Cardiac Hypertrophy

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66 Substances Researched for Cardiac Hypertrophy
NameACCKFocus
Resveratrol611Locked
Curcumin710Locked
Asiatic Acid48Locked
EGCG (Epigallocatechin gallate)47Locked
Ginsenosides36Locked
Puerarin35Locked
Astragaloside24Locked
Crocetin24Locked
Naringenin 24Locked
Allicin23Locked
Tanshinone IIA23Locked
Tetrahydrocurcumin23Locked
Apigenin12Locked
Banana12Locked
Berberine12Locked
Burdock12Locked
Caffeic acid phenethyl ester12Locked
Carotenoids12Locked
Carvacrol12Locked
Catechin 12Locked
Chicken extract12Locked
Chrysanthemum Morifolium12Locked
Citrus naringin12Locked
Copper12Locked
Corydalis Yanhusuo12Locked
Cucurbitacin B 12Locked
Cyanidin 3-glucoside12Locked
Fisetin12Locked
Fish Oil12Locked
Fucoidan12Locked
Fucoxanthin 12Locked
Gastrodin12Locked
Ginger12Locked
Ginseng (American)12Locked
Hesperidin12Locked
Kefir12Locked
Lycopene12Locked
Magnesium12Locked
Melatonin12Locked
Myricetin12Locked
Nobiletin 12Locked
Oridonin12Locked
Paeoniflorin12Locked
Piceatannol 12Locked
Piperlongumine 12Locked
Polyphenols12Locked
Quercetin12Locked
Saffron12Locked
Sesamin12Locked
Stilbenes12Locked
Tannic Acid12Locked
Vitamin D12Locked
neohesperidin12Locked
Alpha-Lipoic Acid11Locked
Antioxidant formulas11Locked
Betulinic acid11Locked
Cocoa11Locked
Coenzyme Q1011Locked
Honokiol11Locked
Lotus 11Locked
Luteolin11Locked
Magnolia11Locked
Magnolol11Locked
NAC (N-acetyl-L-cysteine)11Locked
Spirulina11Locked
Sulforaphane11Locked
3 Problem Substances Researched for Cardiac Hypertrophy
NameACCKFocus
Fructose24Locked
Isoproterenol12Locked
Rosiglitazone (trade name Avandia)12Locked
2 Therapeutic Actions Researched for Cardiac Hypertrophy
NameACCKFocus
Dietary Modification: Caloric Restriction 12Locked
Fasting/Caloric Restriction12Locked
1 Problematic Actions Researched for Cardiac Hypertrophy
NameACCKFocus
Western Diet12Locked

View the Evidence:
107 Abstracts with Cardiac Hypertrophy Research

[+]

Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy.Jan 23, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2019 05 24 ;10(6):403. Epub 2019 May 24. PMID: 31127082
Article Published Date : Jan 23, 2019
Study Type : Animal Study
Additional Links
Substances : Oridonin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

These findings indicate a novel role for naringin in protecting against fructose-induced cardiac hypertrophy.Jun 20, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Jun 21 ;8(1):9464. Epub 2018 Jun 21. PMID: 29930336
Article Published Date : Jun 20, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Cardiac Hypertrophy, High Fructose Diet
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

6-Gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway.Jan 17, 2021

Pubmed Data : Acta Pharmacol Sin. 2021 Jan 18. Epub 2021 Jan 18. PMID: 33462378
Article Published Date : Jan 17, 2021
Study Type : Animal Study
Additional Links
Substances : Gingerol
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

A soluble non-bacterial fraction of kefir had beneficial on blood pressure and cardiac hypertrophy in hypertensive rats.Jul 31, 2018

Pubmed Data : Nutrition. 2018 Jul - Aug;51-52:66-72. Epub 2018 Feb 7. PMID: 29605766
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Kefir
Diseases : Cardiac Hypertrophy, Hypertension
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A Western-style diet induces cardiac hypertrophy and fibrosis in an animal model.Oct 01, 2010

Pubmed Data : Acta Pharmacol Sin. 2010 Oct;31(10):1350-8. Epub 2010 Sep 13. PMID: 20835264
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy, Cardiovascular Diseases
Anti Therapeutic Actions : Western Diet
[+]

