Cardiac Hypertrophy

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23 Substances Researched for Cardiac Hypertrophy
NameACCKFocus
Resveratrol59Locked
Curcumin68Locked
Crocetin24Locked
Apigenin12Locked
Carotenoids12Locked
Chicken extract12Locked
Copper12Locked
Corydalis Yanhusuo12Locked
EGCG (Epigallocatechin gallate)12Locked
Fish Oil12Locked
Magnesium12Locked
Naringenin 12Locked
Quercetin12Locked
Saffron12Locked
Stilbenes12Locked
Alpha-Lipoic Acid11Locked
Antioxidant formulas11Locked
Cocoa11Locked
Coenzyme Q1011Locked
NAC (N-acetyl-L-cysteine)11Locked
Puerarin11Locked
Spirulina11Locked
Sulforaphane11Locked
2 Problem Substances Researched for Cardiac Hypertrophy
NameACCKFocus
Fructose24Locked
Rosiglitazone (trade name Avandia)12Locked
2 Therapeutic Actions Researched for Cardiac Hypertrophy
NameACCKFocus
Dietary Modification: Caloric Restriction 12Locked
Fasting/Caloric Restriction12Locked
1 Problematic Actions Researched for Cardiac Hypertrophy
NameACCKFocus
Western Diet12Locked

View the Evidence:
78 Abstracts with Cardiac Hypertrophy Research

[+]

Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy.Jan 23, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2019 05 24 ;10(6):403. Epub 2019 May 24. PMID: 31127082
Article Published Date : Jan 23, 2019
Study Type : Animal Study
Additional Links
Substances : Oridonin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

These findings indicate a novel role for naringin in protecting against fructose-induced cardiac hypertrophy.Jun 20, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Jun 21 ;8(1):9464. Epub 2018 Jun 21. PMID: 29930336
Article Published Date : Jun 20, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Cardiac Hypertrophy, High Fructose Diet
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

A soluble non-bacterial fraction of kefir had beneficial on blood pressure and cardiac hypertrophy in hypertensive rats.Jul 31, 2018

Pubmed Data : Nutrition. 2018 Jul - Aug;51-52:66-72. Epub 2018 Feb 7. PMID: 29605766
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Kefir
Diseases : Cardiac Hypertrophy, Hypertension
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A Western-style diet induces cardiac hypertrophy and fibrosis in an animal model.Oct 01, 2010

Pubmed Data : Acta Pharmacol Sin. 2010 Oct;31(10):1350-8. Epub 2010 Sep 13. PMID: 20835264
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy, Cardiovascular Diseases
Anti Therapeutic Actions : Western Diet
[+]

Allicin provided cardioprotection for cardiac hypertrophy.Nov 30, 2018

Pubmed Data : Phytomedicine. 2018 Dec 1 ;51:241-254. Epub 2018 Oct 19. PMID: 30466623
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Allicin
Diseases : Cardiac Hypertrophy, Endothelial Dysfunction
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Apigenin could improve hypertensive cardiac hypertrophy and abnormal myocardial glucolipid metabolism in rats.Mar 17, 2016

Pubmed Data : Food Funct. 2016 Mar 18. Epub 2016 Mar 18. PMID: 26987380
Article Published Date : Mar 17, 2016
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : Cardiac Hypertrophy, Hypertension
Pharmacological Actions : Cardioprotective, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
Additional Keywords : Risk Reduction
[+]

Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2017 Nov ;135(3):97-104. Epub 2017 Aug 10. PMID: 29108833
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
Additional Keywords : Phytotherapy
[+]

Asiatic acid attenuates cardiac hypertrophy.Jul 31, 2014

Pubmed Data : Int J Mol Med. 2014 Aug ;34(2):499-506. Epub 2014 May 14. PMID: 24827470
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Asiatic acid attenuates the progression of left ventricular hypertrophy and heart failure induced by pressure overload.Nov 30, 2015

Pubmed Data : J Cardiovasc Pharmacol. 2015 Dec ;66(6):558-68. PMID: 26647013
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy, Heart Failure
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation
[+]

Asiatic acid may be a novel therapeutic agent for cardiac hypertrophy.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Thorac Dis. 2015 Oct ;7(10):1787-97. PMID: 26623102
Article Published Date : Sep 30, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Asiatic acid protects against cardiac hypertrophy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2016 ;12(7):861-71. Epub 2016 May 25. PMID: 27313499
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy, Heart Failure
Pharmacological Actions : Cardioprotective
[+]

