Cardiac Hypertrophy

Name	AC	CK
Resveratrol	6	11
Curcumin	7	10
Asiatic Acid	4	8
EGCG (Epigallocatechin gallate)	4	7
Ginsenosides	3	6
Puerarin	3	5
Astragaloside	2	4
Crocetin	2	4
Naringenin	2	4
Allicin	2	3
Tanshinone IIA	2	3
Tetrahydrocurcumin	2	3
Apigenin	1	2
Banana	1	2
Berberine	1	2
Burdock	1	2
Caffeic acid phenethyl ester	1	2
Carotenoids	1	2
Carvacrol	1	2
Catechin	1	2
Chicken extract	1	2
Chrysanthemum Morifolium	1	2
Citrus naringin	1	2
Copper	1	2
Corydalis Yanhusuo	1	2
Cucurbitacin B	1	2
Cyanidin 3-glucoside	1	2
Fisetin	1	2
Fish Oil	1	2
Fucoidan	1	2
Fucoxanthin	1	2
Gastrodin	1	2
Ginger	1	2
Ginseng (American)	1	2
Hesperidin	1	2
Kefir	1	2
Lycopene	1	2
Magnesium	1	2
Melatonin	1	2
Myricetin	1	2
Nobiletin	1	2
Oridonin	1	2
Paeoniflorin	1	2
Piceatannol	1	2
Piperlongumine	1	2
Polyphenols	1	2
Quercetin	1	2
Saffron	1	2
Sesamin	1	2
Stilbenes	1	2
Tannic Acid	1	2
Vitamin D	1	2
neohesperidin	1	2
Alpha-Lipoic Acid	1	1
Antioxidant formulas	1	1
Betulinic acid	1	1
Cocoa	1	1
Coenzyme Q10	1	1
Honokiol	1	1
Lotus	1	1
Luteolin	1	1
Magnolia	1	1
Magnolol	1	1
NAC (N-acetyl-L-cysteine)	1	1
Spirulina	1	1
Sulforaphane	1	1

Name	AC	CK
Fructose	2	4
Isoproterenol	1	2
Rosiglitazone (trade name Avandia)	1	2

Name	AC	CK	Focus
Dietary Modification: Caloric Restriction	1	2
Fasting/Caloric Restriction	1	2

Name	AC	CK	Focus
Western Diet	1	2

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Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways.Oct 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacol Sci. 2017 Nov ;135(3):97-104. Epub 2017 Aug 10. PMID: 29108833

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Cardioprotective

Additional Keywords : Phytotherapy

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Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling.Jan 05, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacol Exp Ther. 2018 Sep ;366(3):458-469. Epub 2018 Jun 26. PMID: 29945930

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Puerarin

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Antioxidants, Cardioprotective, Nrf2 activation

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Copper deficiency and fructose consumption is associated with cardiac abnormalities in rats. Dec 01, 1988

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Pubmed Data : Atherosclerosis. 1988 Dec;74(3):203-14. PMID: 3240332

Article Published Date : Dec 01, 1988

Study Type : Animal Study

Additional Links

Diseases : Cardiac Hypertrophy, Cardiovascular Diseases, Copper Deficiency, Myocarditis

Problem Substances : Fructose

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Pubmed Data : Cardiovasc Res. 2005 Nov 1;68(2):213-23. Epub 2005 Jun 15. PMID: 15963478

Article Published Date : Nov 01, 2005

Study Type : Animal Study

Additional Links

Substances : Fish Oil

Diseases : Cardiac Hypertrophy

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Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacol Res Perspect. 2018 04 ;6(2):e00385. Epub 2018 Feb 19. PMID: 29468071

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Curcumin, Tetrahydrocurcumin

Diseases : Cardiac Hypertrophy, Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective

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Pharmacological Actions : Antioxidants, Cardioprotective

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Gastrodin could be used in the prevention of cardiac hypertrophy.Jul 05, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Mol Med Rep. 2022 Nov ;26(5). Epub 2022 Sep 2. PMID: 36052855

Article Published Date : Oct 31, 2022

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Cardiac Hypertrophy, Cardiomegaly

Pharmacological Actions : Anti-Apoptotic, Autophagy Up-regulation, Cardioprotective

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Molecular mechanisms of Nigella sativa- and Nigella sativa exercise-induced cardiac hypertrophy in rats.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Phytomedicine. 2021 Feb ;82:153461. Epub 2021 Jan 6. PMID: 33497927

Article Published Date : Jan 31, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Piperlongumine

Diseases : Cardiac Hypertrophy, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

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Plantago asiatica L. seeds extract protects against cardiomyocyte injury in isoproterenol- induced cardiac hypertrophy.Sep 30, 2021