A. paniculata extract can be used for prevention and treatment of cardiovascular disease in obese patients.Nov 03, 2016

Pubmed Data : J Ethnopharmacol. 2016 Nov 4 ;192:170-177. Epub 2016 Jul 9. PMID: 27401291
Article Published Date : Nov 03, 2016
Study Type : Animal Study
Additional Links
Substances : Andrographis
Diseases : Cardiac Hypertrophy, High Fat Diet
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cardioprotective, Cyclooxygenase 2 Inhibitors
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Activation of SIRT1 by resveratrol alleviates pressure overload-induced cardiac hypertrophy.Sep 07, 2021

Pubmed Data : Pharmacology. 2021 Sep 8:1-15. Epub 2021 Sep 8. PMID: 34518478
Article Published Date : Sep 07, 2021
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Allicin provided cardioprotection for cardiac hypertrophy.Nov 30, 2018

Pubmed Data : Phytomedicine. 2018 Dec 1 ;51:241-254. Epub 2018 Oct 19. PMID: 30466623
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Allicin
Diseases : Cardiac Hypertrophy, Endothelial Dysfunction
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response.Dec 31, 2021

Pubmed Data : Life Sci. 2022 Jan 1 ;288:120159. Epub 2021 Nov 18. PMID: 34801516
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Aloe Vera
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective
[+]

Apigenin could improve hypertensive cardiac hypertrophy and abnormal myocardial glucolipid metabolism in rats.Mar 17, 2016

Pubmed Data : Food Funct. 2016 Mar 18. Epub 2016 Mar 18. PMID: 26987380
Article Published Date : Mar 17, 2016
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : Cardiac Hypertrophy, Hypertension
Pharmacological Actions : Cardioprotective, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
Additional Keywords : Risk Reduction
[+]

Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2017 Nov ;135(3):97-104. Epub 2017 Aug 10. PMID: 29108833
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
Additional Keywords : Phytotherapy
[+]

Asiatic acid attenuates cardiac hypertrophy.Jul 31, 2014

Pubmed Data : Int J Mol Med. 2014 Aug ;34(2):499-506. Epub 2014 May 14. PMID: 24827470
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Asiatic acid attenuates the progression of left ventricular hypertrophy and heart failure induced by pressure overload.Nov 30, 2015

Pubmed Data : J Cardiovasc Pharmacol. 2015 Dec ;66(6):558-68. PMID: 26647013
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy, Heart Failure
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation
[+]

Asiatic acid may be a novel therapeutic agent for cardiac hypertrophy.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Thorac Dis. 2015 Oct ;7(10):1787-97. PMID: 26623102
Article Published Date : Sep 30, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Asiatic acid protects against cardiac hypertrophy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2016 ;12(7):861-71. Epub 2016 May 25. PMID: 27313499
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy, Heart Failure
Pharmacological Actions : Cardioprotective
[+]

Astragaloside IV exerts a myocardial protective effect against cardiac hypertrophy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:4625912. Epub 2019 Jun 11. PMID: 31285785
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Caffeic acid phenethyl ester may play an important role in the regulation of cardiac hypertrophy induced by pressure overload.Apr 23, 2017

Pubmed Data : Life Sci. 2017 Apr 24. Epub 2017 Apr 24. PMID: 28449869
Article Published Date : Apr 23, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Calcitriol increases ventricular K+ currents in isolated mouse cardiomyocytes.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2018 ;9:1186. Epub 2018 Aug 24. PMID: 30197603
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Cardiac Hypertrophy, Heart Failure
Pharmacological Actions : Cardioprotective
[+]

Carvacrol decreases hypertrophy markers in in-vivo and in-vitro models of hypertrophy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2019 ;18(3):1380-1394. PMID: 32641948
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carvacrol
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Chicken-meat extract (both BEC and laboratory prepared) has anti-cardiac hypertrophic, anti-hypertensive and anti-arteriosclerotic actions. Sep 01, 2003

Pubmed Data : Nutrition. 2003 Sep;19(9):794-9. PMID: 11432770
Article Published Date : Sep 01, 2003
Study Type : Animal Study
Additional Links
Substances : Chicken extract
Diseases : Arteriosclerosis, Cardiac Hypertrophy, Hypertension
Pharmacological Actions : Cardioprotective
[+]

Chronic treatment of rats with Corydalis yanhusuo extract attenuates thee development of cardiac hypertrophy.Aug 01, 2007

Pubmed Data : J Pharm Pharmacol. 2007 Aug;59(8):1159-65. PMID: 17725860
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Substances : Corydalis Yanhusuo
Diseases : Cardiac Hypertrophy
[+]

Chrysanthemum morifolium extract improves hypertension-induced cardiac hypertrophy.Nov 30, 2016

