Chemically-Induced Liver Damage

Name	AC	CK
Curcumin	47	94
Polyphenols	12	23
Ginsenosides	12	22
Milk Thistle	2	22
Flavonoids	12	21
Nigella sativa (aka Black Seed)	9	18
Puerarin	9	16
Turmeric	8	16
Anthocyanins	7	14
Ginger	7	14
Melatonin	3	14
Resveratrol	7	14
Alpha-Lipoic Acid	6	12
Beet	6	12
Dandelion	6	12
Grape Seed Extract	6	12
Honey	6	12
Thymoquinone	6	12
Blueberry	5	10
Garlic	5	10
Honeysuckle	5	10
Lactobacillus plantarum	5	10
Reishi Mushroom	5	10
Turmeric: Fermented	1	10
Vitamin C	5	10
Vitamin E	5	10
Artichoke	5	9
Mangiferin	4	9
Pomegranate	5	9
Rose	5	9
Rosemary	5	9
Bael	4	8
Berberine	4	8
Camel Milk	4	8
Chlorella (Algae)	4	8
Chokeberry	4	8
Citrus naringin	5	8
Fermented Foods and Beverages	4	8
Jujube	4	8
Moringa oleifera	4	8
NAC (N-acetyl-L-cysteine)	5	8
Naringenin	4	8
Olive leaf extract	4	8
Quercetin	4	8
Selenium	4	8
Silymarin	4	8
Sweet Potato: Purple	4	8
White Tea	4	8
Caffeic acid phenethyl ester	4	7
EGCG (Epigallocatechin gallate)	4	7
Fucoidan	4	7
Ginkgo biloba	4	7
Radish	4	7
Bee Propolis	3	6
Black Tea	3	6
Blue Honeysuckle	3	6
Carrot	3	6
Catechin	3	6
Chlorogenic Acid	3	6
Diallyl sulfide	3	6
Diosmin	3	6
Ellagic Acid	3	6
Fenugreek	3	6
Geraniol	3	6
Green Tea	3	6
Hesperidin	3	6
Licorice	4	6
Luteolin	3	6
Lycopene	3	6
Mulberry	4	6
Olive Oil	3	6
Oregano	4	6
Royal Jelly	3	6
Sea buckthorn	3	6
Solanum nigrum (black nightshade)	3	6
Sulforaphane	4	6
Apple	3	5
Medicinal Mushrooms	3	5
Rooibos	3	5
Ursolic Acid	3	5
Acacia catechu	2	4
Apricot	2	4
Asiatic Acid	2	4
Ayurvedic formulation: Liv52	2	4
Bamboo	2	4
Beeswax	2	4
Berries: All	2	4
Burdock	2	4
Carvacrol	2	4
Chamomile	2	4
Chicory	2	4
Chrysin	2	4
Citrus Peel	2	4
Coenzyme Q10	2	4
Crocin	2	4
Dates	2	4
Dill	2	4
Embelia ribes	2	4
Flaxseed	2	4
Garden Cress (Lepidium sativum)	2	4
Garlic: Aged	2	4
Genistein	2	4
Guduchi	2	4
Henna	2	4
Hibiscus sabdariffa	2	4
Isoliquiritigenin	2	4
Lactobacillus casei	2	4
Lotus	3	4
Lychee	2	4
Myricetin	2	4
Nobiletin	2	4
Onion	2	4
Oyster Mushroom	2	4
Paeonol	2	4
Papaya	2	4
Passion Flower	2	4
Pomegranate Peel	2	4
Potato	2	4
Propolis: Bee	2	4
Raspberry ketone	2	4
Safflower	2	4
Sesamol	2	4
Shiitake Mushroom	2	4
Spirulina	2	4
Vitamin D	2	4
Walnut	2	4
Yeast	2	4
Yellow Tea	2	4
Zerumbone	2	4
Zinc	2	4
Barley	2	3
D-Limonene	2	3
Fig	2	3
Gallic Acid	2	3
Guava	2	3
Lactobacillus fermentum	2	3
Nutmeg	2	3
Oleanolic acid	2	3
Paeoniflorin	2	3
Thistle	2	3
Zataria multiflora	2	3
Ajwain	1	2
Almond	1	2
Aloe Vera	1	2
Andrographis	1	2
Angelica	1	2
Anise	1	2
Antrodia camphorata	1	2
Apigenin	2	2
Apocynin	1	2
Apple Cider Vinegar	1	2
Apple Polyphenols	1	2
Apples	1	2
Apricot Kernel	1	2
Artesunate	1	2
Ashwagandha	1	2
Astaxanthin	1	2
Banana Peel	1	2
Banana Stem	1	2
Barberry	1	2
Basil	1	2
Bee Pollen	1	2
Bee Venom	1	2
Berbamine	1	2
Beta Sitosterol	1	2
Betanin	1	2
Bilberry	1	2
Biochanin A	1	2
Bitter Apple	1	2
Bitter Melon	1	2
Bitter Orange	1	2
