Cerebral Ischemia

Name	AC	CK
Ginsenosides	14	23
Panax Notoginseng	2	22
Ginkgo biloba	7	21
Curcumin	10	20
Astragaloside	10	17
Resveratrol	9	16
Safflower	8	15
Berberine	7	13
Astaxanthin	7	12
Magnesium	2	12
Flavonoids	6	11
Tanshinone IIA	8	11
Isoflavones	1	10
Policosanol	1	10
Cannabidiol	5	9
Paeoniflorin	5	9
Quercetin	5	9
Gastrodin	4	8
Thymoquinone	4	8
Beta-Caryophyllene	4	7
Crocin	5	7
Sulforaphane	4	7
Fucoidan	3	6
Ginseng	3	6
Ligustrazine	3	6
Pterostilbene	3	6
Saffron	3	6
Myricetin	4	5
Ursolic Acid	3	5
Apigenin	2	4
Carvacrol	2	4
Chlorogenic Acid	2	4
Chrysanthemum Indicum	2	4
Chrysin	2	4
Citrus naringin	2	4
Coenzyme Q10	2	4
Cordyceps Militaris	2	4
Cordyceps sinensis	2	4
Ferulic acid	2	4
Genistein	2	4
Ginseng (Korean)	2	4
Goji	2	4
Honeysuckle	2	4
Melatonin	2	4
Noni	2	4
Piperine	2	4
Red Sage	2	4
Barberry	2	3
Celery	2	3
Garlic: Aged	2	3
Ginger	2	3
Nobiletin	2	3
Allicin	1	2
Anthocyanins	1	2
Antrodia camphorata	1	2
Arginine	1	2
Artesunate	1	2
Ashwagandha	1	2
Asiatic Acid	1	2
Astragalus	1	2
Bacopa	1	2
Bee Propolis	1	2
Betulinic acid	1	2
Biochanin A	1	2
Black Pepper	1	2
Bloodroot	1	2
Blueberry	1	2
Buckwheat	1	2
Burdock	1	2
Cannabinoids	1	2
Citrus Peel	1	2
D-Limonene	1	2
DHA (Docosahexaenoic Acid)	1	2
Dill	1	2
Ellagic Acid	1	2
Embelia ribes	1	2
Emodin	1	2
Eugenol	1	2
Fisetin	1	2
Flaxseed	1	2
Formononetin	1	2
Frankincense	1	2
Fruit: All	1	2
Fucoxanthin	1	2
Garlic	1	2
Genipin	1	2
Glycyrrhiza glabra	1	2
Grape Seed Extract	1	2
Green Tea	1	2
Hibiscus rosa-sinensis	1	2
Huperzine	1	2
Hyperforin	1	2
Isoliquiritigenin	1	2
Kaempferol	1	2
Lavender: Essential Oil	1	2
Linden (Tilia)	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Lithium	1	2
Long Pepper	1	2
Lupeol	1	2
Luteolin	1	2
Lysine	1	2
Magnolol	1	2
Mulberry	1	2
NAC (N-acetyl-L-cysteine)	1	2
Nigella sativa (aka Black Seed)	1	2
Okra	1	2
Oleuropein	1	2
Onion	1	2
P-Coumaric Acid	1	2
Paeonol	1	2
Peony	1	2
Polyphenols	1	2
Pomegranate	1	2
Psychedelics:All	1	2
Puerarin	1	2
Purslane	1	2
Pycnogenol (Pine Bark)	1	2
Rehmannia	1	2
Reishi Mushroom	1	2
Rhubarb	1	2
Rice	1	2
Rosemaric Acid	1	2
Rosmarinic acid	1	2
Rutin	1	2
Safranal	1	2
Salvia divinorum	1	2
Salvia miltiorrhiza	1	2
Schisandra	1	2
Sesame Seed Oil	1	2
Sesamol	1	2
Silymarin	1	2
Stilbenes	1	2
Tangeretin	1	2
Theanine	1	2
Turkey Tail Mushroom	1	2
Urolithin A	1	2
Valerian	1	2
Vitamin C	1	2
Vitexins	2	2
Wogonin	1	2
Xanthohumol	1	2
Cinnamon	1	1
Dandelion	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Diosgenin	1	1
Geraniol	1	1
Parthenolide	1	1
Pistachio nut	1	1
Rhodiola (Tibetan Ginseng)	1	1
Taurine	1	1
Tomatidine	1	1

