Cerebral Hypoperfusion

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25 Substances Researched for Cerebral Hypoperfusion
NameACCKFocus
Melatonin36Locked
Ume (Japanese apricot) 24Locked
Vanillic Acid24Locked
Baicalein12Locked
Berberine12Locked
Cannabidiol12Locked
Capsaicin12Locked
Carvacrol12Locked
Chrysin12Locked
Cucurbitacin B 12Locked
EGCG (Epigallocatechin gallate)12Locked
Ginkgo biloba12Locked
Gotu Kola12Locked
Grape Seed Extract12Locked
Huperzine12Locked
Luteolin12Locked
Mangosteen12Locked
Nicotinamide12Locked
Nigella sativa (aka Black Seed)12Locked
Polyphenols12Locked
Psyllium12Locked
Reishi Mushroom12Locked
Resveratrol12Locked
Shikonin12Locked
Thymoquinone12Locked
2 Problem Substances Researched for Cerebral Hypoperfusion
NameACCKFocus
Gluten13Locked
Wheat13Locked
4 Therapeutic Actions Researched for Cerebral Hypoperfusion
NameACCKFocus
Dietary Modification: Wheat/Gluten Free13Locked
Electroacupuncture12Locked
Exercise12Locked
Fasting/Caloric Restriction12Locked
1 Problematic Actions Researched for Cerebral Hypoperfusion
NameACCKFocus
Electroconvulsive Therapy110Locked

View the Evidence:
34 Abstracts with Cerebral Hypoperfusion Research

[+]

Electroconvulsive therapy-induced neuroimaging alterations measured by cerebral blood flow in adolescents with major depressive disorder.Apr 13, 2023

Pubmed Data : J Affect Disord. 2023 Apr 14 ;327:385-390. Epub 2023 Feb 8. PMID: 36758871
Article Published Date : Apr 13, 2023
Study Type : Human Study
Additional Links
Diseases : Brain Damage, Cerebral Hypoperfusion
Anti Therapeutic Actions : Electroconvulsive Therapy
[+]

Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet.Oct 31, 1997

Pubmed Data : J Intern Med. 1997 Nov ;242(5):421-3. PMID: 9408073
Article Published Date : Oct 31, 1997
Study Type : Human: Case Report
Additional Links
Diseases : Celiac Disease, Cerebral Hypoperfusion, Schizophrenic Disorders
Therapeutic Actions : Dietary Modification: Wheat/Gluten Free
Problem Substances : Gluten, Wheat
Adverse Pharmacological Actions : Neurotoxic
[+]

Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion.Dec 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Aging Neurosci. 2025 ;17:1521353. Epub 2025 Apr 11. PMID: 40290868
Article Published Date : Dec 31, 2024
Study Type : Animal Study
Additional Links
Substances : Baicalein
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Angiogenesis Inducing Agents, Anti-Inflammatory Agents, Neuroprotective Agents, SIRT1 Activator
[+]

Berberine protects against chronic cerebral hypoperfusion-induced cognitive impairment and hippocampal damage.Jun 09, 2022

Pubmed Data : J Chem Neuroanat. 2022 Jun 10:102119. Epub 2022 Jun 10. PMID: 35697268
Article Published Date : Jun 09, 2022
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Antioxidants, Matrix metalloproteinase-9 (MMP-9) inhibitor, Neuroprotective Agents, Nrf2 activation, Vascular Endothelial Growth Factor A Inhibitor
[+]

C. asiatica has therapeutic potential when given immediately after ischemic insult or when administered one year after ischemic insult.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2018 May-Jun;8(3):210-226. PMID: 29881707
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Gotu Kola
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Neuroprotective Agents
[+]

Capsaicin improves cognitive function in rats with chronic cerebral hypoperfusion.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Neurosci. 2022 ;16:822702. Epub 2022 Mar 17. PMID: 35370565
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Capsaicin
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Neuroprotective Agents
[+]

Carvacrol suppresses learning and memory dysfunction and hippocampal damages caused by chronic cerebral hypoperfusion.Dec 31, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 04 ;393(4):581-589. Epub 2019 Nov 15. PMID: 31729545
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Carvacrol
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Neuroprotective Agents
[+]

CBD has neuroprotective effects in middle-aged diabetic rats subjected to chronic cerebral hypoperfusion.Nov 13, 2018

Pubmed Data : Neurotox Res. 2018 Nov 14. Epub 2018 Nov 14. PMID: 30430393
Article Published Date : Nov 13, 2018
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Cerebral Hypoperfusion, Diabetes: Memory Problems, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Chrysin prevents cognitive and hippocampal long-term potentiation deficits and inflammation in rat with cerebral hypoperfusion and reperfusion injury.May 31, 2019