Black Currant	1	2
Black Raspberry	1	2
Broccoli Sprouts	1	2
Buckwheat	1	2
Butterbur	1	2
Caffeine	1	2
Capsaicin	1	2
Carnosic Acid	1	2
Celery	1	2
Celosia cristata (cockscomb)	1	2
Centella asiatica	1	2
Chickpea	1	2
Choline	1	2
Cinnamon	1	2
Cissus quadrangularis	1	2
Coconut Oil	1	2
Coconut Water	1	2
Coffee: Green/Unroasted	1	2
Cordyceps Militaris	1	2
Cordyceps sinensis	1	2
Cranberry	1	2
Crocetin	1	2
Cucurbitacin B	1	2
Cumin	1	2
Curcumol	1	2
DHA (Docosahexaenoic Acid)	1	2
Date Seeds	1	2
Dibenzoylmethane (DBM)	1	2
Earthworms	1	2
Echinacea	1	2
Eggplant	1	2
Eriodictyol	1	2
Eugenol	1	2
False Black Pepper	1	2
Fennel	1	2
Ferulic acid	1	2
Feverfew	1	2
Fisetin	1	2
Fish Oil	1	2
Folic Acid	1	2
Frankincense	1	2
Gingerol	1	2
Ginseng	1	2
Ginseng (Siberian)	1	2
Goat Milk	1	2
Gotu Kola	1	2
Grape	1	2
Graviola	1	2
Harmine	1	2
Holy Basil	1	2
Horehound	1	2
Hu Zhang (Polygonum cuspidatum)	1	2
Hydrogen Water	1	2
Hydroxytyrosol	1	2
Indian Mulberry	2	2
Indole-3-Carbinol	1	2
Isothiocyanates	1	2
Juniper	1	2
Kefir	1	2
Kombucha Tea	2	2
Lactobacillus probiotics	1	2
Lactobacillus salivarius	1	2
Lactoferrin	1	2
Lavender	2	2
Lignans	1	2
Ligustrazine	1	2
Liquiritigenin	1	2
Litchi	1	2
Lobelia	1	2
Long Pepper	1	2
Loquat	1	2
Loquat Seeds	1	2
Lutein	1	2
Mango	1	2
Miso	1	2
Modified Arabinoxylan Rice Bran (MGN-3)	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Myrica rubra	1	2
Nettle	1	2
Noni	1	2
Oak	1	2
Okra	1	2
Oleuropein	1	2
Olive	1	2
Orange	1	2
Oridonin	1	2
Orthosiphon	1	2
Palash	1	2
Palmitoylethanolamide	1	2
Panax Notoginseng	1	2
Pecan	1	2
Peppermint	1	2
Phellinus Linteus	1	2
Phosphatidylcholine	1	2
Pine Bark Extract	1	2
Piper cubeba (Cubeb)	1	2
Piperine	1	2
Plant Stem Cells	1	2
Plantago asiatica	1	2
Pomegranate Seed	1	2
Probiotics	1	2
Propolis: Brazillian	1	2
Prunella vulgaris	1	2
Pterocarpus marsupium	1	2
Pterostilbene	1	2
Pumpkin	1	2
Pumpkin Seed Oil/Meal	1	2
Rice: Brown	1	2
Rice: Parboiled	1	2
Rosmarinic acid	1	2
Saffron	1	2
Safranal	1	2
Saikosaponin	1	2
Schisandra	1	2
Seaweed	1	2
Sesame Seed Oil	1	2
Sesamin	1	2
Sessile Joyweed	1	2
Shikonin	1	2
Silibinin	1	2
Silica Hydride	1	2
Soy	1	2
Stevia	1	2
Strawberry	1	2
Tannic Acid	1	2
Taro	1	2
Taurine	1	2
Terminalia chebula	1	2
Thymol	1	2
Toona sinensis	1	2
Tyrosine	1	2
Urine	1	2
Urine: Cow	1	2
Vanillin	1	2
Verbascoside	1	2
Water: Electrolyzed Reduced	1	2
Watercress	1	2
Xanthohumol	1	2
Yoghurt	1	2
beta-Carotene	1	2
Agrimony	1	1
Allicin	1	1
Astragaloside	1	1
Astragalus	1	1
Blackberry	1	1
Caraway	1	1
Chaga Mushroom (Inonotus obliquus)	1	1
Clove	1	1
Coffee	1	1
Coriandor	1	1
Curcuminoids	1	1
Cyperus longus	1	1
Dong Quai	1	1
Gynostemma	1	1
Haritaki (Terminalia chebula)	1	1
Hydrangea	1	1
Motherwort	1	1
Mung Bean	1	1
Phyllanthus urinaria	1	1
Poria cocos	1	1
Punicalagin	1	1
Rice: Black	1	1
Sweet Potato	1	1
Tangeretin	1	1
Tetrahydrocurcumin	1	1
Water Mint	1	1