Astragaloside IV exerts a myocardial protective effect against cardiac hypertrophy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:4625912. Epub 2019 Jun 11. PMID: 31285785
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Caffeic acid phenethyl ester may play an important role in the regulation of cardiac hypertrophy induced by pressure overload.Apr 23, 2017

Pubmed Data : Life Sci. 2017 Apr 24. Epub 2017 Apr 24. PMID: 28449869
Article Published Date : Apr 23, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Calcitriol increases ventricular K+ currents in isolated mouse cardiomyocytes.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2018 ;9:1186. Epub 2018 Aug 24. PMID: 30197603
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Cardiac Hypertrophy, Heart Failure
Pharmacological Actions : Cardioprotective
[+]

Chicken-meat extract (both BEC and laboratory prepared) has anti-cardiac hypertrophic, anti-hypertensive and anti-arteriosclerotic actions. Sep 01, 2003

Pubmed Data : Nutrition. 2003 Sep;19(9):794-9. PMID: 11432770
Article Published Date : Sep 01, 2003
Study Type : Animal Study
Additional Links
Substances : Chicken extract
Diseases : Arteriosclerosis, Cardiac Hypertrophy, Hypertension
Pharmacological Actions : Cardioprotective
[+]

Chronic treatment of rats with Corydalis yanhusuo extract attenuates thee development of cardiac hypertrophy.Aug 01, 2007

Pubmed Data : J Pharm Pharmacol. 2007 Aug;59(8):1159-65. PMID: 17725860
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Substances : Corydalis Yanhusuo
Diseases : Cardiac Hypertrophy
[+]

Chrysanthemum morifolium extract improves hypertension-induced cardiac hypertrophy.Nov 30, 2016

Pubmed Data : Pharm Biol. 2016 Dec ;54(12):2895-2900. Epub 2016 Jun 7. PMID: 27268080
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Chrysanthemum Morifolium
Diseases : Cardiac Hypertrophy, Hypertension
Pharmacological Actions : Vasodilator Agents
[+]

Contributions of Nrf2 to puerarin prevention of cardiac hypertrophy.Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2018 Sep ;366(3):458-469. Epub 2018 Jun 26. PMID: 29945930
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective, Nrf2 activation
[+]

Copper deficiency and fructose consumption is associated with cardiac abnormalities in rats. Dec 01, 1988

Pubmed Data : Atherosclerosis. 1988 Dec;74(3):203-14. PMID: 3240332
Article Published Date : Dec 01, 1988
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy, Cardiovascular Diseases, Copper Deficiency, Myocarditis
Problem Substances : Fructose
[+]

Copper reverses cardiac hypertrphy in the rat model.Jul 01, 2008

Pubmed Data : J Mol Cell Cardiol. 2008 Jul;45(1):106-17. Epub 2008 Apr 9. PMID: 18495151
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Copper
Diseases : Cardiac Hypertrophy
[+]

Crocetin has a cardioprotective effect in cardiac hypertrophy induced by norepinephrine in rats.Apr 01, 2006

Pubmed Data : Pharmazie. 2006 Apr;61(4):348-52. PMID: 16649553
Article Published Date : Apr 01, 2006
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocetin, Saffron
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Crocetin protects against cardiac hypertrophy. May 01, 2009

Pubmed Data : J Cell Mol Med. 2009 May;13(5):909-25. Epub 2008 Dec 24. PMID: 19413885
Article Published Date : May 01, 2009
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Cardiac Hypertrophy, Cardiomegaly
Pharmacological Actions : Antioxidants, Cardioprotective, NF-kappaB Inhibitor
[+]

Cucurbitacin B protects against cardiac hypertrophy through increasing the autophagy level in cardiomyocytes.Apr 07, 2017

Pubmed Data : J Cell Biochem. 2017 Apr 8. Epub 2017 Apr 8. PMID: 28390176
Article Published Date : Apr 07, 2017
Study Type : Animal Study
Additional Links
Substances : Cucurbitacin B
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Autophagy Up-regulation, Cardioprotective
[+]

Curcumin may inhibit cardiac hypertrophy and myocardial infarction.Oct 19, 2009

Pubmed Data : Lab Invest. 2009 Oct 19. PMID: 18292806
Article Published Date : Oct 19, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy, Cardiomegaly, Heart Failure, Myocardial Infarction
Pharmacological Actions : Cardioprotective, Enzyme Inhibitors
[+]

