells

[+]

Berberine maintains the neutrophil N1 phenotype to reverse cancer cell resistance to doxorubicin.Dec 31, 2018

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Pubmed Data : Front Pharmacol. 2019 ;10:1658. Epub 2020 Jan 29. PMID: 32063859

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Pubmed Data : Anticancer Res. 2017 03 ;37(3):1191-1196. PMID: 28314281

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Beta-Caryophyllene

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Beta-elemene can inhibit breast cancer stem cells and the sphere-forming rate in MCF-7/ADM cells and reduce breast cancer resistance protein expression.Mar 26, 2015

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[+]

Caffeic acid phenethyl ester promotes oxaliplatin sensitization in colon cancer by inhibiting autophagy.Jun 24, 2024

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Pubmed Data : Sci Rep. 2024 Jun 25 ;14(1):14624. Epub 2024 Jun 25. PMID: 38918541

Article Published Date : Jun 24, 2024

Study Type : In Vitro Study

Additional Links

Substances : Caffeic Acid

Diseases : Cancers: Drug Resistant, Colon Cancer

Pharmacological Actions : Antineoplastic Agents, Autophagy Inhibitors, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin

[+]

Camptothecin acts synergistically with imatinib and overcomes imatinib resistance in chronic myelogenous leukemia (CML) cells.Jul 08, 2007

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Pubmed Data : Cancer Lett. 2007 Jul 8;252(1):75-85. Epub 2007 Jan 16. PMID: 17223257

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2018 Jun ;15(6):9641-9646. Epub 2018 Apr 26. PMID: 29928339

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Pubmed Data : Artif Cells Nanomed Biotechnol. 2018 Feb 6:1-12. Epub 2018 Feb 6. PMID: 29405784

Article Published Date : Feb 05, 2018

Study Type : In Vitro Study

Additional Links

Substances : Carvacrol

Diseases : Cancers: Drug Resistant, Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Inhibitors, Cell cycle arrest, Chemotherapeutic

[+]

Cashew contains an anticancer catechol with activity against multidrug resistant cancer cell lines.Apr 21, 2009

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Pubmed Data : J Ethnopharmacol. 2009 Apr 21;122(3):450-6. Epub 2009 Feb 10. PMID: 19429311

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : In Vivo. 2022 Sep-Oct;36(5):2020-2031. PMID: 36099129

Article Published Date : Aug 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Tripterygium wilfordii

Diseases : Cancers: Drug Resistant, Prostate Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Docetaxel

[+]

Chemosensitizing effect of nordihydroguaiaretic acid and its tetra-acetylated derivative on parental and multiresistant TA3 mouse mammary adenocarcinoma cells.Oct 31, 2009

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : In Vivo. 2009 Nov-Dec;23(6):959-67. PMID: 20023240

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Med. 2019 Dec 31. Epub 2019 Dec 31. PMID: 31891230

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2018 Nov ;21(11):1192-1197. PMID: 30483395

Article Published Date : Oct 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Crocetin

Diseases : Cancers: Multi-Drug Resistant, Ovarian Cancer

Pharmacological Actions : Chemotherapeutic

[+]

Crocin enhances the sensitivity to paclitaxel in human breast cancer cells by reducing BIRC5 expression.Jan 31, 2024

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Pubmed Data : Chem Biol Drug Des. 2024 Feb ;103(2):e14467. PMID: 38661582

Curcumin inhibits the survival of multiple myeloma cells. Apr 15, 2004

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Pubmed Data : Blood. 2004 Apr 15;103(8):3175-84. Epub 2003 Dec 18. PMID: 15070700

Article Published Date : Apr 15, 2004

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Drug Resistant, Multiple Myeloma

Pharmacological Actions : Apoptotic, Interleukin-6 Downregulation, NF-kappaB Inhibitor

[+]

Curcumin is highlighted in overcoming therapeutic resistance and could be important for better treatment of lung cancer in combination therapy.Dec 31, 2015

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Pubmed Data : Adv Exp Med Biol. 2016 ;890:57-74. PMID: 26703799

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Pubmed Data : Br J Haematol. 2005 Oct;131(1):59-66. PMID: 16173963

Article Published Date : Oct 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Drug Resistant, Lymphoma, Natural killer/T-cell lymphoma (NKTL)

Pharmacological Actions : Chemosensitizer, Enzyme Inhibitors, NF-kappaB Inhibitor

[+]

Curcumin may offer a therapeutic advantage in the clinical management of refractory bladder cancer. Oct 01, 2011

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Pubmed Data : Cancer Prev Res (Phila). 2011 Oct ;4(10):1698-709. Epub 2011 Aug 11. PMID: 21836020

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Pubmed Data : Zhonghua Xue Ye Xue Za Zhi. 2006 Apr;27(4):254-8. PMID: 16875558

