Chemically-Induced Liver Damage

Name	AC	CK
Curcumin	49	98
Flavonoids	27	49
Ginsenosides	20	38
Polyphenols	13	26
Alpha-Lipoic Acid	13	24
Puerarin	13	23
Milk Thistle	2	22
Naringenin	11	22
Nigella sativa (aka Black Seed)	11	22
Melatonin	6	20
Thymoquinone	10	20
Ginger	9	18
NAC (N-acetyl-L-cysteine)	10	18
Resveratrol	9	18
Turmeric	9	18
Berberine	8	16
Grape Seed Extract	8	16
Moringa oleifera	8	16
Quercetin	8	16
Selenium	8	16
Garlic	8	15
Anthocyanins	7	14
Coenzyme Q10	7	14
Dandelion	7	14
Honey	7	14
Papaya	7	14
Rose	8	14
Royal Jelly	7	14
Vitamin E	7	14
Vitamin C	7	13
Beet	6	12
Black Tea	6	12
Chlorella (Algae)	6	12
Chlorogenic Acid	6	12
Citrus naringin	7	12
Hesperidin	6	11
Mangiferin	5	11
Pomegranate	6	11
Blueberry	5	10
Carvacrol	5	10
Chokeberry	5	10
Ellagic Acid	5	10
Green Tea	5	10
Honeysuckle	5	10
Lactobacillus plantarum	5	10
Lycopene	5	10
Reishi Mushroom	5	10
Silymarin	5	10
Sweet Potato: Purple	5	10
Turmeric: Fermented	1	10
White Tea	5	10
Andrographis	5	9
Artichoke	5	9
Bael	5	9
EGCG (Epigallocatechin gallate)	5	9
Fucoidan	5	9
Rosemary	5	9
Ursolic Acid	5	9
Astaxanthin	4	8
Camel Milk	4	8
Chrysin	4	8
Crocin	4	8
Diallyl sulfide	4	8
Diosmin	4	8
Fenugreek	4	8
Fermented Foods and Beverages	4	8
Flaxseed	4	8
Geraniol	4	8
Jujube	4	8
Licorice	5	8
Mulberry	5	8
Olive Oil	4	8
Olive leaf extract	4	8
Rutin	4	8
Sea buckthorn	4	8
Sesamol	4	8
Spirulina	4	8
Sulforaphane	5	8
Vitamin D	4	8
Burdock	3	7
Caffeic acid phenethyl ester	4	7
Ginkgo biloba	4	7
Medicinal Mushrooms	4	7
Paeoniflorin	4	7
Phlorotannins	4	7
Radish	4	7
Bee Propolis	3	6
Biochanin A	3	6
Blue Honeysuckle	3	6
Carrot	3	6
Catechin	3	6
Dates	3	6
Eugenol	3	6
Fisetin	3	6
Garlic: Aged	3	6
Lotus	4	6
Luteolin	3	6
Myricetin	3	6
Nobiletin	3	6
Oregano	4	6
Piperine	3	6
Propolis: Bee	3	6
Solanum nigrum (black nightshade)	3	6
Yellow Tea	3	6
Apple	3	5
Coconut Oil	2	5
Fig	3	5
Gallic Acid	3	5
Garcinia kola	3	5
Nutmeg	3	5
Paeonol	3	5
Procyanidin B2	1	5
Rooibos	3	5
Rosmarinic acid	2	5
Saikosaponin	3	5
Zataria multiflora	3	5
18β-Glycyrrhetinic Acid	2	4
Acacia catechu	2	4
Amygdalin	2	4
Apigenin	3	4
Apocynin	2	4
Apricot	2	4
Asiatic Acid	2	4
Ayurvedic formulation: Liv52	2	4
Baicalein	2	4
Bamboo	2	4
Beeswax	2	4
Berries: All	2	4
Betulinic acid	2	4
Chamomile	2	4
Chicory	2	4
Cissus quadrangularis	2	4
Citrus Peel	2	4
Curcuma Comosa	2	4
Dill	2	4
Echinacea	2	4
Embelia ribes	2	4
Folic Acid	2	4
Garden Cress (Lepidium sativum)	2	4
Genistein	2	4
Gingerol	2	4
Ginseng	2	4
Guduchi	2	4
Harmine	2	4
Henna	2	4
Hibiscus sabdariffa	2	4
Hydrogen Water	2	4
Indole-3-Carbinol	2	4
Isoliquiritigenin	2	4
Isothiocyanates	2	4
Lactobacillus casei	2	4
Lactobacillus rhamnosus GG	2	4
Lactoferrin	2	4
Liquiritigenin	2	4
Litchi	2	4
Long Pepper	2	4
Lupeol	2	4
Lychee	2	4
Nettle	2	4
Oleuropein	2	4
Onion	2	4
Organosulfur Compounds	3	4
Oyster Mushroom	2	4
Passion Flower	2	4
Pomegranate Peel	2	4
Potato	2	4
Pterostilbene	2	4
Raspberry ketone	2	4
Safflower	2	4
Saffron	2	4
Sesame Seed Oil	2	4
Shiitake Mushroom	2	4
Tamarind	2	4
Walnut	2	4
Yeast	2	4
Zerumbone	2	4
Zinc	2	4
Allicin	2	3
Astragaloside	2	3
Barley	2	3
Chaga Mushroom (Inonotus obliquus)	2	3
D-Limonene	2	3
Gotu Kola	2	3
Guava	2	3
Hawthorn	2	3
Lactobacillus fermentum	2	3
Oleanolic acid	2	3
Silibinin	2	3
Sweet Potato	2	3
Thistle	2	3