Name	AC	CK
Statin Drugs	18	100
Acetaminophen	42	88
Paracetamol	39	71
Simvastatin	7	59
Atorvastatin	10	54
Bisphenol A	20	51
Pravastatin	4	43
Lovastatin	6	34
Cadmium	19	33
Fluvastatin	3	30
Isoniazid	3	30
Pesticides	12	23
Lead	10	20
High Fructose Corn Syrup	5	18
Rosuvastatin	4	17
Concanavalin A	9	16
Glyphosate	9	15
Mercury	5	13
Arsenic	7	12
Fluoroquinolone Antibiotic	2	12
Perfluorooctanoic acid (PFOA)	2	12
Tylenol	2	12
Tamoxifen	2	11
Aspartame	4	8
Dichloro-diphenyl-trichloroethane (DDT)	4	8
Tertiary butyl hydroperoxide	7	8
Electronic Cigarettes	4	7
Organophosphate Pesticides	4	7
Chlorpyrifos	3	6
Monosodium Glutamate (MSG)	3	6
Sodium Fluoride	3	6
Acrylamide	3	5
Paraquat	3	5
Aluminum	2	4
Arsenic Trioxide	2	4
Arsenite	2	4
Benzo(a)pyrene	2	4
Butylated Hydroxytoluene (BHT)	2	4
Cisplatin	2	4
Deltamethrin	2	4
Dichlorvos	2	4
Diclofenac	2	4
Fluoxetine (trade name Prozac)	2	4
Formaldehyde	2	4
Furan	2	4
Morphine	2	4
N-nitrosodiethylamine	2	4
Nanoparticles	2	4
Perfluorooctane sulfonate (PFOS)	2	4
Rosiglitazone (trade name Avandia)	2	4
Sucralose (aka Splenda)	2	4
Sugar Sweetened Beverages	2	4
Titanium Nanoparticles	2	4
Zinc Oxide	2	4
2-chlorobenzylidene malononitrile (CS)	1	3
Bisphenol S	2	3
Cerivastatin	1	3
Cholesterol Lowering Drugs	1	3
Fenofibrates	1	3
Quizalofop-P-ethyl	1	3
Triclosan	2	3
Benzene	1	2
Bisphenol F	1	2
Brilliant Blue FCF	1	2
Cobalt	1	2
Copper Oxide	1	2
Cypermethrin	1	2
Dexamethasone	1	2
Dichlorodiphenyldichloroethylene (DDE)	1	2
Erythrosine	1	2
Ethylene Glycol	1	2
FD&C Red #40	1	2
Fluoride	1	2
Food Colorings	1	2
Formaldehyde Releasers	1	2
Fructose	1	2
Glyphosate:Roundup	1	2
Levofloxacin	1	2
Metanil-Yellow Dye	1	2
N-nitrosodimethylamine	1	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2
Organochlorine pesticides	1	2
Organophosphates	1	2
Phthalates	1	2
Ponceau 4R (New Coccine)	1	2
Pyrethroid insecticide	1	2
Selective Serotonin Reuptake Inhibitors (SSRIs)	1	2
Silver	1	2
Sucrose	1	2
Tartrazine (Yellow Food Dye)	1	2
Thiazolidinediones	1	2
Titanium Dioxide	1	2
Toluene	1	2
Zoledronic Acid	1	2
Dimethoate	1	1
Parabens	1	1
Polychlorinated biphenyls (PCBs)	1	1
Zineb	1	1

Name	AC	CK	Focus
Exercise: Aerobic	1	2

Name	AC	CK	Focus
Western Diet	1	2

[+]

Prophylactic therapy of milk thistle on anti-tuberculosis drug-induced liver injury.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2013 ;13:58. Epub 2013 Mar 8. PMID: 23497020