Pubmed Data : Pharm Biol. 2016 Dec ;54(12):2895-2900. Epub 2016 Jun 7. PMID: 27268080
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Chrysanthemum Morifolium
Diseases : Cardiac Hypertrophy, Hypertension
Pharmacological Actions : Vasodilator Agents
[+]

Contributions of Nrf2 to puerarin prevention of cardiac hypertrophy.Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2018 Sep ;366(3):458-469. Epub 2018 Jun 26. PMID: 29945930
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective, Nrf2 activation
[+]

Copper deficiency and fructose consumption is associated with cardiac abnormalities in rats. Dec 01, 1988

Pubmed Data : Atherosclerosis. 1988 Dec;74(3):203-14. PMID: 3240332
Article Published Date : Dec 01, 1988
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy, Cardiovascular Diseases, Copper Deficiency, Myocarditis
Problem Substances : Fructose
[+]

Copper reverses cardiac hypertrphy in the rat model.Jul 01, 2008

Pubmed Data : J Mol Cell Cardiol. 2008 Jul;45(1):106-17. Epub 2008 Apr 9. PMID: 18495151
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Copper
Diseases : Cardiac Hypertrophy
[+]

Crocetin has a cardioprotective effect in cardiac hypertrophy induced by norepinephrine in rats.Apr 01, 2006

Pubmed Data : Pharmazie. 2006 Apr;61(4):348-52. PMID: 16649553
Article Published Date : Apr 01, 2006
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocetin, Saffron
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Crocetin protects against cardiac hypertrophy. May 01, 2009

Pubmed Data : J Cell Mol Med. 2009 May;13(5):909-25. Epub 2008 Dec 24. PMID: 19413885
Article Published Date : May 01, 2009
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Cardiac Hypertrophy, Cardiomegaly
Pharmacological Actions : Antioxidants, Cardioprotective, NF-kappaB Inhibitor
[+]

Cucurbitacin B protects against cardiac hypertrophy through increasing the autophagy level in cardiomyocytes.Apr 07, 2017

Pubmed Data : J Cell Biochem. 2017 Apr 8. Epub 2017 Apr 8. PMID: 28390176
Article Published Date : Apr 07, 2017
Study Type : Animal Study
Additional Links
Substances : Cucurbitacin B
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Autophagy Up-regulation, Cardioprotective
[+]

Curcumin may inhibit cardiac hypertrophy and myocardial infarction.Oct 19, 2009

Pubmed Data : Lab Invest. 2009 Oct 19. PMID: 18292806
Article Published Date : Oct 19, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy, Cardiomegaly, Heart Failure, Myocardial Infarction
Pharmacological Actions : Cardioprotective, Enzyme Inhibitors
[+]

Curcumin prevents cardiac remodeling secondary to chronic renal failure in rats.Oct 01, 2010

Pubmed Data : Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H975-84. Epub 2010 Jul 2. PMID: 20601462
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy, Hypertension, Kidney Failure: Chronic
Pharmacological Actions : Cardioprotective
[+]

Cyanidin 3-O-glucoside ameliorated cardiac hypertrophy and diastolic dysfunction in involved with hypertension.Jun 19, 2018

Pubmed Data : Food Funct. 2018 Jun 20 ;9(6):3466-3480. PMID: 29878020
Article Published Date : Jun 19, 2018
Study Type : Animal Study
Additional Links
Substances : Cyanidin 3-glucoside
Diseases : Cardiac Hypertrophy, Cardiomegaly, Hypertension
Pharmacological Actions : Cardioprotective
[+]

Dietary fish oil attenuates cardiac hypertrophy due to systemic carnitine deficiency. Nov 01, 2005

Pubmed Data : Cardiovasc Res. 2005 Nov 1;68(2):213-23. Epub 2005 Jun 15. PMID: 15963478
Article Published Date : Nov 01, 2005
Study Type : Animal Study
Additional Links
Substances : Fish Oil
Diseases : Cardiac Hypertrophy
[+]

Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res Perspect. 2018 04 ;6(2):e00385. Epub 2018 Feb 19. PMID: 29468071
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumin, Tetrahydrocurcumin
Diseases : Cardiac Hypertrophy, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective
[+]

EGCG may potentially inhibit aging-induced cardiac hypertrophy, fibrosis, and apoptosis, thereby preserving cardiac function.Jan 31, 2018

Pubmed Data : J Cardiovasc Pharmacol. 2018 Feb ;71(2):65-75. PMID: 29419571
Article Published Date : Jan 31, 2018
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