Pubmed Data : Life Sci. 2019 Jun 1 ;226:202-209. Epub 2019 Apr 13. PMID: 30991061
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Brain Inflammation , Brain Ischemia, Cerebral Hypoperfusion, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

EGCG administration had neurorestorative effects after bilateral common carotid artery occlusion.Apr 10, 2016

Pubmed Data : Restor Neurol Neurosci. 2016 Apr 11 ;34(3):367-77. PMID: 27080069
Article Published Date : Apr 10, 2016
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Neurorestorative
[+]

Electroacupuncture alleviated chronic cerebral hypoperfusion damages.Nov 11, 2024

Pubmed Data : Neuroreport. 2024 Nov 12. Epub 2024 Nov 12. PMID: 39526677
Article Published Date : Nov 11, 2024
Study Type : Animal Study
Additional Links
Diseases : Cerebral Hypoperfusion
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Neuroprotective Agents
[+]

F. mume is a potentially valuable drug or nutraceutical for the treatment of vascular dementia.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2016 Feb ;19(2):196-204. Epub 2015 Dec 29. PMID: 26714236
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Substances : Ume (Japanese apricot)
Diseases : Brain Inflammation , Cerebral Hypoperfusion, Dementia
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

F. mume is potentially an effective therapeutic for the treatment of vascular dementia.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 ;15:125. Epub 2015 Apr 22. PMID: 25898017
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Ume (Japanese apricot)
Diseases : Brain Inflammation , Brain Ischemia, Cerebral Hypoperfusion
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Phytotherapy
[+]

Ginkgo biloba extract has specific neuroprotective effects that may be useful for the treatment of chronic cerebral hypoperfusion.Nov 14, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytomedicine. 2016 Nov 15 ;23(12):1356-1364. Epub 2016 Aug 1. PMID: 27765355
Article Published Date : Nov 14, 2016
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Brain Inflammation , Cerebral Hypoperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion.Mar 01, 2010

Pubmed Data : J Neurosci Res. 2010 Mar;88(4):807-15. PMID: 19795377
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Substances : Huperzine
Diseases : Brain Inflammation , Cerebral Hypoperfusion, Cognitive Decline/Dysfunction
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Intake of psyllium seed husk reduces white matter damage in a rat model of chronic cerebral hypoperfusion.Jun 30, 2019

Pubmed Data : Nutr Res. 2019 Jul ;67:27-39. Epub 2019 Apr 11. PMID: 31103857
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Psyllium
Diseases : Cerebral Hypoperfusion, Dementia
Pharmacological Actions : Neuroprotective Agents
[+]

Intermittent fasting pretreatment prevents cognitive impairment in a rat model of chronic cerebral hypoperfusion.May 16, 2017

Pubmed Data : J Nutr. 2017 May 17. Epub 2017 May 17. PMID: 28515159
Article Published Date : May 16, 2017
Study Type : Animal Study
Additional Links
Diseases : Cerebral Hypoperfusion, Cognitive Decline/Dysfunction, Dementia
Therapeutic Actions : Fasting/Caloric Restriction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Luteolin attenuates cognitive dysfunction induced by chronic cerebral hypoperfusion.Aug 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Vet Res. 2021 Sep ;65(3):341-349. Epub 2021 Jul 5. PMID: 34917848
Article Published Date : Aug 31, 2021
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Neuroprotective Agents
[+]

Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion.Sep 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Sep 26 ;8(43):74320-74330. Epub 2017 Aug 22. PMID: 29088788
Article Published Date : Sep 25, 2017
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Brain Damage, Cerebral Hypoperfusion
Pharmacological Actions : Neuroprotective Agents
[+]

Melatonin attenuates cerebral hypoperfusion-induced hippocampal damage and memory deficits in rats by suppressing TRPM7 channels.Mar 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2022 Apr ;29(4):2958-2968. Epub 2022 Jan 18. PMID: 35531206
Article Published Date : Mar 31, 2022
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Melatonin may attenuate chronic cerebral hypoperfusion-induced cognitive impairment and hippocampal neuronal cell damage.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Jun ;11(6):2240-2246. Epub 2016 Apr 1. PMID: 27284307
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Memory deficits and hippocampal inflammation in cerebral hypoperfusion and reperfusion in male rats: Neuroprotective role of vanillic acid.Oct 14, 2018