Click here to read the entire abstract

Pubmed Data : Environ Toxicol. 2017 Feb ;32(2):630-644. Epub 2016 Mar 28. PMID: 28071871

Click here to read the entire abstract

Pubmed Data : Med Clin (Barc). 2002 May 18 ;118(18):717. PMID: 12042141

Article Published Date : May 18, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies

Problem Substances : Cerivastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Acute cholestatic hepatitis induced by fenofibrate has been reported.Oct 01, 2009

Click here to read the entire abstract

Pubmed Data : J Clin Pharm Ther. 2009 Oct;34(5):599-602. PMID: 19744016

Click here to read the entire abstract

Pubmed Data : Eur J Gastroenterol Hepatol. 2005 May ;17(5):589-90. PMID: 15827453

Article Published Date : May 01, 2005

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Hepatitis: Autoimmune , Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Rosuvastatin

Adverse Pharmacological Actions : Hepatotoxic

[+]

Simvastatin has been reported to cause cholestatic hepatitis. Apr 01, 1991

Click here to read the entire abstract

Pubmed Data : Recenti Prog Med. 1991 Apr ;82(4):233-5. PMID: 1857844

6-gingerol, a major ingredient of ginger attenuates diethylnitrosamine-induced liver injury.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Med Sci. 2021 May ;46(3):218-227. PMID: 34083854

Article Published Date : Apr 30, 2021

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Bisphenol Toxicity, Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Bisphenol A

[+]

Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2018 Jan ;54:125-130. Epub 2017 Nov 9. PMID: 29128856

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Chemically-Induced Liver Damage

[+]

Aegle marmelos methanol extract could protect against carbon tetrachloride.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2020 Jun 5 ;25(11). Epub 2020 Jun 5. PMID: 32517066

Article Published Date : Jun 04, 2020

Study Type : Animal Study

Additional Links

Substances : Bee Pollen, Bee Propolis, Honey, Royal Jelly

Diseases : Chemically-Induced Liver Damage, Kidney Damage, Pesticide Toxicity

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Pesticides

[+]

Ameliorative effects of Moringa oleifera leaf extract on levofloxacin-induced hepatic toxicity.Feb 19, 2019

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2019 Feb 20:1-7. Epub 2019 Feb 20. PMID: 30782023

[+]

An unexpected role of cholesterol sulfotransferase and its regulation in sensitizing mice to acetaminophen induced liver injury.Apr 02, 2019

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2015 Feb ;18(2):205-11. PMID: 25825639

Antioxidant and hepato-preventive effect of Citrus aurantium extract against carbon tetrachloride-induced hepatotoxicity.Sep 30, 2019

Click here to read the entire abstract

Pubmed Data : Arch Physiol Biochem. 2019 Oct ;125(4):332-343. Epub 2018 Apr 17. PMID: 29663826

Article Published Date : Sep 30, 2019

Study Type : Animal Study

Additional Links

Substances : Bitter Orange

Diseases : Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Antioxidant and hepatoprotective potential of Lawsonia inermis L. leaves against 2-acetylaminofluorene induced hepatic damage.Jan 17, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2017 Aug ;92:421-428. Epub 2017 May 27. PMID: 28558355

Article Published Date : Jul 31, 2017

Study Type : Animal Study

Additional Links

Substances : Apocynin

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

[+]

Apple cider vinegar could be promising for attenuation of liver cell damages induced by several toxins through its powerful antioxidant properties.Jun 30, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Microsc Ultrastruct. 2020 Jul-Sep;8(3):126-131. Epub 2020 Sep 10. PMID: 33282688

Article Published Date : Jun 30, 2020

Study Type : Animal Study

Additional Links

Substances : Apple Cider Vinegar

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Mercury

[+]

[+]

Aqueous extracts of Rosa damascene may prevent hepatic damage from acetaminophen induced toxicity in rats.Dec 31, 2011

Click here to read the entire abstract

Pubmed Data : J Environ Pathol Toxicol Oncol. 2012 ;31(3):193-201. PMID: 23339694

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Rose

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Arctium lappa root extract prevents lead-induced liver injury.Nov 23, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2019 Nov 24 ;8(12). Epub 2019 Nov 24. PMID: 31771282

Article Published Date : Nov 23, 2019

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Lead

[+]

Artichoke extract ameliorates carbon tetrachloride-induced liver damage and oxidative stress in rats. Sep 01, 2008

Click here to read the entire abstract

Pubmed Data : Exp Toxicol Pathol. 2008 Sep;60(6):475-80. Epub 2008 Jun 25. PMID: 18583118

