Cardiomegaly

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11 Substances Researched for Cardiomegaly
NameACCKFocus
Resveratrol36Locked
Curcumin23Locked
Cardamonin12Locked
Crocetin12Locked
Cyanidin 3-glucoside12Locked
Ginseng (American)12Locked
Paeoniflorin12Locked
Stilbenes12Locked
Tanshinone IIA12Locked
Kaempferol11Locked
P-Coumaric Acid11Locked
1 Problem Substances Researched for Cardiomegaly
NameACCKFocus
Rosiglitazone (trade name Avandia)12Locked

View the Evidence:
33 Abstracts with Cardiomegaly Research

[+]

Cryptotanshinone attenuated pathological cardiac remodeling. Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2023 ;2023:4015199. Epub 2023 Jan 27. PMID: 36743695
Article Published Date : Dec 31, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Cardiomegaly
Pharmacological Actions : Cardioprotective, STAT3 Inhibitor, Transforming growth factor beta (TGF-β) inhibitor
[+]

Acacetin ameliorates cardiac hypertrophy by activating Sirt1/AMPK/PGC-1α pathway.Apr 04, 2022

Pubmed Data : Eur J Pharmacol. 2022 Apr 5 ;920:174858. Epub 2022 Feb 24. PMID: 35219729
Article Published Date : Apr 04, 2022
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Cardiac Hypertrophy, Cardiomegaly
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Nrf2 activation
[+]

Açaí seed extract (ASE) rich in proanthocyanidins improves cardiovascular remodeling.Jan 04, 2022

Pubmed Data : Chem Biol Interact. 2022 Jan 5 ;351:109721. Epub 2021 Oct 27. PMID: 34715092
Article Published Date : Jan 04, 2022
Study Type : Animal Study
Additional Links
Substances : Acai
Diseases : Cardiomegaly, Obesity, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective, Nrf2 activation, SIRT1 Activator
Additional Keywords : Proanthocyanidins
[+]

Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling.Jan 05, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2017 10 6 ;292(40):16440-16462. Epub 2017 Aug 18. PMID: 28821620
Article Published Date : Jan 05, 2017
Study Type : Animal Study
Additional Links
Substances : Terminalia
Diseases : Cardiac Hypertrophy, Cardiomegaly, Myocardial Fibrosis
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
[+]

Betulinic acid improves cardiac-renal dysfunction caused by hypertrophy.Sep 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Sep 30 ;13(10). Epub 2021 Sep 30. PMID: 34684485
Article Published Date : Sep 29, 2021
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Cardiac Hypertrophy, Cardiomegaly
Pharmacological Actions : Cardioprotective, Renoprotective
[+]

Cardamonin protects against adverse cardiac remodeling through mTORC1 inhibition in mice with myocardial infarction.Dec 31, 2017

Pubmed Data : Pharmazie. 2018 09 1 ;73(9):508-512. PMID: 30223933
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Cardamonin
Diseases : Cardiomegaly, Myocardial Infarction
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Clitoria ternatea flower extract attenuates vascular dysfunction and cardiac hypertrophy.Mar 31, 2022

Pubmed Data : J Sci Food Agric. 2022 Apr ;102(6):2253-2261. Epub 2021 Oct 19. PMID: 34622460
Article Published Date : Mar 31, 2022
Study Type : Animal Study
Additional Links
Substances : Butterfly Pea
Diseases : Cardiomegaly, Hypertension
Pharmacological Actions : Antihypertensive Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

Crocetin protects against cardiac hypertrophy. May 01, 2009

Pubmed Data : J Cell Mol Med. 2009 May;13(5):909-25. Epub 2008 Dec 24. PMID: 19413885
Article Published Date : May 01, 2009
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Cardiac Hypertrophy, Cardiomegaly
Pharmacological Actions : Antioxidants, Cardioprotective, NF-kappaB Inhibitor
[+]

Curcumin may inhibit cardiac hypertrophy and myocardial infarction.Oct 19, 2009

Pubmed Data : Lab Invest. 2009 Oct 19. PMID: 18292806
Article Published Date : Oct 19, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cardiac Hypertrophy, Cardiomegaly, Heart Failure, Myocardial Infarction
Pharmacological Actions : Cardioprotective, Enzyme Inhibitors
[+]