EGCG prevents cardiac hypertrophy induced by pressuer overload in rats. Jun 01, 2007

Pubmed Data : J Vet Sci. 2007 Jun;8(2):121-9. PMID: 17519564
Article Published Date : Jun 01, 2007
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cardiac Hypertrophy
[+]

Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2021 Dec ;59(1):1305-1313. PMID: 34607503
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Epigallocatechin-3-gallate improves cardiac hypertrophy and short-term memory deficits in a Williams-Beuren syndrome mouse model.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(3):e0194476. Epub 2018 Mar 19. PMID: 29554110
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Catechin , EGCG (Epigallocatechin gallate)
Diseases : Cardiac Hypertrophy, Williams Syndrome
Pharmacological Actions : Neuroprotective Agents
[+]

Fisetin inhibits cardiac hypertrophy by suppressing oxidative stress.Nov 30, 2018

Pubmed Data : J Nutr Biochem. 2018 Dec ;62:221-229. Epub 2018 Sep 1. PMID: 30312797
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Fructose induces insulin resistance and myocardial hypertrophy in the animal model. Jun 01, 2011

Pubmed Data : Peptides. 2011 Jun 1. Epub 2011 Jun 1. PMID: 21664393
Article Published Date : Jun 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy, Insulin Resistance
Problem Substances : Fructose
Adverse Pharmacological Actions : Cardiotoxic, Endocrine Disruptor: Insulin Resistance
[+]

Fucoidan and fucoxanthin in combination can potentially reduce cardiac hypertrophy, cardiac fibrosis, ROS level,Jan 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2019 Jan 21 ;17(1). Epub 2019 Jan 21. PMID: 30669571
Article Published Date : Jan 20, 2019
Study Type : Animal Study
Additional Links
Substances : Fucoidan, Fucoxanthin
Diseases : Aging: Heart, Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Gastrodin could be used in the prevention of cardiac hypertrophy.Jul 05, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ACS Omega. 2021 Jul 6 ;6(26):16763-16774. Epub 2021 Jun 21. PMID: 34250336
Article Published Date : Jul 05, 2021
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Gastrodin protects against cardiac hypertrophy and fibrosis.Dec 31, 2011

Pubmed Data : Mol Cell Biochem. 2012 Jan ;359(1-2):9-16. Epub 2011 Jul 16. PMID: 21833534
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Ginseng may be an effective therapy to reduce hypertrophy and heart failure associated with excessive catecholamine production.Nov 30, 2016

Pubmed Data : Can J Physiol Pharmacol. 2016 Dec ;94(12):1325-1335. Epub 2016 Aug 17. PMID: 27797280
Article Published Date : Nov 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginseng (American)
Diseases : Cardiac Hypertrophy, Cardiomegaly
Pharmacological Actions : Cardioprotective
Additional Keywords : Plant Extracts
[+]

Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1016-1023. Epub 2018 Nov 6. PMID: 30551351
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Ginsenoside Rg1 exhibited protective effect against transverse aortic constriction-induced left ventricular hypertrophy and cardiac dysfunction.Jun 30, 2013

Pubmed Data : J Cardiovasc Pharmacol. 2013 Jul ;62(1):50-7. PMID: 23846802
Article Published Date : Jun 30, 2013
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Angiogenesis Inducing Agents
[+]

Ginsenoside Rg3 attenuates angiotensin II-induced myocardial hypertrophy.Aug 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Immunopharmacol. 2021 Sep ;98:107841. Epub 2021 Jun 18. PMID: 34153662
Article Published Date : Aug 31, 2021
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, SIRT1 Activator
[+]

Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy.Mar 29, 2021

Pubmed Data : Acta Pharmacol Sin. 2021 Mar 30. Epub 2021 Mar 30. PMID: 33785860
Article Published Date : Mar 29, 2021
Study Type : Animal Study
Additional Links
Substances : Harmine
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, NF-kappaB Inhibitor
[+]

Hesperidin may be further evaluated as a promising molecule for the alleviation of cardiac hypertrophy.Jan 07, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Jan 8:e22283. Epub 2019 Jan 8. PMID: 30623541
Article Published Date : Jan 07, 2019
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
[+]

Hyperoside protects against pressure overload-induced cardiac remodelling.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;51(2):827-841. Epub 2018 Nov 22. PMID: 30466089
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Lactoferrin ameliorates pathological cardiac hypertrophy.Jul 04, 2021