Woodfordia fruticosa	2	3
6-Shogaol	1	2
Ajwain	1	2
Almond	1	2
Aloe Vera	1	2
Andrographolide	2	2
Angelica	1	2
Anise	1	2
Antrodia camphorata	1	2
Apple Cider Vinegar	1	2
Apple Polyphenols	1	2
Apples	1	2
Apricot Kernel	1	2
Artesunate	1	2
Ashwagandha	1	2
Avacado	1	2
Babchi	1	2
Banana	1	2
Banana Peel	1	2
Banana Stem	1	2
Barberry	1	2
Basil	1	2
Bee Pollen	1	2
Bee Venom	1	2
Berbamine	1	2
Beta Sitosterol	1	2
Betanin	1	2
Bilberry	1	2
Bitter Apple	1	2
Bitter Melon	1	2
Bitter Orange	1	2
Bixin	1	2
Black Currant	1	2
Black Raspberry	1	2
Broccoli Sprouts	1	2
Bromelain	1	2
Buckwheat	1	2
Butterbur	1	2
Caffeine	1	2
Capsaicin	1	2
Carnosic Acid	1	2
Celery	1	2
Celosia cristata (cockscomb)	1	2
Centella asiatica	1	2
Chia	1	2
Chickpea	1	2
Choline	1	2
Cinnamon	1	2
Citrus Triterpenoids	1	2
Coconut Water	1	2
Coffee: Green/Unroasted	1	2
Cordyceps Militaris	1	2
Cordyceps sinensis	1	2
Cranberry	1	2
Crocetin	1	2
Cucurbitacin B	1	2
Cumin	1	2
Curcumol	1	2
DHA (Docosahexaenoic Acid)	1	2
Date Seeds	1	2
Dibenzoylmethane (DBM)	1	2
Dragon's Blood	1	2
Earthworms	1	2
Eggplant	1	2
Eriodictyol	1	2
Evening Primrose Oil	1	2
False Black Pepper	1	2
Fennel	1	2
Ferulic acid	1	2
Feverfew	1	2
Fish Oil	1	2
Frankincense	1	2
Ginseng (Siberian)	1	2
Glutamine	1	2
Goat Milk	1	2
Goji	1	2
Grape	1	2
Graviola	1	2
Holy Basil	1	2
Horehound	1	2
Hu Zhang (Polygonum cuspidatum)	1	2
Hydroxytyrosol	1	2
Indian Mulberry	2	2
Jambul	1	2
Juniper	1	2
Kefir	1	2
Kombucha Tea	2	2
Krill	1	2
Lactobacillus probiotics	1	2
Lactobacillus salivarius	1	2
Lavender	2	2
Lemon	1	2
Lignans	1	2
Ligustrazine	1	2
Lobelia	1	2
Loquat	1	2
Loquat Seeds	1	2
Lutein	1	2
Magnolol	1	2
Mango	1	2
Miso	1	2
Modified Arabinoxylan Rice Bran (MGN-3)	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Mugwort	1	2
Myrica rubra	1	2
Noni	1	2
Oak	1	2
Okra	1	2
Olive	1	2
Oolong tea	1	2
Orange	1	2
Oridonin	1	2
Orthosiphon	1	2
Palash	1	2
Palmitoylethanolamide	1	2
Panax Notoginseng	1	2
Pecan	1	2
Peony	1	2
Peppermint	1	2
Phellinus Linteus	1	2
Phloretin	1	2
Phosphatidylcholine	1	2
Piceatannol	1	2
Pine Bark Extract	1	2
Piper cubeba (Cubeb)	1	2
Plant Stem Cells	1	2
Plantago asiatica	1	2
Policosanol	1	2
Pomegranate Seed	1	2
Probiotics	1	2
Propolis: Brazillian	1	2
Prunella vulgaris	1	2
Pterocarpus marsupium	1	2
Pumpkin	1	2
Pumpkin Seed Oil/Meal	1	2
Purslane	1	2
R-alpha lipoic acid	1	2
Raspberry	1	2
Rice: Brown	1	2
Rice: Parboiled	1	2
Safranal	1	2
Schisandra	1	2
Seaweed	1	2
Sesamin	1	2
Sessile Joyweed	1	2
Shikonin	1	2
Silica Hydride	1	2
Soy	1	2
Stevia	1	2
Strawberry	1	2
Tangeretin	2	2
Tannic Acid	1	2
Taro	1	2
Taurine	1	2
Terminalia chebula	1	2
Tetrahydrocurcumin	2	2
Theaflavins	1	2
Thymol	1	2
Toona sinensis	1	2
Triphala	1	2
Tyrosine	1	2
Urine	1	2
Urine: Cow	1	2
Vanillin	1	2
Verbascoside	1	2
Vitexins	1	2
Water: Electrolyzed Reduced	1	2
Watercress	1	2
Xanthohumol	1	2
Yoghurt	1	2
beta-Carotene	1	2
Agrimony	1	1
Astragalus	1	1
Blackberry	1	1
Caraway	1	1
Clove	1	1
Coffee	1	1
Coriandor	1	1
Curcuminoids	1	1
Cyperus longus	1	1
Dong Quai	1	1
Garcinia dulcis	1	1
Gynostemma	1	1
Haritaki (Terminalia chebula)	1	1
Hydrangea	1	1
Motherwort	1	1
Mung Bean	1	1
Perilla	1	1
Phyllanthus urinaria	1	1
Poria cocos	1	1
Punicalagin	1	1
Rice: Black	1	1
Salvia miltiorrhiza	1	1
Tripterygium wilfordii	1	1
Water Mint	1	1