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Pubmed Data : Cancer Biol Ther. 2011 Jan 29;11(2). Epub 2011 Jan 29. PMID: 21088500

Article Published Date : Jan 29, 2011

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Drug Resistant, Melanoma

Pharmacological Actions : Chemosensitizer

[+]

Curcumin reduces multi-drug resistance in uterine cancer cells.Oct 01, 2008

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Pubmed Data : Oncol Rep. 2008 Oct;20(4):731-5. PMID: 18813811

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Pubmed Data : Phytother Res. 2020 Oct ;34(10):2534-2556. Epub 2020 Apr 19. PMID: 32307747

Article Published Date : Sep 30, 2020

Study Type : Review

Additional Links

Substances : Curcumin

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant

Pharmacological Actions : Chemosensitizer

[+]

Curcumin sensitizes cervical cancer cells to curcumin-induced programmed cell death. Feb 25, 2005

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Pubmed Data : J Biol Chem. 2005 Feb 25;280(8):6301-8. Epub 2004 Dec 7. PMID: 15590651

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Pubmed Data : Mol Pharm. 2009 May-Jun;6(3):928-39. PMID: 19278222

Article Published Date : May 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Multi-Drug Resistant, Chemotherapy

Pharmacological Actions : Antineoplastic Agents, Apoptotic, NF-kappaB Inhibitor

Additional Keywords : Drug: Paclitaxel, Drug-Plant-Vitamin Synergies, Drug Synergy

[+]

Curcumin works synergistically with the chemotoxic agent FOLFOX to eliminate colon caner stem cells.Dec 01, 2009

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Pubmed Data : Transl Oncol. 2009 Dec;2(4):321-8. PMID: 19956394

Article Published Date : Dec 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Drug Resistant, Chemotherapy

Pharmacological Actions : Chemosensitizer

Additional Keywords : Cancer Stem Cells, Drug: FOLFOX

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Epstein-Barr virus infection may confer multidrug resistance to breast cancer cells. Sep 20, 1997

Fermented soy therapy may have therapeutic value in treating platinum-resistant ovarian cancer. Jan 01, 2006

Ginsenoside Rg3 could be used as a new regimen to delay acquired resistance of epidermal growth factor receptor-tyrosine kinase inhibitors.Oct 24, 2016

Of the 15 patients, 1 showed confirmed partial response and 4 patients had stable disease.Sep 28, 2016

Oral curcumin is safe and feasible in patients with pancreatic cancer.Sep 22, 2010

Rhus verniciflua stokes (Sumac) extract postively effects overall survival of patients with colorectal cancer refractory to conventional treatment. Jun 01, 2009

A diet rich in sulforaphane and related mustard oils may be considered as a supportive nutritional strategy to enhance therapeutic efficacy in patients suffering from pancreatic cancer.Mar 29, 2014

Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.Jul 31, 2012

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

Capsaicin inhibits 5-FU-induced autophagy and rendering Cholangiocarcinoma cells more susceptible to 5-FU-induced apoptosis.Dec 31, 2014

Ginsenoside-Rb1 targets chemotherapy-resistant ovarian cancer stem cells.Nov 03, 2016

Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer.Jan 29, 2017

Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression.Dec 31, 2017

The annatto constituent cis-bixin has intriguing selective anti-myeloma activity.Sep 30, 2010

These results indicate that all analyzed cell lines including are highly sensitive to the cytotoxic, pro-oxidant effects of high doses of sodium ascorbate.Oct 31, 2015

Wogonin decreased the expression of glycolysis-related proteins, glucose uptake and lactate generation in a dose-dependent manner.Jan 31, 2014

Baicalein enhances cisplatin sensitivity in cervical cancer cells by promoting cuproptosis through the Akt pathway.Sep 30, 2024

Cholesterol inhibition enhances antitumor response of gilteritinib in lung cancer cells.Sep 29, 2024

Cryotherapy for nodal metastasis in NSCLC with acquired resistance to immunotherapy.Jan 11, 2018

Enhanced ASGR2 by microplastic exposure leads to resistance to therapy in gastric cancer.Dec 31, 2021

Enhanced therapeutic efficacy of doxorubicin against multidrug-resistant breast cancer with reduced cardiotoxicity.Nov 30, 2023

FBP1 induced by β-elemene enhances the sensitivity of gefitinib in lung cancer.Jan 31, 2023

Ginsenoside Rb1 for overcoming cisplatin-insensitivity of A549/DDP cells.Jun 30, 2023

Ginsenoside Rg3 overcomes tamoxifen resistance through inhibiting glycolysis in breast cancer cells.Jan 14, 2024

Isorhamnetin induces cell cycle arrest and apoptosis in doxorubicin-resistant breast cancer.May 31, 2023

Paclitaxel-loaded ginsenoside Rg3 liposomes for drug-resistant cancer therapy.Sep 23, 2022