Pubmed Data : Food Funct. 2021 Jul 5. Epub 2021 Jul 5. PMID: 34223567
Article Published Date : Jul 04, 2021
Study Type : Animal Study
Additional Links
Substances : Lactoferrin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Low-dose PCB126 exposure disrupts cardiac metabolism and causes hypertrophy and fibrosis.Aug 30, 2021

Pubmed Data : Environ Pollut. 2021 Aug 31 ;290:118079. Epub 2021 Aug 31. PMID: 34488161
Article Published Date : Aug 30, 2021
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Problem Substances : Polychlorinated biphenyls (PCBs)
Adverse Pharmacological Actions : Cardiotoxic
[+]

Lycopene protects against pressure overload-induced cardiac hypertrophy by attenuating oxidative stress.Mar 31, 2019

Pubmed Data : J Nutr Biochem. 2019 Apr ;66:70-78. Epub 2019 Jan 7. PMID: 30772766
Article Published Date : Mar 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lycopene
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Magnesium administration improves mechanical abnormalities observed in hypertensive rat ventricular myocytes.May 17, 2016

Pubmed Data : J Bioenerg Biomembr. 2016 May 18. Epub 2016 May 18. PMID: 27193439
Article Published Date : May 17, 2016
Study Type : Animal Study
Additional Links
Substances : Magnesium
Diseases : Cardiac Hypertrophy, Hypertension
Pharmacological Actions : Antioxidants, Cardioprotective
Additional Keywords : Risk Reduction
[+]

Melatonin alleviates angiotensin-II-induced cardiac hypertrophy via activating MICU1 pathway.Nov 25, 2020

Pubmed Data : Aging (Albany NY). 2020 Nov 26 ;12. Epub 2020 Nov 26. PMID: 33259334
Article Published Date : Nov 25, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Modest calorie restriction improves cardiac remodeling and diastolic dysfunction in rats. Oct 01, 2006

Pubmed Data : J Mol Cell Cardiol. 2006 Oct;41(4):661-8. Epub 2006 Aug 23. PMID: 16934290
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy
Therapeutic Actions : Dietary Modification: Caloric Restriction , Fasting/Caloric Restriction
[+]

Molecular mechanisms of Nigella sativa- and Nigella sativa exercise-induced cardiac hypertrophy in rats.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:5553022. Epub 2021 Apr 9. PMID: 34055008
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cardiac Hypertrophy
Therapeutic Actions : Exercise
Pharmacological Actions : Cardioprotective
[+]

Moringa oleifera leaves extract alters exercise-induced cardiac hypertrophy adaptation.Dec 31, 2021

Pubmed Data : Pak J Biol Sci. 2022 Jan ;25(3):210-217. PMID: 35234011
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Cardiac Hypertrophy
Therapeutic Actions : Exercise
Pharmacological Actions : Cardioprotective
Additional Keywords : Plant Extracts
[+]

Myocardial hypertrophy is improved with berberine treatment via long non-coding RNA MIAT-mediated autophagy.Oct 13, 2019

Pubmed Data : J Pharm Pharmacol. 2019 Oct 14. Epub 2019 Oct 14. PMID: 31612504
Article Published Date : Oct 13, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berberine
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Autophagy Up-regulation, Cardioprotective, MicroRNA modulator
[+]

Myricetin alleviates pathological cardiac hypertrophy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:6304058. Epub 2019 Dec 6. PMID: 31885808
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective, Nrf2 activation
[+]

Naringenin exerts a pharmacological effect against the progression of cardiac hypertrophy induced by pressure overload. Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2015 Dec ;10(6):2206-2212. Epub 2015 Oct 19. PMID: 26668617
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Cardiac Hypertrophy, Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice.May 16, 2018

Pubmed Data : Biochem Biophys Res Commun. 2018 May 17. Epub 2018 May 17. PMID: 29778538
Article Published Date : May 16, 2018
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Cardiac Hypertrophy, Diabetic Complications
Pharmacological Actions : Cardioprotective
Additional Keywords : Gene Expression Regulation
[+]

Neohesperidin inhibits cardiac remodeling induced by Ang II in vivo and in vitro.Jun 08, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Jun 9 ;129:110364. Epub 2020 Jun 9. PMID: 32531678
Article Published Date : Jun 08, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : neohesperidin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Nobiletin protects against cardiac hypertrophy induced by pressure-overload.Jul 12, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 Jul 13 ;42(4):1313-1325. Epub 2017 Jul 13. PMID: 28700997
Article Published Date : Jul 12, 2017
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Paeoniflorin improves pressure overload-induced cardiac remodelling by modulating the MAPK signalling pathway in spontaneously hypertensive rats.Feb 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Mar ;111:695-704. Epub 2019 Jan 3. PMID: 30611994
Article Published Date : Feb 28, 2019
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Cardiac Hypertrophy, Inflammation, Myocardial Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation
[+]