Name	AC	CK
Statin Drugs	18	100
Acetaminophen	43	90
Bisphenol A	32	73
Paracetamol	40	73
Cadmium	33	59
Simvastatin	7	59
Atorvastatin	10	54
Pesticides	22	51
Pravastatin	4	43
Arsenic	22	42
Glyphosate	13	39
Lead	18	36
Lovastatin	6	34
Fluvastatin	3	30
Isoniazid	3	30
Polystyrene nanoparticles	13	25
High Fructose Corn Syrup	6	20
Sodium Fluoride	10	19
Chlorpyrifos	8	17
Rosuvastatin	4	17
Concanavalin A	9	16
Perfluorooctanoic acid (PFOA)	4	16
Mercury	6	15
Organophosphate Pesticides	7	13
Fluoroquinolone Antibiotic	2	12
Tylenol	2	12
Acrylamide	6	11
Tamoxifen	2	11
Aluminum	5	10
Aspartame	5	10
Monosodium Glutamate (MSG)	5	10
Paraquat	5	9
Dichloro-diphenyl-trichloroethane (DDT)	4	8
Nanoparticles	4	8
Phthalates	4	8
Tertiary butyl hydroperoxide	7	8
Zinc Oxide	4	8
Benzo(a)pyrene	4	7
Bisphenol S	4	7
Electronic Cigarettes	4	7
Arsenic Trioxide	3	6
Formaldehyde	3	6
Titanium Dioxide	3	6
Titanium Nanoparticles	3	6
Antibiotics	2	4
Arsenite	2	4
Butylated Hydroxytoluene (BHT)	2	4
Cisplatin	2	4
Deltamethrin	2	4
Dichlorvos	2	4
Diclofenac	2	4
Fluoride	2	4
Fluoxetine (trade name Prozac)	2	4
Furan	2	4
Morphine	2	4
N-nitrosodiethylamine	2	4
N-nitrosodimethylamine	2	4
Nano Plastic-and Micro-Particles	3	4
Perfluorooctane sulfonate (PFOS)	2	4
Pyrethroid insecticide	2	4
Rosiglitazone (trade name Avandia)	2	4
Sucralose (aka Splenda)	2	4
Sugar Sweetened Beverages	2	4
2-chlorobenzylidene malononitrile (CS)	1	3
Cerivastatin	1	3
Cholesterol Lowering Drugs	1	3
Fenofibrates	1	3
Quizalofop-P-ethyl	1	3
Triclosan	2	3
Aflatoxin	1	2
Aluminum Chloride	1	2
Benzene	1	2
Bisphenol F	1	2
Brilliant Blue FCF	1	2
Cobalt	1	2
Copper Oxide	1	2
Cyclophosphamide	1	2
Cypermethrin	1	2
Dexamethasone	1	2
Dichlorodiphenyldichloroethylene (DDE)	1	2
Erythrosine	1	2
Ethylene Glycol	1	2
FD&C Red #40	1	2
Food Colorings	1	2
Formaldehyde Releasers	1	2
Fructose	1	2
Glyphosate:Roundup	1	2
Levofloxacin	1	2
Metanil-Yellow Dye	1	2
Methotrexate	1	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2
Ochratoxin A	1	2
Organochlorine pesticides	1	2
Organophosphates	1	2
Ponceau 4R (New Coccine)	1	2
Rotenone	1	2
Selective Serotonin Reuptake Inhibitors (SSRIs)	1	2
Silver	1	2
Sodium Benzoate	1	2
Sucrose	1	2
Tartrazine (Yellow Food Dye)	1	2
Thiazolidinediones	1	2
Toluene	1	2
Zoledronic Acid	1	2
Dimethoate	1	1
Parabens	1	1
Polychlorinated biphenyls (PCBs)	1	1
Zineb	1	1