Cyanidin 3-O-glucoside ameliorated cardiac hypertrophy and diastolic dysfunction in involved with hypertension.Jun 19, 2018

Pubmed Data : Food Funct. 2018 Jun 20 ;9(6):3466-3480. PMID: 29878020
Article Published Date : Jun 19, 2018
Study Type : Animal Study
Additional Links
Substances : Cyanidin 3-glucoside
Diseases : Cardiac Hypertrophy, Cardiomegaly, Hypertension
Pharmacological Actions : Cardioprotective
[+]

Echinacoside reverses myocardial remodeling and improves heart function.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2021 01 ;25(1):203-216. Epub 2020 Dec 13. PMID: 33314649
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Echinacea
Diseases : Cardiomegaly, Heart Failure, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Cardioprotective
Problem Substances : Isoproterenol
[+]

Fucoxanthin regulates Nrf2/Keap1 signaling to alleviate myocardial hypertrophy in diabetes.May 19, 2022

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2022 May 20 ;42(5):752-759. PMID: 35673921
Article Published Date : May 19, 2022
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Cardiomegaly, Myocardial Fibrosis
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation
Additional Keywords : Drug: Metformin
[+]

Ginseng may be an effective therapy to reduce hypertrophy and heart failure associated with excessive catecholamine production.Nov 30, 2016

Pubmed Data : Can J Physiol Pharmacol. 2016 Dec ;94(12):1325-1335. Epub 2016 Aug 17. PMID: 27797280
Article Published Date : Nov 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginseng (American)
Diseases : Cardiac Hypertrophy, Cardiomegaly
Pharmacological Actions : Cardioprotective
Additional Keywords : Plant Extracts
[+]

Mechanistic analysis of resveratrol in cardiac hypertrophy by network pharmacology and animal experiments.Oct 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2022 Nov ;26(5). Epub 2022 Sep 2. PMID: 36052855
Article Published Date : Oct 31, 2022
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cardiac Hypertrophy, Cardiomegaly
Pharmacological Actions : Anti-Apoptotic, Autophagy Up-regulation, Cardioprotective
[+]

Modified citrus pectin prevents isoproterenol-induced cardiac hypertrophy.Oct 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Nov ;143:112178. Epub 2021 Sep 25. PMID: 34649308
Article Published Date : Oct 31, 2021
Study Type : Animal Study
Additional Links
Substances : Modified Citrus Pectin
Diseases : Cardiac Hypertrophy, Cardiomegaly
Pharmacological Actions : Cardioprotective
Problem Substances : Isoproterenol
[+]

Naringenin attenuates isoprenaline-induced cardiac hypertrophy.Mar 08, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 Mar 9 ;15(6). Epub 2023 Mar 9. PMID: 36986070
Article Published Date : Mar 08, 2023
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Cardiac Hypertrophy, Cardiomegaly, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Paeoniflorin attenuates pressure overload-induced cardiac remodeling.May 31, 2013

Pubmed Data : J Mol Histol. 2013 Jun ;44(3):357-67. Epub 2013 Feb 17. PMID: 23417833
Article Published Date : May 31, 2013
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Cardiomegaly, Heart Failure, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol attenuates heart failure induced by transverse aortic constriction via ERK1/2 signalling.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2022 Dec ;60(1):562-569. PMID: 35249458
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Cardiomegaly, Heart Failure
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Preventive effects of (-) epicatechin on tachycardia, cardiac hypertrophy.Jun 04, 2022

Pubmed Data : Eur J Pharmacol. 2022 Jun 5 ;924:174909. Epub 2022 Mar 25. PMID: 35346644
Article Published Date : Jun 04, 2022
Study Type : Animal Study
Additional Links
Substances : Epicatechin
Diseases : Cardiomegaly, Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, NF-kappaB Inhibitor
[+]

Resveratrol arrests and regresses the development of pressure overload cardiac hypertrophy in rats.May 01, 2010

Pubmed Data : J Nutr. 2010 May;140(5):962-8. Epub 2010 Mar 24. PMID: 20335634
Article Published Date : May 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cardiac Hypertrophy, Cardiomegaly, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
Additional Keywords : Plant Extracts, Stilbenes
[+]

