Cerebral Hypoperfusion

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23 Substances Researched for Cerebral Hypoperfusion
NameACCKFocus
Melatonin36Locked
Ume (Japanese apricot) 24Locked
Vanillic Acid24Locked
Berberine12Locked
Cannabidiol12Locked
Capsaicin12Locked
Carvacrol12Locked
Chrysin12Locked
Cucurbitacin B 12Locked
EGCG (Epigallocatechin gallate)12Locked
Ginkgo biloba12Locked
Gotu Kola12Locked
Grape Seed Extract12Locked
Huperzine12Locked
Luteolin12Locked
Mangosteen12Locked
Nicotinamide12Locked
Nigella sativa (aka Black Seed)12Locked
Psyllium12Locked
Reishi Mushroom12Locked
Resveratrol12Locked
Shikonin12Locked
Thymoquinone12Locked
2 Problem Substances Researched for Cerebral Hypoperfusion
NameACCKFocus
Gluten13Locked
Wheat13Locked
4 Therapeutic Actions Researched for Cerebral Hypoperfusion
NameACCKFocus
Dietary Modification: Wheat/Gluten Free13Locked
Electroacupuncture12Locked
Exercise12Locked
Fasting/Caloric Restriction12Locked
1 Problematic Actions Researched for Cerebral Hypoperfusion
NameACCKFocus
Electroconvulsive Therapy110Locked

View the Evidence:
32 Abstracts with Cerebral Hypoperfusion Research

[+]

Electroconvulsive therapy-induced neuroimaging alterations measured by cerebral blood flow in adolescents with major depressive disorder.Apr 13, 2023

Pubmed Data : J Affect Disord. 2023 Apr 14 ;327:385-390. Epub 2023 Feb 8. PMID: 36758871
Article Published Date : Apr 13, 2023
Study Type : Human Study
Additional Links
Diseases : Brain Damage, Cerebral Hypoperfusion
Anti Therapeutic Actions : Electroconvulsive Therapy
[+]

Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet.Oct 31, 1997

Pubmed Data : J Intern Med. 1997 Nov ;242(5):421-3. PMID: 9408073
Article Published Date : Oct 31, 1997
Study Type : Human: Case Report
Additional Links
Diseases : Celiac Disease, Cerebral Hypoperfusion, Schizophrenic Disorders
Therapeutic Actions : Dietary Modification: Wheat/Gluten Free
Problem Substances : Gluten, Wheat
Adverse Pharmacological Actions : Neurotoxic
[+]

Berberine protects against chronic cerebral hypoperfusion-induced cognitive impairment and hippocampal damage.Jun 09, 2022

Pubmed Data : J Chem Neuroanat. 2022 Jun 10:102119. Epub 2022 Jun 10. PMID: 35697268
Article Published Date : Jun 09, 2022
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Antioxidants, Matrix metalloproteinase-9 (MMP-9) inhibitor, Neuroprotective Agents, Nrf2 activation, Vascular Endothelial Growth Factor A Inhibitor
[+]

C. asiatica has therapeutic potential when given immediately after ischemic insult or when administered one year after ischemic insult.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2018 May-Jun;8(3):210-226. PMID: 29881707
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Gotu Kola
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Neuroprotective Agents
[+]

Capsaicin improves cognitive function in rats with chronic cerebral hypoperfusion.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Neurosci. 2022 ;16:822702. Epub 2022 Mar 17. PMID: 35370565
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Capsaicin
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Neuroprotective Agents
[+]

Carvacrol suppresses learning and memory dysfunction and hippocampal damages caused by chronic cerebral hypoperfusion.Dec 31, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 04 ;393(4):581-589. Epub 2019 Nov 15. PMID: 31729545
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Carvacrol
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Neuroprotective Agents
[+]

CBD has neuroprotective effects in middle-aged diabetic rats subjected to chronic cerebral hypoperfusion.Nov 13, 2018

Pubmed Data : Neurotox Res. 2018 Nov 14. Epub 2018 Nov 14. PMID: 30430393
Article Published Date : Nov 13, 2018
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Cerebral Hypoperfusion, Diabetes: Memory Problems, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Chrysin prevents cognitive and hippocampal long-term potentiation deficits and inflammation in rat with cerebral hypoperfusion and reperfusion injury.May 31, 2019

Pubmed Data : Life Sci. 2019 Jun 1 ;226:202-209. Epub 2019 Apr 13. PMID: 30991061
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Brain Inflammation , Brain Ischemia, Cerebral Hypoperfusion, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