Name	AC	CK
Exercise	1	2
Exercise: Aerobic	1	2
Exercise: Running	1	2

Name	AC	CK	Focus
Western Diet	1	2

[+]

Prophylactic therapy of milk thistle on anti-tuberculosis drug-induced liver injury.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2013 ;13:58. Epub 2013 Mar 8. PMID: 23497020

Click here to read the entire abstract

Pubmed Data : Chest. 2005 Jul;128(1):116-23. PMID: 16002924

Article Published Date : Jul 01, 2005

Study Type : Human Study

Additional Links

Diseases : Chemically-Induced Liver Damage, Liver Damage: Drug-Induced, Tuberculosis

Additional Keywords : Iatrogenic Disease

Problem Substances : Isoniazid

[+]

Liver failure and damage are rare but severe unintended consequences of statin drug use.Aug 31, 2011

Click here to read the entire abstract

Pubmed Data : J Hepatol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21889469

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Lab Invest. 2015 Aug 24. Epub 2015 Aug 24. PMID: 26302188

Article Published Date : Aug 23, 2015

Study Type : Human In Vitro

Additional Links

Substances : Curcumin

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Hepatoprotective

[+]

Mangiferin could ameliorate methylmercury mediated mitochondrial dysfunction in human hepatic cells in vitro.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : Environ Toxicol. 2017 Feb ;32(2):630-644. Epub 2016 Mar 28. PMID: 28071871

Click here to read the entire abstract

Pubmed Data : Med Clin (Barc). 2002 May 18 ;118(18):717. PMID: 12042141

Article Published Date : May 18, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies

Problem Substances : Cerivastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Acute cholestatic hepatitis induced by fenofibrate has been reported.Oct 01, 2009

Click here to read the entire abstract

Pubmed Data : J Clin Pharm Ther. 2009 Oct;34(5):599-602. PMID: 19744016

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2023 Nov 25 ;28(23). Epub 2023 Nov 25. PMID: 38067501

Click here to read the entire abstract

Pubmed Data : Eur J Gastroenterol Hepatol. 2005 May ;17(5):589-90. PMID: 15827453

Article Published Date : May 01, 2005

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Hepatitis: Autoimmune , Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Rosuvastatin

Adverse Pharmacological Actions : Hepatotoxic

[+]