Name	AC	CK	Focus
Oral Contraceptives	2	40
Aspirin	2	20

Name	AC	CK
Electroacupuncture	12	24
Hyperbaric Treatment	1	10
Acupuncture	3	6
Cryotherapy	1	5
Exercise	1	2
Fasting/Caloric Restriction	1	2
Laser Treatment: Low-Level	1	2

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Effect and mechanisms of quercetin for experimental focal cerebral ischemia.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:9749461. Epub 2022 Feb 25. PMID: 35251482

Article Published Date : Dec 31, 2021

Study Type : Meta Analysis, Review

Additional Links

Substances : Quercetin

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

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Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy.Dec 31, 2017

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A. camphorata provides neuroprotection against MCAO-induced ischemic stroke.Dec 31, 2014

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:232789. Epub 2015 Aug 25. PMID: 26379739

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Antrodia camphorata

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

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A. esculentus flowers protects against transient cerebral ischemia-reperfusion injury.Dec 31, 2017

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Andrographolide may have therapeutic value in the treatment of stroke.Sep 30, 2010

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Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:9925561. Epub 2021 Dec 30. PMID: 35003524

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

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Astragaloside IV attenuates cerebral ischemia‑reperfusion injury.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

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Biochanin A protected the brain against ischemic injury in rats by anti-oxidative and anti-inflammatory actions.Nov 25, 2019

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Pubmed Data : J Exerc Rehabil. 2016 Apr ;12(2):69-78. Epub 2016 Apr 26. PMID: 27162767

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Substances : Cordyceps Militaris

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

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Coriolus versicolor polysaccharides (CVP) regulates neuronal apoptosis in cerebral ischemia-reperfusion injury.Aug 31, 2020

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Pubmed Data : Oncotarget. 2017 Dec 29 ;8(70):115434-115443. Epub 2017 Dec 15. PMID: 29383171

Article Published Date : Dec 28, 2017

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Pubmed Data : Biosci Biotechnol Biochem. 2018 Apr 4:1-9. Epub 2018 Apr 4. PMID: 29618282

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Pubmed Data : Zhongguo Zhen Jiu. 2020 Jun 12 ;40(6):635-9. PMID: 32538016

Article Published Date : Jun 11, 2020

Study Type : Animal Study

Additional Links

Diseases : Cerebral Ischemia

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Neuroprotective Agents

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Effects of thymoquinone on small-molecule metabolites in a rat model of cerebral ischemia reperfusion injury.Jan 06, 2020

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Pubmed Data : Acta Med Iran. 2017 Dec ;55(12):785-792. PMID: 29373886

Article Published Date : Nov 30, 2017

Study Type : Animal Study

Additional Links

Substances : Flaxseed

Diseases : Cerebral Ischemia

Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroprotective Agents

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Formononetin mediates neuroprotection against cerebral ischemia/reperfusion.Sep 14, 2014

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Pubmed Data : J Neurol Sci. 2014 Sep 15 ;344(1-2):100-4. Epub 2014 Jun 22. PMID: 24996490

Article Published Date : Sep 14, 2014

Study Type : Animal Study

Additional Links

Substances : Formononetin

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Neuroprotective Agents

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Formononetin protects against inflammation associated with cerebral ischemia-reperfusion injury.Mar 23, 2022

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Ginseng total saponins enhance neurogenesis after focal cerebral ischemia.Jan 27, 2011

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Pubmed Data : J Ethnopharmacol. 2011 Jan 27;133(2):724-8. Epub 2010 Nov 10. PMID: 21073942

Article Published Date : Jan 27, 2011

Study Type : Animal Study

Additional Links

Substances : Ginseng

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuritogenic, Neuroprotective Agents, Neurorestorative

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Ginsenoside Rb1 administration attenuates focal cerebral ischemic reperfusion injury.Sep 30, 2018

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Pubmed Data : Front Physiol. 2019 ;10:1174. Epub 2019 Sep 13. PMID: 31572219