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Artichoke

Diseases : Chemically-Induced Liver Damage

[+]

Artichoke leaf extract has liver protective effects and causes downregulation of oxidative stress in acute diazinon-induced liver injury.Aug 29, 2019

Click here to read the entire abstract

Pubmed Data : J Basic Clin Physiol Pharmacol. 2019 Aug 30 ;30(5). Epub 2019 Aug 30. PMID: 31469651

Article Published Date : Aug 29, 2019

Study Type : Animal Study

Additional Links

Substances : Artichoke

Diseases : Chemically-Induced Liver Damage, Pesticide-Induced Toxicity: Organophosphates

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Organophosphate Pesticides

[+]

Artichoke leaf extract may be used as a pharmaceutical phytomedicine in the treatment of liver diseases.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Springerplus. 2016 ;5:216. Epub 2016 Feb 29. PMID: 27026910

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2016 Jul 21 ;8(7). Epub 2016 Jul 21. PMID: 27455313

Article Published Date : Jul 20, 2016

Study Type : Animal Study

Additional Links

Substances : Barley

Diseases : Alcohol Toxicity , Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Bees' honey attenuation of metanil-yellow-induced hepatotoxicity in rats.Dec 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:614580. Epub 2013 Jun 3. PMID: 23818929

Article Published Date : Dec 31, 2012

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2012 Jun ;50(6):2027-33. Epub 2012 Mar 24. PMID: 22465004

Article Published Date : May 31, 2012

Study Type : Animal Study

Additional Links

Substances : Beet

Diseases : Chemically-Induced Liver Damage, DNA damage

Pharmacological Actions : Hepatoprotective

Problem Substances : N-nitrosodiethylamine

Adverse Pharmacological Actions : Hepatotoxic

[+]

Beetroot protects the liver against chemical toxicity.Feb 01, 2006

Click here to read the entire abstract

Pubmed Data : Fitoterapia. 2006 Feb;77(2):91-3. Epub 2005 Dec 20. PMID: 16376022

Article Published Date : Feb 01, 2006

Study Type : Animal Study

Additional Links

Substances : Beet

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Beetroot water extract could be used following silver nano particles as a potential therapeutic intervention to minimize liver toxicity.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Nanomedicine. 2020 ;15:3471-3482. Epub 2020 May 15. PMID: 32547008

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

Click here to read the entire abstract

Pubmed Data : J Biochem Mol Toxicol. 2021 Nov ;35(11):e22901. Epub 2021 Sep 2. PMID: 34472159

Pubmed Data : Environ Pollut. 2020 Dec 22 ;271:116304. Epub 2020 Dec 22. PMID: 33401208

Article Published Date : Dec 21, 2020

Study Type : Animal Study

Additional Links

Diseases : Bisphenol Toxicity, Chemically-Induced Liver Damage, Nonalcoholic fatty liver disease (NAFLD)

Problem Substances : Bisphenol F

[+]

Bisphenol S induced dysregulations in liver; iron regulatory genes and inflammatory mediators.Jun 29, 2022

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Pubmed Data : Environ Sci Pollut Res Int. 2022 Jun 30. Epub 2022 Jun 30. PMID: 35771333

Article Published Date : Jun 29, 2022

Study Type : Animal Study

Additional Links

Diseases : Bisphenol Toxicity, Chemically-Induced Liver Damage

Problem Substances : Bisphenol S

[+]

Bitter apple fruit possess significant hepatoprotective and antioxidant activity.Apr 30, 2015

Click here to read the entire abstract

Pubmed Data : Pak J Pharm Sci. 2015 May ;28(3):951-7. PMID: 26004728

[+]

BPA induced liver fibrosis, which is related to the stimulation of the inflammatory response.Dec 06, 2016

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Pubmed Data : Int J Exp Pathol. 2016 Dec 7. Epub 2016 Dec 7. PMID: 27925325

Article Published Date : Dec 06, 2016

Study Type : Animal Study

Additional Links

Diseases : Bisphenol Toxicity, Chemically-Induced Liver Damage, Inflammation, Liver Fibrosis, Oxidative Stress

Problem Substances : Bisphenol A

[+]

Brazilian green propolis suppresses acetaminophen-induced hepatocellular necrosis.Sep 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Toxicol Pathol. 2018 Oct ;31(4):275-282. Epub 2018 Jul 1. PMID: 30393431

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Propolis: Brazillian

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Brewer's yeast (S. cerevisiae) has a protective effect against chemically-induced liver damage in rats. Jun 01, 2009