Simvastatin has been reported to cause cholestatic hepatitis. Apr 01, 1991

Click here to read the entire abstract

Pubmed Data : Recenti Prog Med. 1991 Apr ;82(4):233-5. PMID: 1857844

Click here to read the entire abstract

Pubmed Data : Biol Trace Elem Res. 2023 May 16. Epub 2023 May 16. PMID: 37191759

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Int J Pharm. 2007 Feb 7;330(1-2):155-63. Epub 2006 Sep 23. PMID: 17112692

Article Published Date : Feb 07, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin, Phosphatidylcholine

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

A quantitative study on the protective effects of resveratrol against bisphenol A-induced hepatotoxicity.Apr 30, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Med Sci. 2021 May ;46(3):218-227. PMID: 34083854

Article Published Date : Apr 30, 2021

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Bisphenol Toxicity, Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Bisphenol A

[+]

A standardized pomegranate fruit extract ameliorates thioacetamide-induced liver fibrosis.Feb 28, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Heliyon. 2023 Mar ;9(3):e14256. Epub 2023 Mar 4. PMID: 36938469

Article Published Date : Feb 28, 2023

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

[+]

Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2018 Jan ;54:125-130. Epub 2017 Nov 9. PMID: 29128856

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Chemically-Induced Liver Damage

[+]

Acute exposure to polystyrene nanoparticles promotes liver injury by inducing mitochondrial ROS-dependent necroptosis.Apr 11, 2024

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Part Fibre Toxicol. 2024 Apr 12 ;21(1):20. Epub 2024 Apr 12. PMID: 38610056

Article Published Date : Apr 11, 2024

Study Type : Animal Study

Additional Links

Diseases : Chemically-Induced Liver Damage, Microplastic Toxicity

Problem Substances : Nano Plastic-and Micro-Particles

[+]

Aegle marmelos methanol extract could protect against carbon tetrachloride.Dec 31, 2017

Amelioration of cyclophosphamide-induced DNA damage, oxidative stress, and hepato- and neurotoxicity by Piper longum extract.Dec 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Adv Pharmacol Pharm Sci. 2020 ;2020:2976905. Epub 2020 Jun 24. PMID: 32676584

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Mululuza

Diseases : Chemically-Induced Liver Damage, Heavy Metal Toxicity

Pharmacological Actions : Hepatoprotective

Additional Keywords : Baganda Traditional Medicine

[+]

Ameliorative effects of honey, propolis, pollen, and royal jelly mixture against chronic toxicity of sumithion insecticide.Jun 04, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2020 Jun 5 ;25(11). Epub 2020 Jun 5. PMID: 32517066

Article Published Date : Jun 04, 2020

Study Type : Animal Study

Additional Links

Substances : Bee Pollen, Bee Propolis, Honey, Royal Jelly

Diseases : Chemically-Induced Liver Damage, Kidney Damage, Pesticide Toxicity

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Pesticides

[+]

Ameliorative effects of Moringa oleifera leaf extract on levofloxacin-induced hepatic toxicity.Feb 19, 2019

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Pubmed Data : Drug Chem Toxicol. 2019 Feb 20:1-7. Epub 2019 Feb 20. PMID: 30782023

Problem Substances : Acetaminophen, Paracetamol

[+]

An unexpected role of cholesterol sulfotransferase and its regulation in sensitizing mice to acetaminophen induced liver injury.Apr 02, 2019

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2015 Feb ;18(2):205-11. PMID: 25825639

Antioxidant activity and effectiveness of fig extract in counteracting carbon tetrachloride-induced oxidative damage.Apr 25, 2024

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2024 Apr 26 ;29(9). Epub 2024 Apr 26. PMID: 38731494

Article Published Date : Apr 25, 2024

Study Type : Animal Study

Additional Links

Substances : Fig

Diseases : Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

[+]

Aqueous extracts of Rosa damascene may prevent hepatic damage from acetaminophen induced toxicity in rats.Dec 31, 2011

Click here to read the entire abstract

Pubmed Data : J Environ Pathol Toxicol Oncol. 2012 ;31(3):193-201. PMID: 23339694

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Rose

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Arctium lappa root extract prevents lead-induced liver injury.Nov 23, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2019 Nov 24 ;8(12). Epub 2019 Nov 24. PMID: 31771282