Piceatannol may be a novel therapeutic agent for the prevention of cardiac hypertrophy.May 01, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FEBS Lett. 2014 May 2 ;588(9):1529-36. Epub 2014 Mar 21. PMID: 24662306
Article Published Date : May 01, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Piperlongumine attenuates angiotensin-II-induced cardiac hypertrophy and fibrosis.Jan 31, 2021

Pubmed Data : Phytomedicine. 2021 Feb ;82:153461. Epub 2021 Jan 6. PMID: 33497927
Article Published Date : Jan 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Piperlongumine
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy.Jun 30, 2019

Pubmed Data : Chem Biol Interact. 2019 Jul 1 ;307:21-28. Epub 2019 Apr 19. PMID: 31009642
Article Published Date : Jun 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Plantago
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Pretreatment with zingerone prevented hyperlipidaemia and cardiac hypertrophy.Mar 31, 2015

Pubmed Data : J Biochem Mol Toxicol. 2015 Apr ;29(4):182-8. Epub 2015 Jan 5. PMID: 25558849
Article Published Date : Mar 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginger, Polyphenols
Diseases : Cardiac Hypertrophy, Hyperlipidemia, Myocardial Infarction
Pharmacological Actions : Cardioprotective
[+]

Puerarin ameliorated pressure overload-induced cardiac hypertrophy.Jun 04, 2020

Pubmed Data : Acta Pharmacol Sin. 2020 Jun 5. Epub 2020 Jun 5. PMID: 32504066
Article Published Date : Jun 04, 2020
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Cardiac Hypertrophy, Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

Quercetin prevents cardiac hypertrophy induced by pressure overload in rats. Jun 01, 2009

Pubmed Data : J Vet Med Sci. 2009 Jun;71(6):737-43. PMID: 19578281
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Cardiac Hypertrophy
[+]

Resveratrol arrests and regresses the development of pressure overload cardiac hypertrophy in rats.May 01, 2010

Pubmed Data : J Nutr. 2010 May;140(5):962-8. Epub 2010 Mar 24. PMID: 20335634
Article Published Date : May 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cardiac Hypertrophy, Cardiomegaly, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
Additional Keywords : Plant Extracts, Stilbenes
[+]

Resveratrol may be beneficial against cardiac hypertrophy associated with hypertension and aortic valve stenosis.May 01, 2007

Pubmed Data : Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2138-43. PMID: 17488730
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Aortic Stenosis, Cardiac Hypertrophy, Hypertension
[+]

Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.Aug 10, 2019

Pubmed Data : Life Sci. 2019 Aug 11 ;233:116748. Epub 2019 Aug 11. PMID: 31412263
Article Published Date : Aug 10, 2019
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cardiac Hypertrophy, Hypoxia
Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Cardioprotective
[+]

Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the spontaneously hypertensive rats without lowering blood pressure.Feb 01, 2010

Pubmed Data : Am J Hypertens. 2010 Feb;23(2):192-6. Epub 2009 Nov 26. PMID: 19942861
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Cardiac Hypertrophy, Cardiomegaly, Hypertension, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Resveratrol protects against cardiac hypertrophy in an animal model. Dec 22, 2010

Pubmed Data : Cardiovasc Res. 2010 Dec 22. Epub 2010 Dec 22. PMID: 21115502
Article Published Date : Dec 22, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Rosiglitazone causes cardiac hypertrophy. Jul 01, 2009

Pubmed Data : J Mol Cell Cardiol. 2009 Jul;47(1):85-95. Epub 2009 May 3. PMID: 19397913
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy, Cardiomegaly
Problem Substances : Rosiglitazone (trade name Avandia)
Adverse Pharmacological Actions : Cardiotoxic
[+]

Sesamin improves cardiac function and prevents the development of cardiac hypertrophy.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 ;44(6):2212-2227. Epub 2017 Dec 13. PMID: 29248930
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Sesamin
Diseases : Cardiac Hypertrophy, Inflammation, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Tanshinone IIA inhibits myocardial remodeling induced by pressure overload.Nov 14, 2016