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Pubmed Data : Metab Brain Dis. 2022 Nov 2. Epub 2022 Nov 2. PMID: 36322276

Article Published Date : Nov 01, 2022

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor

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Mechanism of salvianolic acid B neuroprotection against ischemia/reperfusion induced cerebral injury.Jan 14, 2018

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Pubmed Data : Mol Neurobiol. 2021 Sep 8. Epub 2021 Sep 8. PMID: 34498225

Article Published Date : Sep 07, 2021

Study Type : Animal Study

Additional Links

Substances : Lotus

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

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Neuroprotection of resveratrol against focal cerebral ischemia/reperfusion injury in mice through a mechanism targeting gut-brain axis.May 27, 2019

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Pubmed Data : Phytomedicine. 2007 Sep ;14(9):621-7. Epub 2007 Feb 8. PMID: 17291733

Article Published Date : Aug 31, 2007

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed), Thymoquinone

Diseases : Cerebral Ischemia, Lipid Peroxidation

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Phytotherapy

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Nobiletin alleviates cerebral ischemic-reperfusion injury via MAPK signaling pathway.Dec 31, 2018

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Pubmed Data : Biomed Pharmacother. 2021 May 21 ;140:111693. Epub 2021 May 21. PMID: 34029951

Article Published Date : May 20, 2021

Study Type : Animal Study

Additional Links

Substances : Panax Notoginseng

Diseases : Cerebral Ischemia

Pharmacological Actions : Angiogenesis Inducing Agents, Neuroprotective Agents

[+]

Notoginsenoside R1 improves cerebral ischemia/reperfusion injury by promoting neurogenesis.Dec 31, 2020

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Oral pretreatment with MAK exerts moderate but significant protective effects against H/I-induced brain infarction and neurological deficits in type 2 diabetic mice.Dec 31, 2014

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:865986. Epub 2015 Apr 6. PMID: 25945116

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Cerebral Ischemia, Diabetes Mellitus: Type 2, Hypoxia

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents

[+]

Paeoniflorin attenuates cerebral ischemia-induced injury.Feb 26, 2017

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Protection of the Geum japonicum Thunb. var. chinense extracts against oxygen-glucose deprivation and re-oxygenation induced astrocytes injury.Jun 30, 2020

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Pubmed Data : Biomed Pharmacother. 2020 Jul ;127:110123. Epub 2020 Apr 28. PMID: 32361162

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Pubmed Data : Mol Neurobiol. 2015 May 16. Epub 2015 May 16. PMID: 25983033

Article Published Date : May 15, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Pterostilbene

Diseases : Brain: Oxidative Stress, Brain Edema, Cerebral Ischemia

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents

[+]

Puerarin alleviates vascular cognitive impairment in vascular dementia rats.Dec 31, 2020

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Pubmed Data : Lab Anim Res. 2017 Dec ;33(4):308-314. Epub 2017 Dec 31. PMID: 29399028

Article Published Date : Nov 30, 2017

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Cerebral Ischemia, Neuroprotective Agents, QUERCETIN

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Quercetin has a neuroprotective role in focal cerebral ischemia. Jan 28, 2011

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Pubmed Data : Brain Res. 2011 Jan 28. Epub 2011 Jan 28. PMID: 21281608

Article Published Date : Jan 28, 2011

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Cerebral Ischemia, Stroke, Stroke: Attenuation/Recovery

Pharmacological Actions : Neuroprotective Agents

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Quercetin improves blood-brain barrier dysfunction in rats with cerebral ischemia reperfusion via Wnt signaling pathway.Dec 31, 2018

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Pubmed Data : Am J Transl Res. 2019 ;11(8):4683-4695. Epub 2019 Aug 15. PMID: 31497191

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Pubmed Data : Neural Regen Res. 2020 May ;15(5):894-902. PMID: 31719255

Spleen-targeted glabridin-loaded nanoparticles for the treatment of cerebral ischemia-reperfusion injury.Aug 31, 2022

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Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:7290170. Epub 2018 Nov 14. PMID: 30538763

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Geum japonicum , Herb Bennet