Article Published Date : Nov 23, 2019

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Lead

[+]

Artichoke extract ameliorates carbon tetrachloride-induced liver damage and oxidative stress in rats. Sep 01, 2008

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Pubmed Data : Exp Toxicol Pathol. 2008 Sep;60(6):475-80. Epub 2008 Jun 25. PMID: 18583118

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Artichoke

Diseases : Chemically-Induced Liver Damage

[+]

Artichoke leaf extract has liver protective effects and causes downregulation of oxidative stress in acute diazinon-induced liver injury.Aug 29, 2019

Click here to read the entire abstract

Pubmed Data : J Basic Clin Physiol Pharmacol. 2019 Aug 30 ;30(5). Epub 2019 Aug 30. PMID: 31469651

Article Published Date : Aug 29, 2019

Study Type : Animal Study

Additional Links

Substances : Artichoke

Diseases : Chemically-Induced Liver Damage, Pesticide-Induced Toxicity: Organophosphates

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Organophosphate Pesticides

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Artichoke leaf extract may be used as a pharmaceutical phytomedicine in the treatment of liver diseases.Dec 31, 2015

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Pubmed Data : Springerplus. 2016 ;5:216. Epub 2016 Feb 29. PMID: 27026910

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Pubmed Data : Nutrients. 2016 Jul 21 ;8(7). Epub 2016 Jul 21. PMID: 27455313

Article Published Date : Jul 20, 2016

Study Type : Animal Study

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Substances : Barley

Diseases : Alcohol Toxicity , Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Bees' honey attenuation of metanil-yellow-induced hepatotoxicity in rats.Dec 31, 2012

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Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:614580. Epub 2013 Jun 3. PMID: 23818929

Article Published Date : Dec 31, 2012

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Pubmed Data : Food Chem Toxicol. 2012 Jun ;50(6):2027-33. Epub 2012 Mar 24. PMID: 22465004

Article Published Date : May 31, 2012

Study Type : Animal Study

Additional Links

Substances : Beet

Diseases : Chemically-Induced Liver Damage, DNA damage

Pharmacological Actions : Hepatoprotective

Problem Substances : N-nitrosodiethylamine

Adverse Pharmacological Actions : Hepatotoxic

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Beetroot protects the liver against chemical toxicity.Feb 01, 2006

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

Pubmed Data : Environ Pollut. 2020 Dec 22 ;271:116304. Epub 2020 Dec 22. PMID: 33401208

Article Published Date : Dec 21, 2020

Study Type : Animal Study

Additional Links

Diseases : Bisphenol Toxicity, Chemically-Induced Liver Damage, Nonalcoholic fatty liver disease (NAFLD)

Problem Substances : Bisphenol F

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Bisphenol S induced dysregulations in liver; iron regulatory genes and inflammatory mediators.Jun 29, 2022

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Pubmed Data : Environ Sci Pollut Res Int. 2022 Jun 30. Epub 2022 Jun 30. PMID: 35771333

Article Published Date : Jun 29, 2022

Study Type : Animal Study

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Diseases : Bisphenol Toxicity, Chemically-Induced Liver Damage

Problem Substances : Bisphenol S

[+]

Bitter apple fruit possess significant hepatoprotective and antioxidant activity.Apr 30, 2015

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Pubmed Data : Pak J Pharm Sci. 2015 May ;28(3):951-7. PMID: 26004728

[+]

BPA induced liver fibrosis, which is related to the stimulation of the inflammatory response.Dec 06, 2016

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Pubmed Data : Int J Exp Pathol. 2016 Dec 7. Epub 2016 Dec 7. PMID: 27925325

Article Published Date : Dec 06, 2016

Study Type : Animal Study

Additional Links

Diseases : Bisphenol Toxicity, Chemically-Induced Liver Damage, Inflammation, Liver Fibrosis, Oxidative Stress

Problem Substances : Bisphenol A

[+]

Brazilian green propolis suppresses acetaminophen-induced hepatocellular necrosis.Sep 30, 2018

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Pubmed Data : J Toxicol Pathol. 2018 Oct ;31(4):275-282. Epub 2018 Jul 1. PMID: 30393431

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Propolis: Brazillian

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Brewer's yeast (S. cerevisiae) has a protective effect against chemically-induced liver damage in rats. Jun 01, 2009