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Pubmed Data : Phytomedicine. 2021 Oct ;91:153681. Epub 2021 Jul 20. PMID: 34371252

Article Published Date : Sep 30, 2021

Study Type : Animal Study

Additional Links

Substances : Plantago asiatica

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

Additional Keywords : Plant Extracts

Problem Substances : Isoproterenol

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These findings above indicated that astragaloside might be a potential candidate to prevent cardiac hypertrophy.Dec 31, 2017

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Pubmed Data : Biomed Pharmacother. 2018 Jan ;97:1468-1478. Epub 2017 Nov 20. PMID: 29793309

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Cardioprotective

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This study strongly suggests that supplementation of dried Musa balbisiana fruit powder can be useful for the prevention of cardiac hypertrophy.Dec 31, 2019

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Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:7147498. Epub 2020 Jan 27. PMID: 32082481

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Banana

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective

Problem Substances : Isoproterenol

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Cardioprotective potential of amygdalin against angiotensin II induced cardiac hypertrophy.Apr 30, 2021

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Pubmed Data : Environ Toxicol. 2021 May ;36(5):926-934. Epub 2021 Jan 15. PMID: 33448586

Article Published Date : Apr 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Amygdalin

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Catalase Up-Regulation, NF-kappaB Inhibitor, Nrf2 activation

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Cardiovascular modulating effects of magnolol and honokiol.Oct 23, 2019

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Pubmed Data : Curr Drug Targets. 2019 Oct 24. Epub 2019 Oct 24. PMID: 31749425

Click here to read the entire abstract

Pubmed Data : Diabetes Res Clin Pract. 2015 May ;108(2):235-42. Epub 2015 Feb 21. PMID: 25765666

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Cardioprotective

Additional Keywords : Dose Response

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View the Evidence: 114 Abstracts with Cardiac Hypertrophy Research

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Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy.Jan 23, 2019

These findings indicate a novel role for naringin in protecting against fructose-induced cardiac hypertrophy.Jun 20, 2018

6-Gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway.Jan 17, 2021

A soluble non-bacterial fraction of kefir had beneficial on blood pressure and cardiac hypertrophy in hypertensive rats.Jul 31, 2018

A Western-style diet induces cardiac hypertrophy and fibrosis in an animal model.Oct 01, 2010

A. paniculata extract can be used for prevention and treatment of cardiovascular disease in obese patients.Nov 03, 2016

Activation of SIRT1 by resveratrol alleviates pressure overload-induced cardiac hypertrophy.Sep 07, 2021

Allicin provided cardioprotection for cardiac hypertrophy.Nov 30, 2018

Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response.Dec 31, 2021

Apigenin could improve hypertensive cardiac hypertrophy and abnormal myocardial glucolipid metabolism in rats.Mar 17, 2016

Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways.Oct 31, 2017

Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling.Jan 05, 2017

Asiatic acid attenuates cardiac hypertrophy.Jul 31, 2014

Asiatic acid attenuates the progression of left ventricular hypertrophy and heart failure induced by pressure overload.Nov 30, 2015

Asiatic acid may be a novel therapeutic agent for cardiac hypertrophy.Sep 30, 2015

Asiatic acid protects against cardiac hypertrophy.Dec 31, 2015

Astragaloside IV exerts a myocardial protective effect against cardiac hypertrophy.Dec 31, 2018

Betulinic acid improves cardiac-renal dysfunction caused by hypertrophy.Sep 29, 2021

Caffeic acid phenethyl ester may play an important role in the regulation of cardiac hypertrophy induced by pressure overload.Apr 23, 2017

Calcitriol increases ventricular K+ currents in isolated mouse cardiomyocytes.Dec 31, 2017

Cardioprotective effect of Ulmus wallichiana in β-adrenergic agonist induced cardiac hypertrophy.Dec 31, 2015

Carvacrol decreases hypertrophy markers in in-vivo and in-vitro models of hypertrophy.Dec 31, 2018

Chicken-meat extract (both BEC and laboratory prepared) has anti-cardiac hypertrophic, anti-hypertensive and anti-arteriosclerotic actions. Sep 01, 2003

Chronic treatment of rats with Corydalis yanhusuo extract attenuates thee development of cardiac hypertrophy.Aug 01, 2007

Chrysanthemum morifolium extract improves hypertension-induced cardiac hypertrophy.Nov 30, 2016

Contributions of Nrf2 to puerarin prevention of cardiac hypertrophy.Aug 31, 2018

Copper deficiency and fructose consumption is associated with cardiac abnormalities in rats. Dec 01, 1988

Copper reverses cardiac hypertrphy in the rat model.Jul 01, 2008

Crocetin has a cardioprotective effect in cardiac hypertrophy induced by norepinephrine in rats.Apr 01, 2006