Curcumin prevents cardiac remodeling secondary to chronic renal failure in rats.Oct 01, 2010

Pubmed Data : Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H975-84. Epub 2010 Jul 2. PMID: 20601462
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy, Hypertension, Kidney Failure: Chronic
Pharmacological Actions : Cardioprotective
[+]

Cyanidin 3-O-glucoside ameliorated cardiac hypertrophy and diastolic dysfunction in involved with hypertension.Jun 19, 2018

Pubmed Data : Food Funct. 2018 Jun 20 ;9(6):3466-3480. PMID: 29878020
Article Published Date : Jun 19, 2018
Study Type : Animal Study
Additional Links
Substances : Cyanidin 3-glucoside
Diseases : Cardiac Hypertrophy, Cardiomegaly, Hypertension
Pharmacological Actions : Cardioprotective
[+]

Dietary fish oil attenuates cardiac hypertrophy due to systemic carnitine deficiency. Nov 01, 2005

Pubmed Data : Cardiovasc Res. 2005 Nov 1;68(2):213-23. Epub 2005 Jun 15. PMID: 15963478
Article Published Date : Nov 01, 2005
Study Type : Animal Study
Additional Links
Substances : Fish Oil
Diseases : Cardiac Hypertrophy
[+]

Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res Perspect. 2018 04 ;6(2):e00385. Epub 2018 Feb 19. PMID: 29468071
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumin, Tetrahydrocurcumin
Diseases : Cardiac Hypertrophy, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective
[+]

EGCG may potentially inhibit aging-induced cardiac hypertrophy, fibrosis, and apoptosis, thereby preserving cardiac function.Jan 31, 2018

Pubmed Data : J Cardiovasc Pharmacol. 2018 Feb ;71(2):65-75. PMID: 29419571
Article Published Date : Jan 31, 2018
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

EGCG prevents cardiac hypertrophy induced by pressuer overload in rats. Jun 01, 2007

Pubmed Data : J Vet Sci. 2007 Jun;8(2):121-9. PMID: 17519564
Article Published Date : Jun 01, 2007
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cardiac Hypertrophy
[+]

Epigallocatechin-3-gallate improves cardiac hypertrophy and short-term memory deficits in a Williams-Beuren syndrome mouse model.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(3):e0194476. Epub 2018 Mar 19. PMID: 29554110
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Catechin , EGCG (Epigallocatechin gallate)
Diseases : Cardiac Hypertrophy, Williams Syndrome
Pharmacological Actions : Neuroprotective Agents
[+]

Fisetin inhibits cardiac hypertrophy by suppressing oxidative stress.Nov 30, 2018

Pubmed Data : J Nutr Biochem. 2018 Dec ;62:221-229. Epub 2018 Sep 1. PMID: 30312797
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Fructose induces insulin resistance and myocardial hypertrophy in the animal model. Jun 01, 2011

Pubmed Data : Peptides. 2011 Jun 1. Epub 2011 Jun 1. PMID: 21664393
Article Published Date : Jun 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy, Insulin Resistance
Problem Substances : Fructose
Adverse Pharmacological Actions : Cardiotoxic, Endocrine Disruptor: Insulin Resistance
[+]

Fucoidan and fucoxanthin in combination can potentially reduce cardiac hypertrophy, cardiac fibrosis, ROS level,Jan 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2019 Jan 21 ;17(1). Epub 2019 Jan 21. PMID: 30669571
Article Published Date : Jan 20, 2019
Study Type : Animal Study
Additional Links
Substances : Fucoidan, Fucoxanthin
Diseases : Aging: Heart, Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Gastrodin protects against cardiac hypertrophy and fibrosis.Dec 31, 2011

Pubmed Data : Mol Cell Biochem. 2012 Jan ;359(1-2):9-16. Epub 2011 Jul 16. PMID: 21833534
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Ginseng may be an effective therapy to reduce hypertrophy and heart failure associated with excessive catecholamine production.Nov 30, 2016

Pubmed Data : Can J Physiol Pharmacol. 2016 Dec ;94(12):1325-1335. Epub 2016 Aug 17. PMID: 27797280
Article Published Date : Nov 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginseng (American)
Diseases : Cardiac Hypertrophy, Cardiomegaly
Pharmacological Actions : Cardioprotective
Additional Keywords : Plant Extracts
[+]

Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1016-1023. Epub 2018 Nov 6. PMID: 30551351
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Ginsenoside Rg1 exhibited protective effect against transverse aortic constriction-induced left ventricular hypertrophy and cardiac dysfunction.Jun 30, 2013

Pubmed Data : J Cardiovasc Pharmacol. 2013 Jul ;62(1):50-7. PMID: 23846802
Article Published Date : Jun 30, 2013
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Angiogenesis Inducing Agents
[+]

Hesperidin may be further evaluated as a promising molecule for the alleviation of cardiac hypertrophy.Jan 07, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Jan 8:e22283. Epub 2019 Jan 8. PMID: 30623541
Article Published Date : Jan 07, 2019
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
[+]

Lycopene protects against pressure overload-induced cardiac hypertrophy by attenuating oxidative stress.Mar 31, 2019

Pubmed Data : J Nutr Biochem. 2019 Apr ;66:70-78. Epub 2019 Jan 7. PMID: 30772766
Article Published Date : Mar 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lycopene
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Magnesium administration improves mechanical abnormalities observed in hypertensive rat ventricular myocytes.May 17, 2016

Pubmed Data : J Bioenerg Biomembr. 2016 May 18. Epub 2016 May 18. PMID: 27193439
Article Published Date : May 17, 2016
Study Type : Animal Study
Additional Links
Substances : Magnesium
Diseases : Cardiac Hypertrophy, Hypertension
Pharmacological Actions : Antioxidants, Cardioprotective
Additional Keywords : Risk Reduction
[+]

Modest calorie restriction improves cardiac remodeling and diastolic dysfunction in rats. Oct 01, 2006

Pubmed Data : J Mol Cell Cardiol. 2006 Oct;41(4):661-8. Epub 2006 Aug 23. PMID: 16934290
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy
Therapeutic Actions : Dietary Modification: Caloric Restriction , Fasting/Caloric Restriction
[+]

Myocardial hypertrophy is improved with berberine treatment via long non-coding RNA MIAT-mediated autophagy.Oct 13, 2019

Pubmed Data : J Pharm Pharmacol. 2019 Oct 14. Epub 2019 Oct 14. PMID: 31612504
Article Published Date : Oct 13, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berberine
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Autophagy Up-regulation, Cardioprotective, MicroRNA modulator
[+]

Myricetin alleviates pathological cardiac hypertrophy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:6304058. Epub 2019 Dec 6. PMID: 31885808
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective, Nrf2 activation
[+]

Naringenin exerts a pharmacological effect against the progression of cardiac hypertrophy induced by pressure overload. Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2015 Dec ;10(6):2206-2212. Epub 2015 Oct 19. PMID: 26668617
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Cardiac Hypertrophy, Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice.May 16, 2018

Pubmed Data : Biochem Biophys Res Commun. 2018 May 17. Epub 2018 May 17. PMID: 29778538
Article Published Date : May 16, 2018
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Cardiac Hypertrophy, Diabetic Complications
Pharmacological Actions : Cardioprotective
Additional Keywords : Gene Expression Regulation
[+]

Neohesperidin inhibits cardiac remodeling induced by Ang II in vivo and in vitro.Jun 08, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Jun 9 ;129:110364. Epub 2020 Jun 9. PMID: 32531678
Article Published Date : Jun 08, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : neohesperidin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Nobiletin protects against cardiac hypertrophy induced by pressure-overload.Jul 12, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 Jul 13 ;42(4):1313-1325. Epub 2017 Jul 13. PMID: 28700997
Article Published Date : Jul 12, 2017
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Paeoniflorin improves pressure overload-induced cardiac remodelling by modulating the MAPK signalling pathway in spontaneously hypertensive rats.Feb 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Mar ;111:695-704. Epub 2019 Jan 3. PMID: 30611994
Article Published Date : Feb 28, 2019
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Cardiac Hypertrophy, Inflammation, Myocardial Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation
[+]

Piceatannol may be a novel therapeutic agent for the prevention of cardiac hypertrophy.May 01, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FEBS Lett. 2014 May 2 ;588(9):1529-36. Epub 2014 Mar 21. PMID: 24662306
Article Published Date : May 01, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Pretreatment with zingerone prevented hyperlipidaemia and cardiac hypertrophy.Mar 31, 2015