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Pubmed Data : Clin Nutr. 2009 Jun;28(3):338-45. Epub 2009 Feb 23. PMID: 19233522

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Yeast

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Broccoli sprout extract protected the liver from various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis.Sep 20, 2015

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:1421438. Epub 2018 May 2. PMID: 29854073

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Pubmed Data : Carbohydr Polym. 2018 Dec 15 ;202:461-469. Epub 2018 Sep 7. PMID: 30287023

Article Published Date : Dec 14, 2018

Study Type : Animal Study

Additional Links

Substances : Pomegranate Peel

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Polysaccharides

[+]

Chickpea extract exhibits a significant hepatoprotective effect against carbon tetrachloride induced liver injury in rats.Dec 31, 2015

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Pubmed Data : Front Pharmacol. 2016 ;7:344. Epub 2016 Sep 28. PMID: 27733831

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Pubmed Data : In Vivo. 2009 Sep-Oct;23(5):747-54. PMID: 19779110

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Pubmed Data : Life Sci. 2021 Mar 31 ;277:119460. Epub 2021 Mar 31. PMID: 33811899

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Chemically-Induced Liver Damage is a Sub of the following Topic

View the Evidence: 1056 Abstracts with Chemically-Induced Liver Damage Research

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Prophylactic therapy of milk thistle on anti-tuberculosis drug-induced liver injury.Dec 31, 2018

The use of statins for LDL suppression is associated with increased risk for cancer.Jul 31, 2007

Association of lifetime exposure to glyphosate and aminomethylphosphonic acid with liver inflammation and metabolic syndrome at young adulthood.Feb 28, 2023

Atorvastatin-induced acute pancreatitis has been reported.Jan 01, 2011

Autoimmune hepatitis associated with atorvastatin use has been reported.Aug 01, 2003

Bisphenol A was detected above the detection limit in all samples in individuals affected by non-alcoholic fatty liver disease.Jun 04, 2017

Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patientsDec 31, 2012

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran Sep 01, 2009

Exposure of children to even low doses of BPA may adversely affect later liver function.Nov 16, 2017

Fermented turmeric powder is well-tolerated and effective in subjects with elevated alanine transaminase levels.Dec 31, 2012

Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study.Aug 12, 2012

Fluvastatin has been linked to adverse hepatic reactions.Jan 01, 2006

Fructose-associated hepatotoxicity indexed by the lactate dehydrogenase isoenzyme LDH-5.Feb 28, 2019

Higher urinary glyphosate exposure is associated with increased risk of liver dysfunction in adults.Oct 18, 2023

Impact of fine particulate matter on liver injury: evidence from human, mice and cells.May 04, 2024

Isoniazid has been associated with grade 3 or 4 liver failure in 1.4%-5.2% of patients being treated for latent tuberculosis infection.Dec 15, 2009

Isoniazid treatment in latent tuberculosis infection may be associated with moderate-to-severe liver damage without symptoms. Jul 01, 2005

Liver failure and damage are rare but severe unintended consequences of statin drug use.Aug 31, 2011

Microplastics cause hepatotoxicity in diabetic mice by disrupting glucolipid metabolism.Jan 31, 2024

More than half of patients who present at the hospital with acetaminophen-induced liver damage or liver failure have undetectable levels of acetaminophen.Feb 04, 2019

Perfluorooctanoic acid has hepatotoxic effects.Jul 31, 2016

Severe liver toxicity requiring discontinuation occurs in 5% of simvastatin-treated patients and 4.5% of pravastatin-treated patients. Jan 01, 1992

Severe, even fatal liver injuries have resulted as a consequence of isoniazid treatment in individuals with latent tuberculosis.Mar 05, 2010

Tamoxifen treatment for breast cancer may result in fatty liver.Nov 01, 2000

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.Jan 01, 2010

Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue.Aug 11, 2019

Chronic exposure to polystyrene microplastics increased the chemosensitivity of normal human liver cells via ABC transporter inhibition.Dec 05, 2023

Curcumin could modulate hepatocyte epithelial-mesenchymal transition implicated in treatment of liver fibrosis.Aug 23, 2015

Mangiferin could ameliorate methylmercury mediated mitochondrial dysfunction in human hepatic cells in vitro.Jan 31, 2017

Procyanidin B2 alleviates palmitic acid-Induced injury in HepG2 cells.Dec 31, 2020