Pubmed Data : Life Sci. 2018 Oct 15 ;211:126-132. Epub 2018 Sep 6. PMID: 30195619
Article Published Date : Oct 14, 2018
Study Type : Animal Study
Additional Links
Substances : Vanillic Acid
Diseases : Cerebral Hypoperfusion, Memory Disorders, Stroke: Ischemic
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Enhancer
[+]

Nicotinamide improves cognitive function in mice with chronic cerebral hypoperfusion.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurol. 2021 ;12:596641. Epub 2021 Jan 25. PMID: 33569040
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Nicotinamide
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Neuroprotective Agents
[+]

Nigella sativa and thymoquinone attenuate oxidative stress and cognitive impairment following cerebral hypoperfusion in rats.Apr 22, 2019

Pubmed Data : Metab Brain Dis. 2019 Apr 23. Epub 2019 Apr 23. PMID: 31016464
Article Published Date : Apr 22, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Cerebral Hypoperfusion, Dementia
Pharmacological Actions : Neuroprotective Agents
[+]

Oral administration of grape seed polyphenol extract restores memory deficits in chronic cerebral hypoperfusion rats.Dec 31, 2016

Pubmed Data : Behav Pharmacol. 2017 04 ;28(2 and 3-Spec Issue):207-213. PMID: 27984208
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Polysaccharide from Ganoderma lucidum alleviates cognitive impairment in a mouse model of chronic cerebral hypoperfusion.Feb 20, 2022

Pubmed Data : Food Funct. 2022 Feb 21 ;13(4):1941-1952. Epub 2022 Feb 21. PMID: 35088782
Article Published Date : Feb 20, 2022
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom
Diseases : Cerebral Hypoperfusion, Cognitive Decline/Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Neuroprotective Agents, Transforming growth factor beta (TGF-β) upregulation
Additional Keywords : Polysaccharides
[+]

Resveratrol improves cognitive dysfunction in rats with chronic cerebral hypoperfusion.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2019 ;13:859. Epub 2019 Aug 20. PMID: 31481868
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Neuroprotective Agents
[+]

Salidroside attenuates cognitive deficits induced by chronic cerebral hypoperfusion.Mar 14, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroimmunol. 2025 Mar 15 ;400:578544. Epub 2025 Jan 31. PMID: 39908941
Article Published Date : Mar 14, 2025
Study Type : Animal Study
Additional Links
Substances : Polyphenols
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Shikonin attenuates chronic cerebral hypoperfusion-induced cognitive impairment.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:5564246. Epub 2021 Jun 7. PMID: 34211568
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Shikonin
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

The mechanisms of cucurbitacin E as a neuroprotective and memory-enhancing agent in a cerebral hypoperfusion model.Dec 31, 2020

Pubmed Data : Front Pharmacol. 2021 ;12:794933. Epub 2021 Dec 10. PMID: 34955861
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Cucurbitacin B
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Treadmill exercise ameliorates cognitive impairment and white matter injury from blood-brain barrier disruption induced by cerebral hypoperfusion.Jan 17, 2017

Pubmed Data : Neurosci Lett. 2017 Jan 18 ;638:83-89. Epub 2016 Dec 9. PMID: 27956237
Article Published Date : Jan 17, 2017
Study Type : Animal Study
Additional Links
Diseases : Cerebral Hypoperfusion
Therapeutic Actions : Exercise
Pharmacological Actions : Neuroprotective Agents, Prophylactic Agents
Additional Keywords : Blood Brain Barrier
[+]

Vanillic acid attenuates cerebral hyperemia, blood-brain barrier disruption and anxiety-like behaviors.May 31, 2018

Pubmed Data : Metab Brain Dis. 2018 Jun ;33(3):785-793. Epub 2018 Jan 22. PMID: 29356980
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Vanillic Acid
Diseases : Anxiety, Cerebral Hypoperfusion
Pharmacological Actions : Anti-Anxiety Agents, Neuroprotective Agents
[+]

Vanillic acid attenuates effects of transient bilateral common carotid occlusion and reperfusion in rats.Nov 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 Dec ;96:667-674. Epub 2017 Nov 6. PMID: 29035833
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Xanthone-enriched fraction of Garcinia mangostana and α-mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion.Oct 31, 2020

Pubmed Data : J Pharm Pharmacol. 2020 Nov ;72(11):1629-1644. Epub 2020 Aug 2. PMID: 32743849
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Mangosteen
Diseases : Alzheimer's Disease, Cerebral Hypoperfusion, Dementia, Memory Disorders
Pharmacological Actions : Neuroprotective Agents

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