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Pubmed Data : Clin Nutr. 2009 Jun;28(3):338-45. Epub 2009 Feb 23. PMID: 19233522

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Yeast

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Broccoli sprout extract protected the liver from various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis.Sep 20, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Biotech Histochem. 2016 Jan 21:1-12. Epub 2016 Jan 21. PMID: 26796199

Article Published Date : Jan 20, 2016

Study Type : Animal Study

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Substances : Turmeric

Diseases : Cadmium Poisoning , Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Hepatoprotective

[+]

Caffeic acid phenethyl ester mitigates cadmium-induced hepatotoxicity.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ecotoxicol Environ Saf. 2021 Jan 1 ;207:111578. Epub 2020 Nov 3. PMID: 33254423

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Caffeic acid phenethyl ester

Diseases : Chemically-Induced Liver Damage, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, MicroRNA modulator

Problem Substances : Cadmium

[+]

Camel milk either alone or in combination with bee honey ameliorated the toxic effects of carbon tetrachloride.May 29, 2016

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Pubmed Data : Can J Physiol Pharmacol. 2016 May 30:1-10. Epub 2016 May 30. PMID: 27455095

Article Published Date : May 29, 2016

Study Type : Animal Study

Additional Links

Substances : Camel Milk , Honey

Diseases : Chemically-Induced Liver Damage, Liver Cirrhosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Carnosic acid attenuates arsenic-induced hepatotoxicity.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:1421438. Epub 2018 May 2. PMID: 29854073

[+]

Celosia cristata extract prevented oxidative stress-induced liver injury by enhancing hepatocyte antioxidant abilities.Jan 31, 2015

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Pubmed Data : Food Chem. 2015 Feb 1 ;168:572-9. Epub 2014 Jul 31. PMID: 25172750

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Pubmed Data : Carbohydr Polym. 2018 Dec 15 ;202:461-469. Epub 2018 Sep 7. PMID: 30287023

Article Published Date : Dec 14, 2018

Study Type : Animal Study

Additional Links

Substances : Pomegranate Peel

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Polysaccharides

[+]

Chickpea extract exhibits a significant hepatoprotective effect against carbon tetrachloride induced liver injury in rats.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2016 ;7:344. Epub 2016 Sep 28. PMID: 27733831

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Pubmed Data : In Vivo. 2009 Sep-Oct;23(5):747-54. PMID: 19779110

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Pubmed Data : Life Sci. 2021 Mar 31 ;277:119460. Epub 2021 Mar 31. PMID: 33811899

Article Published Date : Mar 30, 2021

Study Type : Animal Study

Additional Links

Substances : Chlorogenic Acid, Coenzyme Q10, Quercetin

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

[+]

Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice.Jan 31, 2017

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Pubmed Data : Indian J Pharmacol. 2010 Dec;42(6):397-400. PMID: 21189914

Article Published Date : Dec 01, 2010

Study Type : Animal Study

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Substances : Cissus quadrangularis

Diseases : Chemically-Induced Liver Damage, Drug-Induced Toxicity , Tuberculosis Drug Induced Toxicity

Pharmacological Actions : Hepatoprotective

[+]

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Pubmed Data : Toxicol Mech Methods. 2020 Jul 27:1-23. Epub 2020 Jul 27. PMID: 32718261

Article Published Date : Jul 26, 2020

Study Type : Animal Study

Additional Links

Substances : Curcumin, Pomegranate

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

[+]

Comparative hepatoprotective effect of Nigella sativa pre- and post-treatment.Dec 31, 2018

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Pubmed Data : Pak J Pharm Sci. 2019 Jan ;32(1):205-212. PMID: 30772810

Pubmed Data : Chem Biol Drug Des. 2017 Dec 17. Epub 2017 Dec 17. PMID: 29250925

Article Published Date : Dec 16, 2017

Study Type : Animal Study

Additional Links

Substances : Cucurbitacin B

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Hepatoprotective, STAT3 Inhibitor

[+]

Curcuma longa extract or curcumin has the ability to alleviate the hepatotoxic effects caused by mercuric chloride in rats.Mar 19, 2017

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Pubmed Data : Exp Toxicol Pathol. 2017 Mar 20. Epub 2017 Mar 20. PMID: 28336172

Article Published Date : Mar 19, 2017

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomolecules. 2019 Nov 5 ;9(11). Epub 2019 Nov 5. PMID: 31694300

Article Published Date : Nov 04, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemically-Induced Liver Damage, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Lead

[+]

Curcumin and capsaicin individually are protective to LDL oxidation both in vivo and in vitro, to iron-induced hepatotoxicity and to carrageenan-induced inflammation.Aug 26, 2009