Pubmed Data : J Biochem Mol Toxicol. 2015 Apr ;29(4):182-8. Epub 2015 Jan 5. PMID: 25558849
Article Published Date : Mar 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginger, Polyphenols
Diseases : Cardiac Hypertrophy, Hyperlipidemia, Myocardial Infarction
Pharmacological Actions : Cardioprotective
[+]

Quercetin prevents cardiac hypertrophy induced by pressure overload in rats. Jun 01, 2009

Pubmed Data : J Vet Med Sci. 2009 Jun;71(6):737-43. PMID: 19578281
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Cardiac Hypertrophy
[+]

Resveratrol arrests and regresses the development of pressure overload cardiac hypertrophy in rats.May 01, 2010

Pubmed Data : J Nutr. 2010 May;140(5):962-8. Epub 2010 Mar 24. PMID: 20335634
Article Published Date : May 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cardiac Hypertrophy, Cardiomegaly, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
Additional Keywords : Plant Extracts, Stilbenes
[+]

Resveratrol may be beneficial against cardiac hypertrophy associated with hypertension and aortic valve stenosis.May 01, 2007

Pubmed Data : Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2138-43. PMID: 17488730
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Aortic Stenosis, Cardiac Hypertrophy, Hypertension
[+]

Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.Aug 10, 2019

Pubmed Data : Life Sci. 2019 Aug 11 ;233:116748. Epub 2019 Aug 11. PMID: 31412263
Article Published Date : Aug 10, 2019
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cardiac Hypertrophy, Hypoxia
Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Cardioprotective
[+]

Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the spontaneously hypertensive rats without lowering blood pressure.Feb 01, 2010

Pubmed Data : Am J Hypertens. 2010 Feb;23(2):192-6. Epub 2009 Nov 26. PMID: 19942861
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Cardiac Hypertrophy, Cardiomegaly, Hypertension, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Resveratrol protects against cardiac hypertrophy in an animal model. Dec 22, 2010

Pubmed Data : Cardiovasc Res. 2010 Dec 22. Epub 2010 Dec 22. PMID: 21115502
Article Published Date : Dec 22, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Rosiglitazone causes cardiac hypertrophy. Jul 01, 2009

Pubmed Data : J Mol Cell Cardiol. 2009 Jul;47(1):85-95. Epub 2009 May 3. PMID: 19397913
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy, Cardiomegaly
Problem Substances : Rosiglitazone (trade name Avandia)
Adverse Pharmacological Actions : Cardiotoxic
[+]

Sesamin improves cardiac function and prevents the development of cardiac hypertrophy.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 ;44(6):2212-2227. Epub 2017 Dec 13. PMID: 29248930
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Sesamin
Diseases : Cardiac Hypertrophy, Inflammation, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Tanshinone IIA inhibits myocardial remodeling induced by pressure overload.Nov 14, 2016

Pubmed Data : Eur J Pharmacol. 2016 Nov 15 ;791:632-639. Epub 2016 Sep 30. PMID: 27693799
Article Published Date : Nov 14, 2016
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Cardiac Hypertrophy, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The cardioprotective effects of tannic acid may be attributed to multitargeted inhibition of oxidative stress, inflammation, fibrosis and apoptosis.Aug 31, 2017

Pubmed Data : J Pharm Pharmacol. 2017 Sep ;69(9):1191-1207. Epub 2017 Jun 20. PMID: 28631819
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Tannic Acid
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Antioxidants, Cardioprotective
[+]

The results suggested that ginsenoside Rg1 attenuates the abdominal aorta coarctation-induced cardiac hypertrophy.Sep 30, 2016

Pubmed Data : J Cardiovasc Pharmacol. 2016 Oct ;68(4):257-264. PMID: 27195652
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These findings above indicated that astragaloside might be a potential candidate to prevent cardiac hypertrophy.Dec 31, 2017

Pubmed Data : Biomed Pharmacother. 2018 Jan ;97:1468-1478. Epub 2017 Nov 20. PMID: 29793309
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

This study strongly suggests that supplementation of dried Musa balbisiana fruit powder can be useful for the prevention of cardiac hypertrophy.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:7147498. Epub 2020 Jan 27. PMID: 32082481
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Banana
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
Problem Substances : Isoproterenol
[+]

A number of natural substances have therapeutic value in the partial prevention of cardiac remodeling and atrial fibrillation. Jan 16, 2010