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

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View the Evidence: 420 Abstracts with Cerebral Ischemia Research

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Effect and mechanisms of quercetin for experimental focal cerebral ischemia.Dec 31, 2021

Low-dose oral contraceptive use significantly increases the risk of both cardiac and vascular arterial events events.Jul 01, 2005

The risk of ischemic stroke is increased in current oral contraceptive users.Jul 05, 2000

These findings further guide the therapeutic strategy for clinical cerebral ischemic stroke.Dec 31, 2019

Aspirin adversely effects cerebral blood flow in vivo, which may explain why research has shown it may increase the risk of ischemic stroke. Jul 01, 1999

Aspirin given after aneurysm treatment does not appreciably reduce the occurrence of delayed ischemic neurological deficit.Sep 01, 2006

Efficacy of alogliptin combined with motor imagery under hyperbaric oxygen in diabetic nephropathy with silent cerebral infarction.Oct 31, 2017

Ginkgo biloba extract can improve cerebral oxygen supply, decrease cerebral oxygen extraction rate and consumptionMar 31, 2015

Isoflavone supplementation reduces C-reactive protein and reverses endothelial dysfunction in patients with ischaemic stroke.Nov 01, 2008

Magnesium deficiency is associated with aneurysmal subarachnoid hemorrhage and resultant delayed ischemia. Feb 01, 2003

Policosanol administered to patients suffering ischemic stroke treated with aspirin and vitamins showed good results on neurological outcomes and recurrent events.Sep 01, 2005

Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy.Dec 31, 2017

Diosgenin revealed potential effect against cerebral ischemia reperfusion through HIKESHI/HSP70/NF-κB anti-inflammatory axis.Feb 14, 2022

Tanshinone IIA microemulsion protects against cerebral ischemia reperfusion injury.Oct 02, 2022

Neuroprotective effect of apigenin against cerebral ischemia/reperfusion injury.Aug 31, 2020

20(R)-Ginsenoside Rg3 protects SH-SY5Y cells against apoptosis induced by oxygen and glucose deprivation/reperfusion.Jan 14, 2017

20(S)-ginsenoside Rg3, a neuroprotective agent, inhibits mitochondrial permeability transition pores in rat brain.Mar 31, 2009

A compound found within Red Sage, salvianolic acid B, alleviates brain damage and reverses some motor function loss in a rat model of stroke. Jul 01, 2005

A. camphorata provides neuroprotection against MCAO-induced ischemic stroke.Dec 31, 2014

A. esculentus flowers protects against transient cerebral ischemia-reperfusion injury.Dec 31, 2017

Ability of post-treatment glycyrrhizic acid to mitigate cerebral ischemia/reperfusion injury.Sep 27, 2020

Acteoside presents protective effects on cerebral ischemia/reperfusion injury.May 31, 2021

Acupuncture attenuates glutamate level in global ischemia model of rat.Feb 01, 2010

Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen species production in cerebral ischaemia.Dec 31, 2014

Acupuncture may improve neurological function, reduce cerebral infarction volume and prolong the time window of thrombolysis.Mar 24, 2020

Administering curcumin may alleviate cerebral inflammation resulting from intracerebral hemorrhage.Mar 25, 2016

Aged garlic extract and S-allylcysteine increase the GLUT3 and GCLC expression levels in cerebral ischemia.Nov 30, 2019

Andrographolide may have therapeutic value in the treatment of stroke.Sep 30, 2010

Anti-inflammatory efficacy of berberine nanomicelle for improvement of cerebral ischemia.Jan 02, 2021

Antihypertension effect of astragaloside IV during cerebral ischemia reperfusion.Dec 31, 2022

Apigenin may play an important neuroprotective role in acute transient focal cerebral ischemia-reperfusion injury in rats.Jun 01, 2008

Arctium lappa L. roots protect against cerebral ischemia through inhibiting apoptosis and AMPK/mTOR-mediated autophagy.Feb 20, 2021

Arjunolic acid protects neurons from oxidative stress associated damage in focal cerebral ischemia and reperfusion.Sep 30, 2015