A case of hepatitis caused by simvastatin has been reported. Jan 01, 1991

Acute cholestatic hepatitis associated with atorvastatin use has been reported. Jan 01, 2006

Acute cholestatic hepatitis associated with pravastatin has been reported. May 01, 1999

Acute cholestatic hepatitis induced by cerivastatin has been reported. May 18, 2002

Acute cholestatic hepatitis induced by fenofibrate has been reported.Oct 01, 2009

Acute exposure to CS tear gas has been reported to cause several health problems in an individual.Dec 26, 1981

Acute hepatitis induced by lovastatin has been reported. Sep 01, 1994

Arctium lappa L. root polysaccharides ameliorate CCl4-induced acute liver injury.Oct 21, 2023

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury. Jul 01, 2008

Atorvastatin-induced cholestatic hepatitis in a young woman with systemic lupus erythematosus has been reported.Aug 09, 1999

Cholestatic jaundice induced by atorvastatin has been observed. Jul 01, 2009

Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury.May 16, 2022

Hepatitis associated with treatment with lovastatin has been reported. Mar 01, 1998

Liver fibrosis has been attributed to lipid lowering medications.Sep 01, 2001

Lovastatin monotherapy has been reported to have been a cause of rhabdomyolysis, acute renal failure and hepatopathy.Jul 01, 1997

Mixed cholestatic/hepatocellular liver injury induced by the herbicide quizalofop-p-ethyl has been reported. Oct 01, 2007

Multi-omics approach characterizes the role of Bisphenol F in disrupting hepatic lipid metabolism.Apr 30, 2024

Protective effect of baicalin on bhlorpyrifos-induced liver injury and its mechanism.Nov 24, 2023

Reversible acute hepatitis induced by rosuvastatin has been reported.Jul 01, 2008

Rosmarinic acid exerts anti-inflammatory effect and relieves oxidative stress via Nrf2 activation in carbon tetrachloride-induced liver damage.Dec 31, 2021

Rosuvastatin-associated hepatitis with autoimmune features has been reported. May 01, 2005

Simvastatin has been reported to cause cholestatic hepatitis. Apr 01, 1991

Simvastatin has been reported to cause liver lesions.Apr 13, 1996

Virgin coconut oil complements with its polyphenol components mitigate sodium fluoride toxicity in vitro and in vivo.Aug 17, 2021

Alleviative effect of lactoferrin interventions against the hepatotoxicity induced by titanium dioxide nanoparticles.May 15, 2023

The protective effect of chrysin against carbon tetrachloride-induced kidney and liver tissue damage.Apr 29, 2020

"Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury."Oct 01, 2012

"Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats."Oct 01, 2006

6-gingerol, a major ingredient of ginger attenuates diethylnitrosamine-induced liver injury.Dec 31, 2020

6-Shogaol alleviates CCl4-induced liver fibrosis by attenuating inflammatory response.Apr 27, 2022

A comparative study on the hepatoprotective effect of selenium-nanoparticles and dates flesh extract on carbon tetrachloride induced liver damage.Sep 11, 2023

A curcumin-phospholipid complex works synergistically to protect the livers of rats following chemical exposure. Feb 07, 2007

A quantitative study on the protective effects of resveratrol against bisphenol A-induced hepatotoxicity.Apr 30, 2021

A standardized pomegranate fruit extract ameliorates thioacetamide-induced liver fibrosis.Feb 28, 2023

A water extract of the leaves of Z. jujuba is efficacious for prevention and treatment of carbon tetrachloride induced hepatic injury in mice.Feb 21, 2017

A. cerana honey can prevent bromobenzene-induced hepatic damage in mice. Jan 15, 2018

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

A. marmelos attenuates carbon tetrachloride-mediated hepatic oxidative stress, toxicity, tumor promotion.Mar 31, 2009

A. sessilis has hepatoprotective activity against carbon tetrachloride liver damage.Mar 31, 2018

Acacia catechu extract affords hepato-protection against DMBA in rats through modulation of phase I, II and anti-oxidative enzymes.Dec 31, 2013

Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.Dec 31, 2017

Acute exposure to polystyrene nanoparticles promotes liver injury by inducing mitochondrial ROS-dependent necroptosis.Apr 11, 2024

Chemically-Induced Liver Damage

View the Evidence:
1056 Abstracts with Chemically-Induced Liver Damage Research