EGCG administration had neurorestorative effects after bilateral common carotid artery occlusion.Apr 10, 2016

Pubmed Data : Restor Neurol Neurosci. 2016 Apr 11 ;34(3):367-77. PMID: 27080069
Article Published Date : Apr 10, 2016
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Neurorestorative
[+]

Electroacupuncture alleviated chronic cerebral hypoperfusion damages.Nov 11, 2024

Pubmed Data : Neuroreport. 2024 Nov 12. Epub 2024 Nov 12. PMID: 39526677
Article Published Date : Nov 11, 2024
Study Type : Animal Study
Additional Links
Diseases : Cerebral Hypoperfusion
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Neuroprotective Agents
[+]

F. mume is a potentially valuable drug or nutraceutical for the treatment of vascular dementia.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2016 Feb ;19(2):196-204. Epub 2015 Dec 29. PMID: 26714236
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Substances : Ume (Japanese apricot)
Diseases : Brain Inflammation , Cerebral Hypoperfusion, Dementia
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

F. mume is potentially an effective therapeutic for the treatment of vascular dementia.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 ;15:125. Epub 2015 Apr 22. PMID: 25898017
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Ume (Japanese apricot)
Diseases : Brain Inflammation , Brain Ischemia, Cerebral Hypoperfusion
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Phytotherapy
[+]

Ginkgo biloba extract has specific neuroprotective effects that may be useful for the treatment of chronic cerebral hypoperfusion.Nov 14, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytomedicine. 2016 Nov 15 ;23(12):1356-1364. Epub 2016 Aug 1. PMID: 27765355
Article Published Date : Nov 14, 2016
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Brain Inflammation , Cerebral Hypoperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion.Mar 01, 2010

Pubmed Data : J Neurosci Res. 2010 Mar;88(4):807-15. PMID: 19795377
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Substances : Huperzine
Diseases : Brain Inflammation , Cerebral Hypoperfusion, Cognitive Decline/Dysfunction
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Intake of psyllium seed husk reduces white matter damage in a rat model of chronic cerebral hypoperfusion.Jun 30, 2019

Pubmed Data : Nutr Res. 2019 Jul ;67:27-39. Epub 2019 Apr 11. PMID: 31103857
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Psyllium
Diseases : Cerebral Hypoperfusion, Dementia
Pharmacological Actions : Neuroprotective Agents
[+]

Intermittent fasting pretreatment prevents cognitive impairment in a rat model of chronic cerebral hypoperfusion.May 16, 2017

Pubmed Data : J Nutr. 2017 May 17. Epub 2017 May 17. PMID: 28515159
Article Published Date : May 16, 2017
Study Type : Animal Study
Additional Links
Diseases : Cerebral Hypoperfusion, Cognitive Decline/Dysfunction, Dementia
Therapeutic Actions : Fasting/Caloric Restriction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Luteolin attenuates cognitive dysfunction induced by chronic cerebral hypoperfusion.Aug 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Vet Res. 2021 Sep ;65(3):341-349. Epub 2021 Jul 5. PMID: 34917848
Article Published Date : Aug 31, 2021
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Neuroprotective Agents
[+]

Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion.Sep 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Sep 26 ;8(43):74320-74330. Epub 2017 Aug 22. PMID: 29088788
Article Published Date : Sep 25, 2017
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Brain Damage, Cerebral Hypoperfusion
Pharmacological Actions : Neuroprotective Agents
[+]

Melatonin attenuates cerebral hypoperfusion-induced hippocampal damage and memory deficits in rats by suppressing TRPM7 channels.Mar 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2022 Apr ;29(4):2958-2968. Epub 2022 Jan 18. PMID: 35531206
Article Published Date : Mar 31, 2022
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Melatonin may attenuate chronic cerebral hypoperfusion-induced cognitive impairment and hippocampal neuronal cell damage.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Jun ;11(6):2240-2246. Epub 2016 Apr 1. PMID: 27284307
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Memory deficits and hippocampal inflammation in cerebral hypoperfusion and reperfusion in male rats: Neuroprotective role of vanillic acid.Oct 14, 2018

Pubmed Data : Life Sci. 2018 Oct 15 ;211:126-132. Epub 2018 Sep 6. PMID: 30195619
Article Published Date : Oct 14, 2018
Study Type : Animal Study
Additional Links
Substances : Vanillic Acid
Diseases : Cerebral Hypoperfusion, Memory Disorders, Stroke: Ischemic
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Enhancer
[+]