Pubmed Data : Med Hypotheses. 2010 Jan 16. Epub 2010 Jan 16. PMID: 20083360
Article Published Date : Jan 16, 2010
Study Type : Commentary
Additional Links
Substances : Alpha-Lipoic Acid, Antioxidant formulas, Cocoa, Coenzyme Q10, NAC (N-acetyl-L-cysteine), Spirulina
Diseases : Atrial Fibrillation, Cardiac Arrhythmias, Cardiac Hypertrophy
[+]

Cardiovascular modulating effects of magnolol and honokiol.Oct 23, 2019

Pubmed Data : Curr Drug Targets. 2019 Oct 24. Epub 2019 Oct 24. PMID: 31749425
Article Published Date : Oct 23, 2019
Study Type : Review
Additional Links
Substances : Honokiol, Magnolia, Magnolol
Diseases : Atherosclerosis, Cardiac Hypertrophy, Hypertension, Thrombosis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Curcumin (from Turmeric) protects against cardiac hypertrophy.Mar 01, 2008

Pubmed Data : J Clin Invest. 2008 Mar;118(3):879-93. PMID: 18292803
Article Published Date : Mar 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy
[+]

Curcumin reduces angiotensin II-mediated cardiomyocyte growth via LOX-1 inhibition.Apr 01, 2010

Pubmed Data : J Cardiovasc Pharmacol. 2010 Apr;55(4):417-24. PMID: 20422739
Article Published Date : Apr 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy, Oxidative Stress
Pharmacological Actions : Antiproliferative , Lipoxygenase Inhibitors, NF-kappaB Inhibitor
[+]

Curcumin supplementation can improve high glucose and insulin-induced cardiomyocytes hypertrophy in vitro.Apr 30, 2015

Pubmed Data : Diabetes Res Clin Pract. 2015 May ;108(2):235-42. Epub 2015 Feb 21. PMID: 25765666
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
Additional Keywords : Dose Response
[+]

EGCG may be an effective agent for preventing cardiac hypertrophy.Mar 31, 2019

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2019 Apr 1 ;51(4):422-430. PMID: 30877756
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Luteolin suppresses lipopolysaccharide‑induced cardiomyocyte hypertrophy and autophagy in vitro.Feb 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Mar ;19(3):1551-1560. Epub 2019 Jan 2. PMID: 30628693
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Luteolin
Diseases : Cardiac Hypertrophy, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cardioprotective
[+]

Nelumbo nucifera extract suppresses angiotensin II-induced cardiomyocyte hypertrophy.Apr 25, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Apr 26 ;24(9). Epub 2019 Apr 26. PMID: 31027372
Article Published Date : Apr 25, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Puerarin administration enhances miR-15b and miR-195 expression in an Ang II-induced cardiac hypertrophy model.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2016 ;22:1516-23. Epub 2016 May 5. PMID: 27145790
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective, MicroRNA modulator
[+]

Resveratrol treatment effectively suppressed myocardial hypertrophy and apoptosis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2016 ;39(2):780-9. Epub 2016 Jul 29. PMID: 27467279
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Sulforaphane attenuates Ang II-induced hypertrophy of H9c2 cardiomyocytes mediated by the inhibition of intracellular signaling pathways including Akt and NF-κB.Apr 30, 2014

Pubmed Data : Herz. 2014 May ;39(3):390-6. Epub 2013 Jun 21. PMID: 23784363
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Tanshinone IIA prevents Leu27IGF-II-induced cardiomyocyte hypertrophy mediated by estrogen receptor and subsequent Akt activation.Dec 31, 2014

Pubmed Data : Am J Chin Med. 2015 ;43(8):1567-91. Epub 2015 Nov 30. PMID: 26621443
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
Additional Keywords : Phytotherapy
[+]

Targeted Curcumin delivery efficiently regressed cardiac hypertrophy by modulating apoptotic load within cardiac microenvironment.Dec 31, 2015

Pubmed Data : Toxicol Appl Pharmacol. 2016 Jan 1 ;290:54-65. Epub 2015 Nov 21. PMID: 26612707
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
Additional Keywords : Increased Bioavailability
[+]

These findings reveal a novel mechanism of allicin attenuating cardiac hypertrophy.Apr 30, 2019

Pubmed Data : Phytomedicine. 2019 May ;58:152765. Epub 2018 Nov 19. PMID: 31005720
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Allicin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Autophagy Inhibitors, Cardioprotective

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