Pubmed Data : Eur J Pharmacol. 2016 Nov 15 ;791:632-639. Epub 2016 Sep 30. PMID: 27693799
Article Published Date : Nov 14, 2016
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Cardiac Hypertrophy, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The cardioprotective effects of tannic acid may be attributed to multitargeted inhibition of oxidative stress, inflammation, fibrosis and apoptosis.Aug 31, 2017

Pubmed Data : J Pharm Pharmacol. 2017 Sep ;69(9):1191-1207. Epub 2017 Jun 20. PMID: 28631819
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Tannic Acid
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Antioxidants, Cardioprotective
[+]

The results suggested that ginsenoside Rg1 attenuates the abdominal aorta coarctation-induced cardiac hypertrophy.Sep 30, 2016

Pubmed Data : J Cardiovasc Pharmacol. 2016 Oct ;68(4):257-264. PMID: 27195652
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The work here provides novel experimental evidence supporting the notion that Rb1 protects against cardiac hypertrophy.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Inflamm Res. 2021 ;14:1789-1806. Epub 2021 May 5. PMID: 33981156
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, MicroRNA modulator, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These findings above indicated that astragaloside might be a potential candidate to prevent cardiac hypertrophy.Dec 31, 2017

Pubmed Data : Biomed Pharmacother. 2018 Jan ;97:1468-1478. Epub 2017 Nov 20. PMID: 29793309
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

This study strongly suggests that supplementation of dried Musa balbisiana fruit powder can be useful for the prevention of cardiac hypertrophy.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:7147498. Epub 2020 Jan 27. PMID: 32082481
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Banana
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
Problem Substances : Isoproterenol
[+]

Zerumbone prevents pressure overload-induced left ventricular systolic dysfunction by inhibiting cardiac hypertrophy and fibrosis.Oct 31, 2021

Pubmed Data : Phytomedicine. 2021 Nov ;92:153744. Epub 2021 Sep 14. PMID: 34563985
Article Published Date : Oct 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Zerumbone
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

A number of natural substances have therapeutic value in the partial prevention of cardiac remodeling and atrial fibrillation. Jan 16, 2010

Pubmed Data : Med Hypotheses. 2010 Jan 16. Epub 2010 Jan 16. PMID: 20083360
Article Published Date : Jan 16, 2010
Study Type : Commentary
Additional Links
Substances : Alpha-Lipoic Acid, Antioxidant formulas, Cocoa, Coenzyme Q10, NAC (N-acetyl-L-cysteine), Spirulina
Diseases : Atrial Fibrillation, Cardiac Arrhythmias, Cardiac Hypertrophy
[+]

Acute effect of thymoquinone on action potential and ionic currents of rat cardiac myocytes.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bratisl Lek Listy. 2021 ;122(6):424-431. PMID: 34002617
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Betulinic acid protects DOX-triggered cardiomyocyte hypertrophy.Dec 23, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Dec 24 ;26(1). Epub 2020 Dec 24. PMID: 33374365
Article Published Date : Dec 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cardiac Hypertrophy, Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective, Chemoprotective Agents
[+]

Cardioprotective potential of amygdalin against angiotensin II induced cardiac hypertrophy.Apr 30, 2021

Pubmed Data : Environ Toxicol. 2021 May ;36(5):926-934. Epub 2021 Jan 15. PMID: 33448586
Article Published Date : Apr 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Amygdalin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Catalase Up-Regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Cardiovascular modulating effects of magnolol and honokiol.Oct 23, 2019

Pubmed Data : Curr Drug Targets. 2019 Oct 24. Epub 2019 Oct 24. PMID: 31749425
Article Published Date : Oct 23, 2019
Study Type : Review
Additional Links
Substances : Honokiol, Magnolia, Magnolol
Diseases : Atherosclerosis, Cardiac Hypertrophy, Hypertension, Thrombosis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Curcumin (from Turmeric) protects against cardiac hypertrophy.Mar 01, 2008

Pubmed Data : J Clin Invest. 2008 Mar;118(3):879-93. PMID: 18292803
Article Published Date : Mar 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy
[+]

Curcumin reduces angiotensin II-mediated cardiomyocyte growth via LOX-1 inhibition.Apr 01, 2010

Pubmed Data : J Cardiovasc Pharmacol. 2010 Apr;55(4):417-24. PMID: 20422739
Article Published Date : Apr 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy, Oxidative Stress
Pharmacological Actions : Antiproliferative , Lipoxygenase Inhibitors, NF-kappaB Inhibitor
[+]