Crocetin protects against cardiac hypertrophy. May 01, 2009

Cucurbitacin B protects against cardiac hypertrophy through increasing the autophagy level in cardiomyocytes.Apr 07, 2017

Curcumin may inhibit cardiac hypertrophy and myocardial infarction.Oct 19, 2009

Curcumin prevents cardiac remodeling secondary to chronic renal failure in rats.Oct 01, 2010

Cyanidin 3-O-glucoside ameliorated cardiac hypertrophy and diastolic dysfunction in involved with hypertension.Jun 19, 2018

Dietary fish oil attenuates cardiac hypertrophy due to systemic carnitine deficiency. Nov 01, 2005

Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy.Dec 31, 2017

EGCG may potentially inhibit aging-induced cardiac hypertrophy, fibrosis, and apoptosis, thereby preserving cardiac function.Jan 31, 2018

EGCG prevents cardiac hypertrophy induced by pressuer overload in rats. Jun 01, 2007

Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.Nov 30, 2021

Epigallocatechin-3-gallate improves cardiac hypertrophy and short-term memory deficits in a Williams-Beuren syndrome mouse model.Dec 31, 2017

Fisetin inhibits cardiac hypertrophy by suppressing oxidative stress.Nov 30, 2018

Fructose induces insulin resistance and myocardial hypertrophy in the animal model. Jun 01, 2011

Fucoidan and fucoxanthin in combination can potentially reduce cardiac hypertrophy, cardiac fibrosis, ROS level,Jan 20, 2019

Gastrodin could be used in the prevention of cardiac hypertrophy.Jul 05, 2021

Gastrodin protects against cardiac hypertrophy and fibrosis.Dec 31, 2011

Ginseng may be an effective therapy to reduce hypertrophy and heart failure associated with excessive catecholamine production.Nov 30, 2016

Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro.Dec 31, 2018

Ginsenoside Rg1 exhibited protective effect against transverse aortic constriction-induced left ventricular hypertrophy and cardiac dysfunction.Jun 30, 2013

Ginsenoside Rg3 attenuates angiotensin II-induced myocardial hypertrophy.Aug 31, 2021

Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy.Mar 29, 2021

Hesperidin may be further evaluated as a promising molecule for the alleviation of cardiac hypertrophy.Jan 07, 2019

Hyperoside protects against pressure overload-induced cardiac remodelling.Dec 31, 2017

Lactoferrin ameliorates pathological cardiac hypertrophy.Jul 04, 2021

Low-dose PCB126 exposure disrupts cardiac metabolism and causes hypertrophy and fibrosis.Aug 30, 2021

Lycopene protects against pressure overload-induced cardiac hypertrophy by attenuating oxidative stress.Mar 31, 2019

Magnesium administration improves mechanical abnormalities observed in hypertensive rat ventricular myocytes.May 17, 2016

Mechanistic analysis of resveratrol in cardiac hypertrophy by network pharmacology and animal experiments.Oct 31, 2022

Melatonin alleviates angiotensin-II-induced cardiac hypertrophy via activating MICU1 pathway.Nov 25, 2020

Modest calorie restriction improves cardiac remodeling and diastolic dysfunction in rats. Oct 01, 2006

Modified citrus pectin prevents isoproterenol-induced cardiac hypertrophy.Oct 31, 2021

Molecular mechanisms of Nigella sativa- and Nigella sativa exercise-induced cardiac hypertrophy in rats.Dec 31, 2020

Moringa oleifera leaves extract alters exercise-induced cardiac hypertrophy adaptation.Dec 31, 2021

Myocardial hypertrophy is improved with berberine treatment via long non-coding RNA MIAT-mediated autophagy.Oct 13, 2019

Myricetin alleviates pathological cardiac hypertrophy.Dec 31, 2018

Naringenin exerts a pharmacological effect against the progression of cardiac hypertrophy induced by pressure overload. Nov 30, 2015

Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice.May 16, 2018

Neohesperidin inhibits cardiac remodeling induced by Ang II in vivo and in vitro.Jun 08, 2020

Nobiletin protects against cardiac hypertrophy induced by pressure-overload.Jul 12, 2017

Paeoniflorin improves pressure overload-induced cardiac remodelling by modulating the MAPK signalling pathway in spontaneously hypertensive rats.Feb 28, 2019

Piceatannol may be a novel therapeutic agent for the prevention of cardiac hypertrophy.May 01, 2014

Piperlongumine attenuates angiotensin-II-induced cardiac hypertrophy and fibrosis.Jan 31, 2021

Plantago asiatica L. seeds extract protects against cardiomyocyte injury in isoproterenol- induced cardiac hypertrophy.Sep 30, 2021

Cardiac Hypertrophy

View the Evidence:
114 Abstracts with Cardiac Hypertrophy Research