Nicotinamide improves cognitive function in mice with chronic cerebral hypoperfusion.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurol. 2021 ;12:596641. Epub 2021 Jan 25. PMID: 33569040
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Nicotinamide
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Neuroprotective Agents
[+]

Nigella sativa and thymoquinone attenuate oxidative stress and cognitive impairment following cerebral hypoperfusion in rats.Apr 22, 2019

Pubmed Data : Metab Brain Dis. 2019 Apr 23. Epub 2019 Apr 23. PMID: 31016464
Article Published Date : Apr 22, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Cerebral Hypoperfusion, Dementia
Pharmacological Actions : Neuroprotective Agents
[+]

Oral administration of grape seed polyphenol extract restores memory deficits in chronic cerebral hypoperfusion rats.Dec 31, 2016

Pubmed Data : Behav Pharmacol. 2017 04 ;28(2 and 3-Spec Issue):207-213. PMID: 27984208
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Polysaccharide from Ganoderma lucidum alleviates cognitive impairment in a mouse model of chronic cerebral hypoperfusion.Feb 20, 2022

Pubmed Data : Food Funct. 2022 Feb 21 ;13(4):1941-1952. Epub 2022 Feb 21. PMID: 35088782
Article Published Date : Feb 20, 2022
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom
Diseases : Cerebral Hypoperfusion, Cognitive Decline/Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Neuroprotective Agents, Transforming growth factor beta (TGF-β) upregulation
Additional Keywords : Polysaccharides
[+]

Resveratrol improves cognitive dysfunction in rats with chronic cerebral hypoperfusion.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2019 ;13:859. Epub 2019 Aug 20. PMID: 31481868
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Neuroprotective Agents
[+]

Shikonin attenuates chronic cerebral hypoperfusion-induced cognitive impairment.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:5564246. Epub 2021 Jun 7. PMID: 34211568
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Shikonin
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

The mechanisms of cucurbitacin E as a neuroprotective and memory-enhancing agent in a cerebral hypoperfusion model.Dec 31, 2020

Pubmed Data : Front Pharmacol. 2021 ;12:794933. Epub 2021 Dec 10. PMID: 34955861
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Cucurbitacin B
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Treadmill exercise ameliorates cognitive impairment and white matter injury from blood-brain barrier disruption induced by cerebral hypoperfusion.Jan 17, 2017

Pubmed Data : Neurosci Lett. 2017 Jan 18 ;638:83-89. Epub 2016 Dec 9. PMID: 27956237
Article Published Date : Jan 17, 2017
Study Type : Animal Study
Additional Links
Diseases : Cerebral Hypoperfusion
Therapeutic Actions : Exercise
Pharmacological Actions : Neuroprotective Agents, Prophylactic Agents
Additional Keywords : Blood Brain Barrier
[+]

Vanillic acid attenuates cerebral hyperemia, blood-brain barrier disruption and anxiety-like behaviors.May 31, 2018

Pubmed Data : Metab Brain Dis. 2018 Jun ;33(3):785-793. Epub 2018 Jan 22. PMID: 29356980
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Vanillic Acid
Diseases : Anxiety, Cerebral Hypoperfusion
Pharmacological Actions : Anti-Anxiety Agents, Neuroprotective Agents
[+]

Vanillic acid attenuates effects of transient bilateral common carotid occlusion and reperfusion in rats.Nov 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 Dec ;96:667-674. Epub 2017 Nov 6. PMID: 29035833
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Xanthone-enriched fraction of Garcinia mangostana and α-mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion.Oct 31, 2020

Pubmed Data : J Pharm Pharmacol. 2020 Nov ;72(11):1629-1644. Epub 2020 Aug 2. PMID: 32743849
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Mangosteen
Diseases : Alzheimer's Disease, Cerebral Hypoperfusion, Dementia, Memory Disorders
Pharmacological Actions : Neuroprotective Agents

Copyright: alila / 123RF Stock Photo

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'Gluten Brain': Wheat Cuts Off Blood Flow To Frontal Cortex
Written by Sayer Ji, Founder
Wheat consumption has been linked to psychiatric conditions like schizophrenia for over 60 years, but recent research indicates the mind-altering properties of this popular food are, in part, caused by it cutting off blood flow to the frontal cortex of the brain.

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