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Pubmed Data : J Agric Food Chem. 2009 Aug 26;57(16):7401-8. PMID: 16956363

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Pubmed Data : Biol Trace Elem Res. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654258

Article Published Date : Oct 24, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin, Selenium

Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Diclofenac

[+]

Curcumin and turmeric extract might be recommendable to recover liver activity.Jul 25, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Balkan Med J. 2016 May ;33(3):252-7. Epub 2016 May 1. PMID: 27308068

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Nanoparticles

[+]

Curcumin functions as an anti-inflammatory and antioxidant agent on arsenic-induced hepatic and kidney injury.Jul 16, 2021

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Pubmed Data : Environ Toxicol. 2021 Jul 17. Epub 2021 Jul 17. PMID: 34272803

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Biomed. 2012 May ;2(5):385-8. PMID: 23569935

Article Published Date : Apr 30, 2012

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Pubmed Data : J Biochem Mol Toxicol. 2019 Feb 27:e22307. Epub 2019 Feb 27. PMID: 30811752

Article Published Date : Feb 26, 2019

Study Type : Animal Study

Additional Links

Substances : Diallyl sulfide

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

[+]

Diallyl sulfide and curcumin effectively reduced Thallium acetate induced liver toxicity.Dec 31, 2014

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Pubmed Data : Cell J. 2015 ;17(2):379-88. Epub 2015 Jul 11. PMID: 26199917

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumin, Diallyl sulfide

Diseases : Chemically-Induced Liver Damage, Oxidative Stress, Thallium Poisoning

Pharmacological Actions : Hepatoprotective

Chemically-Induced Liver Damage jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

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Chemically-Induced Liver Damage is a Sub of the following Topic

View the Evidence: 910 Abstracts with Chemically-Induced Liver Damage Research

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Prophylactic therapy of milk thistle on anti-tuberculosis drug-induced liver injury.Dec 31, 2018

The use of statins for LDL suppression is associated with increased risk for cancer.Jul 31, 2007

Atorvastatin-induced acute pancreatitis has been reported.Jan 01, 2011

Autoimmune hepatitis associated with atorvastatin use has been reported.Aug 01, 2003

Bisphenol A was detected above the detection limit in all samples in individuals affected by non-alcoholic fatty liver disease.Jun 04, 2017

Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patientsDec 31, 2012

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran Sep 01, 2009

Exposure of children to even low doses of BPA may adversely affect later liver function.Nov 16, 2017

Fermented turmeric powder is well-tolerated and effective in subjects with elevated alanine transaminase levels.Dec 31, 2012

Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study.Aug 12, 2012

Fluvastatin has been linked to adverse hepatic reactions.Jan 01, 2006

Fructose-associated hepatotoxicity indexed by the lactate dehydrogenase isoenzyme LDH-5.Feb 28, 2019

Isoniazid has been associated with grade 3 or 4 liver failure in 1.4%-5.2% of patients being treated for latent tuberculosis infection.Dec 15, 2009

Isoniazid treatment in latent tuberculosis infection may be associated with moderate-to-severe liver damage without symptoms. Jul 01, 2005

Liver failure and damage are rare but severe unintended consequences of statin drug use.Aug 31, 2011

More than half of patients who present at the hospital with acetaminophen-induced liver damage or liver failure have undetectable levels of acetaminophen.Feb 04, 2019

Perfluorooctanoic acid has hepatotoxic effects.Jul 31, 2016

Severe liver toxicity requiring discontinuation occurs in 5% of simvastatin-treated patients and 4.5% of pravastatin-treated patients. Jan 01, 1992

Severe, even fatal liver injuries have resulted as a consequence of isoniazid treatment in individuals with latent tuberculosis.Mar 05, 2010

Tamoxifen treatment for breast cancer may result in fatty liver.Nov 01, 2000

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.Jan 01, 2010

Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue.Aug 11, 2019

Curcumin could modulate hepatocyte epithelial-mesenchymal transition implicated in treatment of liver fibrosis.Aug 23, 2015

Mangiferin could ameliorate methylmercury mediated mitochondrial dysfunction in human hepatic cells in vitro.Jan 31, 2017

Procyanidin B2 alleviates palmitic acid-Induced injury in HepG2 cells.Dec 31, 2020

A case of hepatitis caused by simvastatin has been reported. Jan 01, 1991

Acute cholestatic hepatitis associated with atorvastatin use has been reported. Jan 01, 2006

Acute cholestatic hepatitis associated with pravastatin has been reported. May 01, 1999

