Cardiac Hypertrophy

Name	AC	CK
Resveratrol	8	15
Ginsenosides	6	13
Curcumin	7	10
Flavonoids	5	10
EGCG (Epigallocatechin gallate)	5	9
Asiatic Acid	4	8
Astragaloside	3	6
Naringenin	3	6
Puerarin	4	6
Sinomenine	2	5
Andrographis	2	4
Crocetin	2	4
Gastrodin	2	4
Licorice	2	4
Tanshinone IIA	3	4
Allicin	2	3
Betulinic acid	2	3
Biochanin A	1	3
Honokiol	2	3
Hydrogen: Molecular	1	3
Quercetin	2	3
Tetrahydrocurcumin	2	3
Aloe Vera	1	2
Apigenin	1	2
Banana	1	2
Berberine	1	2
Burdock	1	2
Caffeic acid phenethyl ester	1	2
Carotenoids	1	2
Carvacrol	1	2
Catechin	1	2
Chicken extract	1	2
Chrysanthemum Morifolium	1	2
Citrus naringin	1	2
Copper	1	2
Corydalis Yanhusuo	1	2
Cucurbitacin B	1	2
Cyanidin 3-glucoside	1	2
Elm tree	1	2
Fisetin	1	2
Fish Oil	1	2
Fucoidan	1	2
Fucoxanthin	1	2
Ginger	1	2
Gingerol	1	2
Ginkgo biloba	1	2
Ginseng (American)	1	2
Harmine	1	2
Hesperidin	1	2
Kefir	1	2
Lactoferrin	1	2
Lupeol	1	2
Lycopene	1	2
Magnesium	1	2
Melatonin	1	2
Modified Citrus Pectin	1	2
Moringa oleifera	1	2
Myricetin	1	2
NAC (N-acetyl-L-cysteine)	2	2
Nigella sativa (aka Black Seed)	1	2
Nobiletin	1	2
Olive leaf extract	1	2
Oridonin	1	2
Paeoniflorin	1	2
Paeonol	1	2
Piceatannol	1	2
Piperlongumine	1	2
Plantago	1	2
Plantago asiatica	1	2
Polyphenols	1	2
Reishi Mushroom	1	2
Saffron	1	2
Sesamin	1	2
Stilbenes	1	2
Syringic Acid	1	2
Tannic Acid	1	2
Terminalia	1	2
Thymoquinone	2	2
Vitamin C	2	2
Vitamin D	1	2
Zerumbone	1	2
neohesperidin	1	2
Alpha-Lipoic Acid	1	1
Amygdalin	1	1
Antioxidant formulas	1	1
Astaxanthin	1	1
Cocoa	1	1
Coenzyme Q10	1	1
Lotus	1	1
Luteolin	1	1
Magnolia	1	1
Magnolol	1	1
Rutin	1	1
Selenium	1	1
Spirulina	1	1
Sulforaphane	1	1
Wogonin	1	1

Name	AC	CK
Isoproterenol	5	12
Fructose	2	4
Polychlorinated biphenyls (PCBs)	1	2
Rosiglitazone (trade name Avandia)	1	2

Name	AC	CK
Exercise	2	4
Dietary Modification: Caloric Restriction	1	2
Fasting/Caloric Restriction	1	2

Name	AC	CK	Focus
Western Diet	1	2

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Apigenin could improve hypertensive cardiac hypertrophy and abnormal myocardial glucolipid metabolism in rats.Mar 17, 2016

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Pubmed Data : Food Funct. 2016 Mar 18. Epub 2016 Mar 18. PMID: 26987380

Article Published Date : Mar 17, 2016

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Cardiac Hypertrophy, Hypertension

Pharmacological Actions : Cardioprotective, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor

Additional Keywords : Risk Reduction

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Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways.Oct 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacol Sci. 2017 Nov ;135(3):97-104. Epub 2017 Aug 10. PMID: 29108833

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Cardioprotective

Additional Keywords : Phytotherapy

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Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling.Jan 05, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrition. 2003 Sep;19(9):794-9. PMID: 11432770

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacol Exp Ther. 2018 Sep ;366(3):458-469. Epub 2018 Jun 26. PMID: 29945930

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Puerarin

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Antioxidants, Cardioprotective, Nrf2 activation

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Copper deficiency and fructose consumption is associated with cardiac abnormalities in rats. Dec 01, 1988

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Pubmed Data : Atherosclerosis. 1988 Dec;74(3):203-14. PMID: 3240332

Article Published Date : Dec 01, 1988

Study Type : Animal Study

Additional Links

Diseases : Cardiac Hypertrophy, Cardiovascular Diseases, Copper Deficiency, Myocarditis

Problem Substances : Fructose

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Pharmacological Actions : Antioxidants, Cardioprotective