Curcumin supplementation can improve high glucose and insulin-induced cardiomyocytes hypertrophy in vitro.Apr 30, 2015

Pubmed Data : Diabetes Res Clin Pract. 2015 May ;108(2):235-42. Epub 2015 Feb 21. PMID: 25765666
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
Additional Keywords : Dose Response
[+]

EGCG may be an effective agent for preventing cardiac hypertrophy.Mar 31, 2019

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2019 Apr 1 ;51(4):422-430. PMID: 30877756
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Luteolin suppresses lipopolysaccharide‑induced cardiomyocyte hypertrophy and autophagy in vitro.Feb 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Mar ;19(3):1551-1560. Epub 2019 Jan 2. PMID: 30628693
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Luteolin
Diseases : Cardiac Hypertrophy, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cardioprotective
[+]

N-acetyl cysteine, selenium, and ascorbic acid rescue diabetic cardiac hypertrophy.Nov 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Nov 30 ;26(23). Epub 2021 Nov 30. PMID: 34885867
Article Published Date : Nov 29, 2021
Study Type : In Vitro Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Selenium, Vitamin C
Diseases : Cardiac Hypertrophy, Mitochondrial Dysfunction
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Hypolipidemic
[+]

Nelumbo nucifera extract suppresses angiotensin II-induced cardiomyocyte hypertrophy.Apr 25, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Apr 26 ;24(9). Epub 2019 Apr 26. PMID: 31027372
Article Published Date : Apr 25, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Puerarin administration enhances miR-15b and miR-195 expression in an Ang II-induced cardiac hypertrophy model.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2016 ;22:1516-23. Epub 2016 May 5. PMID: 27145790
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective, MicroRNA modulator
[+]

Resveratrol treatment effectively suppressed myocardial hypertrophy and apoptosis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2016 ;39(2):780-9. Epub 2016 Jul 29. PMID: 27467279
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Rutin modulates MAPK pathway differently from quercetin in angiotensin II-induced H9c2 cardiomyocyte hypertrophy.May 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 May 11 ;22(10). Epub 2021 May 11. PMID: 34064664
Article Published Date : May 10, 2021
Study Type : In Vitro Study
Additional Links
Substances : Quercetin, Rutin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Sulforaphane attenuates Ang II-induced hypertrophy of H9c2 cardiomyocytes mediated by the inhibition of intracellular signaling pathways including Akt and NF-κB.Apr 30, 2014

Pubmed Data : Herz. 2014 May ;39(3):390-6. Epub 2013 Jun 21. PMID: 23784363
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Tanshinone IIA alleviates cardiac hypertrophy through m6A modification of galectin-3.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioengineered. 2022 02 ;13(2):4260-4270. PMID: 35191812
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Tanshinone IIA prevents Leu27IGF-II-induced cardiomyocyte hypertrophy mediated by estrogen receptor and subsequent Akt activation.Dec 31, 2014

Pubmed Data : Am J Chin Med. 2015 ;43(8):1567-91. Epub 2015 Nov 30. PMID: 26621443
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
Additional Keywords : Phytotherapy
[+]

Targeted Curcumin delivery efficiently regressed cardiac hypertrophy by modulating apoptotic load within cardiac microenvironment.Dec 31, 2015

Pubmed Data : Toxicol Appl Pharmacol. 2016 Jan 1 ;290:54-65. Epub 2015 Nov 21. PMID: 26612707
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
Additional Keywords : Increased Bioavailability
[+]

Tetrahydrocurcumin has cardioprotective cardiac hypertrophy.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:9187065. Epub 2020 Dec 26. PMID: 33425220
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tetrahydrocurcumin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

These findings reveal a novel mechanism of allicin attenuating cardiac hypertrophy.Apr 30, 2019

Pubmed Data : Phytomedicine. 2019 May ;58:152765. Epub 2018 Nov 19. PMID: 31005720
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Allicin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Autophagy Inhibitors, Cardioprotective
[+]

Thymoquinone ameliorates pressure overload-induced cardiac hypertrophy.Dec 23, 2021

Pubmed Data : J Cell Mol Med. 2021 Dec 24. Epub 2021 Dec 24. PMID: 34953026
Article Published Date : Dec 23, 2021
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Wogonin inhibits cardiac hypertrophy by activating Nrf-2-mediated antioxidant responses.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cardiovasc Ther. 2021 ;2021:9995342. Epub 2021 Jul 1. PMID: 34290825
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective, Nrf2 activation

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