Acute cholestatic hepatitis induced by cerivastatin has been reported. May 18, 2002

Acute cholestatic hepatitis induced by fenofibrate has been reported.Oct 01, 2009

Acute exposure to CS tear gas has been reported to cause several health problems in an individual.Dec 26, 1981

Acute hepatitis induced by lovastatin has been reported. Sep 01, 1994

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury. Jul 01, 2008

Atorvastatin-induced cholestatic hepatitis in a young woman with systemic lupus erythematosus has been reported.Aug 09, 1999

Cholestatic jaundice induced by atorvastatin has been observed. Jul 01, 2009

Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury.May 16, 2022

Hepatitis associated with treatment with lovastatin has been reported. Mar 01, 1998

Liver fibrosis has been attributed to lipid lowering medications.Sep 01, 2001

Lovastatin monotherapy has been reported to have been a cause of rhabdomyolysis, acute renal failure and hepatopathy.Jul 01, 1997

Mixed cholestatic/hepatocellular liver injury induced by the herbicide quizalofop-p-ethyl has been reported. Oct 01, 2007

Reversible acute hepatitis induced by rosuvastatin has been reported.Jul 01, 2008

Rosmarinic acid exerts anti-inflammatory effect and relieves oxidative stress via Nrf2 activation in carbon tetrachloride-induced liver damage.Dec 31, 2021

Rosuvastatin-associated hepatitis with autoimmune features has been reported. May 01, 2005

Simvastatin has been reported to cause cholestatic hepatitis. Apr 01, 1991

Simvastatin has been reported to cause liver lesions.Apr 13, 1996

Virgin coconut oil complements with its polyphenol components mitigate sodium fluoride toxicity in vitro and in vivo.Aug 17, 2021

The protective effect of chrysin against carbon tetrachloride-induced kidney and liver tissue damage.Apr 29, 2020

"Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury."Oct 01, 2012

"Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats."Oct 01, 2006

6-gingerol, a major ingredient of ginger attenuates diethylnitrosamine-induced liver injury.Dec 31, 2020

6-Shogaol alleviates CCl4-induced liver fibrosis by attenuating inflammatory response.Apr 27, 2022

A curcumin-phospholipid complex works synergistically to protect the livers of rats following chemical exposure. Feb 07, 2007

A quantitative study on the protective effects of resveratrol against bisphenol A-induced hepatotoxicity.Apr 30, 2021

A water extract of the leaves of Z. jujuba is efficacious for prevention and treatment of carbon tetrachloride induced hepatic injury in mice.Feb 21, 2017

A. cerana honey can prevent bromobenzene-induced hepatic damage in mice. Jan 15, 2018

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

A. marmelos attenuates carbon tetrachloride-mediated hepatic oxidative stress, toxicity, tumor promotion.Mar 31, 2009

A. sessilis has hepatoprotective activity against carbon tetrachloride liver damage.Mar 31, 2018

Acacia catechu extract affords hepato-protection against DMBA in rats through modulation of phase I, II and anti-oxidative enzymes.Dec 31, 2013

Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.Dec 31, 2017

Aegle marmelos methanol extract could protect against carbon tetrachloride.Dec 31, 2017

Aerobic exercise and eugenol supplementation ameliorated liver injury induced by chlorpyrifos.Feb 24, 2020

Aged garlic extract supplementation could be used to reverse the hepatic injury following ethephon exposure through its antioxidant capacity.Dec 20, 2019

Ajwain attenuates chemically-induced liver damage in rats. Feb 01, 2009

Alkaloidal extract from Carica papaya seeds ameliorates CCl 4-induced hepatocellular carcinoma.Jul 31, 2021

Almond skin extract has hepatoprotective properties against chemically-induced liver cell damage.Apr 29, 2010

Alpha lipoic acid possess protective effects against chlorpyrifos induced liver injury.Feb 22, 2018

Alpha-lipoic acid ameliorates sodium valproate-induced liver injury.Apr 30, 2020

Alpha-lipoic acid could prevent from mitochondria dysfunction.Apr 16, 2021

Alpha-lipoic acid protected against valproic acid-induced liver damage and hematological disturbance.Dec 03, 2020

Alpha-Lipoic acid protects against microcystin-LR induced hepatotoxicity through regeneration of glutathione via activation of Nrf2 Jun 30, 2020

Ameliorative effect of betanin on experimental cisplatin-induced liver injury.Mar 03, 2021

Chemically-Induced Liver Damage

View the Evidence:
910 Abstracts with Chemically-Induced Liver Damage Research