Tangeretin synergizes with 5-fluorouracil to induce autophagy through MicroRNA-21 in colorectal cancer cells.Dec 31, 2021

Tripterygium glycosides reverse chemotherapy resistance in ovarian cancer.Jul 11, 2023

Two case reports of intravenous honokiol in drug-resistant cancer.Dec 31, 2019

Oridonin enhances the anticancer activity of NVP-BEZ235 against neuroblastoma cells in vitro and in vivo through autophagy.Jul 31, 2016

20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.Dec 31, 2018

A multiple-targets alkaloid nuciferine overcomes paclitaxel-induced drug resistance in vitro and in vivo.Sep 09, 2020

A variety of carotenoids induce reduce resistance to chemotherapy in multidrug resistant lymphoma and human breast cancer cell lines. Mar 01, 2004

Acetyl-11-keto-β-boswellic acid suppresses docetaxel-resistant prostate cancer cells.Aug 30, 2018

AHCC improves treatment outcome and reduces side effects in anticancer drug treated mice. Jan 01, 2009

An antioxidant-rich extract of seaweed polyphenols combined with current PC treatment modalities may inhibit tumor relapse by targeting therapy-orchestrated autophagy in residual cells.Dec 31, 2014

Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on multi-drug resistant hepatoma. Aug 13, 2008

Apigenin could inhibit the growth of cisplatin-resistant colon cancer cells in vitro and in vivo.Feb 28, 2019

Baicalein reversed the resistance of human A549 lung adenocarcinoma cells to cisplatin.May 31, 2017

Berberine reverses breast cancer multidrug resistance.Apr 26, 2021

Bufalin could be an effective additional treatment to overcome acquired resistance to osimertinib in NSCLC cells.Sep 14, 2019

Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells.Jan 31, 2013

Cholesterol derived from LDL acts as a chemosensitizer in multidrug resistant lymphoblastic leukemia cells.Oct 01, 2007

Cinnamic acid treatment increased the sensitivity of cancer stem cells to chemotherapeutic drugs through apoptosis.Dec 31, 2012

Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy.Dec 31, 2015

Cucurbitacin B inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in NSCLC.Feb 18, 2022

Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo.Sep 13, 2010

Curcumin has anticancer, chemosensitization and radiosensitization effects in prostate cancer.Mar 01, 2007

Curcumin holds promise as an adjuvant to broaden the spectrum of gefitinib therapy to improve the efficacy of gefitinib among the NSCLC patients with different EGFR status.Dec 31, 2010

Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells.Sep 30, 2013

Dietary intake of watercress may help reverse cisplatin resistance in biliary tract cancer patients.Feb 29, 2016

Drug-induced expression of EpCAM contributes to therapy resistance in esophageal adenocarcinoma.Nov 30, 2018

EGCG enhances 5FU sensitivity in chemoresistant colorectal cancer by targeting cancer stem cells.Mar 28, 2016

Emodin alleviates gemcitabine resistance in pancreatic cancer.Oct 31, 2020

Emodin reverses resistance to gemcitabine in pancreatic cancer.Dec 31, 2022

Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein.Sep 04, 2019

Exosomal miRNA-205 promotes breast cancer chemoresistance and tumorigenesis through E2F1.Jul 21, 2021

Fisetin inhibited tumor growth in athymic nude mouse xenograft model. Mar 24, 2018

Functional combination of resveratrol and tamoxifen to overcome tamoxifen-resistance in breast cancer cells.Jun 28, 2024

Galangin, a compound found within Alpinia galanga, acts as a chemosensitizer in drug-resistant leukemia cells. Jul 08, 2008

Ginkgo biloba exocarp extracts could down regulate drug resistance related gene expression.Sep 30, 2016

Ginsenoside Rg3 in combination with artesunate overcomes sorafenib resistance in hepatoma cell and mouse models.Apr 30, 2022

Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter.Feb 29, 2020

Green tea (-)-epigalocatechin-3-gallate induces cell death in gastrointestinal stromal tumor including imatinib-resistant cells.Oct 01, 2009

Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer.Jul 01, 2010

Hesperidin as adjuvant therapy with DOX would enhance the therapeutic efficacy and alleviate the resistance to DOX in treatment of solid tumors.Jun 22, 2015

Indole-3 carbinol reverses multidrug resistant melanoma in vivo. Feb 01, 1996

Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells.Dec 31, 2014

Indole-3-carbinol would be effective for enhancing sensitivity of pancreatic cancer cells to gemcitabine.Mar 31, 2013

Isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells.Oct 31, 2014

Liquiritin induces apoptosis and autophagy in cisplatin-resistant gastric cancer cells.Oct 31, 2017

Cancers: Drug Resistant

View the Evidence:
668 Abstracts with Cancers: Drug Resistant Research