Resveratrol may have a beneficial effect on Ang II-induced cardiac remodeling.Jun 01, 2010

Pubmed Data : Blood Press. 2010 Jun;19(3):196-205. PMID: 20429690
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cardiomegaly, Hypertension, Mitochondrial Dysfunction
Additional Keywords : Mitochondrial Biogenesis, Stilbenes
[+]

Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the spontaneously hypertensive rats without lowering blood pressure.Feb 01, 2010

Pubmed Data : Am J Hypertens. 2010 Feb;23(2):192-6. Epub 2009 Nov 26. PMID: 19942861
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Cardiac Hypertrophy, Cardiomegaly, Hypertension, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Rosiglitazone causes cardiac hypertrophy. Jul 01, 2009

Pubmed Data : J Mol Cell Cardiol. 2009 Jul;47(1):85-95. Epub 2009 May 3. PMID: 19397913
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy, Cardiomegaly
Problem Substances : Rosiglitazone (trade name Avandia)
Adverse Pharmacological Actions : Cardiotoxic
[+]

Salvianolic acid ameliorates pressure overload-induced cardiac endothelial dysfunction.Dec 31, 2021

Pubmed Data : Am J Chin Med. 2022 ;50(7):1869-1885. Epub 2022 Sep 17. PMID: 36121714
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Cardiomegaly, Endothelial Dysfunction, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Taxifolin ameliorates DEHP-induced cardiomyocyte hypertrophy.Nov 30, 2019

Pubmed Data : Environ Pollut. 2019 Dec ;255(Pt 1):113155. Epub 2019 Sep 11. PMID: 31539850
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Cardiomegaly, Phthalate Toxicity
Pharmacological Actions : Cardioprotective
Problem Substances : Phthalates
[+]

This study indicated a protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats.Feb 06, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Feb 7 ;8(6):10161-10170. PMID: 28053285
Article Published Date : Feb 06, 2017
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Cardiomegaly, Hypertension
Pharmacological Actions : Cardioprotective
[+]

Curcumin may play a therapeutic role in heart failure.Oct 01, 2007

Pubmed Data : J Food Sci. 2007 Oct;72(8):S612-7. PMID: 20467147
Article Published Date : Oct 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cardiomegaly, Heart Failure
[+]

Ginkgolide A alleviates cardiac remodeling in mice with myocardial infarction.May 14, 2022

Pubmed Data : Eur J Pharmacol. 2022 May 15 ;923:174932. Epub 2022 Mar 31. PMID: 35367419
Article Published Date : May 14, 2022
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Cardiomegaly, Inflammation, Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Kaempferol attenuates cardiac hypertrophy.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Planta Med. 2017 Jul ;83(10):837-845. Epub 2017 Feb 20. PMID: 28219095
Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Cardiomegaly, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective
[+]

Paeonol alleviates isoproterenol-induced chronic heart failure.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2023 ;2023:3271057. Epub 2023 Feb 4. PMID: 36785789
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Cardiomegaly, Heart Failure
Pharmacological Actions : Cardioprotective
[+]

Preventive effects of p-coumaric acid on cardiac hypertrophy and alterations in electrocardiogram, lipids, and lipoproteinsSep 30, 2013

Pubmed Data : Food Chem Toxicol. 2013 Oct ;60:348-54. Epub 2013 May 10. PMID: 23669407
Article Published Date : Sep 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Cardiomegaly, Myocardial Infarction
Pharmacological Actions : Cardioprotective
[+]

Sesamin suppresses angiotensin-II-enhanced oxidative stress and hypertrophic markers in H9c2 cells.Aug 31, 2023

Pubmed Data : Environ Toxicol. 2023 Sep ;38(9):2165-2172. Epub 2023 Jun 26. PMID: 37357850
Article Published Date : Aug 31, 2023
Study Type : In Vitro Study
Additional Links
Diseases : Cardiomegaly, Cardiovascular Diseases, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

The prevention role of theaflavin-3,3'-digallate in angiotensin II Induced pathological cardiac hypertrophy.Mar 25, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Mar 26 ;14(7). Epub 2022 Mar 26. PMID: 35406003
Article Published Date : Mar 25, 2022
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Cardiomegaly, Heart Failure
Pharmacological Actions : Antioxidants, Cardioprotective

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