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Ganoderma lucidum polysaccharides attenuates pressure-overload-induced pathological cardiac hypertrophy.Dec 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2023 ;14:1127123. Epub 2023 Mar 23. PMID: 37033616

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

Additional Keywords : Polysaccharides

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Gastrodin could be used in the prevention of cardiac hypertrophy.Jul 05, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Hyperoside protects against pressure overload-induced cardiac remodelling.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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Molecular mechanisms of Nigella sativa- and Nigella sativa exercise-induced cardiac hypertrophy in rats.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Phytomedicine. 2021 Feb ;82:153461. Epub 2021 Jan 6. PMID: 33497927

Article Published Date : Jan 31, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Piperlongumine

Diseases : Cardiac Hypertrophy, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

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Plantago asiatica L. seeds extract protects against cardiomyocyte injury in isoproterenol- induced cardiac hypertrophy.Sep 30, 2021

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Pubmed Data : Phytomedicine. 2021 Oct ;91:153681. Epub 2021 Jul 20. PMID: 34371252

Article Published Date : Sep 30, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Physiol Biochem. 2017 ;44(6):2212-2227. Epub 2017 Dec 13. PMID: 29248930

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Sesamin

Diseases : Cardiac Hypertrophy, Inflammation, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective

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Syringic acid mitigates isoproterenol-induced cardiac hypertrophy and fibrosis by downregulating Ereg.Jun 30, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Biomed Pharmacother. 2018 Jan ;97:1468-1478. Epub 2017 Nov 20. PMID: 29793309

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Cardioprotective

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This study strongly suggests that supplementation of dried Musa balbisiana fruit powder can be useful for the prevention of cardiac hypertrophy.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:7147498. Epub 2020 Jan 27. PMID: 32082481

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Banana

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective

Problem Substances : Isoproterenol

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Betulinic acid protects DOX-triggered cardiomyocyte hypertrophy.Dec 23, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Diabetes Res Clin Pract. 2015 May ;108(2):235-42. Epub 2015 Feb 21. PMID: 25765666

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Cardioprotective

Additional Keywords : Dose Response

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View the Evidence: 135 Abstracts with Cardiac Hypertrophy Research

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Biochanin A inhibits cardiac hypertrophy and fibrosis in vivo and in vitro.Dec 31, 2023

Hydrogen (H2) iInhibits isoproterenol-induced cardiac hypertrophy via antioxidative pathways.Dec 31, 2015

Inhibition of cholesteryl ester transfer protein contributes to the protection of ginsenoside Re against isoproterenol-induced cardiac hypertrophy.Apr 30, 2024

Liquiritin attenuates pathological cardiac hypertrophy.Dec 31, 2021

Sinomenine ameliorates cardiac hypertrophy by activating Nrf2/ARE signaling pathway.Nov 30, 2021

Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy.Jan 23, 2019

These findings indicate a novel role for naringin in protecting against fructose-induced cardiac hypertrophy.Jun 20, 2018

6-Gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway.Jan 17, 2021

A soluble non-bacterial fraction of kefir had beneficial on blood pressure and cardiac hypertrophy in hypertensive rats.Jul 31, 2018

A Western-style diet induces cardiac hypertrophy and fibrosis in an animal model.Oct 01, 2010

A. paniculata extract can be used for prevention and treatment of cardiovascular disease in obese patients.Nov 03, 2016

Acacetin ameliorates cardiac hypertrophy by activating Sirt1/AMPK/PGC-1α pathway.Apr 04, 2022

Activation of SIRT1 by resveratrol alleviates pressure overload-induced cardiac hypertrophy.Sep 07, 2021

Allicin provided cardioprotection for cardiac hypertrophy.Nov 30, 2018

Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response.Dec 31, 2021

Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress.Nov 30, 2023

Apigenin could improve hypertensive cardiac hypertrophy and abnormal myocardial glucolipid metabolism in rats.Mar 17, 2016

Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways.Oct 31, 2017

Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling.Jan 05, 2017

Asiatic acid attenuates cardiac hypertrophy.Jul 31, 2014

Asiatic acid attenuates the progression of left ventricular hypertrophy and heart failure induced by pressure overload.Nov 30, 2015

Asiatic acid may be a novel therapeutic agent for cardiac hypertrophy.Sep 30, 2015

Asiatic acid protects against cardiac hypertrophy.Dec 31, 2015

Astragaloside IV attenuates cardiac hypertrophy.Jul 31, 2023

Astragaloside IV exerts a myocardial protective effect against cardiac hypertrophy.Dec 31, 2018

Betulinic acid improves cardiac-renal dysfunction caused by hypertrophy.Sep 29, 2021

Caffeic acid phenethyl ester may play an important role in the regulation of cardiac hypertrophy induced by pressure overload.Apr 23, 2017

Calcitriol increases ventricular K+ currents in isolated mouse cardiomyocytes.Dec 31, 2017