Artemisinin alleviates cerebral ischemia/reperfusion injury.Dec 31, 2021

Artesunate attenuates inflammatory injury and inhibits the NF-κB pathway in a mouse model of cerebral ischemia.Oct 31, 2021

Artesunate may exert protective effects against cerebral ischemia/reperfusion injury.Apr 30, 2018

Asiatic acid is neuroprotective in a mouse model of focal cerebral ischemia.Aug 14, 2009

Astaxanthin is able to suppress learning and memory impairment caused by repeated cerebral ischemia.May 03, 2017

Astaxanthin may have significant protective effects for patients vulnerable or prone to ischemic events.Jan 31, 2017

Astaxanthin protects the brain from oxidative damage and reduces neuronal deficits due to cerebral ischemia reperfusion injury.Feb 18, 2020

Astaxanthin reduces ischemic brain injury in adult rats. Jun 01, 2009

Astragaloside IV alleviates cerebral ischemia-reperfusion injury.Dec 10, 2019

Astragaloside IV alleviates cerebral ischemia-reperfusion injury. Dec 31, 2020

Astragaloside IV attenuates cerebral ischemia‑reperfusion injury.Dec 31, 2020

Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice.Feb 02, 2017

Astragaloside IV can effectively protect the blood-brain barrier and reduce the area of cerebral infarction.Dec 31, 2019

Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis.Feb 28, 2021

Astragaloside Ⅳ inhibits inflammation after cerebral ischemia.Dec 24, 2020

Astragaloside-IV might alleviate ischemia reperfusion-induced apoptosis.Oct 18, 2019

Bacopa monnieri was beneficial for the prevention of cognitive deficits related to cerebral ischemia.Apr 21, 2015

Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization.Oct 31, 2021

Bakuchiol ameliorates cerebral ischemia-reperfusion injury by modulating NLRP3 inflammasome and Nrf2 signaling.Jan 09, 2021

Beneficial effects of resveratrol postconditioning on cerebral ischemia in mice.Jul 23, 2019

Berberine ameliorates MCAO induced cerebral ischemia-reperfusion injury.Jan 21, 2018

Berberine attenuates cerebral ischemia-reperfusion injury induced neuronal apoptosis.Dec 31, 2020

Berberine attenuates ischemia-reperfusion injury.Sep 27, 2018

Berberine can promote angiogenesis in the rat with cerebral ischemia-reperfusion injury.Sep 30, 2018

Berberine confers neuroprotection in coping with focal cerebral ischemia.May 07, 2017

Berberine exerts neuroprotective activities against cerebral ischemia/reperfusion injury.Sep 10, 2021

Berberine via upregulation of miR-29b promotes ischemia-induced angiogenesis and improves heart functions.Jul 18, 2017

Beta-caryophyllene alleviates ischemic brain damage potentially by inhibiting necroptotic neuronal death and inflammatory response.Dec 31, 2016

Betaine protects rats against ischemia/reperfusion injury-induced brain damage.Dec 31, 2021

Betulinic acid protects against cerebral ischemia-reperfusion injury.Sep 30, 2017

Biochanin A alleviates cerebral ischemia/reperfusion injury. Dec 31, 2020

Biochanin A protected the brain against ischemic injury in rats by anti-oxidative and anti-inflammatory actions.Nov 25, 2019

Buckwheat polyphenols protective effect against long-lasting impairment of spatial memory associated with hippocampal neuronal damage in rats subjected to repeated cerebral ischemia.Apr 01, 2004

Cannabidiol confers neuroprotection in a model of transient global cerebral ischemia.Jul 23, 2021

Cannabidiol improves metabolic dysfunction in middle-aged diabetic rats submitted to a chronic cerebral hypoperfusion.Sep 05, 2019

Cannabidiol will have a palliative action and open new therapeutic possibilities for treating cerebrovascular disorders.Feb 28, 2007

Cardioprotective effect of gossypin against myocardial ischemic/reperfusion.Dec 31, 2021

Carthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia-reperfusion.Nov 30, 2016

Carthamus tinctorius L. Extract ameliorates cerebral ischemia-reperfusion injury.Feb 29, 2020

Cerebral Ischemia

View the Evidence:
420 Abstracts with Cerebral Ischemia Research